Phase variable changes in genes lgtA and lgtC within the lgtABCDE operon of Neisseria gonorrhoeae can modulate gonococcal susceptibility to normal human serum

Journal of Endotoxin Research

Volumn 8, Issue 1, 2002, Pages 47-58

  Shafer, William M ^a,b   Datta, Anup ^c   Kumar Kolli, V S ^c   Mahbubur Rahman, M ^c   Balthazar, Jacqueline T ^a,b   Martin, Larry E ^b   Veal, Wendy L ^b   Stephens, David S ^a,b   Carlson, Russell ^c  

^a ATLANTA VA MEDICAL CENTER   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL ENZYME; COMPLEMENT; GENE PRODUCT; IGTA PROTEIN; IGTC PROTEIN; MONOCLONAL ANTIBODY; OLIGOSACCHARIDE; POLYNUCLEOTIDE; UNCLASSIFIED DRUG;

ALPHA CHAIN; ARTICLE; BACTERIAL GENETICS; BACTERIAL STRAIN; BACTERIOLYSIS; BIOSYNTHESIS; CONTROLLED STUDY; GENE DELETION; GENE INSERTION; HOST RESISTANCE; HUMAN; INFECTION SENSITIVITY; NEISSERIA GONORRHOEAE; NONHUMAN; OPERON; PROTEIN STRUCTURE; SERUM;

AMINO ACID SEQUENCE; BACTERIAL PROTEINS; BLOOD BACTERICIDAL ACTIVITY; GENES, BACTERIAL; GLYCOSYLTRANSFERASES; GONORRHEA; HUMANS; MOLECULAR SEQUENCE DATA; N-ACETYLGLUCOSAMINYLTRANSFERASES; NEISSERIA GONORRHOEAE; OPERON; SEQUENCE HOMOLOGY, AMINO ACID; VIRULENCE;

ANIMALIA; BACTERIA (MICROORGANISMS); INSERTION SEQUENCES; NEISSERIA; NEISSERIA GONORRHOEAE; PROKARYOTA;

EID: 0036129847     PISSN: 09680519     EISSN: None     Source Type: Journal    
DOI: 10.1179/096805102125000083     Document Type: Article

References (48)

1. Gonococci are survivors
2. IgA protease production as a characteristic distinguishing pathogenic from harmless Neisseriaceae
3. Lipooligosaccharides (LOS) of Neisseria gonorrhoeae and Neisseria meningitidis have components that are immunochemically similar to precursors of human group antigen
4. Molecular basis for serum resistance in Neisseria gonorrhoeae
5. Phase and antigenic variation of pili and outer membrane protein II of Neisseria gonorrhoeae
6. The repertoire of silent pilus genes in Neisseria gonorrhoeae: Evidence for gene conversion
7. Relation of protein I and colony opacity to serum killing of Neisseria gonorrhoeae
8. Variation of gonococcal lipooligosaccharide structures is due to alterations in poly-G tracts in lgt genes encoding glycosyl transferases
9. Genetic basis for biosynthesis, structure and function of meningococcal lipooligosaccharide
10. The lipooligosaccharides of pathogenic Gram-negative bacteria
11. Antigenic variation in Neisseria gonorrhoeae: Production of multiple lipooligosaccharides
12. Phenotypic variation in epitope expression of the Neisseria gonorrhoeae lipooligosaccharide
13. Gonococci causing disseminated gonococcal infection are resistant to the bactericidal action of normal human serum
14. Natural serum bactericidal activity against Neisseria gonorrhoeae isolated from disseminated, locally invasive and uncomplicated disease
15. Penicillin sensitivity and serum resistance are independent attributes of strains of Neisseria gonorrhoeae causing disseminated gonococcal infection
16. Sialylation of neisserial lipopolysaccharide: A major influence on pathogenicity
17. Elaboration of a 3.6 kilodalton lipooligosaccharide, antibody against which is absent from human serum, is associated with serum resistance of Neisseria gonorrhoeae
18. The lipooligosaccharides of the pathogenic Neisseria
19. Evidence that the serum resistance genetic locus (sac-3) of Neisseria gonorrhoeae is involved in lipopolysaccharide structure
20. Expression of paragloboside-like lipooligosaccharides may be a necessary component of gonococcal pathogenesis in men
21. Genetic locus for the biosynthesis of the variable portion of Neisseria gonorrhoeae lipooligosaccharide
22. Modulation of Neisseria gonorrhoeae susceptibility to vertebrate antibacterial peptides due to a member of the resistance/nodulation/division efflux pump family
23. Morphological heterogeneity among Salmonella lipopolysaccharide chemotypes in silver-stained polyacrylamide gels
24. Increased resolution of lipopolysaccharides and lipooligosaccharides utilizing Tricine-sodium dodecyl sulfate-polyacrylamide gel electrophoresis
25. Inner core biosynthesis of lipooligosaccharide (LOS) in Neisseria meningitidis serogroup B: Identification and the role in LOS assembly of the α-1,2 N-acetylglucosamine transferase (RfaK)
26. Selection and immunological analysis of lipooligosaccharide mutants of Neisseria gonorrhoeae
27. Epitope expression of gonococcal lipooligosaccharide. Importance of the lipoidal moiety for expression of an epitope that exists in the oligosaccharide moiety of LOS
28. Characterization of chimeric lipopolysaccharides from Escherichia coli strain JM109 transformed with lipooligosaccharide synthesis genes (lsg) from Haemophilus influenzae
29. The membrane phospholipids of Neisseria meningitidis and Neisseria gonorrhoeae as characterized by fast atom bombardment mass spectrometry
30. Isolation and characterization of plant cell walls and cell wall components
31. A simple and rapid method for the permethylation of carbohydrates
32. Determination, by methylation analysis, of the glycosyl-linkage compositions of microgram quantities of complex carbohydrates
33. Analysis in Neisseria meningitidis and other Neisseria species of genes homologous to the FKBP immunophilin family
34. Loss of function mutations in the mtr efflux system of Neisseria gonorrhoeae
35. Non-polar mutagenesis of the ipa genes defines IpaB, IpaC and IpaD as effectors of Shigella flexneri entry into epithelial cells
36. Use of a non-selective transformation technique to construct a multiply restriction/modification-deficient mutant of Neisseria gonorrhoeae
37. The structural basis for pyocin resistance in Neisseria gonorrhoeae lipooligosaccharides
38. Structural determination of oligosaccharides derived from lipooligosaccharides of Neisseria gonorrhoeae F62 by chemical, enzymatic, and two-dimensional NMR methods
39. Binding of complement H to loop 5 of porin protein 1A: A molecular mechanism of serum resistance of nonsialylated Neisseria gonorrhoeae
40. Confirmation of association of protein I serotype of Neisseria gonorrhoeae with the ability to cause disseminated infection
41. Neisseria gonorrhoeae acquire a new principal outer membrane protein when transformed to resistance to serum bactericidal activity
42. Genetics of serum resistance in Neisseria gonorrhoeae: The sac-1 genetic locus
43. +) in Neisseria gonorrhoeae that affects sensitivity to normal human serum
44. Identification of the gene (lgtG) encoding the lipooligosaccharide β-chain synthesizing glucosyl transferase from Neisseria gonorrhoeae
45. Phase variation of lipopolysaccharides directs interconversion of invasive and immuno-resistant phenotypes of Neisseria gonorrhoeae
46. Porin polypeptide contributes to surface charge of gonococci
47. The nucleotide sequence of the por gene from Neisseria gonorrhoeae strain P9 encoding outer membrane protein PIB
48. Genetic diversity and mosaicism at the por locus of Neisseria gonorrhoeae