Limited local and systemic antibody responses to Neisseria gonorrhoeae during uncomplicated genital infections

Infection and Immunity

Volumn 67, Issue 8, 1999, Pages 3937-3946

  Hedges, Spencer R ^a   Mayo, Matthew S ^b   Mestecky, Jiri ^a,c   Hook III, Edward W ^c   Russell, Michael W ^a  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODY RESPONSE; ARTICLE; ENZYME LINKED IMMUNOSORBENT ASSAY; GENITAL TRACT INFECTION; HUMAN; HUMAN CELL; HUMORAL IMMUNITY; IMMUNE RESPONSE; MEMORY CELL; MUCOSAL IMMUNITY; NEISSERIA GONORRHOEAE; PRIORITY JOURNAL; REINFECTION; SEXUALLY TRANSMITTED DISEASE; UTERINE CERVIX MUCUS;

EID: 0032769613     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/iai.67.8.3937-3946.1999     Document Type: Article

References (51)

1. Beck, E. J., S. Mandalia, K. Leonard, R. J. Griffith, J. R. Harris, and D. L. Miller. 1996. Case-control study of sexually transmitted diseases as cofactors for HIV-1 transmission. Int. J. STD AIDS 7:34-38.
2. Bélec, L., T. Dupré, T. Prazuck, C. Tévi-Bénissan, J.-M. Kanga, O. Pathey, X.-S. Lu, and J. Pillot. 1995. Cervicovaginal overproduction of specific IgG to human immunodeficiency virus (HIV) contrasts with normal or impaired IgA local response in HIV infection. J. Infect. Dis. 172:691-697.
3. Boslego, J. W., E. C. Tramont, R. C. Chung, D. G. McChesney, J. Ciak, J. C. Sadoff, M. V. Piziak, J. D. Brown, C. C. Brinton, Jr., S. W. Wood, and J. R. Bryan. 1991. Efficacy trial of a parenteral gonococcal pilus vaccine in men. Vaccine 9:154-162.
4. Chipperfield, E. J., and B. A. Evans. 1975. Effect of local infection and oral contraception on immunoglobulin levels in cervical mucus. Infect. Immun. 11:215-221.
5. Crowley-Nowick, P. A., M. C. Bell, R. Brockwell, R. P. Edwards, S. Chen, E. E. Partridge, and J. Mestecky. 1997. Rectal immunization for induction of specific antibody in the genital tract of women. J. Clin. Immunol. 17:370-379.
6. Forrest, B. D., D. J. C. Shearman, and J. T. LaBrooy. 1990. Specific immune responses in humans following rectal delivery of live typhoid vaccine. Vaccine 8:209-212.
7. Fynan, E. F., R. G. Webster, D. H. Fuller, J. R. Haynes, J. C. Santoro, and H. L. Robinson. 1993. DNA vaccines: protective immunizations by parenteral, mucosal, and gene-gun inoculations. Proc. Natl. Acad. Sci. USA 90: 11478-11482.
8. Glass, R. I., A. M. Svennerholm, M. R. Khan, S. Huda, M. I. Huq, and J. Holmgren. 1985. Seroepidemiological studies of El Tor cholera in Bangladesh: association of serum antibody levels with protection. J. Infect. Dis. 151:236-242.
9. Govers, J., and J. P. Girard. 1972. Some immunological properties of human cervical and vaginal secretions. Gynecol. Investig. 3:184-194.
10. Guttormsen, H. K., L. M. Wetzler, and A. Naess. 1994. Humoral immune response to the class 3 outer membrane protein during the course of meningococcal disease. Infect. Immun. 61:4734-4742.
11. Haack, B. M., F. Emmrich, and K. Resch. 1993. Cholera toxin inhibits T cell receptor signaling by covalent modification of the CD3-ζ subunit. J. Immunol. 150:2599-2606.
12. Hajishengallis, G., S. K. Hollingshead, T. Koga, and M. W. Russell. 1995. Mucosal immunization with a bacterial protein antigen genetically coupled to cholera toxin A2/B subunits. J. Immunol. 154:4322-4332.
13. Hajishengallis, G., S. M. Michalek, and M. W. Russell. 1996. Persistence of serum and salivary antibody responses after oral immunization with a bacterial protein antigen genetically linked to the A2/B subunits of cholera toxin. Infect. Immun. 64:665-667.
14. Hedges, S. R., D. Sibley, M. S. Mayo, E. Hook III, and M. W. Russell. 1998. Cytokine and antibody responses in women infected with Neisseria gonorrhoeae: effects of concomitant infections. J. Infect. Dis. 178:742-751.
