Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues

Journal of Steroid Biochemistry and Molecular Biology

Volumn 65, Issue 1-6, 1998, Pages 301-310

  Bélanger, Alain ^a   Hum, Dean W ^a   Beaulieu, Martin ^a   Lévesque, Éric ^a   Guillemette, Chantal ^a   Tchernof, André ^a   Bélanger, Guy ^a   Turgeon, David ^a   Dubois, Stéphanie ^a  

^a LAVAL UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ANDROSTANEDIOL; ANDROSTANOLONE; COMPLEMENTARY DNA; EPIDERMAL GROWTH FACTOR; GLUCURONIDE; GLUCURONOSYLTRANSFERASE; METRIBOLONE;

CHROMOSOME 4Q; CONFERENCE PAPER; ENZYME REGULATION; FEMALE; GENE MAPPING; GLUCURONIDATION; HORMONAL REGULATION; HORMONE RESPONSE; HUMAN; HUMAN CELL; HUMAN TISSUE; MALE; STEROID METABOLISM; TISSUE DISTRIBUTION;

AMINO ACID SEQUENCE; ANDROGENS; CHROMOSOMES, HUMAN, PAIR 4; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCURONOSYLTRANSFERASE; HUMANS; ISOENZYMES; MALE; MOLECULAR SEQUENCE DATA; PROSTATIC NEOPLASMS;

VERTEBRATA;

EID: 0032052827     PISSN: 09600760     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-0760(97)00183-0     Document Type: Conference Paper

References (19)

1. Clarke D. J. and Burchell B. The uridine diphosphate glucuronosyltransferase multigene family: Function and regulation. In Handb. Exp. Pharm. ed. Frederic, C. K., F. C., 1994, 112 3-43.
2. Tephly T. R., Green M., Puig J., Irshaid Y. Endogenous substrates for UDP-glucuronosyltransferases. Xenobiotica. 18:1988;1201-1210.
3. Mauvais-Jarvis P., Charransol G., Bobas-Masson F. B. Simultaneous determination of urinary androstanediol and testosterone as an evaluation of human androgenicity. J. Clin. Endocrinol. Metab. 36:1973;452-459.
4. Morimoto I., Edmiston A., Hawks D., Horton R. Studies on the origin of androstanediol and androstanediol glucuronide in young and elderly men. J. Clin. Endocrinol. Metab. 52:1981;772-778.
5. Moghissi E., Ablan F., Horton R. Origin of plasma androstanediol glucuronide in men. J. Clin. Endocrinol. Metab. 59:1984;417-421.
6. Brochu M., Bélanger A. Increase in plasma steroid glucuronide levels in men from infancy to adulthood. J. Clin. Endocrinol. Metab. 64:1987;1283-1287.
7. Bélanger A., Brochu M., Lacoste D., Noel C., Labrie F., Dupont A., Cusan L., Caron S., Couture J. Steroid glucuronides: Human circulatory levels and formation by LNCaP cells. J. Steroid Biochem. Mol. Biol. 40:1991;593-598.
8. Bélanger A., Brochu M., Cliche J. Levels of plasma steroid glucuronides in intact and castrated men with prostatic cancer. J. Clin. Endocrinol. Metab. 62:1986;812-815.
9. Brochu M., Bélanger A., Tremblay R. R. Plasma levels of C-19 steroids and 5 alpha-reduced steroid glucuronides in hyperandrogenic and idiopathic hirsute women. Fertil. Steril. 48:1987;948-953.
10. Pang S., MacGillivray M., Wang M., Jeffries S., Clark A., Rosenthal I., Wiegensberg M., Riddick L. 3 Alpha-androstanediol glucuronide in virilizing congenital adrenal hyperplasia: A useful serum metabolic marker of integrated adrenal androgen secretion. J. Clin. Endocrinol. Metab. 73:1991;166-174.
11. Dutton G. J. Developmental aspects of drug conjugation, with special reference to glucuronidation. Annu. Rev. Pharmacol. Toxicol. 18:1978;17-35.
12. Labrie F. Intracrinology. Mol. Cell. Endocrinol. 78:1991;C113-C118.
13. Guillemette C., Bélanger A. Glucuronosyltransferase activity in human cancer cell line LNCaP. Mol. Cell. Endocrinol. 107:1995;131-139.
14. Chen F., Ritter J. K., Wang M. G., Mcbride O. W., Lubet R. A., Owens I. S. Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms. Biochemistry. 32:1993;10648-10657.
15. Beaulieu M., Lévesque E., Hum D. W., Bélanger A. Isolation and characterization of a novel cDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids. J. Biol. Chem. 271:1996;22855-22862.
16. Durocher F., Morissette J., Dufort I., Simard J., Luu-The V. Genetic linkage mapping of the dehydroepiandrosterone sulfotransferase (STD) gene on the chromosome 19q13.3 region. Genomics. 29:1995;781-783.
17. Durocher F., Morissette J., Labrie Y., Labrie F., Simard J. Mapping of the HSD17B2 gene encoding type II 17beta-hydroxysteroid dehydrogenase close to D16S422 on chromosome 16q24.1-q24.2. Genomics. 25:1994;724-726.
18. Green M., Oturu E. M., Tephly T. R. Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. Drug Metab. Disp. 22:1994;799-805.
19. Bélanger A., Couture J., Caron S., Roy R. Determination of non-conjugated and conjugated steroid levels in plasma and prostate after separation on C-18 columns. Ann. N.Y. Acad. Sci. 595:1990;251-259.