Effects of the immunoglobulin A1 protease on Neisseria gonorrhoeae trafficking across polarized T84 epithelial monolayers

Infection and Immunity

Volumn 68, Issue 2, 2000, Pages 906-911

  Hopper, Sylvia ^a   Vasquez, Brandi ^a   Merz, Alex ^a   Clary, Susan ^a   Wilbur, J Scott ^a   So, Magdalene ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

IMMUNOGLOBULIN A1; MEMBRANE PROTEIN; PROTEINASE;

ARTICLE; BACTERIAL INFECTION; BACTERIUM MUTANT; CELL GROWTH; CELL LINE; ENZYME ANALYSIS; HUMAN; HUMAN CELL; NEISSERIA GONORRHOEAE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; TRANSCYTOSIS;

ANTIGENS, CD; CELL POLARITY; EPITHELIUM; HUMANS; LYSOSOMAL-ASSOCIATED MEMBRANE PROTEIN 1; LYSOSOME-ASSOCIATED MEMBRANE GLYCOPROTEINS; MEMBRANE GLYCOPROTEINS; MOVEMENT; MUTATION; NEISSERIA GONORRHOEAE; SERINE ENDOPEPTIDASES; TUMOR CELLS, CULTURED;

EID: 0033978770     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.68.2.906-911.2000     Document Type: Article

References (48)

