Analysis of the maximum theoretical yield for the synthesis of erythromycin precursors in Escherichia coli

Biotechnology and Bioengineering

Volumn 95, Issue 4, 2006, Pages 638-644

  González Lergier, Joanna ^a   Broadbelt, Linda J ^a   Hatzimanikatis, Vassily ^a  

^a Northwestern University   (United States)

Author keywords

6 Deoxyerythronolide (6dEB) synthesis; Genome scale model; Heterologous antibiotic production; In silico pathway analysis; Linear optimization; Metabolic flux analysis

Indexed keywords

CARBON; ESCHERICHIA COLI; FLUXES; GLUCOSE; METABOLISM; SYNTHESIS (CHEMICAL);

6-DEOXYERYTHRONOLIDE (6DEB) SYNTHESIS; GENOME SCALE MODEL; HETEROLOGOUS ANTIBIOTIC PRODUCTION; IN SILICO PATHWAY ANALYSIS; LINEAR OPTIMIZATION; METABOLIC FLUX ANALYSIS;

MICROORGANISMS;

6 DEOXYERYTHRONOLIDE B; CARBON; ERYTHROMYCIN; ERYTHRONOLIDE DERIVATIVE; GLUCOSE; OXYGEN; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL METABOLISM; CARBON SOURCE; CHEMICAL ANALYSIS; ESCHERICHIA COLI; METABOLIC ENGINEERING; NONHUMAN; OXYGEN CONSUMPTION; PRECURSOR; PROTEIN SYNTHESIS; THEORETICAL MODEL;

ANTI-BACTERIAL AGENTS; CARBON; DRUG INDUSTRY; ERYTHROMYCIN; ESCHERICHIA COLI; GLUCOSE; INDUSTRIAL MICROBIOLOGY; MODELS, BIOLOGICAL;

ESCHERICHIA COLI;

EID: 33750554276     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.20925     Document Type: Article

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