Extracellular matrix genes as hypoxia-inducible targets

Cell and Tissue Research

Volumn 339, Issue 1, 2010, Pages 19-29

  Myllyharju, Johanna ^a   Schipani, Ernestina ^b  

^a UNIVERSITY OF OULU   (Finland)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

Cartilage; Extracellular matrix; Hypoxia; Hypoxia inducible factor; Joint

Indexed keywords

COLLAGEN; GLUCOSE; HYPOXIA INDUCIBLE FACTOR; HYPOXIA INDUCIBLE FACTOR 1ALPHA; IRON; OXYGEN;

ANGIOGENESIS; APOPTOSIS; CELL DIFFERENTIATION; CELL PROLIFERATION; CELL SURVIVAL; CHONDROGENESIS; EXTRACELLULAR MATRIX; FETUS GROWTH; GENE EXPRESSION; GENE TARGETING; GLUCOSE UTILIZATION; HEMATOPOIESIS; HUMAN; IRON TRANSPORT; JOINT; MOLECULAR MECHANICS; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN FUNCTION; REVIEW;

ANIMALS; ANOXIA; CHONDROGENESIS; EXTRACELLULAR MATRIX; GENE EXPRESSION REGULATION; HUMANS; TRANSCRIPTION FACTORS;

EID: 72449166912     PISSN: 0302766X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00441-009-0841-7     Document Type: Review

References (116)

1. H Akiyama MC Chaboissier JF Martin A Schedl B de Crombrugghe 2002 The transcription factor Sox9 has essential roles in successive steps of the chondrocyte differentiation pathway and is required for expression of Sox5 and Sox6 Genes Dev 16 2813 2828 1:CAS:528:DC%2BD38Xos1Sisr0%3D 12414734
2. R Amarilio SV Viukov A Sharir I Eshkar-Oren RS Johnson E Zelzer 2007 HIF1α regulation of Sox9 is necessary to maintain differentiation of hypoxic prechondrogenic cells during early skeletogenesis Development 134 3917 3928 1:CAS:528:DC%2BD2sXhsVeku7vJ 17913788
3. JT Berg EC Breen Z Fu O Mathieu-Costello JB West 1998 Alveolar hypoxia increases gene expression of extracellular matrix proteins and platelet-derived growth factor-B in lung parenchyma Am J Respir Crit Care Med 158 1921 1928
4. D ten Berge A Brouwer J Korving JF Martin F Meijlink 1998 Prx1 and Prx2 in skeletogenesis: roles in the craniofacial region, inner ear and limbs Development 125 3831 3842 9729491
5. 2 availability on human cancer Nat Rev Cancer 8 967 975 1:CAS:528: DC%2BD1cXhsVWhu7fO 18987634
6. J Bohensky SP Terkhorn TA Freeman CS Adams JA Garcia IM Shapiro V Srinivas 2009 Regulation of autophagy in human and murine cartilage. Hypoxia-inducible factor 2 suppresses chondrocyte autophagy Arthritis Rheum 60 1406 1415 19404942
7. RK Bruick SL McKnight 2001 A conserved family of prolyl 4-hydroxylases that modify HIF Science 294 1337 1340 1:CAS:528:DC%2BD3MXotlKmtbo%3D 11598268
8. LJ Brunet JA McMahon AP McMahon RM Harland 1998 Noggin, cartilage morphogenesis, and joint formation in the mammalian skeleton Science 280 1455 1457 1:STN:280:DyaK1c3msleisQ%3D%3D 9603738
9. NS Chandel MC Simon 2008 Hypoxia-inducible factor: roles in development, physiology, and disease Cell Death Differ 15 619 620 1:CAS:528: DC%2BD1cXjtl2ju7s%3D 18345017
10. J-T Chi Z Wang DSA Nuyten EH Rodriguez ME Schaner A Salim Y Wang GB Kristensen Å Helland A-L Børresen-Dale A Giaccia MT Longaker T Hastie GP Yang MJ van de Vijver PO Brown 2006 Gene expression programs in response to hypoxia PLOS Med 3 e47 16417408
11. R Chowdury A Hardy CJ Schofield 2008 The human oxygen sensing machinery and its manipulation Chem Soc Rev 37 1308 1319
