메뉴 건너뛰기




Volumn 141, Issue 3, 2008, Pages 325-334

The human side of hypoxia-inducible factor

Author keywords

Erythropoiesis; Erythropoietin; Iron; Oxygen sensing; Polycythaemia

Indexed keywords

DEFEROXAMINE; ERYTHROPOIETIN; HEMOGLOBIN; HYPOXIA INDUCIBLE FACTOR 1; PROCOLLAGEN PROLINE 2 OXOGLUTARATE 4 DIOXYGENASE; VON HIPPEL LINDAU PROTEIN;

EID: 42049115510     PISSN: 00071048     EISSN: 13652141     Source Type: Journal    
DOI: 10.1111/j.1365-2141.2008.07029.x     Document Type: Conference Paper
Times cited : (231)

References (101)
  • 2
    • 0015256050 scopus 로고
    • Plasma erythropoietin in men and mice during acclimatization to different altitudes
    • Abbrecht, P.H. Littell, J.K. (1972) Plasma erythropoietin in men and mice during acclimatization to different altitudes. Journal of Applied Physiology, 32, 54 58.
    • (1972) Journal of Applied Physiology , vol.32 , pp. 54-58
    • Abbrecht, P.H.1    Littell, J.K.2
  • 3
    • 42049112947 scopus 로고    scopus 로고
    • Disturbance in the HIF-1α pathway associated with erythrocytosis: Further evidences brought by frameshift and nonsense mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene
    • d.o.i.:
    • Al-Sheikh, M., Moradkhani, K., Lopez, M., Wajcman, H. Prehu, C 2007) Disturbance in the HIF-1α pathway associated with erythrocytosis: further evidences brought by frameshift and nonsense mutations in the prolyl hydroxylase domain protein 2 (PHD2) gene. Blood Cells, Molecules and Diseases. d.o.i.:
    • (2007) Blood Cells, Molecules and Diseases.
    • Al-Sheikh, M.1    Moradkhani, K.2    Lopez, M.3    Wajcman, H.4    Prehu, C.5
  • 5
    • 0036082090 scopus 로고    scopus 로고
    • Desferrioxamine elevates pulmonary vascular resistance in humans: Potential for involvement of HIF-1
    • Balanos, G.M., Dorrington, K.L. Robbins, P.A. (2002) Desferrioxamine elevates pulmonary vascular resistance in humans: potential for involvement of HIF-1. Journal of Applied Physiology, 92, 2501 2507.
    • (2002) Journal of Applied Physiology , vol.92 , pp. 2501-2507
    • Balanos, G.M.1    Dorrington, K.L.2    Robbins, P.A.3
  • 6
    • 0038056173 scopus 로고    scopus 로고
    • Pulmonary hypertension in chronic obstructive pulmonary disease
    • Barbera, J.A., Peinado, V.I. Santos, S. (2003) Pulmonary hypertension in chronic obstructive pulmonary disease. European Respiratory Journal, 21, 892 905.
    • (2003) European Respiratory Journal , vol.21 , pp. 892-905
    • Barbera, J.A.1    Peinado, V.I.2    Santos, S.3
  • 7
    • 0041465022 scopus 로고    scopus 로고
    • HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia
    • Berra, E., Benizri, E., Ginouves, A., Volmat, V., Roux, D. Pouyssegur, J. (2003) HIF prolyl-hydroxylase 2 is the key oxygen sensor setting low steady-state levels of HIF-1α in normoxia. EMBO Journal, 22, 4082 4090.
    • (2003) EMBO Journal , vol.22 , pp. 4082-4090
    • Berra, E.1    Benizri, E.2    Ginouves, A.3    Volmat, V.4    Roux, D.5    Pouyssegur, J.6
  • 8
    • 85047691081 scopus 로고    scopus 로고
    • Heterozygous deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia
    • Brusselmans, K., Compernolle, V., Tjwa, M., Wiesener, M.S., Maxwell, P.H., Collen, D. Carmeliet, P. (2003) Heterozygous deficiency of hypoxia-inducible factor-2α protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia. Journal of Clinical Investigation, 111, 1519 1527.
