The PRT protein family

Current Opinion in Structural Biology

Volumn 11, Issue 6, 2001, Pages 733-739

  Sinha, Sangita C ^a   Smith, Janet L ^b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b PURDUE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ISOPROTEIN; MAGNESIUM ION; NUCLEOTIDE; PHOSPHATE; PHOSPHORIBOSYL PYROPHOSPHATE; PHOSPHORIBOSYLTRANSFERASE; REGULATOR PROTEIN; RIBOSEPHOSPHATE PYROPHOSPHOKINASE;

AMINO TERMINAL SEQUENCE; CATALYSIS; CRYSTAL STRUCTURE; IMAGE ANALYSIS; METAL BINDING; NUCLEOTIDE METABOLISM; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN FAMILY; PROTEIN FOLDING; PROTEIN FUNCTION; REGULATORY MECHANISM; REVIEW; SEQUENCE HOMOLOGY;

EID: 0035690384     PISSN: 0959440X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0959-440X(01)00274-3     Document Type: Review

References (44)

1. Crystal structure of orotate phosphoribosyltransferase
2. Structure of the allosteric regulatory enzyme of purine biosynthesis
3. The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP
4. The crystal structure of the orotate phosphoribosyltransferase complexed with orotate and α-D-5-phosphoribosyl-1-pyrophosphate
5. A flexible loop at the dimer interface is a part of the active site of the adjacent monomer of Escherichia coli orotate phosphoribosyltransferase
6. Crystal structure of the hypoxanthine-guanine-xanthine phosphoribosyltransferase from the protozoan parasite Tritrichomonas foetus
7. Crystal structures of Toxoplasma gondii hypoxanthine/guanine/xanthine PRTase reveal the catalytic role of a long flexible loop
8. Crystal structure of Escherichia coli xanthine phosphoribosyltransferase
9. Mechanism of the synergistic end-product regulation of Bacillus subtilis glutamine phosphoribosylpyrophosphate amidotransferase by nucleotides
10. Coupled formation of an amidotransferase interdomain ammonia and a phosphoribosyltransferase active site
11. Crystal structure of glutamine phosphoribosylpyrophosphate amidotransferase from Escherichia coli
12. Adaptation of an enzyme to regulatory function: Structure of Bacillus subtilis PyrR, a pyr RNA-binding attenuation protein and uracil phosphoribosyltransferase
13. Crystal structures of Toxoplasma gondii uracil phosphoribosyltransferase reveal the atomic basis of pyrimidine discrimination and prodrug binding
14. Structures of free and complexed forms of Escherichia coli xanthine-guanine phosphoribosyltransferase
15. A 1.4 Å crystal structure for the hypoxanthine phosphoribosyltransferase of Trypanosoma cruzi
16. Approaching the transition state in the crystal structure of a phosphoribosyltransferase
17. 2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding
18. The 2.0 Å structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor
19. Crystal structure of adenine phosphoribosyltransferase from Leishmania donovani
20. The 2.0 Å structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor
21. Crystal structures of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase-GMP and -IMP complexes: Comparison of purine binding interactions with the XMP complex
22. 2+ ions bound: Insights into the catalytic mechanism
23. Structural basis for the function of Bacillus subtilis phosphoribosylpyrophosphate synthetase
24. Crystal structures of Giardia lamblia guanine phosphoribosyltransferase at 1.75 Å
25. Substrate deformation in a hypoxanthine-guanine phosphoribosyl-transferase ternary complex: The structural basis for catalysis
26. A new function for a common fold: The crystal structure of quinolinic acid phosphoribosyltransferase
27. Crystal structure of quinolinic acid phosphoribosyltransferase from Mycobacterium tuberculosis: A potential TB drug target
28. Phosphoribosylpyrophosphate synthetase of Escherichia coli. Properties of the purified enzyme and primary structure of the prs gene
29. Nucleotide sequence and deduced amino acid sequence of Escherichia coli adenine phosphoribosyltransferase and comparison with other analogous enzymes
30. Forming and inhibiting PRT active sites
31. Different oligomeric states are involved in the allosteric behavior of uracil phosphoribosyltransferase from Escherichia coli
32. Locations and functional roles of conserved lysine residues in Salmonella typhimurium orotate phosphoribosyltransferase
33. Structure and function of Salmonella typhimurium orotate phosphoribosyltransferase: Protein complementation reveals shared active sites
34. Tryptophan fluorescence monitors multiple conformational changes required for glutamine phosphoribosylpyrophosphate amidotransferase interdomain signaling and catalysis
35. Interdomain signaling in glutamine phosphoribosyltransferase amidotransferase
36. Temperature-dependent function of the glutamine phosphoribosylpyrophosphate amidotransferase ammonia channel and coupling with glycinamide ribonucleotide synthetase in a hyperthermophile
37. Dual role for the glutamine phosphoribosylpyrophosphate amidotransferase ammonia channel
38. Enzymes using glutamine as an amide donor
39. Purine phosphoribosyltransferases
40. Identification of the Bacillus subtilis pur operon repressor
41. Regulation of the Bacillus subtilis pyrimidine biosynthetic operon by transcriptional attenuation: Control of gene expression by an mRNA-binding protein
42. MOLSCRIPT: A program to produce both detailed and schematic plots of protein structures
43. Raster3D: Photorealistic molecular graphics