Hypoxia in cartilage: HIF-1α is essential for chondrocyte growth arrest and survival

Genes and Development

Volumn 15, Issue 21, 2001, Pages 2865-2876

  Schipani, Ernestina ^a   Ryan, Heather E ^b   Didrickson, Susanna ^b   Kobayashi, Tatsuya ^a   Knight, Melissa ^a   Johnson, Randall S ^b  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b SECTION OF MOLECULAR BIOLOGY   (United States)

Author keywords

Cartilage; Hypoxia

Indexed keywords

BROXURIDINE; CYCLIN DEPENDENT KINASE INHIBITOR; HYPOXIA INDUCIBLE FACTOR 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; OXYGEN; PROTEIN P57; VASCULOTROPIN;

ANGIOGENESIS; ANIMAL CELL; APOPTOSIS; ARTICLE; BONE DEVELOPMENT; CANCER; CARTILAGE CELL; CELL HYPOXIA; CELL SURVIVAL; GENE DELETION; GROWTH INHIBITION; HEART INFARCTION; MOUSE; NONHUMAN; OXYGEN TISSUE LEVEL; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; REGULATORY MECHANISM; STROKE; TISSUE SPECIFICITY; TRANSCRIPTION REGULATION;

ALLELES; ANIMALS; ANOXIA; BONE AND BONES; BROMODEOXYURIDINE; CARTILAGE; CELL DIVISION; CELL SURVIVAL; CHONDROCYTES; ENDOTHELIAL GROWTH FACTORS; HYPERTROPHY; HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; IN SITU NICK-END LABELING; INTEGRASES; LYMPHOKINES; MICE; MICE, KNOCKOUT; MICE, TRANSGENIC; OXYGEN; PHENOTYPE; POLYPYRIMIDINE TRACT-BINDING PROTEIN; RIBONUCLEOPROTEINS; RNA-BINDING PROTEINS; TIME FACTORS; TRACHEA; TRANSCRIPTION FACTORS; UP-REGULATION; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTORS; VIRAL PROTEINS;

EID: 0035499204     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (38)

1. Role of HIF-1α in hypoxia-mediated apoptosis, cell proliferation and tumour angiogenesis
2. Coordinate up-regulation of hypoxia inducible factor (HIF)-1α and HIF-1 target genes during multi-stage epidermal carcinogenesis and wound healing
3. Toward a molecular understanding of skeletal development
4. Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: Similarities with the erythropoietin 3′ enhancer
5. VEGF couples hypertrophic cartilage remodeling, ossification and angiogenesis during endochondral bone formation
6. Conditional inactivation of VEGF-A in areas of collagen2a1 expression results in embryonic lethality in the heterozygous state
7. Cartilage to bone - Angiogenesis leads the way
8. The oxygen consumption of luminous bacteria
9. 2 homeostasis by hypoxia-inducible factor 1 alpha
10. Expression of ARNT, ARNT2, HIF1α, HIF2α and Ah receptor mRNAs in the developing mouse
11. Suppression of tumor growth through disruption of hypoxia-inducible transcription
12. Direct relationship between radiobiological hypoxia in tumors and monoclonal antibody detection of EF5 cellular adducts
13. Parathyroid hormone-related peptide delays terminal differentiation of chondrocytes during endochondral bone development
14. Induction of phosphoglycerate kinase 1 gene expression by hypoxia. Roles of Arnt and HIF1α
15. Detection of hypoxic cells by monoclonal antibody recognizing 2-nitroimidazole adducts
16. Hypoxia-inducible factor 1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth
17. Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 during mouse development
18. Adaptation of chondrocytes to low oxygen tension: Relationship between hypoxia and cellular metabolism
19. Targeting tumors through the HIF system
20. Angiogenesis: How a tumor adapts to hypoxia
21. HIF-1α is required for solid tumor formation and embryonic vascularization
22. Hypoxia-inducible factor-1 alpha is a positive factor in solid tumor growth
23. Transcription factor HIF-1 is a necessary mediator of the pasteur effect in mammalian cells
24. 2 homeostasis by hypoxia-inducible factor 1
25. Expression of hypoxia-inducible factor 1: Mechanisms and consequences
26. Hypoxia, clonal selection, and the role of HIF-1 in tumor progression
27. Transcriptional regulation of genes encoding glycolytic enzymes by hypoxia-inducible factor 1
28. Generalized lacZ expression with the ROSA26 Cre reporter strain
29. MMP-9/gelatinase B is a key regulator of growth plate angiogenesis and apoptosis of hypertrophic chondrocytes
30. In vivo expression of mRNAs encoding hypoxia-inducible factor 1
31. Selection and analysis of a mutant cell line defective in the hypoxia-inducible factor-1 alpha subunit (HIF-1α)
32. Regulation of the collagen II gene in vitro and in transgenic mice
33. Ablation of the CDK inhibitor p57Kip2 results in increased apoptosis and delayed differentiation during mouse development
34. Insulin induces transcription of target genes through the hypoxia-inducible factor HIF-1α/ARNT
35. Altered cell differentiation and proliferation in mice lacking p57KIP2 indicates a role in Beckwith-Wiedemann syndrome
36. Modulation of hypoxia-inducible factor 1α expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
37. Loss of PTEN facilitates HIF-1-mediated gene expression