15. Hook, E. W., W. E. Brady, C. A. Reichart, D. M. Upchurch, L. A. Sherman, and J. N. Wasserheit. 1989. Determinants of emergence of antibiotic-resis3 tant Neisseria gunorrhoeae. J. Infect. Dis. 159:900-907.
16. Hordnes, K., T. Tynning, A. I. Kvam, R. Jonsson, and B. Haneberg. 1996. Colonization in the rectum and uterine cervix with group B streptococci may induce specific antibody responses in cervical secretions of pregnant women. Infect. Immun. 64:1643-1652.
17. Islam, D., B. Wretlind, M. Ryd, A. A. Lindberg, and B. Christensson. 1995. Immunoglobulin subclass distribution and dynamics of Shigella-specific antibody responses in serum and stool samples in shigellosis. Infect. Immun. 63:2054-2061.
18. Kantele, A., M. Häkkinen, Z. Moldoveanu, A. Lu, E. Savilahti, R. D. Alvarez, S. Michalek, and J. Mestecky. 1998. Differences in immune responses induced by oral and rectal immunizations with Salmonella typhi Ty21a: evidence for compartmentalization within the common mucosal immune system. Infect. Immun. 66:5630-5635.
19. Kearns, D. H., R. J. O'Reilly, L. Lee, and B. G. Welch. 1973. Secretory IgA antibodies in the urethral exudate of men with uncomplicated urethritis due to Neisseria gonorrhoeae. J. Infect. Dis. 127:99-101.
20. Kelsall, B., and W. Strober. 1999. Gut associated lymphoid tissue: antigen handling and T-lymphocyte responses, p. 293-317. In P. L. Ogra, J. Mestecky, M. E. Lamm, W. Strober, J. Bienenstock, and J. R. McGhee (ed.), Mucosal immunology. Academic Press, London, England.
21. Kozlowski, P. A., S. Cu-Uvin, M. R. Neutra, and T. P. Flanigan. 1997. Comparison of the oral rectal and vaginal immunization routes for induction of antibodies in rectal and genital tract secretions. Infect. Immun. 65:1387-1394.
22. Le Bacq, F., P. R. Mason, L. Gwanzura, V. J. Robertson, and A. S. Latif. 1993. HIV and other sexually transmitted diseases at a rural hospital in Zimbabwe. Gen. Med. 69:352-356.
23. Lehner, T., L. A. Bergmeier, C. Panagiotidi, L. Tao, R. Brookes, L. S. Klavinskis, P. Walker, J. Walker, R. G. Ward, L. Hussain, A. J. H. Gearing, and S. E. Adams. 1992. Induction of mucosal and systemic immunity to a recombinant simian immunodeficiency viral protein. Science 258:1365-1369.
24. McChesney, D., E. C. Tramont, J. W. Boslego, J. Ciak, J. Sadoff, and C. C. Brinton. 1982. Genital antibody response to a parenteral gonococcal pilus vaccine. Infect. Immun. 36:1006-1012.
25. McMillan, A., G. McNeillage, and H. Young. 1979. Antibodies to Neisseria gonorrhoeae: a study of the urethral exudates of 232 men. J. Infect. Dis. 140:89-95.
26. McMillan, A., G. McNeillage, H. Young, and S. S. R. Bain. 1979. Secretory antibody response of the cervix to infection with Neisseria gonorrhoeae. Br. J. Vener. Dis. 55:265-270.
27. Menge, A. C., S. M. Michalek, M. W. Russell, and J. Mestecky. 1993. Immune response of the female rat genital tract after oral and local immunization with keyhole limpet hemocyanin conjugated to cholera toxin B subunit. Infect. Immun. 61:2162-2171.
28. Mestecky, J. 1987. The common mucosal immune system and current strategies for induction of immune response in external secretions. J. Clin. Immunol. 7:265-276.
29. Meyer, T. F., C. P. Gibbs, and R. Haas. 1990. Variation and control of protein expression in Neisseria. Annu. Rev. Microbiol. 44:451-477.
30. Nardelli-Haefliger, D., J.-P. Kraehenbuhl, R. Curtiss, F. Schödel, A. Potts, S. Kelly, and P. de Grandi. 1996. Oral and rectal immunization of adult female volunteers with a recombinant attenuated Salmonella typhi vaccine strain. Infect. Immun. 64:5219-5224.
31. Ogra, P. L., and S. S. Ogra. 1973. Local antibody response to poliovaccine in the female genital tract. J. Immunol. 110:1307-1311.
32. O'Leary, A. D., and E. C. Sweeney. 1986. Lymphoglandular complexes of the colon: structure and distribution. Histopathology 10:267-283.
