Computational analysis of phenotypic space in heterologous polyketide biosynthesis-Applications to Escherichia coli, Bacillus subtilis, and Saccharomyces cerevisiae

Journal of Theoretical Biology

Volumn 262, Issue 2, 2010, Pages 197-207

  Boghigian, Brett A ^a   Lee, Kyongbum ^a   Pfeifer, Blaine A ^a  

^a Tufts University   (United States)

Author keywords

FBA; Metabolic engineering; MoMA; Polyketide

Indexed keywords

6 DEOXYERYTHRONOLIDE B; POLYKETIDE; UNCLASSIFIED DRUG;

COLIFORM BACTERIUM; METABOLISM; METABOLITE; OPTIMIZATION; PHENOTYPE;

ARTICLE; BACILLUS SUBTILIS; CARBON SOURCE; CELL GROWTH; CELL METABOLISM; CONTROLLED STUDY; CULTURE MEDIUM; DRUG SYNTHESIS; ESCHERICHIA COLI; MATHEMATICAL MODEL; MUTANT; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SIMULATION; SPECIES COMPARISON;

BACILLUS SUBTILIS; COMPUTATIONAL BIOLOGY; COMPUTER SIMULATION; CULTURE MEDIA; ESCHERICHIA COLI; GENE KNOCKOUT TECHNIQUES; GENOME; MACROLIDES; METABOLIC NETWORKS AND PATHWAYS; MODELS, BIOLOGICAL; PHENOTYPE; SACCHAROMYCES CEREVISIAE; SUCCINATE DEHYDROGENASE;

BACILLUS SUBTILIS; ESCHERICHIA COLI; SACCHAROMYCES CEREVISIAE; STREPTOMYCES COELICOLOR;

EID: 70450257748     PISSN: 00225193     EISSN: 10958541     Source Type: Journal    
DOI: 10.1016/j.jtbi.2009.10.006     Document Type: Article

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