Crystal structure of Toxoplasma gondii hypoxanthine-guanine phosphoribosyltransferase with XMP, pyrophosphate, and two Mg2+ ions bound: Insights into the catalytic mechanism

Biochemistry

Volumn 38, Issue 44, 1999, Pages 14495-14506

  Héroux, Annie ^a   White, E Lucile ^a   Ross, Larry J ^a   Davis, Richard L ^a,b   Borhani, David W ^a  

^a SOUTHERN RESEARCH INSTITUTE   (United States)

^b IntegriDerm   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MAGNESIUM ION; PYROPHOSPHATE; UNCLASSIFIED DRUG; XANTHINE DERIVATIVE; XANTHOSINE PHOSPHATE;

ARTICLE; CATALYSIS; CRYSTAL STRUCTURE; ENZYME ACTIVE SITE; ENZYME MECHANISM; ENZYME SUBSTRATE COMPLEX; METAL BINDING; MOLECULAR RECOGNITION; NONHUMAN; PRIORITY JOURNAL; TOXOPLASMA GONDII;

ANIMALS; BASE SEQUENCE; CATALYSIS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; DIPHOSPHATES; DNA PRIMERS; HUMANS; HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; KINETICS; MAGNESIUM; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RIBONUCLEOTIDES; TOXOPLASMA;

FELIS CATUS; TOXOPLASMA GONDII;

EID: 0033517729     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi990508i     Document Type: Article

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