A few amino acid substitutions can convert deoxyribonucleoside kinase specificity from pyrimidines to purines

EMBO Journal

Volumn 21, Issue 7, 2002, Pages 1873-1880

  Knecht, Wolfgang ^a   Sandrini, Michael P B ^a   Johansson, Kenth ^a   Eklund, Hans ^a   Munch Petersen, Birgitte ^a   Piškur, Jure ^a  

^a TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

Deoxyribonucleoside kinases; Directed mutagenesis; Enzyme specificity; Nucleoside analogs; Protein evolution

Indexed keywords

AMINO ACID; DEOXYRIBONUCLEOSIDE; PHOSPHOTRANSFERASE; PURINE; PYRIMIDINE;

AMINO ACID SUBSTITUTION; ARTICLE; CRYSTAL STRUCTURE; DROSOPHILA MELANOGASTER; ENZYME PHOSPHORYLATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE; EVOLUTION; NONHUMAN; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; DEOXYRIBONUCLEOSIDES; HUMANS; MICE; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PHOSPHORYLATION; PHOSPHOTRANSFERASES (ALCOHOL GROUP ACCEPTOR); PURINES; PYRIMIDINES; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

DROSOPHILA MELANOGASTER; HEXAPODA; MAMMALIA; MELANOGASTER;

EID: 0037007213     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1093/emboj/21.7.1873     Document Type: Article

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