    • (2003) Journal of Clinical Investigation , vol.111 , pp. 1519-1527
    • Brusselmans, K.1    Compernolle, V.2    Tjwa, M.3    Wiesener, M.S.4    Maxwell, P.H.5    Collen, D.6    Carmeliet, P.7
  • 10
    • 25144457125 scopus 로고    scopus 로고
    • Transcriptional repression of human cad gene by hypoxia inducible factor-1α
    • Chen, K.F., Lai, Y.Y., Sun, H.S. Tsai, S.J. (2005) Transcriptional repression of human cad gene by hypoxia inducible factor-1α. Nucleic Acids Research, 33, 5190 5198.
    • (2005) Nucleic Acids Research , vol.33 , pp. 5190-5198
    • Chen, K.F.1    Lai, Y.Y.2    Sun, H.S.3    Tsai, S.J.4
  • 12
    • 8644224030 scopus 로고    scopus 로고
    • Human pulmonary vascular responses to hypoxia and hypercapnia
    • Dorrington, K.L. Talbot, N.P. (2004) Human pulmonary vascular responses to hypoxia and hypercapnia. Pflügers Archive, 449, 1 15.
    • (2004) Pflügers Archive , vol.449 , pp. 1-15
    • Dorrington, K.L.1    Talbot, N.P.2
  • 14
    • 0000625749 scopus 로고
    • Physiological observations made on Pike's Peak, Colorado, with special reference to adaptation to low barometric pressure
    • Douglas, C.G., Haldane, J.S., Henderson, Y. Schneider, E.C. (1913) Physiological observations made on Pike's Peak, Colorado, with special reference to adaptation to low barometric pressure. Philosophical Transactions of the Royal Society B, 203, 185 318.
    • (1913) Philosophical Transactions of the Royal Society B , vol.203 , pp. 185-318
    • Douglas, C.G.1    Haldane, J.S.2    Henderson, Y.3    Schneider, E.C.4
  • 17
    • 0000009635 scopus 로고
    • Humoral regulation of red cell production
    • Erslev, A. (1953) Humoral regulation of red cell production. Blood, 8, 349 357.
    • (1953) Blood , vol.8 , pp. 349-357
    • Erslev, A.1
  • 18
    • 0028359320 scopus 로고
    • Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase a genes: Similarities with the erythropoietin 3′ enhancer
    • Firth, J.D., Ebert, B.L., Pugh, C.W. Ratcliffe, P.J. (1994) Oxygen-regulated control elements in the phosphoglycerate kinase 1 and lactate dehydrogenase A genes: similarities with the erythropoietin 3′ enhancer. Proceedings of the National Academy of Sciences U S A, 91, 6496 6500.
    • (1994) Proceedings of the National Academy of Sciences U S a , vol.91 , pp. 6496-6500
    • Firth, J.D.1    Ebert, B.L.2    Pugh, C.W.3    Ratcliffe, P.J.4
  • 21
    • 2342631195 scopus 로고    scopus 로고
    • Congenital disorder of oxygen sensing: Association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors
    • Gordeuk, V.R., Sergueeva, A.I., Miasnikova, G.Y., Okhotin, D., Voloshin, Y., Choyke, P.L., Butman, J.A., Jedlickova, K., Prchal, J.T. Polyakova, L.A. (2004) Congenital disorder of oxygen sensing: association of the homozygous Chuvash polycythemia VHL mutation with thrombosis and vascular abnormalities but not tumors. Blood, 103, 3924 3932.
