Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract

Molecular Pharmacology

Volumn 59, Issue 3, 2001, Pages 405-414

  Tukey, Robert H ^a   Strassburg, Christian P ^b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCURONOSYLTRANSFERASE;

CATALYSIS; CELL COMPARTMENTALIZATION; ENDOPLASMIC RETICULUM; ENZYME REGULATION; ENZYME SUBSTRATE; FIRST PASS EFFECT; GASTROINTESTINAL TRACT; GENETIC ANALYSIS; GLUCURONIDATION; HUMAN; HUMAN TISSUE; INTESTINE ABSORPTION; METABOLIC ACTIVATION; MULTIGENE FAMILY; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; SHORT SURVEY;

EID: 0035115599     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: 10.1124/mol.59.3.405     Document Type: Short Survey

References (80)

1. Cloning and characterization of a simian UDP-glucuronosyltransferase enzyme UGT2B20, a novel C19 steroid-conjugating protein
2. UGT2B23, a novel uridine diphosphate-glucuronosyltransferase enzyme expressed in steroid target tissues that conjugates androgen and estrogen metabolites
3. Isolation and characterization of a simian UDP-glucuronosyltransferase UGT2B18 active on 3-hydroxyandrogens
4. Isolation and characterization of a novel CDNA encoding a human UDP-glucuronosyltransferase active on C19 steroids
5. Isolation and characterization of a human orphan UDP-glucuronosyltransferase, UGT2B11
6. Chromosomal localization, structure, and regulation of the UGT2B17 gene, encoding a C19 steroid metabolizing enzyme
7. Characterization and regulation of UDP-glucuronosyltransferases in steroid target tissues
8. Expression and characterization of a novel UDP-glucuronosyltransferase. UGT2B9, from cynomolgus monkey
9. Duodenal biopsies for xenobiotic metabolism studies in human individuals. Identification of bilirubin UDP-GTs in the human alimentary, tract in accordance with the gut as a putative metabolic organ
10. The genetic basis of the reduced expression of bilirubin UDP-glucuronosyltransferase 1 in Gilbert's syndrome
11. Bilirubin UDP-glucuronosyltransferase 1 is the only relevant bilirubin glucuronidating isoform in man
12. Isolation and characterization of the human UGT2B7 gene
13. Characterization of a cloned human dihydrotestosterone/androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms
14. Cloning and expression of human UDP-glucuronosyltransferase (UGT) 1A8
15. Genetic polymorphism in the human UGT1A6 (planar phenol) UDP-glucuronosyltransferase: Pharmacological implications
16. The glucuronidation of opioids, other xenobiotics, and androgens by human UGT2B7Y(268) and UGT2B7H(268)
17. Characterization and primary sequence of a human hepatic microsomal estriol UDP-glucuronosyltransferase
18. Molecular basis of polymorphic drug metabolism
19. Commentary: Control of UDP-glucuronyltransferase activity
20. Developmental aspects of drug conjugation, with special reference to glucuronidation
21. The isolation of a compound of uridine diphosphate and glucuronic acid from liver
22. The molecular biology of cytochrome P450s
23. Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells
24. Chromosomal mapping of a human phenol UDP-glucuronosyltransferase, GNT1
25. Molecular basis of multiple UDP-glucuronosyltransferase isoenzyme deficiencies in the hyperbilirubinemic rat (Gunn rat)
26. Cloning and characterization of CDNA encoding 3-methylcholanthrene inducible rat MRNA for UDP-glucuronosyltransferase
27. The 3-methylcholanthrene-inducible UDP-glucuronosyltransferase deficiency in the hyperbilirubinemic rat (Gunn rat) is caused by a -1 frameshift mutation
28. Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA
29. Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase
30. cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily
31. Complementary deoxyribonucleic acid cloning and expression of a human liver uridine diphosphate-glucuronosyltransferase glucuronidating carboxylic acid-containing drugs
32. Conserved domains of glycosyltransferases
33. CYP3A Gene expression in human gut epithelium
34. Identification of rifampin-inducible P450IIIA4 (CYP3A4) in human small bowel enterocytes
35. Localization and genomic organization of a new hepatocellular organic anion transporting polypeptide
36. Conjugate export pumps of the multidrug resistance protein (MRP) family: Localization, substrate specificity, and MRP2-mediated drug resistance
37. Hepatobiliary transport
38. UDP-glucuronosyltransferase (UGT1Al*28 and UGT1A6*2) polymorphisms in Caucasians and Asians: Relationships to serum bilirubin concentrations
