Physiology and metabolic fluxes of wild-type and riboflavin-producing Bacillus subtilis

Applied and Environmental Microbiology

Volumn 62, Issue 10, 1996, Pages 3687-3696

  Sauer, Uwe ^a   Hatzimanikatis, Vassily ^a   Hohmann, Hans Peter ^b   Manneberg, Michael ^b   Van Loon, Adolphus P G M ^b   Bailey, James E ^a  

^a ETH ZURICH   (Switzerland)

^b F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

RIBOFLAVIN;

AMINO ACID COMPOSITION; ARTICLE; BACILLUS SUBTILIS; BACTERIAL GROWTH; BIOMASS; CELL GROWTH; CITRIC ACID CYCLE; ESCHERICHIA COLI; GLYCOLYSIS; GROWTH RATE; SPECIES DIFFERENTIATION;

BACILLUS SUBTILIS; BACTERIA (MICROORGANISMS); ESCHERICHIA COLI;

EID: 0029781898     PISSN: 00992240     EISSN: None     Source Type: Journal    
DOI: 10.1128/aem.62.10.3687-3696.1996     Document Type: Article

References (53)

1. Arbige, M. V., B. A. Bulthuis, J. Schultz, and D. Crabb. 1993. Fermentation of Bacillus, p. 871-895. In A. L. Sonenshein, J. A. Hoch, and R. Losick (ed.), Bacillus subtilis and other gram-positive bacteria: biochemistry, physiology, and molecular genetics. American Society for Microbiology, Washington, D.C.
2. Archibald, A. R., I. C. Hancock, and C. R. Harwood. 1993. Cell wall structure, synthesis, and turnover, p. 381-410. In A. L. Sonenshein, J. A. Hoch, and R. Losick (ed.), Bacillus subtilis and other gram-positive bacteria: biochemistry, physiology, and molecular genetics. American Society for Microbiology, Washington, D.C.
3. Bacher, A. 1991. Biosynthesis of flavins, p. 215-259. In F. Müller (ed.), Chemistry and biochemistry of flavoenzymes, vol. 1. CRC Press, Inc., Boca Raton, Fla.
4. Bailey, J. E. 1993. Host-vector interactions in Escherichia coli. Adv. Biochem. Eng. Biotechnol. 48:29-52.
5. Bergmeyer, H. U. 1985. Methods of enzymatic analysis, vol. IV. VCH Publishers, Deerfield Beach, Fla.
6. Bulthuis, B. A., G. M. Koningstein, A. H. Stouthamer, and H. W. van Verseveld. 1989. A comparison between aerobic growth of Bacillus licheniformis in continuous culture and partial-recycling fermentor, with contributions to the discussion on maintenance energy demand. Arch. Microbiol. 152:499-507.
7. Chesbro, W., M. Arbige, and R. Eifert. 1990. When nutrient limitation places bacteria in the domains of slow growth: metabolic, morphologic, and cell cycle behavior. FEMS Microbiol. Ecol. 74:103-119.
8. Coquard, D., M. Huccas, M. Ott, J. M. van Dijl, A. P. G. M. van Loon, and H.-P. Hohmann. The riboflavin regulatory gene ribC has significant homology to flavin kinase and FAD synthase. Submitted for publication.
9. Csonka, L. N., and D. G. Fraenkel. 1977. Pathways of NADPH formation in Escherichia coli. J. Biol. Chem. 252:3382-3391.
10. de Hollander, J. A. 1991. Application of a metabolic balancing technique to the analysis of microbial fermentation data. Antonie Leeuwenhoek 60:275-292.
11. de Mendoza, D., R. Grau, and J. E. Cronan, Jr. 1993. Biosynthesis and function of membrane lipids, p. 411-421. In A. L. Sonenshein, J. A. Hoch, and R. Losick (ed.), Bacillus subtilis and other gram-positive bacteria: biochemistry, physiology, and molecular genetics. American Society for Microbiology, Washington, D.C.
12. Diesterhaft, M. D., and E. Freese. 1973. Role of pyruvate carboxylase, phosphoenolpyruvate carboxykinase, and malic enzyme during growth and sporulation of Bacillus subtilis. J. Biol. Chem. 248:6062-6070.
13. Farmer, I. S., and C. W. Jones. 1976. The effect of temperature on the molar growth yield and maintenance requirement of Escherichia coli W during aerobic growth in continuous culture. FEBS Lett. 67:359-363.