12. KD Cowden Dahl BH Fryer FA Mack V Compernolle E Maltepe DM Adelman P Carmeliet MC Simon 2005 Hypoxia-inducible factors 1α and 2α regulate trophoblast differentiation Mol Cell Biol 25 10479 10491 1:CAS:528: DC%2BD2MXht1OnsL%2FL 16287860
13. NC Denko LA Fontana KM Hudson PD Sutphin S Raychaudhuri R Altman AJ Giaccia 2003 Investigating hypoxic tumor physiology through gene expression patterns Oncogene 22 5907 5914 1:CAS:528:DC%2BD3sXmslemtLg%3D 12947397
14. AG Durmowicz WC Parks DM Hyde RP Mecham KR Stenmark 1994 Persistence, re-expression, and induction of pulmonary arterial fibronectin, tropoelastin, and type I procollagen mRNA expression in neonatal hypoxic pulmonary hypertension Am J Pathol 145 1411 1420 1:STN:280:DyaK2M%2FosFSisw%3D%3D 7992844
15. M Egerbacher G Haeusler 2003 Integrins in growth plate cartilage Pediatr Endocrinol Rev 1 2 8 16437008
16. GP Elvidge L Glenny RJ Appelhoff PJ Ratcliffe J Ragoussis JM Gleadle 2006 Concordant regulation of gene expression by hypoxia and 2-oxoglutarate- dependent dioxygenase inhibition. The role of HIF-1α, HIF-2α, and other pathways J Biol Chem 281 15215 15226 1:CAS:528:DC%2BD28XltVequ70%3D 16565084
17. ACR Epstein JM Gleadle LA McNeill KS Hewitson J O'Rourke DR Mole M Mukherji E Metzen MI Wilson A Dhanda Y-M Tian N Masson DL Hamilton P Jaakkola R Barstead J Hodgkin PH Maxwell CW Pugh CJ Schofield PJ Ratcliffe 2001 C. elegans EGL-9 and mammalian homologs define a family of dioxygenases that regulate HIF by prolyl hydroxylation Cell 107 43 54 1:CAS:528:DC%2BD3MXnsFOntL0%3D 11595184
18. JT Erler KL Bennewith M Nicolau N Dornhöfer C Kong Q-T Le J-TA Chi SS Jeffrey AJ Giaccia 2006 Lysyl oxidase is essential for hypoxia-induced metastasis Nature 440 1222 1226 1:CAS:528:DC%2BD28XjvVGltb8%3D 16642001
19. JT Erler KL Bennewith TR Cox G Lang D Bird A Koong Q-T Le AJ Giaccia 2009 Hypoxia-induced lysyl oxidase is a critical mediator of bone marrow cell recruitment to form the premetastatic niche Cancer Cell 15 35 44 1:CAS:528:DC%2BD1MXptVGqug%3D%3D 19111879
20. M Fähling A Perlewitz A Doller B-J Thiele 2004 Regulation of collagen prolyl 4-hydroxylase and matrix metalloproteinases in fibrosarcoma cells by hypoxia Comp Biochem Physiol C Toxicol Pharmacol 139 119 126 15556073
21. M Fähling R Mrowka A Steege G Nebrich A Perlewitz PB Persson B-J Thiele 2006 Translational control of collagen prolyl 4-hydroxylase-α(I) gene expression under hypoxia J Biol Chem 281 26089 26101 16837461
22. V Falanga TA Martin H Takagi RS Kirsner T Helfman J Pardes MS Ochoa 1993 Low oxygen tension increases mRNA levels of α1(I) procollagen in human dermal fibroblasts J Cell Physiol 157 408 412 1:CAS:528:DyaK2cXlslWi 8227170
23. P Fraisl M Mazzone T Schmidt P Carmeliet 2009 Regulation of angiogenesis by oxygen and metabolism Dev Cell 16 167 179 1:CAS:528:DC%2BD1MXis1alu7c%3D 19217420
24. C Grimmer N Balbus U Lang T Aigner T Cramer L Müller B Swoboda D Pfander 2006 Regulation of type II collagen synthesis during osteoarthritis by prolyl-4-hydroxylases: possible influence of low oxygen tension Am J Pathol 169 491 502 1:CAS:528:DC%2BD28XosFalu7s%3D 16877351