    • (2004) Blood , vol.103 , pp. 3924-3932
    • Gordeuk, V.R.1    Sergueeva, A.I.2    Miasnikova, G.Y.3    Okhotin, D.4    Voloshin, Y.5    Choyke, P.L.6    Butman, J.A.7    Jedlickova, K.8    Prchal, J.T.9    Polyakova, L.A.10
  • 23
    • 0003028645 scopus 로고
    • Physiological variariations of the cardiac output of man. VII. the effect of high altitude and its related functions: An account of experiments conducted on the summit of Pikes Peaks, Colorado
    • Grollman, A. (1930) Physiological variariations of the cardiac output of man. VII. The effect of high altitude and its related functions: an account of experiments conducted on the summit of Pikes Peaks, Colorado. American Journal of Physiology, 93, 19 40.
    • (1930) American Journal of Physiology , vol.93 , pp. 19-40
    • Grollman, A.1
  • 25
    • 0031733828 scopus 로고    scopus 로고
    • Molecular characterization and chromosomal localization of a third α-class hypoxia inducible factor subunit, HIF3α
    • Gu, Y.Z., Moran, S.M., Hogenesch, J.B., Wartman, L. Bradfield, C.A. (1998) Molecular characterization and chromosomal localization of a third α-class hypoxia inducible factor subunit, HIF3α. Gene Expression, 7, 205 213.
    • (1998) Gene Expression , vol.7 , pp. 205-213
    • Gu, Y.Z.1    Moran, S.M.2    Hogenesch, J.B.3    Wartman, L.4    Bradfield, C.A.5
  • 30
  • 32
    • 0029753008 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit
    • Huang, L.E., Arany, Z., Livingston, D.M. Bunn, H.F. (1996) Activation of hypoxia-inducible transcription factor depends primarily upon redox-sensitive stabilization of its α subunit. Journal of Biological Chemistry, 271, 32253 32259.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 32253-32259
    • Huang, L.E.1    Arany, Z.2    Livingston, D.M.3    Bunn, H.F.4
  • 36
    • 0029944965 scopus 로고    scopus 로고
    • Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1
    • Jiang, B.H., Rue, E., Wang, G.L., Roe, R. Semenza, G.L. (1996) Dimerization, DNA binding, and transactivation properties of hypoxia-inducible factor 1. Journal of Biological Chemistry, 271, 17771 17778.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 17771-17778
    • Jiang, B.H.1    Rue, E.2    Wang, G.L.3    Roe, R.4    Semenza, G.L.5
  • 37
    • 0037154262 scopus 로고    scopus 로고
    • Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α
    • Kline, D.D., Peng, Y.-J., Manalo, D.J., Semenza, G.L. Prabhakar, N.R. (2002) Defective carotid body function and impaired ventilatory responses to chronic hypoxia in mice partially deficient for hypoxia-inducible factor 1α. Proceedings of the National Academy of Sciences U S A, 99, 821 826.
    • (2002) Proceedings of the National Academy of Sciences U S a , vol.99 , pp. 821-826
    • Kline, D.D.1    Peng, Y.-J.2    Manalo, D.J.3    Semenza, G.L.4    Prabhakar, N.R.5
  • 38
    • 0037446983 scopus 로고    scopus 로고
    • Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells
    • Knowles, H.J., Raval, R.R., Harris, A.L. Ratcliffe, P.J. (2003) Effect of ascorbate on the activity of hypoxia-inducible factor in cancer cells. Cancer Research, 63, 1764 1768.
    • (2003) Cancer Research , vol.63 , pp. 1764-1768
    • Knowles, H.J.1    Raval, R.R.2    Harris, A.L.3    Ratcliffe, P.J.4
  • 39
    • 0036469038 scopus 로고    scopus 로고
    • Asparagine hydroxylation of the HIF transactivation domain: A hypoxic switch
    • Lando, D., Peet, D.J., Whelan, D.A., Gorman, J.J. Whitelaw, M.L. (2002) Asparagine hydroxylation of the HIF transactivation domain: a hypoxic switch. Science, 295, 858 861.