39. Isolation and characterization of UGT2B15(Y85): A UDP- glucuronosyltransferase encoded by a polymorphic gene
40. Characterization and substrate specificity of UGT2B4 (E458): A UDP-glucuronosyltransferase encoded by a polymorphic gene
41. Characterization of the UDP-glucuronosyltransferase 1A locus in lagomorphs: Evidence for duplication of the UGT1A6 gene
42. Expression and functional domains of rabbit liver UDP-glucuronosyltransferase 2B16 and 2B13
43. Expression of chimeric cDNAs in cell culture defines a region of UDP glucuronosyltransferase involved in substrate selection
44. The UDP glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence
45. Hepatic and extrahepatic glucuronidation of bile acids in man. Characterization of bile acid uridine 5′-diphosphate-glucuronosyltransferase in hepatic, renal, and intestinal microsomes
46. Identification of bilirubin UDP-GTs in the human alimentary tract in accordance with the gut as a putative metabolic organ
47. Structure and function of uridine diphosphate glucuronosyltransferases
48. Determinants of UDP glucuronosyltransferase membrane association and residency in the endoplasmic reticulum
49. Molecular mechanisms of genetic polymorphisms of drug metabolism
50. cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3
51. Characterization of two UDP-glucuronosyltransferases that are predominantly expressed in human colon
52. Structure of the human UGT2B4 gene encoding a bile acid UDP-glucuronosyltransferase
53. Isolation of a human YAC contig encompassing a cluster of UGT2 genes and its regional localization to chromosome 4q13
54. Genetic variation in bilirubin UDP-glucuronosyltransferase gene promoter and Gilbert's syndrome
55. Tissue distribution of drug-metabolizing enzymes in humans
56. Glucuronodation of 1-napthol in nuclear and microsomal fractions of the human intestine
57. Effective glucuronidation of 6 alpha-hydroxylated bile acids by human hepatic and renal microsomes
58. Immunocharacterization of UDP-glucuronyltransferase isoenzymes in human liver, intestine and kidney
59. Biotransformation enzymes in human intestine: Critical low levels in the colon?
60. UDP-glucuronosyltransferases in human intestinal mucosa
61. Two human liver cDNAs encode UDP-glucuronosyltransferases with 2 log differences in activity toward parallel substrates including hyodeoxycholic acid and certain estrogen derivatives
62. A novel complex locus UGT1 encodes human bilirubin, phenol and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini
63. Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAS with expression in COS-1 cells
64. Expression and inducibility of the human bilirubin UDP-glucuronosyltransferase UGT1A1 in liver and cultured primary hepatecytes: Evidence for both genetic and environmental influences
65. Cloning and expression of human liver UDP-glucuronosyltransferase in COS-1 cells. 3,4-Catechol estrogens and estriol as primary substrates
66. A phenylalanine codon deletion at the UGT1 gene complex locus of a Crigler-Najjar type i patient generates a pH-sensitive bilirubin UDP-glucuronosyltransferase
67. Polymorphic gene expression and interindividual variation of udp-glucuronosyltransferase activity in human small intestine
68. Differential down regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer
69. Expression of the UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8
70. Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium
71. UDP-glucuronosyltransferase activity in human liver and colon
72. Differential expression of the UGT1A locus in human liver, biliary and gastric tissue. Identification of UGT1A7 and UGT1A10 transcripts in extrahepatic tissue
73. Regulation and function of family 1 and family 2 UDP- glucuronosyltransferase genes (UGT1A, UGT2B) in human oesophagus
74. Characterization of a human bilirubin UDP-glucuronosyltransferase stably expressed in hamster lung fibroblast cell cultures
75. Human UDP-glucuronosyltransferases metabolism, expression, and disease
76. Isolation and characterization of the human UGT2B15 gene, localized within a cluster of UGT2B genes and pseudogenes on chromosome 4
77. A new method for predicting signal sequence cleavage sites
78. Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line Hep G2
79. Cloning and stable expression of a new member of the human liver phenol/ bilirubin: UDP-glucuronosyltransferase cDNA family