25. M Gruber C-J Hu RS Johnson EJ Brown B Keith MC Simon 2007 Acute postnatal ablation of HIF-2α results in anemia Proc Natl Acad Sci USA 104 2301 2306 1:CAS:528:DC%2BD2sXisVWrtr0%3D 17284606
26. X Guo TF Day X Jiang L Garrett-Beal L Topol Y Yang 2004 Wnt/β-catenin signaling is sufficient and necessary for synovial joint formation Genes Dev 18 2404 2417 1:CAS:528:DC%2BD2cXot1yrur4%3D 15371327
27. MV Gustafsson X Zheng T Pereira K Gradin S Jin J Lundkvist JL Ruas L Poellinger U Lendahl M Bondesson 2005 Hypoxia requires Notch signaling to maintain the undifferentiated cell state Dev Cell 9 617 628 1:CAS:528: DC%2BD2MXht1alsLrL 16256737
28. C Hartmann CJ Tabin 2001 Wnt-14 plays a pivotal role in inducing synovial joint formation in the developing appendicular skeleton Cell 104 341 351 1:CAS:528:DC%2BD3MXis1ejsLs%3D 11239392
29. J Heikkinen M Risteli C Wang J Latvala M Rossi M Valtavaara R Myllylä 2000 Lysyl hydroxylase 3 is a multifunctional protein possessing collagen glucosyltransferase activity J Biol Chem 275 36158 36163 1:CAS:528:DC%2BD3cXosVSku7s%3D 10934207
30. KS Hewitson LA McNeill MV Riordan Y-M Tian AN Bullock RW Welford JM Elkins NJ Oldham S Bhattacharya JM Gleadle PJ Ratcliffe CW Pugh CJ Schofield 2002 Hypoxia-inducible factor (HIF) asparagine hydroxylase is identical to factor inhibiting HIF (FIH) and is related to the cupin structural family J Biol Chem 277 26351 26355 1:CAS:528:DC%2BD38XlsFKrtbk%3D 12042299
31. DF Higgins MP Biju Y Akai A Wutz RS Johnson VH Haase 2004 Hypoxic induction of CTGF is directly mediated by HIF-1 Am J Physiol Renal Physiol 287 F1223 F1232 1:CAS:528:DC%2BD2cXhtVOmu7jM 15315937
32. DF Higgins K Kimura M Iwano VH Haase 2008 Hypoxia-inducible factor signaling in the development of tissue fibrosis Cell Cycle 7 1128 1132 1:CAS:528:DC%2BD1cXosVKrs74%3D 18418042
33. M Hirsilä P Koivunen V Günzler KI Kivirikko J Myllyharju 2003 Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor J Biol Chem 278 30772 30780 12788921
34. K-H Hofbauer B Gess C Lohaus HE Meyer D Katschinski A Kurtz 2003 Oxygen tension regulates the expression of a group of procollagen hydroxylases Eur J Biochem 270 4515 4522 1:CAS:528:DC%2BD3sXpt1KnsLY%3D 14622280 (Pubitemid 37452528)
35. T Holster O Pakkanen R Soininen R Sormunen M Nokelainen KI Kivirikko J Myllyharju 2007 Loss of assembly of the main basement membrane collagen, type IV, but not fibril-forming collagens and embryonic death in collagen prolyl 4-hydroxylase I null mice J Biol Chem 282 2512 2519 1:CAS:528: DC%2BD2sXmsVehtQ%3D%3D 17135260
36. Y Horino S Takahashi T Miura Y Takahashi 2002 Prolonged hypoxia accelerates the posttranscriptional process of collagen synthesis in cultured fibroblasts Life Sci 71 3031 3045 1:CAS:528:DC%2BD38Xot1ahtrs%3D 12408871
37. IK Hornstra S Birge B Starcher AJ Bailey RP Mecham SD Shapiro 2003 Lysyl oxidase is required for vascular and diaphragmatic development in mice J Biol Chem 278 14387 14393 1:CAS:528:DC%2BD3sXjtVShsLc%3D 12473682
38. C-J Hu L-Y Wang LA Chodosh B Keith MC Simon 2003 Differential roles of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α in hypoxic gene regulation Mol Cell Biol 23 9361 9374 1:CAS:528:DC%2BD3sXpslGqtbc%3D 14645546