14. Florent, J. 1985. Vitamins, p. 115-157. In G. Reed and H.-J. Rehm (ed.), Biotechnology, vol. 4. VCH Verlagsgesellschaft, Weinheim, Germany.
15. Fraenkel, D. G. 1987. Glycolysis, pentose phosphate pathway, and Entner-Doudoroff pathway, p. 142-150. In F. C. Neidhardt, J. L. Ingraham, K. B. Low, B. Magasanik, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella typhimurium: cellular and molecular biology. American Society for Microbiology, Washington, D.C.
16. Fraenkel, D. G., and R. T. Vinopal. 1973. Carbohydrate metabolism in bacteria. Annu. Rev. Microbiol. 27:69-100.
17. Frankena, J., H. W. van Verseveld, and A. H. Stouthamer. 1985. A continuous culture study of the bioenergetic aspects of growth and production of exocellular protease in Bacillus licheniformis. Appl. Microbiol. Biotechnol. 22:169-176.
18. Goel, A., J. Ferrance, J. Jeong, and M. M. Ataai. 1993. Analysis of metabolic fluxes in hatch and continuous cultures of Bacillus subtilis. Biotechnol. Bioeng. 42:686-696.
19. Gottschalk, G. 1986. Bacterial metabolism, 2nd ed. Springer-Verlag, New York.
20. Harwood, C. R. 1992. Bacillus subtilis and its relatives: molecular biological workhorses. Trends Biotechnol. 10:247-256.
21. Harwood, C. R., and S. M. Cutting. 1990. Molecular biological methods for Bacillus. John Wiley & Sons, Chichester, England.
22. Heijnen, J. J., J. A. Roels, and A. H. Stouthamer. 1979. Application of balancing methods in modeling the penicillin fermentation. Biotechnol. Bioeng. 21:2175-2201.
23. Holms, W. H. 1986. The central metabolic pathways of Escherichia coli: relationship between flux and control at a branch point, efficiency of conversion to biomass, and excretion of acetate. Curr. Top. Cell. Regul. 28:69-105.
24. Kaneda, T. 1991. Iso- and anteiso-fatty acids in bacteria: biosynthesis, function, and taxonomic significance. Microbiol. Rev. 55:288-302.
25. 14C and estimation of the rates of transaldolase, transketolase, the contribution of the pentose cycle, and ribose phosphate synthesis. Biochemistry 6:2227-2247.
26. Lopez, J. M., C. L. Marks, and E. Freese. 1979. The decrease of guanine nucleotides initiates sporulation of Bacillus subtilis. Biochim. Biophys. Acta 587:238-252.
27. Mainzer, S. E., and W. P. Hempfling. 1976. Effects of growth temperature on yield and maintenance during glucose-limited continuous culture of Escherichia coli. J. Bacteriol. 126:251-256.
28. Manneberg, M., H.-W. Lahm, and M. Fountoulakis. 1995. Oxidation of cysteine and methionine residues during acid hydrolysis of proteins in the presence of sodium azide. Anal. Biochem. 224:122-127.
29. Manneberg, M., H.-W. Lahm, and M. Fountoulakis. 1995. Quantification of cysteine residues following oxidation to cysteic acid in the presence of sodium azide. Anal. Biochcm. 231:349-353.
30. Marx, A., A. A. de Graaf, W. Wiechert, L. Eggeling, and H. Sahm. 1996. Determination of the fluxes in the central metabolism of Corynebacterium glutamicum by nuclear magnetic resonance spectroscopy combined with metabolite balancing. Biotechnol. Bioeng. 49:111-129.
31. 18O] glucose. Variations in its activity in Escherichia coli with growth conditions. Biochemistry 6:69-79.
32. Moore, S. 1972. Chemistry and biology of peptides, p. 629-653. In J. Melenhofer (ed.), Proteins. Ann Arbor Publishers, Ann Arbor, Mich.
33. Neidhardt, F. C., J. L. Ingraham, and M. Schaechter. 1990. Physiology of the bacterial cell: a molecular approach. Sinauer Associates, Inc., Sunderland, Mass.
34. Pennock, J., and D. W. Tempest. 1988. Metabolic and energetic aspects of the growth of Bacillus stearothermophilus in glucose-limited and glucose-sufficient chemostat culture. Arch. Microbiol. 150:452-459.
