Genomic organization of the UGT2b gene cluster on human chromosome 4q13

Pharmacogenetics

Volumn 10, Issue 3, 2000, Pages 251-260

  Riedy, Michael ^a   Wang, Jian Ying ^b   Miller, Andrew P ^b   Buckler, Alan ^b   Hall, Jeff ^a   Guida, Marco ^a  

^a PPGx Inc   (United States)

^b Axys Pharmaceuticals Inc   (United States)

Author keywords

Polymorphism; Pseudogene; SNP; UDP glucuronosyltransferase

Indexed keywords

DNA FRAGMENT; GLUCURONOSYLTRANSFERASE;

ARTICLE; CHROMOSOMAL LOCALIZATION; CHROMOSOME 4Q; ETHNIC GROUP; EVOLUTION; GENE CLUSTER; GENE DUPLICATION; GENE FREQUENCY; GENE MAPPING; GENE MUTATION; GENE REARRANGEMENT; GENE SEQUENCE; GENETIC ORGANIZATION; HUMAN; HUMAN CELL; MULTIGENE FAMILY; PRIORITY JOURNAL; PROTEIN FAMILY; PSEUDOGENE;

EID: 0034050743     PISSN: 0960314X     EISSN: None     Source Type: Journal    
DOI: 10.1097/00008571-200004000-00006     Document Type: Article

References (28)

1. Beaulieu M, Levesque E, Tchernof A, Beatty B, Belanger A, Hum DW. Chromosomal localization, structure and regulation of the UGT2B17 gene, encoding a C19 steroid-metabolizing enzyme. DNA Cell Biol 1997; 16:1143-1154.
2. Beaulieu M, Levesque E, Hum DW, Belanger A. Isolation and characterization of a human orphan UDP-glucuronosyltransferase, UGT2B11. Biochem Biophys Res Comm 1998; 248:44-50.
3. Burchell B, Nebert DW, Nelson DR, Bock KW, Iyanagi T, Jansen PLM, et al. The UDP glucuronosyltransferase gene superfamily: suggested nomenclature based on evolutionary divergence. DNA Cell Biol 1991; 10:487-494.
4. Chen F, Ritter JK, Wang MG, McBride OW, Lubet RA, Owens IS. Characterization of a cloned human dihydrotestosterone/ androstanediol UDP-glucuronosyltransferase and its comparison to other steroid isoforms. Biochemistry 1993; 32:10648-10657.
5. Chen D, Park Y, Kemper B. Differential protein binding and transcriptional activities of HNF-4 elements in three closely related CYP2C genes. DNA Cell Biol 1994; 13:771-779.
6. Coulombe N, Lefebvre A, Lehoux JG. Characterization of the hamster CYP11B2 gene encoding adrenal cytochrome P450 aldosterone synthase. DNA Cell Biol 1997; 16:993-1002.
7. Dalton TP, Shertzer HG, Puga A. Regulation of gene expression by reactive oxygen. Ann Rev Pharmacol Toxicol 1999; 39:67-101.
8. Green M, Oturu EM, Tephly TR. Stable expression of a human liver UDP-glucuronosyltransferase (UGT2B15) with activity toward steroid and xenobiotic substrates. Drug Metabol Dispos 1994; 22:206-219.
9. Guillemette C, Levesque E, Beaulieu M, Turgeon D, Hum DW, Belanger A. Differential regulation of two UDP-glucuronosyltransferases. UGT2B15 and UGT2B17, in human prostate LNCaP cells. Endocrinology 1997; 138:2998-3005.
10. Haque SJ, Petersen DD, Nebert DW, Mackenzie PI. Isolation, sequence and developmental expression of rat UGT2B2: the gene encoding a constitutive UDP-glucuronosyltransferase that metabolizes etiocholanolone and androsterone. DNA Cell Biol 1991; 10:515-524.
11. Jaiswal AK, Burnett P, Adesnik M, McBride OW. Nucleotide and deduced amino acid sequence of a human cDNA (NQO2) corresponding to a second member of the NAD (P)H: quinoneoxidoreductase gene family. Extensive polymorphism at the NQO2 gene locus on chromosome 6. Biochemistry 1990; 29:1899-1906.
12. Levesque E, Beaulieu M, Green MD, Tephly TR, Belanger A, Hum DW. Isolation and characterization of UGT2B15 (Y85): a UDP-glucuronosyltransferase encoded by a polymorphic gene. Pharmacogenetics 1997; 7:317-325.
13. Mackenzie PI. Rat liver UDP-glucuronosyltransferase: identification of cDNAs encoding two enzymes which glucuronidate testosterone, dihydrotestosterone, and B-estradiol. J Biol Chem 1987; 262:9744-9749.
14. Mackenzie PI. Rat liver UDP-glucuronosyltransferase: sequence and expression of a cDNA encoding a phenobarbitol-inducible form. J Biol Chem 1996; 261:6119-6125.
15. Mackenzie PI, Rodbourn L. Organization of the rat UDP-glucuronosyltransferase. UDPGTr-2, gene and characterization of its promoter. J Biol Chem 1990; 265:11328-11332.
16. Mackenzie PI, Owens IS, Burchell B, Bock KW, Bairoch A, Belanger A, et al. The UDP glycosyltransferase gene superfamily: recommended nomenclature update based upon evolutionary divergence. Pharmacogenetics 1997; 7:225-269.
17. Monaghan G. Gene structure and physical mapping of the human UDP-glucuronosyltransferase subfamily 2 genes. PhD thesis. University of Dundee, Dundee; 1994.
18. Monaghan G, Clarke DJ, Povey S, Chee GS, Boxer M, Burchell B. Isolation of a human YAC contig encompassing a cluster of UGT2B genes and its regional localization to chromosome 4q13. Genomics 1994; 23:496-499.
19. Monaghan G, Burchell B. Boxer M. Acid UDP-glucuronosyltransferase. Mammal Genome 1997; 8:692-694.
20. Owens IS, Ritter JK. The novel bilirubin/phenol UDP-glucuronosyltrasferase UGT1 gene locus: implications for multiple nonhemolytic familial hyperbilirubinemia phenotypes. Pharmacogenetics 1992; 2:93-108.
21. Parra I, Windle B. High resolution visual mapping of stretched DNA by fluorescent hybridization. Nature Genet 1991; 5:17-21.
22. Riley RJ, Workman P. DT-diaphorase and cancer chemotherapy. Biochem Pharmacol 1992; 43:39-42.
23. Shervington A. Identification of sequences involved in both basal expression and phenobarbital induction of a CYP2B2 gene using in-vitro transcription system. Biochem Mol Biol Intl 1998; 45:303-313.
24. Sogawa K, Fujii-Kuriyama Y. Ah receptor, a novel ligand-activated transcription factor. J Biochem (Tokio) 1997; 122:1075-1079.
25. Suzuki T, Johnston PN, Board PG. Structure and organization of the human alpha class glutathione S-transferase genes and related pseudogenes. Genomics 1993; 18:680-686.
26. Tephly TR UDP-glucuronosyltransferases: a family of detoxifying enzymes. Trends Pharmacol Sci 1990; 11:276-279.
27. Toda K, Nomoto S, Shizuta Y. Identification and characterization of transcriptional regulatory elements of the human aromatase cytochrome P450 gene (CYP19). J Steroid Biochem Mol Biol 1996; 56:151-159.
28. Trask BJ. Fluorescence in situ hybridization. In: Birren B, Green E, Heiter P, Myers R, editors. Genome analysis: a laboratory manual. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press; 1998.