Point mutations in the guanine phosphoribosyltransferase from Giardia lamblia modulate pyrophosphate binding and enzyme catalysis

European Journal of Biochemistry

Volumn 259, Issue 3, 1999, Pages 565-571

  Page, Jon P ^a   Munagala, Narsimha R ^a   Wang, Ching C ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Giardia; GPRTase; Purine specificity; Pyrophosphate binding; Steady state kinetics

Indexed keywords

GLYCINE; GUANINE; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MUTANT PROTEIN; PHOSPHORIBOSYL PYROPHOSPHATE; PYROPHOSPHATE;

ARTICLE; ENZYME BINDING; ENZYME MECHANISM; ENZYME PURIFICATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; GIARDIA LAMBLIA; NONHUMAN; PARASITE SURVIVAL; POINT MUTATION; PRIORITY JOURNAL; TRICHOMONAS FOETUS;

5'-GUANYLIC ACID; ANIMALS; DIPHOSPHATES; ENZYME INHIBITORS; GIARDIA LAMBLIA; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; KINETICS; MUTAGENESIS, SITE-DIRECTED; PHOSPHORIBOSYL PYROPHOSPHATE; POINT MUTATION; PROTEIN BINDING; PROTOZOAN PROTEINS; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT; SUBSTRATE SPECIFICITY;

FELIS CATUS; GIARDIA; GIARDIA INTESTINALIS; PROTOZOA; TRICHOMONAS; TRITRICHOMONAS FOETUS;

EID: 0033083290     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00020.x     Document Type: Article

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