39. W Huang X Zhou V Lefebvre B de Crombrugghe 2000 Phosphorylation of SOX9 by cyclic AMP-dependent protein kinase A enhances SOX9's ability to transactivate a Col2a1 chondrocyte-specific enhancer Mol Cell Biol 20 4149 4158 1:CAS:528:DC%2BD3cXjt1Cmt7w%3D 10805756
40. 2 sensing Science 292 464 468 1:CAS:528:DC%2BD3MXjtVentbw%3D 11292862
41. M Ivan T Haberberger DC Gervasi KS Michelson V Günzler K Kondo H Yang I Sorokina RC Conaway JW Conaway WG Kaelin Jr 2002 Biochemical purification and pharmacological inhibition of a mammalian prolyl hydroxylase acting on hypoxia-inducible factor Proc Natl Acad Sci USA 99 13459 13464 1:CAS:528:DC%2BD38XotVKmsrY%3D 12351678
42. 2-regulated prolyl hydroxylation Science 292 468 472 1:CAS:528:DC%2BD3MXjtVentb0%3D 11292861
43. C-H Jeong H-J Lee J-H Cha JH Kim KR Kim J-H Kim D-K Yoon K-W Kim 2007 Hypoxia-inducible factor-1α inhibits self-renewal of mouse embryonic stem cells in vitro via negative regulation of the leukemia inhibitory factor-STAT3 pathway J Biol Chem 282 13672 13679 1:CAS:528:DC%2BD2sXks1Ggu7o%3D 17360716
44. A Jögi I Øra H Nilsson A Lindeheim Y Makino L Poellinger H Axelson S Påhlman 2002 Hypoxia alters gene expression in human neuroblastoma cells towards an immature and neural crest-like phenotype Proc Natl Acad Sci USA 99 7021 7026 12011461
45. WG Kaelin Jr PJ Ratcliffe 2008 Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway Mol Cell 30 393 402 1:CAS:528: DC%2BD1cXmslOitLg%3D 18498744
46. G Karsenty 2003 The complexities of skeletal biology Nature 423 316 318 1:CAS:528:DC%2BD3sXjs1ynu7w%3D 12748648
47. R Khatri E Schipani 2008 About the importance of being desulfated Genes Dev 22 2750 2754 1:CAS:528:DC%2BD1cXht12ht7zL 18923073
48. T Kietzmann U Roth K Jungermann 1999 Induction of the plasminogen activator inhibitor-1 gene expression by mild hypoxia via a hypoxia response element binding the hypoxia-inducible factor-1 in rat hepatocytes Blood 94 4177 4185 1:CAS:528:DyaK1MXnvFOjsbc%3D 10590062
49. DM Kingsley 2001 Genetic control of bone and joint formation Novartis Found Symp 232 213 222 1:CAS:528:DC%2BD38Xht1Omur0%3D 11277082
50. KI Kivirikko T Pihlajaniemi 1998 Collagen hydroxylases and the protein disulfide isomerase subunit of prolyl 4-hydroxylases Adv Enzymol Relat Areas Mol Biol 72 325 398 1:CAS:528:DyaK1cXmsV2nsbs%3D 9559057
51. AC Koong NC Denko KM Hudson C Schindler L Swiersz C Koch S Evans H Ibrahim QT Le DJ Terris AJ Giaccia 2000 Candidate genes for the hypoxic tumor phenotype Cancer Res 60 883 887 1:CAS:528:DC%2BD3cXhs1Shsr4%3D 10706099
52. U Kornak S Mundlos 2003 Genetic disorders of the skeleton: a developmental approach Am J Hum Genet 73 447 474 1:CAS:528:DC%2BD3sXnt1Wqsr4%3D 12900795
53. L Kukkola R Hieta KI Kivirikko J Myllyharju 2003 Identification and characterization of a third human, rat, and mouse collagen prolyl 4-hydroxylase isoenzyme J Biol Chem 278 47685 47693 1:CAS:528:DC%2BD3sXpt1Cqtbg%3D 14500733
54. JE Lafont S Talma CL Murphy 2007 Hypoxia-inducible factor 2α is essential for hypoxic induction of the human articular chondrocyte phenotype Arthritis Rheum 56 3297 3306 1:CAS:528:DC%2BD2sXht12rtLnE 17907154
55. D Lando DJ Peet DA Whelan JJ Gorman ML Whitelaw 2002 Asparagine hydroxylation of the HIF transactivation domain-a hypoxic switch Science 295 858 861 1:CAS:528:DC%2BD38XhtFemtrs%3D 11823643
