Ternary complex structure of human HGPRTase, PRPP, Mg2+, and the inhibitor HPP reveals the involvement of the flexible loop in substrate binding

Protein Science

Volumn 8, Issue 5, 1999, Pages 1023-1031

  Balendiran, Ganesaratnam K ^a,f   Molina, José A ^b,f   Xu, Yiming ^c,g   Torres Martinez, Jan ^d   Stevens, Robert ^e   Focia, Pamela J ^d   Eakin, Ann E ^d   Sacchettini, James C ^a   Craig III, Sydney P ^d  

^a TEXAS A AND M UNIVERSITY   (United States)

^b UNIVERSITY OF PUERTO RICO   (Puerto Rico)

^c TEMPLE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF NORTH CAROLINA   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

^f UNIVERSITY OF PUERTO RICO AT CAYEY   (Puerto Rico)

^g ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Birth defects; Inhibitor design; PRPP; PRTase; Purine analog; Rapid quench experiments; Steady state kinetic studies

Indexed keywords

HYPOXANTHINE PHOSPHORIBOSYLTRANSFERASE; MAGNESIUM ION; PHOSPHORIBOSYL PYROPHOSPHATE; PYRAZOLOPYRIMIDINE DERIVATIVE;

ARTICLE; BIRTH DEFECT; CATALYSIS; COMPLEX FORMATION; CRYSTAL STRUCTURE; CRYSTALLIZATION; ELECTRON; ENZYME BINDING; ENZYME STRUCTURE; GOUT; HUMAN; HYDROGEN BOND; KINETICS; MOLECULAR INTERACTION; MUTATION; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; REDUCTION; SITE DIRECTED MUTAGENESIS; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS;

FELIS CATUS; TRIXIS;

EID: 0032900978     PISSN: 09618368     EISSN: None     Source Type: Journal    
DOI: 10.1110/ps.8.5.1023     Document Type: Article

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