33. O'Leary, A. D., and E. C. Sweeney. 1987. Lymphoglandular complexes of the normal colon: histochemistry and immunohistochemistry. Ir. J. Med. Sci. 156:142-148.
34. O'Reilly, R. J., L. Lee, and B. G. Welch. 1976. Secretory IgA antibody responses to Neisseria gonorrhoeae in the genital secretions of infected females. J. Infect. Dis. 133:113-125.
35. Parazzini, F., L. C. D'Oro, L. Naldi, C. Bianchi, L. Chatenoud, E. Ricci, T. Cainelli, B. Pansera, C. Mezzanotte, G. P. Tessari, and A. Locatelli. 1996. Sexually transmitted diseases and risk of HIV infection. Acta. Dermatol. Venereol. 76:147-149.
36. Plant, A. G., J. V. Gilbert, M. S. Artenstein, and J. D. Capra. 1975. Neisseria gonorrhoeae and Neisseria meningitidis: extracellular enzyme that cleaves human immunoglobulin A. Science 190:1103-1105.
37. Plummer, F. A., J. N. Simonsen, H. Chubb, L. Slaney, J. Kimata, M. Bosire, J. O. Ndinya-Achola, and E. N. Ngugi. 1989. Epidemiologic evidence for the development of serovar-specific immunity after gonococcal infection. J. Clin. Investig. 83:1472-1476.
38. Qadri, F., C. Wenneras, M. J. Albert, J. Hossain, K. Mannoor, Y. A. Begum, G. Mohi, M. A. Salam, R. B. Sack, and A. M. Svennerbolm. 1997. Comparison of immune responses in patients infected with Vibrio cholerae O139 and O1. Infect. Immun. 65:3571-3576.
39. Rice, P. A., H. E. Vayo, M. R. Tam, and M. S. Blake. 1986. Immunoglobulin G antibodies directed against protein III block killing of serum resistant Neisseria gonorrhoeae by immune serum. J. Exp. Med. 164:1735-1748.
40. Russell, M. W., T. A. Brown, J. Radl, J. J. Haaijman, and J. Mestecky. 1986. Assay of human IgA subclass antibodies in serum and secretions by means of monoclonal antibodies. J. Immunol. Methods 87:87-93.
41. Sminia, T., and G. Kraal. 1999. Nasal-associated lymphoid tissue, p. 357-364. In P. L. Ogra, J. Mestecky, M. E. Lamm, W. Strober, J. Bienenstock, and J. R. McGhee (ed.), Mucosal immunology. Academic Press, London, England.
42. Smith, H., J. A. Cole, and N. J. Parsons. 1992. The sialylation of gonococcal lipopolysaccharide by host factors: a major impact on pathogenicity. FEMS Microbiol. Lett. 100:287-292.
43. Strindel, H. 1935. Bartels Tonsille des Mastdarmes' und ihre Stellung in der Pathologie des Lymphatischen Apparates des Mastdarmes. Zentrbl. Chir. 62:2594-2607.
44. Tapchaisri, P., and S. Sirisinha. 1976. Serum and secretory antibody responses to Neisseria gonorrhoeae in patients with gonococcal infections. Br. J. Vener. Dis. 52:374-380.
45. Thapar, M. A., E. L. Parr, and M. B. Parr. 1990. Secretory immune responses in mouse vaginal fluid after pelvic, parenteral, or vaginal immunization. Immunology 70:121-125.
46. Tramont, E. C. 1977. Inhibition of adherence of Neisseria gonorrhoeae by human genital secretions. J. Clin. Investig. 59:117-124.
47. Tramont, E. C., J. C. Sadoff, J. W. Boslego, J. Ciak, D. McChesney, C. C. Brinton, S. Wood, and E. Takafuji. 1981. Gonococcal pilus vaccine. Studies of antigenicity and inhibition of attachment. J. Clin. Investig. 68:881-888.
48. Waldman, R. H., J. Cruz, and S. Rowe. 1972. Immunoglobulin levels and antibodies to Candida albicans in human cervicovaginal secretions. Clin. Exp. Immunol. 10:427-434.
49. Wu, H.-Y., H. Nguyen, and M. W. Russell. 1997. Nasal lymphoid tissue (NALT) as a mucosal immune inductive site. Scand. J. Immunol. 46:506-513.
50. Wu, H.-Y., and M. W. Russell. 1993. Induction of mucosal immunity by intranasal application of a streptococcal surface protein antigen with the cholera toxin B subunit. Infect. Immun. 61:314-322.
51. Wu, H.-Y., and M. W. Russell. 1994. Comparison of systemic and mucosal priming for mucosal immune responses to a bacterial protein antigen given with or coupled to cholera toxin (CT) B subunit, and effects of pre-existing anti-CT immunity. Vaccine 12:215-222.