1. Ayala, P., L. Lin, S. Hopper, M. Fukuda, and M. So. 1998. Infection of epithelial cells by pathogenic neisseriae reduces the levels of multiple lysosomal constituents. Infect. Immun. 66:5001-5007.
2. Blake, M., K. K. Holmes, and J. Swanson. 1979. Studies on gonococcus infection. XVII. IgA1-cleaving protease in vaginal washings from women with gonorrhea. J. Infect. Dis. 139:89-92.
3. Bos, M. P., F. Grunert, and R. J. Belland. 1997. Differential recognition of members of the carcinoembryonic antigen family by Opa variants of Neisseria gonorrhoeae. Infect. Immun. 65:2353-2361.
4. Buchanan, T. M., W. A. Pearce, G. K. Schoolnik, and R. J. Arko. 1977. Protection against infection with Neisseria gonorrhoeae by immunization with outer membrane protein complex and purified pili. J. Infect. Dis. 136 (Suppl.):S132-S137.
5. Carlsson, S. R., J. Roth, F. Piller, and M. Fukuda. 1988. Isolation and characterization of human lysosomal membrane glycoproteins, h-lamp1 and h-lamp-2. J. Biol. Chem. 263:18911-18919.
6. Chen, J. W., G. L. Chen, M. P. D'Souza, T. L. Murphy, and J. T. August. 1986. Lysosomal membrane glycoproteins: properties of LAMP-1 and LAMP-2. Biol. Soc. Symp. 51:97-112.
7. Chen, T., and E. C. Gotschlich. 1996. CGM1a antigen of neutrophils, a receptor of gonococcal opacity proteins. Proc. Natl. Acad. Sci. USA 93: 14851-14856.
8. Chen, T., F. Grunert, A. Medina-Marino, and E. C. Gotschlich. 1997. Several carcinoembryonic antigens (CD66) serve as receptors for gonococcal opacity proteins. J. Exp. Med. 185:1557-1564.
9. Cooper, M. D., Z. A. McGee, M. H. Mulks, J. M. Kooney, and T. L. Hindman. 1984. Attachment to and invasion of human fallopian tube mucosa by an IgA1 protease-deficient mutant of Neisseria gonorrhoeae and its wild type parent. J. Infect. Dis. 150:737-744.
10. Dharmsathaphorn, K., and J. L. Madara. 1990. Established intestinal cell lines as model systems for electrolyte transport studies. Methods Enzymol. 192:354-389.
11. Grassme, H. U., R. M. Ireland, and J. P. van Putten. 1996. Gonococcal opacity protein promotes bacterial entry-associated rearrangements of the epithelial cell actin cytoskeleton. Infect. Immun. 64:1621-1630.
12. Gray-Owen, S. D., C. Dehio, A. Haude, F. Grunert, and T. F. Meyer. 1997. CD66 carcinoembryonic antigens mediate interactions between Opa-expressing Neisseria gonorrhoeae and human polymorphonuclear phagocytes. EMBO J. 16:3435-3445.
13. Gray-Owen, S. D., D. R. Lorenzen, A. Haude, T. F. Meyer, and C. Dehio. 1997. Differential Opa specificities for CD66 receptors influence tissue interactions and cellular response to Neisseria gonorrhoeae. Mol. Microbiol. 26: 971-980.
14. Hagblom, P., E. Segal, E. Billyard, and M. So. 1985. Intragenic recombination leads to pilus antigenic variation in Neisseria gonorrhoeae. Nature 315: 156-158.
15. Hauck, C. R., and T. F. Meyer. 1997. The lysosomal/phagosomal membrane protein h-lamp-1 is a target of the IgA1 protease of Neisseria gonorrhoeae. FEBS Lett. 405:86-90.
16. Hedges, S. R., M. S. Mayo, L. Kallman, J. Mestecky, E. W. Hook III, and M. W. Russell. 1998. Evaluation of immunoglobulin A1 (IgA1) protease and IgA1 protease-inhibitory activity in human female genital infection with Neisseria gonorrhoeae. Infect. Immun. 66:5826-5832.
17. James, J. F., and J. Swanson. 1978. Studies on gonococcus infection. XIII. Occurrence of color/opacity colonial variants in clinical cultures. Infect. Immun. 19:332-340.
18. Jerse, A. E., M. S. Cohen, P. M. Drown, L. G. Whicker, S. F. Isbey, H. S. Seifert, and J. G. Cannon. 1994. Multiple gonococcal opacity proteins are expressed during experimental urethral infection in the male. J. Exp. Med. 179:911-920.
19. Johannsen, D. B., D. M. Johnston, H. O. Koymen, M. S. Cohen, and J. G. Cannon. 1999. A Neisseria gonorrhoeae immunoglobulin A1 protease mutant is infectious in the human challenge model of urethral infection. Infect. Immun. 67:3009-3013.
20. Johnson, A. P., D. Taylor-Robinson, and Z. A. McGee. 1977. Species specificity of attachment and damage to oviduct mucosa by Neisseria gonorrhoeae. Infect. Immun. 18:833-839.
21. Kallstrom, H., M. K. Liszewski, J. P. Atkinson, and A. B. Jonsson. 1997. Membrane cofactor protein (MCP or CD46) is a cellular pilus receptor for pathogenic Neisseria. Mol. Microbiol. 25:639-647.
22. Kellogg, D. S., Jr., I. R. Cohen, L. C. Norms, A. L. Schroeter, and G. Reising. 1968. Neisseria gonorrhoeae. II. Colonial variation and pathogenicity during 35 months in vitro. J. Bacteriol. 96:596-605.
23. Kellogg, D. S., Jr., W. L. Peacock, Jr., W. E. Deacon, L. Brown, and C. I. Pirkle. 1963. Neisseria gonorrhoeae. I. Virulence genetically linked to clonal variation. J. Bacteriol. 85:1274-1279.
24. Kupsch, E. M., B. Knepper, T. Kuroki, I. Heuer, and T. F. Meyer. 1993. Variable opacity (Opa) outer membrane proteins account for the cell tropisms displayed by Neisseria gonorrhoeae for human leukocytes and epithelial cells. EMBO J. 12:641-650.