    • (2002) Science , vol.295 , pp. 858-861
    • Lando, D.1    Peet, D.J.2    Whelan, D.A.3    Gorman, J.J.4    Whitelaw, M.L.5
  • 40
    • 34247211079 scopus 로고    scopus 로고
    • Association of polymorphisms of 1772 (C - >t) and 1790 (G - >a) in HIF1A gene with hypoxia adaptation in high altitude in Sherpas
    • Liu, K.X., Sun, X.C., Wang, S.W. Hu, B. (2007) Association of polymorphisms of 1772 (C - >T) and 1790 (G - >A) in HIF1A gene with hypoxia adaptation in high altitude in Sherpas. Zhonghua Yi Xue Yi Chuan Xue Za Zhi, 24, 230 232.
    • (2007) Zhonghua Yi Xue Yi Chuan Xue Za Zhi , vol.24 , pp. 230-232
    • Liu, K.X.1    Sun, X.C.2    Wang, S.W.3    Hu, B.4
  • 41
    • 0000655498 scopus 로고    scopus 로고
    • Identification of a hypoxia response element in the transferrin receptor gene
    • Lok, C.N. Ponka, P. (1999) Identification of a hypoxia response element in the transferrin receptor gene. Journal of Biological Chemistry, 274, 24147 24152.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 24147-24152
    • Lok, C.N.1    Ponka, P.2
  • 43
    • 0027461553 scopus 로고
    • Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: Evidence for a widespread oxygen-sensing mechanism
    • Maxwell, P.H., Pugh, C.W. Ratcliffe, P.J. (1993) Inducible operation of the erythropoietin 3' enhancer in multiple cell lines: evidence for a widespread oxygen-sensing mechanism. Proceedings of the National Academy of Sciences USA, 90, 2423 2427.
    • (1993) Proceedings of the National Academy of Sciences USA , vol.90 , pp. 2423-2427
    • Maxwell, P.H.1    Pugh, C.W.2    Ratcliffe, P.J.3
  • 45
    • 13244273759 scopus 로고    scopus 로고
    • Genetic association analysis of chronic mountain sickness in an Andean high-altitude population
    • Mejia, O.M., Prchal, J.T., Leon-Velarde, F., Hurtado, A. Stockton, D.W. (2005) Genetic association analysis of chronic mountain sickness in an Andean high-altitude population. Haematologica, 90, 13 19.
    • (2005) Haematologica , vol.90 , pp. 13-19
    • Mejia, O.M.1    Prchal, J.T.2    Leon-Velarde, F.3    Hurtado, A.4    Stockton, D.W.5
  • 46
    • 0022253153 scopus 로고
    • Serum erythropoietin in humans at high altitude and its relation to plasma renin
    • Milledge, J.S. Cotes, P.M. (1985) Serum erythropoietin in humans at high altitude and its relation to plasma renin. Journal of Applied Physiology, 59, 360 364.
    • (1985) Journal of Applied Physiology , vol.59 , pp. 360-364
    • Milledge, J.S.1    Cotes, P.M.2
  • 48
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth, E., Tuttle, M.S., Powelson, J., Vaughn, M.B., Donovan, A., Ward, D.M., Ganz, T. Kaplan, J. (2004) Hepcidin regulates cellular iron efflux by binding to ferroportin and inducing its internalization. Science, 306, 2090 2093.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3    Vaughn, M.B.4    Donovan, A.5    Ward, D.M.6    Ganz, T.7    Kaplan, J.8
  • 49
    • 34147202137 scopus 로고    scopus 로고
    • Desferrioxamine enhances hypoxic ventilatory response and induces tyrosine hydroxylase gene expression in the rat brainstem in vivo
    • Nguyen, M.V., Pouvreau, S., El Hajjaji, F.Z., Denavit-Saubie, M. Pequignot, J.M. (2007) Desferrioxamine enhances hypoxic ventilatory response and induces tyrosine hydroxylase gene expression in the rat brainstem in vivo. Journal of Neuroscience Research, 85, 1119 1125.
