메뉴 건너뛰기




Volumn 18, Issue 8, 2008, Pages 683-697

Single nucleotide polymorphism discovery and functional assessment of variation in the UDP-glucuronosyltransferase 2B7 gene

Author keywords

Haplotype; Pharmacogenetics; Single nucleotide polymorphism; Splicing variant; UDP glucuronosyltransferase 2B7

Indexed keywords

GLUCURONOSYLTRANSFERASE 2B7; MESSENGER RNA; MORPHINE 3 GLUCURONIDE; EPIRUBICIN; GLUCURONOSYLTRANSFERASE; MORPHINE 6 GLUCURONIDE; MORPHINE DERIVATIVE; MORPHINE-3-GLUCURONIDE; MORPHINE-6-GLUCURONIDE; UDP GLUCURONOSYLTRANSFERASE, UGT2B7; UDP-GLUCURONOSYLTRANSFERASE, UGT2B7;

EID: 55749107288     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e3283037fe4     Document Type: Article
Times cited : (82)

References (30)
  • 2
    • 34247618754 scopus 로고    scopus 로고
    • Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7
    • Miley MJ, Zielinska AK, Keenan JE, Bratton SM, Radominska-Pandya A, Redinbo MR. Crystal structure of the cofactor-binding domain of the human phase II drug-metabolism enzyme UDP-glucuronosyltransferase 2B7. J Mol Biol 2007; 369:498-511.
    • (2007) J Mol Biol , vol.369 , pp. 498-511
    • Miley, M.J.1    Zielinska, A.K.2    Keenan, J.E.3    Bratton, S.M.4    Radominska-Pandya, A.5    Redinbo, M.R.6
  • 4
    • 19344362807 scopus 로고    scopus 로고
    • Opioid metabolites
    • Review
    • Lotsch J. Opioid metabolites. J Pain Symptom Manage 2005; 29 (Suppl):S10-S24. Review.
    • (2005) J Pain Symptom Manage , vol.29 , Issue.SUPPL.
    • Lotsch, J.1
  • 6
    • 0027433317 scopus 로고
    • Complementary deoxyribonucleic acid cloning and expression of a human liver urine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs
    • Jin C, Miners JO, Lillywhite KJ, Mackenzie PI. Complementary deoxyribonucleic acid cloning and expression of a human liver urine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs. J Pharmacol Exp Ther 1993; 264:475-479.
    • (1993) J Pharmacol Exp Ther , vol.264 , pp. 475-479
    • Jin, C.1    Miners, J.O.2    Lillywhite, K.J.3    Mackenzie, P.I.4
  • 7
    • 0031894377 scopus 로고    scopus 로고
    • The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268)
    • Coffman BL, King CD, Rios GR, Tephly TR. The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268). Drug Metab Dispos 1998; 26:73-77.
    • (1998) Drug Metab Dispos , vol.26 , pp. 73-77
    • Coffman, B.L.1    King, C.D.2    Rios, G.R.3    Tephly, T.R.4
  • 8
    • 0035029212 scopus 로고    scopus 로고
    • Epirubicin glucuronidation is catalyzed by human UDP-glucuronosyltransferase 2B7
    • Innocenti F, Iyer L, Ramirez J, Green MD, Ratain MJ. Epirubicin glucuronidation is catalyzed by human UDP-glucuronosyltransferase 2B7. Drug Metab Dispos 2001; 29:686-692.
    • (2001) Drug Metab Dispos , vol.29 , pp. 686-692
    • Innocenti, F.1    Iyer, L.2    Ramirez, J.3    Green, M.D.4    Ratain, M.J.5
  • 9
    • 0033645752 scopus 로고    scopus 로고
    • Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: Ethnic diversity of alleles and potential clinical significance
    • Bhasker CR, McKinnon W, Stone A, Lo AC, Kubota T, Ishizaki T, et al. Genetic polymorphism of UDP-glucuronosyltransferase 2B7 (UGT2B7) at amino acid 268: ethnic diversity of alleles and potential clinical significance. Pharmacogenetics 2000; 10:679-685.