25. Lin, L., P. Ayala, J. Larson, M. Mulks, M. Fukuda, S. R. Carlsson, C. Enns, and M. So. 1997. The Neisseria type 2 IgA1 protease cleaves LAMP1 and promotes survival of bacteria within epithelial cells. Mol. Microbiol. 24: 1083-1094.
26. Madara, J. L., J. Stafford, K. Dharmsathaphorn, and S. Carlson. 1987. Structural analysis of a human intestinal epithelial cell line. Gastroenterology 92:1133-1145.
27. Makino, S., J. P. van Putten, and T. F. Meyer. 1991. Phase variation of the opacity outer membrane protein controls invasion by Neisseria gonorrhoeae into human epithelial cells. EMBO J. 10:1307-1315.
28. McGee, Z., D. Stephens, L. Hoffman, W. Schlech III, and R. Horn. 1983. Mechanisms of mucosal invasion by pathogenic Neisseria. Rev. Infect. Dis. 5(Suppl. 4, Sept.-Oct.):S708-S714.
29. McGee, Z. A., and M. L. Woods, Jr. 1987. Use of organ cultures in microbiological research. Annu. Rev. Microbiol. 41:291-300.
30. McGee, Z. A., A. P. Johnson, and D. Taylor-Robinson. 1981. Pathogenic mechanisms of Neisseria gonorrhoeae: observations on damage to human fallopian tubes in organ culture by gonococci of colony type 1 or type 4. J. Infect. Dis. 143:413-122.
31. Merz, A. J., C. A. Enns, and M. So. 1999. Type IV pili of pathogenic neisseriae elicit cortical plaque formation in epithelial cells. Mol. Microbiol. 32:1316-1332.
32. Merz, A. J., D. B. Rifenbery, C. G. Arvidson, and M. So. 1996. Traversal of a polarized epithelium by pathogenic Neisseriae: facilitation by type IV pili and maintenance of epithelial barrier function. Mol. Med. 2:745-754.
33. - gonococci and meningococci to epithelial cells elicits cortical actin rearrangements and clustering of tyrosine-phosphorylated proteins. Infect. Immun. 65:4341-4349.
34. Plaut, A. G., J. V. Gilbert, M. S. Artenstein, and J. D. Capra. 1975. Neisseria gonorrhoeae and Neisseria meningitidis: extracellular enzyme cleaves human immunoglobulin A. Science 190:1103-1105.
35. Prall, F., P. Nollau, M. Neumaier, H. D. Haubeck, Z. Drzeniek, U. Helmchen, T. Loning, and C. Wagener. 1996. CD66a (BGP), an adhesion molecule of the carcinoembryonic antigen family, is expressed in epithelium, endothelium, and myeloid cells in a wide range of normal human tissues. J. Histochem. Cytochem. 44:35-41.
36. Pujol, C., E. Eugene, L. de Saint Martin, and X. Nassif. 1997. Interaction of Neisseria meningitidis with a polarized monolayer of epithelial cells. Infect. Immun. 65:4836-4842.
37. Pujol, C., E. Eugene, M. Marceau, and X. Nassif. 1999. The meningococcal PilT protein is required for induction of intimate attachment to epithelial cells following pilus-mediated adhesion. Proc. Natl. Acad. Sci. USA 96: 4017-4022.
38. Shoberg, R. J., and M. H. Mulks. 1991. Proteolysis of bacterial membrane proteins by Neisseria gonorrhoeae type 2 immunoglobulin A1 protease. Infect. Immun. 59:2535-2541.
39. Stephens, D. S., and M. M. Farley. 1991. Pathogenic events during infection of the human nasopharynx with Neisseria meningitidis and Haemophilus influenzae. Rev. Infect. Dis. 13:22-33.
40. Swanson, J. 1973. Studies on gonococcus infection. IV. Pili: their role in attachment of gonococci to tissue culture cells. J. Exp. Med. 137:571-589.
41. van Putten, J. P., T. D. Duensing, and R. L. Cole. 1998. Entry of OpaA+ gonococci into HEp-2 cells requires concerted action of glycosaminoglycans, fibronectin and integrin receptors. Mol. Microbiol. 29:369-379.
42. Virji, M., and J. S. Everson, 1981. Comparative virulence of opacity variants of Neisseria gonorrhoeae strain P9. Infect. Immun. 31:965-970.
43. Virji, M., K. Makepeace, D. J. Ferguson, and S. M. Watt. 1996. Carcinoembryonic antigens (CD66) on epithelial cells and neutrophils are receptors for Opa proteins of pathogenic Neisseriae. Mol. Microbiol. 22:941-950.
44. Virji, M., S. M. Watt, S. Barker, K. Makepeace, and R. Doyonnas. 1996. The N-domain of the human CD66a adhesion molecule is a target for Opa proteins of Neisseria meningitidis and Neisseria gonorrhoeae. Mol. Microbiol. 22:929-939.
45. Waldbeser, L. S., R. S. Ajioka, A. J. Merz, D. Puaoi, L. Lin, M. Thomas, and M. So. 1994. The opaH locus of Neisseria gonorrhoeae MS11A is involved in epithelial cell invasion. Mol. Microbiol. 13:919-928.
46. Wang, J., S. D. Gray-Owen, A. Knorre, T. F. Meyer, and C. Dehio. 1998. Opa binding to cellular CD66 receptors mediates the transcellular traversal of Neisseria gonorrhoeae across polarized T84 epithelial cell monolayers. Mol. Microbiol. 30:657-671.
47. Weel, G. F. L., C. T. P. Hopman, and J. P. M. Van Putten. 1991. In situ expression and localization of Neisseria gonorrhoeae opacity proteins in infected epithelial cells: apparent role of Opa proteins in cellular invasion. J. Exp. Med. 173:1395-1405.
48. Zhang, K., D. Baeckstrom, H. Brevinge, and G. C. Hansson. 1997. Comparison of sialyl-Lewis a carrying CD43 and MUC1 mucins secreted from a colon carcinoma cell line for E-selectin binding and inhibition of leukocyte adhesion. Tumor Biol. 18:175-187.