    • (2007) Journal of Neuroscience Research , vol.85 , pp. 1119-1125
    • Nguyen, M.V.1    Pouvreau, S.2    El Hajjaji, F.Z.3    Denavit-Saubie, M.4    Pequignot, J.M.5
  • 50
  • 51
    • 33846870322 scopus 로고    scopus 로고
    • Role of hypoxia-inducible factor-1α as a cancer therapy target
    • Patiar, S. Harris, A.L. (2006) Role of hypoxia-inducible factor-1α as a cancer therapy target. Endocrine-Related Cancer, 13, S61 S75.
    • (2006) Endocrine-Related Cancer , vol.13
    • Patiar, S.1    Harris, A.L.2
  • 52
    • 33947606593 scopus 로고    scopus 로고
    • The heart and pulmonary circulation at high altitudes: Healthy highlanders and chronic mountain sickness
    • Penaloza, D. Arias-Stella, J. (2007) The heart and pulmonary circulation at high altitudes: healthy highlanders and chronic mountain sickness. Circulation, 115, 1132 1146.
    • (2007) Circulation , vol.115 , pp. 1132-1146
    • Penaloza, D.1    Arias-Stella, J.2
  • 53
    • 33751329032 scopus 로고    scopus 로고
    • Heterozygous HIF-1α deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia
    • Peng, Y.J., Yuan, G., Ramakrishnan, D., Sharma, S.D., Bosch-Marce, M., Kumar, G.K., Semenza, G.L. Prabhakar, N.R. (2006) Heterozygous HIF-1α deficiency impairs carotid body-mediated systemic responses and reactive oxygen species generation in mice exposed to intermittent hypoxia. Journal of Physiology, 577, 705 716.
    • (2006) Journal of Physiology , vol.577 , pp. 705-716
    • Peng, Y.J.1    Yuan, G.2    Ramakrishnan, D.3    Sharma, S.D.4    Bosch-Marce, M.5    Kumar, G.K.6    Semenza, G.L.7    Prabhakar, N.R.8
  • 54
    • 34247212833 scopus 로고    scopus 로고
    • Genetically heterogeneous origins of idiopathic erythrocytosis
    • Percy, M.L. (2007) Genetically heterogeneous origins of idiopathic erythrocytosis. Hematology, 12, 131 139.
    • (2007) Hematology , vol.12 , pp. 131-139
    • Percy, M.L.1
  • 56
    • 34548848799 scopus 로고    scopus 로고
    • A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove
    • Percy, M.J., Furlow, P.W., Beer, P.A., Lappin, T.R., McMullin, M.F. Lee, F.S. (2007) A novel erythrocytosis-associated PHD2 mutation suggests the location of a HIF binding groove. Blood, 110, 2193 2196.
    • (2007) Blood , vol.110 , pp. 2193-2196
    • Percy, M.J.1    Furlow, P.W.2    Beer, P.A.3    Lappin, T.R.4    McMullin, M.F.5    Lee, F.S.6
  • 59
    • 0016118725 scopus 로고
    • Familial erythrocytosis among the residents of the Chuvash ASSR
    • Polyakova, L.A. (1974) Familial erythrocytosis among the residents of the Chuvash ASSR. Problemy Gematologii i Perelivaniia Krovi, 19, 30 33.
    • (1974) Problemy Gematologii I Perelivaniia Krovi , vol.19 , pp. 30-33
    • Polyakova, L.A.1
  • 61
    • 0030937718 scopus 로고    scopus 로고
    • Activation of hypoxia-inducible factor-1; Definition of regulatory domains within the α subunit
    • Pugh, C.W., O'Rourke, J.F., Nagao, M., Gleadle, J.M. Ratcliffe, P.J. (1997) Activation of hypoxia-inducible factor-1; definition of regulatory domains within the α subunit. Journal of Biological Chemistry, 272, 11205 11214.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 11205-11214
    • Pugh, C.W.1    O'Rourke, J.F.2    Nagao, M.3    Gleadle, J.M.4    Ratcliffe, P.J.5
  • 62
    • 0000232970 scopus 로고
    • Man's respiratory response during and after acclimatization to high altitude
    • Rahn, H. Otis, A.B. (1949) Man's respiratory response during and after acclimatization to high altitude. American Journal of Physiology, 157, 445 462.