    • (2000) Pharmacogenetics , vol.10 , pp. 679-685
    • Bhasker, C.R.1    McKinnon, W.2    Stone, A.3    Lo, A.C.4    Kubota, T.5    Ishizaki, T.6
  • 10
    • 0038209379 scopus 로고    scopus 로고
    • A pharmacogenetic study of uridine diphosphate- glucuronosyltransferase 2B7 in patients receiving morphine
    • Sawyer MB, Innocenti F, Das S, Cheng C, Ramirez J, Pantle-Fisher FH, et al. A pharmacogenetic study of uridine diphosphate- glucuronosyltransferase 2B7 in patients receiving morphine. Clin Pharmacol Ther 2003; 73:566-574.
    • (2003) Clin Pharmacol Ther , vol.73 , pp. 566-574
    • Sawyer, M.B.1    Innocenti, F.2    Das, S.3    Cheng, C.4    Ramirez, J.5    Pantle-Fisher, F.H.6
  • 11
    • 0037251316 scopus 로고    scopus 로고
    • Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: Identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients
    • Holthe M, Rakvag TN, Klepstad P, Idle JR, Kaasa S, Krokan HE, et al. Sequence variations in the UDP-glucuronosyltransferase 2B7 (UGT2B7) gene: identification of 10 novel single nucleotide polymorphisms (SNPs) and analysis of their relevance to morphine glucuronidation in cancer patients. Pharmacogenomics J 2003; 3:17-26.
    • (2003) Pharmacogenomics J , vol.3 , pp. 17-26
    • Holthe, M.1    Rakvag, T.N.2    Klepstad, P.3    Idle, J.R.4    Kaasa, S.5    Krokan, H.E.6
  • 12
    • 27144529586 scopus 로고    scopus 로고
    • Clinical response to morphine in cancer patients and genetic variation in candidate genes
    • Ross JR, Rutter D, Welsh K, Joel SP, Goller K, Wells AU, et al. Clinical response to morphine in cancer patients and genetic variation in candidate genes. Pharmacogenomics J 2005; 5:324-336.
    • (2005) Pharmacogenomics J , vol.5 , pp. 324-336
    • Ross, J.R.1    Rutter, D.2    Welsh, K.3    Joel, S.P.4    Goller, K.5    Wells, A.U.6
  • 13
    • 1542286160 scopus 로고    scopus 로고
    • A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity
    • Duguay Y, Baar C, Skorpen F, Guillemette C. A novel functional polymorphism in the uridine diphosphate-glucuronosyltransferase 2B7 promoter with significant impact on promoter activity. Clin Pharmacol Ther 2004; 75:223-233.
    • (2004) Clin Pharmacol Ther , vol.75 , pp. 223-233
    • Duguay, Y.1    Baar, C.2    Skorpen, F.3    Guillemette, C.4
  • 15
    • 39749110077 scopus 로고    scopus 로고
    • UGT2B7 promoter variant -840G > A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease
    • Darbari DS, van Schaik RH, Capparelli EV, Rana S, McCarter R, van den Anker J. UGT2B7 promoter variant -840G > A contributes to the variability in hepatic clearance of morphine in patients with sickle cell disease. Am J Hematol 2008; 83:200-202.
    • (2008) Am J Hematol , vol.83 , pp. 200-202
    • Darbari, D.S.1    van Schaik, R.H.2    Capparelli, E.V.3    Rana, S.4    McCarter, R.5    van den Anker, J.6
  • 16
    • 0035799361 scopus 로고    scopus 로고
    • Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase
    • Levesque E, Turgeon D, Carrier JS, Montminy V, Beaulieu M, Belanger A. Isolation and characterization of the UGT2B28 cDNA encoding a novel human steroid conjugating UDP-glucuronosyltransferase. Biochemistry 2001; 40:3869-3881.
    • (2001) Biochemistry , vol.40 , pp. 3869-3881
    • Levesque, E.1    Turgeon, D.2    Carrier, J.S.3    Montminy, V.4    Beaulieu, M.5    Belanger, A.6
