Drosophila models pioneer a new approach to drug discovery for Parkinson's disease

Drug Discovery Today

Volumn 11, Issue 3-4, 2006, Pages 119-126

  Whitworth, Alexander J ^a   Wes, Paul D ^b   Pallanck, Leo J ^c  

^a UNIVERSITY OF SHEFFIELD   (United Kingdom)

^b ELAN PHARMACEUTICALS   (United States)

^c UNIVERSITY OF WASHINGTON   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN; PARKIN;

DISEASE MODEL; DJ 1A GENE; DJ 1B GENE; DROSOPHILA; DRUG RESEARCH; GENE; GENE MUTATION; GENETIC ANALYSIS; MULTIGENE FAMILY; MUTATIONAL ANALYSIS; NERVOUS SYSTEM; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PROTEIN ANALYSIS; REVIEW; TRANSGENIC ANIMAL;

ALPHA-SYNUCLEIN; ANIMALS; DISEASE MODELS, ANIMAL; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; DRUG DESIGN; HUMANS; NERVE TISSUE PROTEINS; PARKINSON DISEASE;

EID: 33644862373     PISSN: 13596446     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1359-6446(05)03693-7     Document Type: Review

References (42)

1. J.L. Eriksen Molecular pathogenesis of Parkinson disease Arch. Neurol. 62 2005 353 357
2. R. Kruger Genes in familial parkinsonism and their role in sporadic Parkinson's disease J Neurol 251 Suppl 6 2004 VI/2-6
3. G.M. Rubin Comparative genomics of the eukaryotes Science 287 2000 2204 2215
4. M.H. Polymeropoulos Mutation in the alpha-synuclein gene identified in families with Parkinson's disease Science 276 1997 2045 2047
5. M.G. Spillantini Alpha-synuclein in Lewy bodies Nature 388 1997 839 840
6. M.B. Feany, W.W. Bender A Drosophila model of Parkinson's disease Nature 404 2000 394 398
7. J.M. Warrick Suppression of polyglutamine-mediated neurodegeneration in Drosophila by the molecular chaperone HSP70 Nat. Genet. 23 1999 425 428
8. P.K. Auluck Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease Science 295 2002 809 810
9. P.K. Auluck, N.M. Bonini Pharmacological prevention of Parkinson disease in Drosophila Nat. Med. 8 2002 1185 1186
10. T. Kitada Mutations in the parkin gene cause autosomal recessive juvenile parkinsonism Nature 392 1998 605 608
11. H. Shimura Ubiquitination of a new form of alpha-synuclein by parkin from human brain: implications for Parkinson's disease Science 293 2001 263 269
12. Y. Yang Parkin suppresses dopaminergic neuron-selective neurotoxicity induced by Pael-R in Drosophila Neuron 37 2003 911 924
13. A.F. Haywood, B.E. Staveley Parkin counteracts symptoms in a Drosophila model of Parkinson's disease BMC Neurosci. 5 2004 14 26
14. H. Fujiwara alpha-Synuclein is phosphorylated in synucleinopathy lesions Nat. Cell Biol. 4 2002 160 164
15. M. Okochi Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein J. Biol. Chem. 275 2000 390 397
16. M. Takahashi Phosphorylation of alpha-synuclein characteristic of synucleinopathy lesions is recapitulated in alpha-synuclein transgenic Drosophila Neurosci. Lett. 336 2003 155 158
17. L. Chen, M.B. Feany Alpha-synuclein phosphorylation controls neurotoxicity and inclusion formation in a Drosophila model of Parkinson disease Nat. Neurosci. 8 2005 657 663
18. A.N. Pronin Synucleins are a novel class of substrates for G protein-coupled receptor kinases J. Biol. Chem. 275 2000 26515 26522
19. W.W. Smith Alpha-synuclein phosphorylation enhances eosinophilic cytoplasmic inclusion formation in SH-SY5Y cells J. Neurosci. 25 2005 5544 5552