    • (1949) American Journal of Physiology , vol.157 , pp. 445-462
    • Rahn, H.1    Otis, A.B.2
  • 64
    • 0033894551 scopus 로고    scopus 로고
    • Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans
    • Ren, X., Dorrington, K.L., Maxwell, P.H. Robbins, P.A. (2000) Effects of desferrioxamine on serum erythropoietin and ventilatory sensitivity to hypoxia in humans. Journal of Applied Physiology, 89, 680 686.
    • (2000) Journal of Applied Physiology , vol.89 , pp. 680-686
    • Ren, X.1    Dorrington, K.L.2    Maxwell, P.H.3    Robbins, P.A.4
  • 66
    • 0000093975 scopus 로고
    • The polycythemia of high altitudes: Iron metabolism and related aspects
    • Reynafarje, C., Lozano, R. Valdivieso, J. (1959) The polycythemia of high altitudes: iron metabolism and related aspects. Blood, 14, 433 455.
    • (1959) Blood , vol.14 , pp. 433-455
    • Reynafarje, C.1    Lozano, R.2    Valdivieso, J.3
  • 68
    • 34548691285 scopus 로고    scopus 로고
    • Role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude
    • Robbins, P.A. (2007) Role of the peripheral chemoreflex in the early stages of ventilatory acclimatization to altitude. Respiratory Physiology and Neurobiology, 158, 237 242.
    • (2007) Respiratory Physiology and Neurobiology , vol.158 , pp. 237-242
    • Robbins, P.A.1
  • 69
    • 0030792094 scopus 로고    scopus 로고
    • Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1
    • Rolfs, A., Kvietikova, I., Gassmann, M. Wenger, R.H. (1997) Oxygen-regulated transferrin expression is mediated by hypoxia-inducible factor-1. Journal of Biological Chemistry, 272, 20055 20062.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 20055-20062
    • Rolfs, A.1    Kvietikova, I.2    Gassmann, M.3    Wenger, R.H.4
  • 70
    • 0030961006 scopus 로고    scopus 로고
    • Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes
    • Salceda, S. Caro, J. (1997) Hypoxia-inducible factor 1α (HIF-1α) protein is rapidly degraded by the ubiquitin-proteasome system under normoxic conditions. Its stabilization by hypoxia depends on redox-induced changes. Journal of Biological Chemistry, 272, 22642 22647.
    • (1997) Journal of Biological Chemistry , vol.272 , pp. 22642-22647
    • Salceda, S.1    Caro, J.2
  • 74
    • 8344237449 scopus 로고    scopus 로고
    • Hydroxylation of HIF-1: Oxygen sensing at the molecular level
    • Semenza, G.L. (2004) Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology (Bethesda), 19, 176 182.
    • (2004) Physiology (Bethesda) , vol.19 , pp. 176-182
    • Semenza, G.L.1
  • 75
    • 33645786505 scopus 로고    scopus 로고
    • Development of novel therapeutic strategies that target HIF-1
    • Semenza, G.L. (2006) Development of novel therapeutic strategies that target HIF-1. Expert Opinion on Therapeutic Targets, 10, 267 280.
    • (2006) Expert Opinion on Therapeutic Targets , vol.10 , pp. 267-280
    • Semenza, G.L.1
  • 76
    • 0026468180 scopus 로고
    • A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation
    • Semenza, G. Wang, G. (1992) A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation. Molecular and Cellular Biology, 12, 5447 5454.