56. D Lando DJ Peet JJ Gorman DA Whelan ML Whitelaw RK Bruick 2002 FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor Genes Dev 16 1466 1471 1:CAS:528:DC%2BD38XltVGmtLw%3D 12080085
57. J Lee DW Siemann CJ Koch EM Lord 1996 Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts Int J Cancer 67 372 378 1:STN:280:DyaK28zitFShsA%3D%3D 8707411
58. V Lefebvre P Smits 2005 Transcriptional control of chondrocyte fate and differentiation Birth Defects Res Part C Embryo Today 75 200 212 1:CAS:528:DC%2BD2MXhtFGju7zE
59. Q Lin Y-J Lee Z Yun 2006 Differentiation arrest by hypoxia J Biol Chem 281 30678 30683 1:CAS:528:DC%2BD28XhtVCrsLvI 16926163
60. M Logan JF Martin A Nagy C Lobe EN Olsen CJ Tabin 2002 Expression of Cre recombinase in the developing mouse limb bud driven by a Prx1 enhancer Genesis 33 77 80 1:CAS:528:DC%2BD38XltlOrsL0%3D 12112875
61. EM Lord L Harwell CJ Koch 1993 Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts Cancer Res 53 5721 5726 1:CAS:528:DyaK2cXhtVWju74%3D 8242628
62. HA Lucero HM Kagan 2006 Lysyl oxidase: an oxidative enzyme and effector of cell function Cell Mol Life Sci 63 2304 2316 1:CAS:528:DC%2BD28XhtFyrtrrF 16909208
63. JM Mäki 2009 Lysyl oxidases in mammalian development and certain pathological conditions Histol Histopathol 24 651 660 19283672
64. JM Mäki J Räsänen H Tikkanen R Sormunen K Mäkikallio KI Kivirikko R Soininen 2002 Inactivation of the lysyl oxidase gene Lox leads to aortic aneurysms, cardiovascular dysfunction, and perinatal death in mice Circulation 106 2503 2509 12417550
65. JM Mäki R Sormunen S Lippo R Kaarteenaho-Wiik R Soininen J Myllyharju 2005 Lysyl oxidase is essential for normal development and function of the respiratory system and for the integrity of elastic and collagen fibers in various tissues Am J Pathol 167 927 936 16192629
66. SJ Morrison M Csete AK Groves W Melega B Wold DJ Anderson 2000 Culture in reduced levels of oxygen promotes clonogenic sympathoadrenal differentiation by isolated neural crest stem cells J Neurosci 20 7370 7376 1:CAS:528: DC%2BD3cXnt1ajtrs%3D 11007895
67. Myllyharju J (2005) Intracellular post-translational modifications of collagens. In: Brinckmann J, Müller PK, Nothbom H (eds) Topics in current chemistry, vol 247. Collagen, primer in structure, processing and assembly. Springer, Heidelberg, pp 115-147
68. J Myllyharju 2008 Prolyl 4-hydroxylases, key enzymes in the synthesis of collagens and regulation of the response to hypoxia, and their roles as treatment targets Ann Med 40 402 417 1:CAS:528:DC%2BD1cXhtVGnsbfK 19160570
69. J Myllyharju KI Kivirikko 2004 Collagens, modifying enzymes and their mutations in humans, flies and worms Trends Genet 20 33 43 1:CAS:528: DC%2BD3sXpvFyrtr4%3D 14698617
70. JT Norman IM Clark PL Garcia 2000 Hypoxia promotes fibrogenesis in human renal fibroblasts Kidney Int 58 2351 2366 1:CAS:528:DC%2BD3MXitFShtA%3D%3D 11115069
71. BR Olsen 1996 Role of cartilage collagens in formation of the skeleton Ann N Y Acad Sci 785 124 130 1:CAS:528:DyaK28XkvVahsbw%3D 8702118