20. Y. Pesah Whole-mount analysis reveals normal numbers of dopaminergic neurons following misexpression of alpha-Synuclein in Drosophila Genesis 41 2005 154 159
21. R.G. Pendleton Effects of pharmacological agents upon a transgenic model of Parkinson's disease in Drosophila melanogaster. J. Pharmacol. Exp. Ther. 300 2002 91 96
22. F. Friggi-Grelin Targeted gene expression in Drosophila dopaminergic cells using regulatory sequences from tyrosine hydroxylase J. Neurobiol. 54 2003 618 627
23. S.Q. Lima, G. Miesenbock Remote control of behavior through genetically targeted photostimulation of neurons Cell 121 2005 141 152
24. P.K. Auluck Mechanisms of Suppression of {alpha}-Synuclein Neurotoxicity by Geldanamycin in Drosophila J. Biol. Chem. 280 2005 2873 2878
25. J.C. Greene Mitochondrial pathology and apoptotic muscle degeneration in Drosophila parkin mutants Proc. Natl. Acad. Sci. U. S. A. 100 2003 4078 4083
26. Y. Pesah Drosophila parkin mutants have decreased mass and cell size and increased sensitivity to oxygen radical stress Development 131 2004 2183 2194
27. G.H. Cha Parkin negatively regulates JNK pathway in the dopaminergic neurons of Drosophila Proc. Natl. Acad. Sci. U. S. A. 102 2005 10345 10350
28. A.J. Whitworth Increased glutathione S-transferase activity rescues dopaminergic neuron loss in a Drosophila model of Parkinson's disease Proc. Natl. Acad. Sci. U. S. A. 102 2005 8024 8029
29. M. Muftuoglu Mitochondrial complex I and IV activities in leukocytes from patients with parkin mutations Mov. Disord. 19 2004 544 548
30. J.J. Palacino Mitochondrial dysfunction and oxidative damage in parkin-deficient mice J. Biol. Chem. 279 2004 18614 18622
31. F. Darios Parkin prevents mitochondrial swelling and cytochrome c release in mitochondria-dependent cell death Hum. Mol. Genet. 12 2003 517 526
32. J.C. Greene Genetic and genomic studies of Drosophila parkin mutants implicate oxidative stress and innate immune responses in pathogenesis Hum. Mol. Genet. 14 2005 799 811
33. J.D. Hayes Glutathione Transferases Annu Rev Pharmacol Toxicol 45 2004 51 88
34. T. Nguyen Regulatory mechanisms controlling gene expression mediated by the antioxidant response element Annu. Rev. Pharmacol. Toxicol. 43 2003 233 260
35. V. Bonifati Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism Science 299 2003 256 259
36. F.M. Menzies Roles of Drosophila DJ-1 in Survival of Dopaminergic Neurons and Oxidative Stress Curr. Biol. 15 2005 1578 1582
37. M. Meulener Drosophila DJ-1 Mutants Are Selectively Sensitive to Environmental Toxins Associated with Parkinson's Disease Curr. Biol. 15 2005 1572 1577
38. J. Park Drosophila DJ-1 mutants show oxidative stress-sensitive locomotive dysfunction Gene 361C 2005 133 139
39. R.H. Kim DJ-1, a novel regulator of the tumor suppressor PTEN Cancer Cell 7 2005 263 273
40. Y. Yang Inactivation of Drosophila DJ-1 leads to impairments of oxidative stress response and phosphatidylinositol 3-kinase/Akt signaling Proc. Natl. Acad. Sci. U. S. A. 102 2005 13670 13675
41. J. Brokars Fly Fishing on the Brain Biol.-IT World 2002 June 2002 issue (www.bio-itworld.com/archive/061202/fishing.html)
42. D.J. Moore Molecular pathophysiology of Parkinson's disease Annu. Rev. Neurosci. 28 2005 57 87