    • (1992) Molecular and Cellular Biology , vol.12 , pp. 5447-5454
    • Semenza, G.1    Wang, G.2
  • 77
    • 0030460724 scopus 로고    scopus 로고
    • Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase a gene promoters contain essential binding sites for hypoxia-inducible factor 1
    • Semenza, G.L., Jiang, B.H., Leung, S.W., Passantino, R., Concordet, J.P., Maire, P. Giallongo, A. (1996) Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1. Journal of Biological Chemistry, 271, 32529 32537.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 32529-32537
    • Semenza, G.L.1    Jiang, B.H.2    Leung, S.W.3    Passantino, R.4    Concordet, J.P.5    Maire, P.6    Giallongo, A.7
  • 80
    • 35948972354 scopus 로고    scopus 로고
    • Iron, pre-eclampsia and hypoxia-inducible factor
    • Smith, T.G. Robbins, P.A. (2007) Iron, pre-eclampsia and hypoxia-inducible factor. BJOG, 114, 1581 1582.
    • (2007) BJOG , vol.114 , pp. 1581-1582
    • Smith, T.G.1    Robbins, P.A.2
  • 82
    • 5644240828 scopus 로고    scopus 로고
    • Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (HIF) in regulating HIF transcriptional target genes
    • Stolze, I.P., Tian, Y.M., Appelhoff, R.J., Turley, H., Wykoff, C.C., Gleadle, J.M. Ratcliffe, P.J. (2004) Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (HIF) in regulating HIF transcriptional target genes. Journal of Biological Chemistry, 279, 42719 42725.
    • (2004) Journal of Biological Chemistry , vol.279 , pp. 42719-42725
    • Stolze, I.P.1    Tian, Y.M.2    Appelhoff, R.J.3    Turley, H.4    Wykoff, C.C.5    Gleadle, J.M.6    Ratcliffe, P.J.7
  • 83
    • 0033588021 scopus 로고    scopus 로고
    • Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation
    • Tacchini, L., Bianchi, L., Bernelli-Zazzera, A. Cairo, G. (1999) Transferrin receptor induction by hypoxia. HIF-1-mediated transcriptional activation and cell-specific post-transcriptional regulation. Journal of Biological Chemistry, 274, 24142 24146.
    • (1999) Journal of Biological Chemistry , vol.274 , pp. 24142-24146
    • Tacchini, L.1    Bianchi, L.2    Bernelli-Zazzera, A.3    Cairo, G.4
  • 84
    • 14144253561 scopus 로고    scopus 로고
    • Two temporal components within the human pulmonary vascular response to ∼2 h of isocapnic hypoxia
    • Talbot, N.P., Balanos, G.M., Dorrington, K.L. Robbins, P.A. (2005) Two temporal components within the human pulmonary vascular response to ∼2 h of isocapnic hypoxia. Journal of Applied Physiology, 98, 1125 1139.
    • (2005) Journal of Applied Physiology , vol.98 , pp. 1125-1139
    • Talbot, N.P.1    Balanos, G.M.2    Dorrington, K.L.3    Robbins, P.A.4
  • 85
    • 0031020884 scopus 로고    scopus 로고
    • Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells
    • Tian, H., McKnight, S. Russell, D. (1997) Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells. Genes and Development, 11, 72 82.
    • (1997) Genes and Development , vol.11 , pp. 72-82
    • Tian, H.1    McKnight, S.2    Russell, D.3
  • 86
    • 0000685312 scopus 로고
    • Sur l'augmentation considérable du nombre des globules rouges dans le sang chez les habitants des hauts plateaux de 1'Amérique du Sud
    • Viault, F. (1890) Sur l'augmentation considérable du nombre des globules rouges dans le sang chez les habitants des hauts plateaux de 1'Amérique du Sud. Comptes Rendus Hebdomaires des Seances de l'Académie des Sciences, Paris, 111, 917 918.