35. Perkins, J. B., and J. G. Pero. 1993. Biosynthesis of riboflavin, biotin, folic acid, and cobalamin, p. 319-334. In A. L. Sonenshein, J. A. Hoch, and R. Losick (ed.), Bacillus subtilis and other gram-positive bacteria: biochemistry, physiology, and molecular genetics. American Society for Microbiology, Washington, D.C.
36. Perkins, J. B., J. G. Pero, and A. Sloma. 1991. Riboflavin overproducing strains of bacteria. European patent application 0-405-370-A1.
37. Pirt, S. J. 1965. The maintenance energy of bacteria in growing cultures. Proc. R. Soc. London Ser. B. 163:224-231.
38. Reardon, K., T.-H. Scheper, and J. E. Bailey. 1987. Metabolic pathway rates and culture fluorescence in batch fermentations of Clostridium acetobutylicum. Biotechnol. Prog. 3:153-167.
39. Russell, J. B., and G. M. Cook. 1995. Energetics of bacterial growth: balance of anabolic and catabolic reactions. Microbiol. Rev. 59:48-62.
40. Saito, H., T. Shibaat, and T. Ando. 1979. Mapping of genes determining nonpermissiveness and host specific restriction to bacteriophages in Bacillus subtilis Marburg. Mol. Gen. Genet. 170:117-122.
41. 1 ATPase: DNA sequence of the atp operon and characterization of atp mutants. J. Bacteriol. 176:6802-6811.
42. Sonenshein, A. L., J. A. Hoch, and R. Losick (ed.). 1993. Bacillus subtilis and other gram-positive bacteria: biochemistry, physiology, and molecular genetics. American Society for Microbiology, Washington, D.C.
43. Spackman, D. H., W. H. Stein, and S. Moore. 1958. Automatic recording apparatus for use in the chromatography of amino acids. Anal. Chem. 30: 1190-1206.
44. Stouthamer, A. H. 1979. The search for correlation between theoretical and experimental growth yields, p. 1-48. In J. R. Quayle (ed.), Microbial biochemistry, vol. 21. University Park Press, Baltimore.
45. Stouthamer, A. H., and C. Bettenhausen. 1973. Utilization of energy for growth and maintenance in continuous and batch cultures of microorganisms. Biochim. Biophys. Acta 301:53-70.
46. Stouthamer, A. H., and H. W. van Verseveld. 1987. Microbial energetics should be considered in manipulating metabolism for biotechnological purposes. Trends Biotechnol. 5:149-155.
47. ATP and maintenance energy as biological interpretable phenomena. Annu. Rev. Microbiol. 38:459-486.
48. Tempest, D. W., and O. M. Neijssel. 1987. Growth yield and energy distribution, p. 797-806. In F. C. Neidhardt, J. L. Ingraham, K. B. Low, B. Magasanik, M. Schaechter, and H. E. Umbarger (ed.), Escherichia coli and Salmonella typhimurium: cellular and molecular biology. American Society for Microbiology, Washington, D.C.
49. Vallino, J., and G. Stephanopoulos. 1990. Flux determination in cellular bioreaction network: application to lysine fermentation, p. 205-219. In S. K. Sikdar, M. Bier, and P. Todd (ed.), Frontiers in bioprocessing. CRC Press, Inc., Boca Raton, Fla.
50. Varma, A., and B. O. Palsson. 1994. Metabolic flux balancing: basic concepts, scientific, and practical use. Bio/Technology 12:994-998.
51. Varma, A., and B. O. Palsson. 1994. Stoichiometric flux balance models quantitatively predict growth and metabolic by-product secretion in wild-type Escherichia coli W3110. Appl. Environ. Microbiol. 60:3724-3731.
52. Wallace, R. J., and W. H. Holms. 1986. Maintenance coefficients and rates of turnover of cell material in Escherichia coli ML308 at different growth temperatures. FEMS Microbiol. Lett. 37:317-320.
53. Wood, T. D. 1985. The pentose phosphate pathway. Academic Press, Inc., Orlando, Fla.