Acidic residues in the purine binding site govern the 6-oxopurine specificity of the Leishmania donovani xanthine phosphoribosyltransferase

International Journal of Biochemistry and Cell Biology

Volumn 42, Issue 2, 2010, Pages 253-262

  Ullman, Buddy ^a   Cyr, Normand ^b   Choi, Kenneth ^b   Jardim, Armando ^b  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b MCGILL UNIVERSITY   (Canada)

Author keywords

HGPRT; Leishmania; Phosphoribosyltransferase; Purine metabolism; XPRT

Indexed keywords

AMINO ACID DERIVATIVE; ASPARTIC ACID; GLUTAMIC ACID; HYPOXANTHINE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MUTANT PROTEIN; NUCLEIC ACID BASE; PHOSPHORIBOSYLTRANSFERASE; PURINE; UNCLASSIFIED DRUG; XANTHINE; XANTHINE PHOSPHORIBOSYLTRANSFERASE;

ARTICLE; BINDING SITE; CATALYSIS; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GENE MUTATION; LEISHMANIA DONOVANI; NONHUMAN; PROTEIN DOMAIN; REGULATORY MECHANISM; RESIDUE ANALYSIS;

5'-GUANYLIC ACID; AMINO ACID SEQUENCE; BINDING SITES; BIOCATALYSIS; HUMANS; HYDROGEN-ION CONCENTRATION; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; KINETICS; LEISHMANIA DONOVANI; MAGNESIUM; MANGANESE; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PENTOSYLTRANSFERASES; PROTEIN CONFORMATION; PURINONES; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

LEISHMANIA DONOVANI;

EID: 73749085906     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2009.10.020     Document Type: Article

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