72. B Ostadal F Kolar V Pelouch J Widimsky 1995 Ontogenetic differences in cardiopulmonary adaptation to chronic hypoxia Physiol Res 44 45 51 1:CAS:528:DyaK2MXkvF2mtLg%3D 8789299
73. M Pacifici RV Iozzo 1988 Remodeling of the rough endoplasmic reticulum during stimulation of procollagen secretion by ascorbic acid in cultured chondrocytes. A biochemical and morphological study J Biol Chem 263 2483 2492 1:CAS:528:DyaL1cXhtFSjurc%3D 3276690
74. SL Payne MJC Hendrix DA Kirschmann 2007 Paradoxical roles for lysyl oxidases in cancer-a prospect J Cell Biochem 101 1338 1354 1:CAS:528: DC%2BD2sXpt1agt7w%3D 17471532
75. M Perhonen W Wang X Han H Ruskoaho TE Takala 1997 Right ventricular collagen type III and IV gene expression increases during early phases of endurance training in hypobaric hypoxic condition Basic Res Cardiol 92 299 309 1:CAS:528:DyaK2sXotFShsLs%3D 9486351
76. PJ Pollard C Loenarz DR Mole MA McDonough JM Gleadle CJ Schofield PJ Ratcliffe 2008 Regulation of Jumonji-domain-containing histone demethylases by hypoxia-inducible factor (HIF)-1α Biochem J 416 387 394 1:CAS:528:DC%2BD1cXhsVentrjJ 18713068
77. S Provot E Schipani 2007 Fetal growth plate: a developmental model of cellular adaptation to hypoxia Ann N Y Acad Sci 1117 26 39 1:CAS:528: DC%2BD1cXhtVGmtL0%3D 18056035
78. S Provot D Zinyk Y Gunes R Khatri Q Le HM Kronenberg RS Johnson MT Longaker AJ Giaccia E Schipani 2007 HIF-1α regulates differentiation of limb bud mesenchyme and joint development J Cell Biol 177 451 464 1:CAS:528:DC%2BD2sXltF2gt74%3D 17470636
79. EB Rankin MP Biju Q Liu TL Unger J Rha RS Johnson MC Simon B Keith VH Haase 2007 Hypoxia-inducible factor-2 (HIF-2) regulates hepatic erythropoietin in vivo J Clin Invest 117 1068 1077 1:CAS:528:DC%2BD2sXktVOit70%3D 17404621
80. PJ Ratcliffe 2006 HIF-1 and HIF-2: working alone or together in hypoxia? J Clin Invest 117 862 865
81. K Rautavuoma K Takaluoma K Passoja A Pirskanen AP Kvist KI Kivirikko J Myllyharju 2002 Characterization of three fragments that constitute the monomers of the human lysyl hydroxylase isoenzymes 1-3. The 30-kDa N-terminal fragment is not required for lysyl hydroxylase activity J Biol Chem 277 23084 23091 1:CAS:528:DC%2BD38XltVGrsLg%3D 11956192
82. K Rautavuoma K Takaluoma R Sormunen J Myllyharju KI Kivirikko R Soininen 2004 Premature aggregation of type IV collagen and early lethality in lysyl hydroxylase 3 null mice Proc Natl Acad Sci USA 101 14120 14125 1:CAS:528:DC%2BD2cXosVylsL0%3D 15377789
83. JC Robins N Akeno A Mukherjee RR Dalal BJ Aronow P Koopman TL Clemens 2005 Hypoxia induces chondrocyte-specific gene expression in mesenchymal cells in association with transcriptional activation of Sox9 Bone 37 313 322 1:CAS:528:DC%2BD2MXos1agtLY%3D 16023419
84. H Ruotsalainen L Sipilä M Vapola R Sormunen AM Salo L Uitto DK Mercer SP Robins M Risteli A Aszodi R Fässler R Myllylä 2006 Glycosylation catalyzed by lysyl hydroxylase 3 is essential for basement membranes J Cell Sci 119 625 635 1:CAS:528:DC%2BD28XislSrt74%3D 16467571
85. RC Sainson AL Harris 2006 Hypoxia-regulated differentiation: let's step it up a Notch Trends Mol Med 12 141 143 1:CAS:528:DC%2BD28XjvFWlsbY%3D 16513423
