Polymorphic expression of the UDP-glucuronosyltransferase UGT1A gene locus in human gastric epithelium

Molecular Pharmacology

Volumn 54, Issue 4, 1998, Pages 647-654

  Strassburg, Christian P ^a   Nguyen, Nghia ^a   Manns, Michael P ^b   Tukey, Robert H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HANNOVER MEDICAL SCHOOL   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; CARCINOGEN; GLUCURONOSYLTRANSFERASE;

ADULT; AGED; ARTICLE; DNA POLYMORPHISM; DNA SYNTHESIS; DRUG METABOLISM; ENZYME ACTIVITY; FEMALE; GENE CONTROL; GENE EXPRESSION; GENE LOCUS; GLUCURONIDATION; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; MALE; PRIORITY JOURNAL; STOMACH CARCINOMA; STOMACH EPITHELIUM;

ADENOCARCINOMA; ADULT; AGED; EPITHELIUM; EXONS; FEMALE; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUCURONOSYLTRANSFERASE; HUMANS; MALE; MIDDLE AGED; POLYMORPHISM, GENETIC; PROTEIN ISOFORMS; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; RNA, NEOPLASM; STOMACH; STOMACH NEOPLASMS; VARIATION (GENETICS);

EID: 0031756678     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (28)

1. Bock KW and Lilienblum W (1994) Roles of uridine diphosphate glucuronosyltransferases in chemical carcinogenesis, in Conjugation-Deconjugation Reactions in Drug Metabolism and Toxicity (Kauffman FC, ed.) pp 391-428, Springer-Verlag, Berlin.
2. Bock KW, Lilienblum W, Fischer G, Schirmer G, and Bock-Hennig BS (1987) The role of conjugation reactions in detoxification. Arch Toxicol 60:22-29.
3. Bradford MM (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 72:248-254.
4. Burchell B, Brierley CH, Monaghan G, and Clark DJ (1998) The structure and function of the UDP-glucuronosyltransferase gene family. Adv Pharmacol 42:335-338.
5. Burchell B, Nebert DW, Nelson DR, Bock KW, Iyanagi T, Jansen PM, Lancet D, Mulder GJ, Chowdhury JR, Siest G, Tephly TR, and Mackenzie PI (1991) The UDP glucuronosyltransferase gene superfamily. Suggested nomenclature based on evolutionary divergence. DNA Cell Biol 10:487-494.
6. Daly AK (1995) molecular basis of polymorphic drug metabolism. J Mol Med 73: 539-553.
7. Dutton GJ (1980) Glucuronidation of drugs and other compounds. CRC Press, Boca Raton.
8. Ebner T and Burchell B (1993) Substrate specificities of two stably expressed human liver UDP-glucuronosyltransferases of the UGT1 gene family. Drug Metab Dispos 21:50-55.
9. Ebner T, Remmel RP, and Burchell B (1993) Human bilirubin UDP-Glucuronosyltransferase catalyzes the glucuronidation of ethinylestradiol. Mol Pharmacol 43: 649-654.
10. Fournel-Gigleux S, Sutherland L, Sabolovic N, Burchell B, and Siest G (1991) Stable expression of two human UDP-glucuronosyltransferase cDNAs in V79 cell cultures. J Pharmacol Exp Ther 39:177-183.
11. Green MD and Tephly TR (1996) Glucuronidation of amines and hydroxylated xenobiotics and endobiotics catalyzed by expressed human UGT1.4 protein. Drug Metab Dispos 24:356-363.
12. Harding D, Fournel-Gigleux S, Jackson MR, and Burchell B (1988) Cloning and substrate specificity of a human phenol UDP-glucuronosyltransferase expressed in COS-7 cells. Proc Natl Acad Sci USA 85:8381-8385.
13. Jackson MR, McCarthy LR, Harding D, Wilson S, Coughtrie MWH, and Burchell B (1987) Cloning of a human liver microsomal UDP-glucuronosyltransferase cDNA. Biochem J 242:581-588.