    • (1890) Comptes Rendus Hebdomaires des Seances de l'Académie des Sciences, Paris , vol.111 , pp. 917-918
    • Viault, F.1
  • 87
    • 2342572983 scopus 로고    scopus 로고
    • Optimal hemoglobin concentration and high altitude: A theoretical approach for Andean men at rest
    • Villafuerte, F.C., Cardenas, R. Monge, C.C. (2004) Optimal hemoglobin concentration and high altitude: a theoretical approach for Andean men at rest. Journal of Applied Physiology, 96, 1581 1588.
    • (2004) Journal of Applied Physiology , vol.96 , pp. 1581-1588
    • Villafuerte, F.C.1    Cardenas, R.2    Monge, C.C.3
  • 88
    • 0014095282 scopus 로고
    • Cardiopulmonary responses of resting man during early exposure to high altitude
    • Vogel, J.A. Harris, C.W. (1967) Cardiopulmonary responses of resting man during early exposure to high altitude. Journal of Applied Physiology, 22, 1124 1128.
    • (1967) Journal of Applied Physiology , vol.22 , pp. 1124-1128
    • Vogel, J.A.1    Harris, C.W.2
  • 89
    • 15044360562 scopus 로고    scopus 로고
    • The pathway for IRP2 degradation involving 2-oxoglutarate-dependent oxygenase(s) does not require the E3 ubiquitin ligase activity of pVHL
    • Wang, J. Pantopoulos, K. (2005) The pathway for IRP2 degradation involving 2-oxoglutarate-dependent oxygenase(s) does not require the E3 ubiquitin ligase activity of pVHL. Biochimica et Biophysica Acta, 1743, 79 85.
    • (2005) Biochimica et Biophysica Acta , vol.1743 , pp. 79-85
    • Wang, J.1    Pantopoulos, K.2
  • 90
    • 0027210562 scopus 로고
    • General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia
    • Wang, G.L. Semenza, G.L. (1993a) General involvement of hypoxia-inducible factor 1 in transcriptional response to hypoxia. Proceedings of the National Academy of Sciences U S A, 90, 4304 4308.
    • (1993) Proceedings of the National Academy of Sciences U S a , vol.90 , pp. 4304-4308
    • Wang, G.L.1    Semenza, G.L.2
  • 91
    • 0027136260 scopus 로고
    • Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: Implications for models of hypoxia signal transduction
    • Wang, G.L. Semenza, G.L. (1993b) Desferrioxamine induces erythropoietin gene expression and hypoxia-inducible factor 1 DNA-binding activity: implications for models of hypoxia signal transduction. Blood, 82, 3610 3615.
    • (1993) Blood , vol.82 , pp. 3610-3615
    • Wang, G.L.1    Semenza, G.L.2
  • 93
    • 1642458415 scopus 로고    scopus 로고
    • Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity
    • Wang, J., Chen, G., Muckenthaler, M., Galy, B., Hentze, M.W. Pantopoulos, K. (2004) Iron-mediated degradation of IRP2, an unexpected pathway involving a 2-oxoglutarate-dependent oxygenase activity. Molecular and Cellular Biology, 24, 954 965.
    • (2004) Molecular and Cellular Biology , vol.24 , pp. 954-965
    • Wang, J.1    Chen, G.2    Muckenthaler, M.3    Galy, B.4    Hentze, M.W.5    Pantopoulos, K.6
  • 94
  • 101
    • 34249106715 scopus 로고    scopus 로고
    • A randomised placebo-controlled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin ≥ 13·2 g/dl
    • Ziaei, S., Norrozi, M., Faghihzadeh, S. Jafarbegloo, E. (2007) A randomised placebo-controlled trial to determine the effect of iron supplementation on pregnancy outcome in pregnant women with haemoglobin ≥ 13·2 g/dl. BJOG, 114, 684 688.
    • (2007) BJOG , vol.114 , pp. 684-688
    • Ziaei, S.1    Norrozi, M.2    Faghihzadeh, S.3    Jafarbegloo, E.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.