  • 17
    • 33846442350 scopus 로고    scopus 로고
    • Regulation of UGT1A1 bilirubin-conjugating pathway: Role of a new splicing event at the UGT1A locus
    • Levesque E, Girard H, Journault K, Lepine J, Guillemette C. Regulation of UGT1A1 bilirubin-conjugating pathway: role of a new splicing event at the UGT1A locus. Hepatology 2007; 45:128-138.
    • (2007) Hepatology , vol.45 , pp. 128-138
    • Levesque, E.1    Girard, H.2    Journault, K.3    Lepine, J.4    Guillemette, C.5
  • 18
    • 0346373654 scopus 로고    scopus 로고
    • Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium
    • Carlson CS, Eberle MA, Rieder MJ, Yi Q, Kruglyak L, Nickerson DA. Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium. Am J Hum Genet 2004; 74:106-120.
    • (2004) Am J Hum Genet , vol.74 , pp. 106-120
    • Carlson, C.S.1    Eberle, M.A.2    Rieder, M.J.3    Yi, Q.4    Kruglyak, L.5    Nickerson, D.A.6
  • 20
    • 24944433166 scopus 로고    scopus 로고
    • Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes
    • Wang J, Smith PJ, Krainer AR, Zhang MQ. Distribution of SR protein exonic splicing enhancer motifs in human protein-coding genes. Nucleic Acids Res 2005; 33:5053-5062.
    • (2005) Nucleic Acids Res , vol.33 , pp. 5053-5062
    • Wang, J.1    Smith, P.J.2    Krainer, A.R.3    Zhang, M.Q.4
  • 21
    • 33644958925 scopus 로고    scopus 로고
    • Haplotype analysis of UDP-glucuronocyltransferase 2B7 gene (UGT2B7) polymorphisms in healthy Japanese subjects
    • Saito K, Moriya H, Sawaguchi T, Hayakawa T, Nakahara S, Goto A, et al. Haplotype analysis of UDP-glucuronocyltransferase 2B7 gene (UGT2B7) polymorphisms in healthy Japanese subjects. Clin Biochem 2006; 39:303-308.
    • (2006) Clin Biochem , vol.39 , pp. 303-308
    • Saito, K.1    Moriya, H.2    Sawaguchi, T.3    Hayakawa, T.4    Nakahara, S.5    Goto, A.6
  • 22
    • 33845888817 scopus 로고    scopus 로고
    • Prevalence of UGT1A9 and UGT2B7 nonsynonymous single nucleotide polymorphisms in West African, Papua New Guinean, and North American populations
    • Mehlotra RK, Bockarie MJ, Zimmerman PA. Prevalence of UGT1A9 and UGT2B7 nonsynonymous single nucleotide polymorphisms in West African, Papua New Guinean, and North American populations. Eur J Clin Pharmacol 2007; 63:1-8.
    • (2007) Eur J Clin Pharmacol , vol.63 , pp. 1-8
    • Mehlotra, R.K.1    Bockarie, M.J.2    Zimmerman, P.A.3
  • 23
    • 0034118356 scopus 로고    scopus 로고
    • Prevalence of polymorphisms in the human UDP-glucuronosyltransferase 2B family: UGT2B4(D458E), UGT2B7(H268Y), and UGT2B15(D85Y)
    • Lampe JW, Bigler J, Bush AC, Potter JD. Prevalence of polymorphisms in the human UDP-glucuronosyltransferase 2B family: UGT2B4(D458E), UGT2B7(H268Y), and UGT2B15(D85Y). Cancer Epidemiol Biomarkers Prev 2000; 9:329-333.
    • (2000) Cancer Epidemiol Biomarkers Prev , vol.9 , pp. 329-333
    • Lampe, J.W.1    Bigler, J.2    Bush, A.C.3    Potter, J.D.4
  • 24
    • 0343249383 scopus 로고    scopus 로고
    • Munzel PA, Schmohl S, Heel H, Kalberer K, Bock-Hennig BS, Bock KW. Induction of human UDP glucuronosyltransferases (UGT1A6, UGT1A9, and UGT2B7) by t-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin in Caco-2 cells. Drug Metab Dispos 1999; 27:569-573.