14. Kim PM, Winn LM, Parman T, and Wells PG (1997) UDP-glucuronosyltransferase-mediated protection against in vitro DNA oxidation and micronucleus formation initiated by phenytoin and its embryotoxic metabolite 5-(p-hydroxyphenyl)-5-phenylhydantoin. J Pharmacol Exp Ther 280:200-209.
15. Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, Fournel-Gigleux S, Green M, Hum DW, Iyanagi T, Lancet D, Louisot P, Magdalou J, Chowdhury JR, Ritter JK, Schachter H, Tephly TR, Tipton KF, and Nebert DW (1997) The UDP glycosyltransferase gene superfamily: recommended nomenclature update based on evolutionary divergence. Pharmacogenetics 7:255-69.
16. McDonnel WM, Hitomi E, and Askari FK (1996) Identification of bilirubin UDP-GTs in the human alimentary tract in accordance with the gut as a putative metabolic organ. Biochem Pharmacol 51:483-488.
17. Meyer UA and Zanger UM (1997) Molecular mechanisms of genetic polymorphisms of drug metabolism. Annu Rev Pharmacol Toxicol 37:269-296.
18. Moghrabi N, Sutherland L, Wooster R, Povey S, Boxer M, and Burchell B (1992) Chromosomal assignment of human phenol and bilirubin UDP-glucuronosyltransferase genes (UGT1A-subfamily). Ann Hum Genet 56:81-91.
19. Mojarrabi B, Butler R, and Mackenzie PI (1996) cDNA cloning and characterization of the human UDP glucuronosyltransferase, UGT1A3. Biochem Biophys Res Commun 225:785-790.
20. Monaghan G, Povey S, Burchell B, and Boxer M (1992) Localization of a bile acid UDP-glucuronosyltransferase gene (UGT2B) to chromosome 4 using the polymerase chain reaction. Genomics 13:908-909.
21. Peters WM, Nagengast FM, and van Tongeren JH (1989) Glutathione S-transferase, cytochrome P450, and uridine 5′-diphosphate-glucuronosyltransferase in human small intestine and liver. Gastroenterology 96:442-448.
22. Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, and Owens IS (1992) A novel complex locus UGT1 encodes human bilirubin, phenol and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini. J Biol Chem 267:3257-3261.
23. Ritter JK, Crawford JM, and Owens IS (1991) Cloning of two human liver bilirubin UDP-glucuronosyltransferase cDNAs with expression in COS-1 cells. J Biol Chem 266:1043-1047.
24. Strassburg CP, Obermayer-Straub P, Alex B, Durazzo M, Rizzetto M, Tukey RH, and Manns MP (1996) Autoantibodies against glucuronosyltransferases differ between viral hepatitis and autoimmune hepatitis. Gastroenterology 111:1576-1586.
25. Strassburg CP, Manns MP, and Tukey RH (1997a) Differential down regulation of the UDP-glucuronosyltransferase 1A locus is an early event in human liver and biliary cancer. Cancer Res 57:2979-2985.
26. Strassburg CP, Manns MP, and Tukey RH (1998) Expression of UDP-glucuronosyltransferase 1A locus in human colon. Identification and characterization of the novel extrahepatic UGT1A8. J Biol Chem 273:8719-8726.
27. Strassburg CP, Oldhafer K, Manns MP, and Tukey RH (1997b) Differential expression of the UGT1A locus in human liver, biliary and gastric tissue. Identification of UGT1A7 and UGT1A1O transcripts in extrahepatic tissue. Mol Pharmacol 52:212-220.
28. Wooster R, Sutherland L, Ebner T, Clarke D, Da Cruz e Silva O, and Burchell B (1991) Cloning and stable expression of a new member of the human liver phenol/bilirubin: UDP-glucuronosyltransferase cDNA family. Biochem J 278:465-469.