Thirteen UDPglucuronosyltransferase genes are encoded at the human UGT1 gene complex locus

Pharmacogenetics

Volumn 11, Issue 4, 2001, Pages 357-368

  Gong, Q H ^a   Cho, J W ^a   Huang, T ^a   Potter, C ^a   Gholami, N ^a   Basu, N K ^a   Kubota, S ^a   Carvalho, S ^a   Pennington, M W ^a   Owens, I S ^a   Popescu, N C ^a  

^a NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Exons 1; Human UGT1 locus; UDP glucuronosyltransferases

Indexed keywords

GLUCURONOSYLTRANSFERASE; ISOENZYME; MESSENGER RNA; URIDINE DIPHOSPHATE GLUCURONIC ACID;

AMINO ACID SEQUENCE; AMINO TERMINAL SEQUENCE; ARTICLE; CARBOXY TERMINAL SEQUENCE; EXON; GENE EXPRESSION; GENE LOCUS; GENETIC ANALYSIS; HUMAN; LIVER; PRIORITY JOURNAL; RNA SPLICING; TATA BOX; TISSUE DISTRIBUTION;

BASE SEQUENCE; CHROMOSOMES, ARTIFICIAL, BACTERIAL; CLONING, MOLECULAR; COSMIDS; DNA PRIMERS; EXONS; GENE LIBRARY; GLUCURONOSYLTRANSFERASE; HUMANS; ISOENZYMES; LIVER; MOLECULAR SEQUENCE DATA; MULTIGENE FAMILY; PSEUDOGENES; RNA CAPS; RNA SPLICING; RNA, MESSENGER; SEQUENCE DELETION; SEQUENCE HOMOLOGY, NUCLEIC ACID; TATA BOX;

EID: 0034966656     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200106000-00011     Document Type: Article

References (11)

1. Altered coding for a strictly conserved di-glycine in the major bilirubin UDPglucuronosyltransferase of a Crigler-Najjar Type I patient
2. Congenital familial non-hemolytic jaundice with kernicterus
3. Enhanced acetaminophen toxicity in rats with bilirubin glucuronosyltransferase deficiency
4. Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-1 cells
5. The UDP-glycosyltransferase gene superfamily: Recommended nomenclature update based on evolutionary divergence
6. Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells
7. A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDPglucuronosyltransferase isozymes with identical carboxyl termini
8. Identification of a genetic alteration in the code for bilirubin UDP-glucuronosyltransferase in the UGT1 gene complex of a Crigler-Najjar type I patient
9. Immunochemical analysis of uridine diphosphate-glucuronosyltransferase in four patients with the Crigler Najjar Syndrome type I
10. Cloning and stable expression of a new member of the human liver phenol/bilirubin-UDP-glucuronosyltransferase cDNA family