    • Munzel PA, Schmohl S, Heel H, Kalberer K, Bock-Hennig BS, Bock KW. Induction of human UDP glucuronosyltransferases (UGT1A6, UGT1A9, and UGT2B7) by t-butylhydroquinone and 2,3,7,8-tetrachlorodibenzo-p-dioxin in Caco-2 cells. Drug Metab Dispos 1999; 27:569-573.
  • 25
    • 0033840250 scopus 로고    scopus 로고
    • Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2
    • Walle T, Otake Y, Galijatovic A, Ritter JK, Walle UK. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2. Drug Metab Dispos 2000; 28:1077-1082.
    • (2000) Drug Metab Dispos , vol.28 , pp. 1077-1082
    • Walle, T.1    Otake, Y.2    Galijatovic, A.3    Ritter, J.K.4    Walle, U.K.5
  • 26
    • 0034595791 scopus 로고    scopus 로고
    • Nonsteroidal anti-inflammatory drugs and phenols glucuronidation in Caco-2 cells: Identification of the UDP-glucuronosyltransferases UGT1A6, 1A3 and 2B7
    • Sabolovic N, Magdalou J, Netter P, Abid A. Nonsteroidal anti-inflammatory drugs and phenols glucuronidation in Caco-2 cells: identification of the UDP-glucuronosyltransferases UGT1A6, 1A3 and 2B7. Life Sci 2000; 67:185-189.
    • (2000) Life Sci , vol.67 , pp. 185-189
    • Sabolovic, N.1    Magdalou, J.2    Netter, P.3    Abid, A.4
  • 27
    • 0030889553 scopus 로고    scopus 로고
    • Arginine 52 and histidine 54 located in a conserved amino-terminal hydrophobic region (LX2-R52-G-H54-X3-V-L) are important amino acids for the functional and structural integrity of the human liver UDP- glucuronosyltransferase UGT1*6
    • Senay C, Ouzzine M, Battaglia E, Pless D, Cano V, Burchell B, et al. Arginine 52 and histidine 54 located in a conserved amino-terminal hydrophobic region (LX2-R52-G-H54-X3-V-L) are important amino acids for the functional and structural integrity of the human liver UDP- glucuronosyltransferase UGT1*6. Mol Pharmacol 1997; 51:406-413.
    • (1997) Mol Pharmacol , vol.51 , pp. 406-413
    • Senay, C.1    Ouzzine, M.2    Battaglia, E.3    Pless, D.4    Cano, V.5    Burchell, B.6
  • 28
    • 0030846868 scopus 로고    scopus 로고
    • UDP-glucuronosyltransferase, the role of the amino terminus in dimerization
    • Meech R, Mackenzie PI. UDP-glucuronosyltransferase, the role of the amino terminus in dimerization. J Biol Chem 1997; 272:26913-26917.
    • (1997) J Biol Chem , vol.272 , pp. 26913-26917
    • Meech, R.1    Mackenzie, P.I.2
  • 29
    • 0034990314 scopus 로고    scopus 로고
    • Analysis of opioid binding to UDP-glucuronosyltransferase 2B7 fusion proteins using nuclear magnetic resonance spectroscopy
    • Coffman BL, Kearney WR, Green MD, Lowery RG, Tephly TR. Analysis of opioid binding to UDP-glucuronosyltransferase 2B7 fusion proteins using nuclear magnetic resonance spectroscopy. Mol Pharmacol 2001; 59:1464-1469.
    • (2001) Mol Pharmacol , vol.59 , pp. 1464-1469
    • Coffman, B.L.1    Kearney, W.R.2    Green, M.D.3    Lowery, R.G.4    Tephly, T.R.5
  • 30
    • 0031010059 scopus 로고    scopus 로고
    • Protein-protein interactions between UDP-glucuronosyltransferase isozymes in rat hepatic microsomes
    • Ikushiro S, Emi Y, Iyanagi T. Protein-protein interactions between UDP-glucuronosyltransferase isozymes in rat hepatic microsomes. Biochemistry 1997; 6:7154-7161.
    • (1997) Biochemistry , vol.6 , pp. 7154-7161
    • Ikushiro, S.1    Emi, Y.2    Iyanagi, T.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.