Substrate deformation in a hypoxanthine-guanine phosphoribosyltransferase ternary complex: The structural basis for catalysis

Structure

Volumn 8, Issue 12, 2000, Pages 1309-1318

  Heroux A ^a   White, E L ^a   Ross, L J ^a   Kuzin, A P ^a   Borhani, D W ^a  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Atomic resolution; Cation interactions; Enzymatic mechanism; Low barrier hydrogen bonds; D 5 phosphoribosyl 1 pyrophosphate

Indexed keywords

HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME MECHANISM; ENZYME STABILITY; ENZYME STRUCTURE; NONHUMAN; PRIORITY JOURNAL; TOXOPLASMA GONDII; X RAY DIFFRACTION;

ANIMALS; BINDING SITES; CATALYSIS; CATIONS, DIVALENT; CRYSTALLOGRAPHY, X-RAY; ELECTROSTATICS; HUMANS; HYDROGEN BONDING; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; LIGANDS; MAGNESIUM; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHOSPHORIBOSYL PYROPHOSPHATE; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RIBOSE; STRUCTURE-ACTIVITY RELATIONSHIP; SUBSTRATE SPECIFICITY; TOXOPLASMA;

PROTOZOA; TOXOPLASMA GONDII;

EID: 0034483903     PISSN: 09692126     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-2126(00)00546-3     Document Type: Article

References (47)

1. Purine and pyrimidine metabolism in parasitic protozoa
2. Purine metabolism in Toxoplasma gondii
3. Parasite enzymes as potential targets for antiparasitic chemotherapy
4. Hypoxanthine-guanine phosphoribosyltransferase as a therapeutic target in protozoal infections
5. Structure-activity relationships for the binding of ligands to xanthine or guanine phosphoribosyl-transferase from Toxoplasma gondii
6. Rational design of selective submicromolar inhibitors of Tritrichomonas foetus hypoxanthine-guanine-xanthine phosphoribosyltransferase
7. A review of the molecular basis of hypoxanthine-guanine phosphoribosyltransferase (HPRT) deficiency
8. A familial disorder of uric acid metabolism and central nervous system function
9. New synthesis of 5H-pyrrolo[3, 2-d]pyrimidines via pyrimido[5, 4-c]pyridazines
10. 2+ ions bound: Insights into the catalytic mechanism
11. Crystal structures of the Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase-GMP and -IMP complexes: Comparison of purine binding interactions with the XMP complex
12. Nuclear magnetic resonance methods for the detection and study of low-barrier hydrogen bonds on enzymes
13. The low barrier hydrogen bond in enzymatic catalysis
14. The crystal structure of human hypoxanthine-guanine phosphoribosyltransferase with bound GMP
15. Catalysis in human hypoxanthine-guanine phosphoribosyltranferase: Asp 137 acts as a general acid/base
16. The 2.0 Å structure of human hypoxanthine-guanine phosphoribosyltransferase in complex with a transition-state analog inhibitor
17. The 2.0 Å structure of malarial purine phosphoribosyltransferase in complex with a transition-state analogue inhibitor
18. Transition-state analogs as inhibitors of human and malarial hypoxanthine-guanine phosphoribosyltransferases
19. Approaching the transition state in the crystal structure of a phosphoribosyltransferase
20. Kinetic mechanism of human hypoxanthine-guanine phosphoribosyltransferase: Rapid phosphoribosyl transfer chemistry
21. New observations on tautomerism and ionization processes in hypoxanthines and 6-thiopurines
22. Mechanism of hydrogen-deuterium exchange in hypoxanthines
23. Protonation of hypoxanthine, guanine, xanthine and caffeine
24. Forming and inhibiting PRT active sites
25. The cation-π interaction
26. Aromatic-aromatic interaction: A mechanism of protein structure stabilization
27. The conserved serine-tyrosine dipeptide in Leishmania donovani hypoxanthine-guanine phosphoribosyltransferase is essential for catalytic activity
28. Cation-π interactions in aromatics of biological and medicinal interest: Electrostatic potential surfaces as a useful qualitative guide
29. Dynamics of amino acid side chains in membrane proteins by high field solid state deuterium nuclear magnetic resonance spectroscopy: Phenylalanine, tyrosine, and tryptophan
30. Chemical basis for enzyme catalysis
31. A molecular survey of hypoxanthine-guanine phosphoribosyltransferase deficiency in man
32. Enzymatic transition-state analysis and transition-state analogs
33. Enzymes work by solvation substitution rather than by desolvation
34. Recent Changes to the MOSFLM package for processing film and image plate data
35. Scala
36. On the treatment of negative intensity observations
37. The CCP4 suite: Programs for protein crystallography
38. AMoRe: An automated package for molecular replacement
39. Crystallographic R factor refinement by molecular dynamics
40. Refinement of macromolecular structures by the maximum-likelihood method
41. Automated refinement of protein models
42. Improved methods for building protein models in electron density maps and location of errors in these models
43. Phase annealing in SHELX-90: Direct methods for larger structures
44. PROCHECK: A program to check the stereochemical quality of protein structures
45. Errors in protein structures
46. Ribbons