86. A Salim RP Nacamuli EF Morgan AJ Giaccia MT Longaker 2004 Transient changes in oxygen tension inhibit osteogenic differentiation and Runx2 expression in osteoblasts J Biol Chem 279 40007 40016 1:CAS:528: DC%2BD2cXnsVKrsrk%3D 15263007
87. E Schipani 2005 Hypoxia and HIF-1α in chondrogenesis Semin Cell Dev Biol 16 539 546 1:CAS:528:DC%2BD2MXpvFelur8%3D 16144691
88. E Schipani HE Ryan S Didrickson T Kobayashi M Knight RS Johnson 2001 Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival Genes Dev 15 2865 2876 1:CAS:528:DC%2BD3MXotlalt7w%3D 11691837
89. CJ Schofield PJ Ratcliffe 2004 Oxygen sensing by HIF hydroxylases Nat Rev Mol Biol 5 343 354 1:CAS:528:DC%2BD2cXjsFSltL8%3D
90. NB Schwartz M Domowicz 2002 Chondrodysplasias due to proteoglycan defects Glycobiology 12 57R 68R 1:CAS:528:DC%2BD38XltVyhtrc%3D 12042245
91. GL Semenza GL Wang 1992 A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation Mol Cell Biol 12 5447 5454 1:CAS:528:DyaK3sXltFShsr0%3D 1448077
92. GL Semenza MK Nejfelt SM Chi SE Antonarkos 1991 Hypoxia-inducible nuclear factors bind to an enhancer element located 3' to the human erythropoietin gene Proc Natl Acad Sci USA 88 5680 5684 1:CAS:528:DyaK3MXlsFWku7w%3D 2062846
93. IM Shapiro KD Mansfield SM Evans EM Lord CJ Koch 1997 Chondrocytes in the endochondral growth cartilage are not hypoxic Am J Physiol 272 C1134 C1143 1:CAS:528:DyaK2sXjt1Kqsrk%3D 9142837
94. MC Simon B Keith 2008 The role of oxygen availability in embryonic development and stem cell function Nat Rev Mol Cell Biol 9 285 296 1:CAS:528:DC%2BD1cXjsFCksbk%3D 18285802
95. AJ van der Slot AM Zuurmond AF Bardoel C Wijmenga HE Pruijs DO Sillence J Brinckmann DJ Abraham CM Black N Verzijl J DeGroot R Hanemaaijer JM TeKoppele TWJ Huizinga RA Bank 2003 Identification of PLOD2 as telopeptide lysyl hydroxylase, an important enzyme in fibrosis J Biol Chem 278 40967 40972 12881513
96. AJ van der Slot AM Zuurmond AJ van den Bogaerdt MMW Ulrich E Middelkoop W Boers HK Ronday J DeGroot TWJ Huizinga RA Bank 2004 Increased formation of pyridinoline cross-links due to higher telopeptide lysyl hydroxylase levels is a general fibrotic phenomenon Matrix Biol 23 251 257 15296939
97. TG Smith PA Robbins PJ Ratcliffe 2008 The human side of hypoxia-inducible factor Br J Haematol 141 325 334 1:CAS:528:DC%2BD1cXmt1ait78%3D 18410568
98. P Smits P Li J Mandel Z Zhang JM Deng RR Behringer B de Crombrugghe V Lefebvre 2001 The transcription factors L-Sox5 and Sox6 are essential for cartilage formation Dev Cell 1 277 290 1:CAS:528:DC%2BD3MXntVGrsLs%3D 11702786
99. EE Storm DM Kingsley 1999 GDF5 coordinates bone and joint formation during digit development Dev Biol 209 11 27 1:CAS:528:DyaK1MXisVais74%3D 10208739
100. L Studer M Csete SH Lee N Kabbani J Walikonis B Wold R McKay 2000 Enhanced proliferation, survival, and dopaminergic differentiation of CNS precursors in lowered oxygen J Neurosci 20 7377 7383 1:CAS:528: DC%2BD3cXnt1ajtrg%3D 11007896
101. KK Svoboda 1998 Chondrocyte-matrix attachment complexes mediate survival and differentiation Microsc Res Tech 43 111 122 1:CAS:528:DyaK1cXntlKrs7s%3D 9822998
102. R Tajima N Kawaguchi Y Horino Y Takahashi K Toriyama K Inou S Torii Y Kitagawa 2001 Hypoxic enhancement of type IV collagen secretion accelerates adipose conversion of 3T3-L1 fibroblasts Biochim Biophys Acta 1540 179 187 1:CAS:528:DC%2BD3MXnt1Shtr0%3D 11583813
103. Y Takahashi S Takahashi Y Shiga T Yoshimi T Miura 2000 Hypoxic induction of prolyl 4-hydroxylase α(I) in cultured cells J Biol Chem 275 14139 14146 1:CAS:528:DC%2BD3cXjt1Cgu74%3D 10799490
104. K Takaluoma M Hyry J Lantto R Sormunen RA Bank KI Kivirikko J Myllyharju R Soininen 2007 Tissue-specific changes in the hydroxylysine content and cross-links of collagens and alterations in fibril morphology in lysyl hydroxylase 1 knock-out mice J Biol Chem 282 6588 6596 1:CAS:528: DC%2BD2sXitVCitr0%3D 17197443
105. K Takaluoma J Lantto J Myllyharju 2007 Lysyl hydroxylase 2 is a specific telopeptide hydroxylase, while all three isoenzymes hydroxylate collagenous sequences Matrix Biol 26 396 403 1:CAS:528:DC%2BD2sXlvVOksL4%3D 17289364
106. M Tamamori H Ito M Hiroe F Marumo RI Hata 1997 Stimulation of collagen synthesis in rat cardiac fibroblasts by exposure to hypoxic culture conditions and suppression of the effect by natriuretic peptides Cell Biol Int 21 175 180 1:CAS:528:DyaK2sXjs1ertL4%3D 9151994
107. KY Tsang D Chan D Cheslett WC Chan CL So IG Melhado TW Chan KM Kwan EB Hunziker Y Yamada JF Bateman KM Cheung KS Cheah 2007 Surviving endoplasmic reticulum stress is coupled to altered chondrocyte differentiation and function PLoS Biol 5 e44 17298185
108. C Wang H Luosujärvi J Heikkinen M Risteli L Uitto R Myllylä 2002 The third activity for lysyl hydroxylase 3: galactosylation of hydroxylysyl residues in collagens in vitro Matrix Biol 21 559 566 1:CAS:528: DC%2BD38XptlWltr0%3D 12475640
109. 2 tension Proc Natl Acad Sci USA 92 5510 5514 1:CAS:528:DyaK2MXmtFOgs7k%3D 7539918
110. V Wang DA Davis M Haque LE Huang R Yarchoan 2005 Differential gene up-regulation by hypoxia-inducible factor-1α and hypoxia-inducible factor-2α in HEK293T cells Cancer Res 65 3299 3306 1:CAS:528: DC%2BD2MXjt1yrsr8%3D 15833863
111. C Warnecke Z Zaborowska J Kurreck VA Erdmann M Wiesener KU Eckardt 2004 Differentiating the functional role of hypoxia-inducible factor (HIF)-1α and HIF-2α (EPAS-1) by the use of RNA interference: erythropoietin is a HIF-2α target gene in Hep3B and Kelly cells FASEB J 18 1462 1464 1:CAS:528:DC%2BD2cXntlKktb0%3D 15240563
112. Y Xu P Malladi M Chiou E Bekerman AJ Giaccia MT Longaker 2007 In vitro expansion of adipose-derived adult stromal cells in hypoxia enhances early chondrogenesis Tissue Eng 13 2981 2993 1:CAS:528:DC%2BD2sXhsVSmtLjF 17916040 (Pubitemid 350233076)
113. F Yu SB White Q Zhao FS Lee 2001 HIF-1α is regulated by stimulus sensitive proline hydroxylation Proc Natl Acad Sci USA 98 9630 9635 1:CAS:528:DC%2BD3MXmtlCnurY%3D 11504942
114. Z Yun HL Maecker RS Johnson AJ Giaccia 2002 Inhibition of PPARγ2 gene expression by the HIF-1-regulated gene DEC1/Stra13: a mechanism for regulation of adipogenesis by hypoxia Dev Cell 2 331 341 1:CAS:528: DC%2BD38Xit1GltbY%3D 11879638
115. Z Yun Q Lin AJ Giaccia 2005 Adaptive myogenesis under hypoxia Mol Cell Biol 25 3040 3055 1:CAS:528:DC%2BD2MXjt12qu7s%3D 15798192
116. K Zhang RJ Kaufman 2006 Protein folding in the endoplasmic reticulum and the unfolded protein response Handb Exp Pharmacol 172 69 91 1:CAS:528: DC%2BD2MXhtlWqsbrI 16610355