Cathepsin B is involved in the trafficking of TNF-α-containing vesicles to the plasma membrane in macrophages

Journal of Immunology

Volumn 181, Issue 1, 2008, Pages 690-697

  Ha, Soon Duck ^a,b   Martins, Andrew ^a,b   Khazaie, Khashayarsha ^c   Han, Jiahuai ^d   Chan, Bosco M C ^a   Kim, Sung Ouk ^a,b  

^a Department of Microbiology and Immunology ^*  (Canada)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

^c NORTHWESTERN UNIVERSITY   (United States)

^d SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHEPSIN B; GREEN FLUORESCENT PROTEIN; N (3 PROPYLCARBAMOYLOXIRANE 2 CARBONYL)ISOLEUCYLPROLINE; PROTEIN PRECURSOR; TUMOR NECROSIS FACTOR ALPHA; CA 074 METHYL ESTER; DIPEPTIDE; ENZYME INHIBITOR;

ANIMAL CELL; ARTICLE; CELL MEMBRANE; CELL VACUOLE; CONTROLLED STUDY; ENZYME ACTIVITY; GENE IDENTIFICATION; INTRACELLULAR TRANSPORT; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; ANIMAL; C57BL MOUSE; CELL CULTURE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; GENETICS; HUMAN; METABOLISM; MOLECULAR GENETICS; MOUSE MUTANT; NUCLEOTIDE SEQUENCE; PROTEIN PROCESSING; PROTEIN TRANSPORT; SECRETION;

ANIMALS; BASE SEQUENCE; CATHEPSIN B; CELL MEMBRANE; CELLS, CULTURED; DIPEPTIDES; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MOLECULAR SEQUENCE DATA; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; TUMOR NECROSIS FACTOR-ALPHA;

EID: 47949098831     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.181.1.690     Document Type: Article

References (47)

1. Palladino, M. A., F. R. Bahjat, E. A. Theodorakis, and L. L. Moldawer. 2003. Anti-TNFα therapies: the next generation. Nat. Rev. Drug Discov. 2: 736-746.
2. Spriggs, D. R., S. Deutsch, and D. W. Kufe. 1992. Genomic structure, induction, and production of TNFα. Immunol. Ser. 56: 3-34.
3. Beutler, B., and V. Kruys. 1995. Lipopolysaccharide signal transduction, regulation of tumor necrosis factor biosynthesis, and signaling by tumor necrosis factor itself. J. Cardiovasc. Pharmacol. 25(SuppI. 2): S1-S8.
4. Stow, J. L., A. P. Manderson, and R. Z. Murray. 2006. SNAREing immunity: the role of SNAREs in the immune system. Nat. Rev. Immunol. 6: 919-929.
5. Akira, S., and K. Takeda. 2004. Toll-like receptor signalling. Nat. Rev. Immunol. 4:499-511.
6. Anderson, P., K. Phillips, G. Stoecklin, and N. Kedersha. 2004. Post-transcriptional regulation of proinflammatory proteins. J. Leukocyte Biol. 76: 42-47.
7. Murray, R. Z., J. G. Kay, D. G. Sangermani, and J. L. Stow. 2005. A role for the phagosome in cytokine secretion. Science 310: 1492-1495.
8. Gearing, A. J., P. Beckett, M. Christodoulou, M. Churchill, J. Clements, A. H. Davidson, A. H. Drummond, W. A. Galloway, R. Gilbert, J. L. Gordon' et al. 1994. Processing of tumour necrosis factorαprecursor by metalloproteinases. Nature 370: 555-557.
9. Mohler, K. M., P. R. Sleath, J. N. Fitzner, D. P. Cerretti, M. Alderson, S. S. Kerwar, D. S. Torrance, C. Otten-Evans, T. Greenstreet, K. Weerawarna et al. 1994. Protection against a lethal dose of endotoxin by an inhibitor of tumour necrosis factor processing. Nature 370: 218-220.
10. Moss, M. L., S. L. Jin, M. E. Milla, D. M. Bickett, W. Burkhart, H. L. Carter, W. J. Chen, W. C. Clay, J. R. Didsbury, D. Hassler, et al. 1997. Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor α Nature 385: 733-736.
11. Black, R. A., C. T. Rauch, C. J. Kozlosky, J. J. Peschon, J. L. Slack, M. F. Wolfson, B. J. Castner, K. L. Stocking, P. Reddy, S. Srinivasan, et al. 1997. A metalloproteinase disintegrin that releases tumour-necrosis factor α from cells. Nature 385: 729-733.
12. Kay, J. G., R. Z. Murray, J. K. Pagan, and J. L. Stow. 2006. Cytokine secretion via cholesterol-rich lipid raftαssociated SNAREs at the phagocytic cup. J. Biol Chem 281: 11949-11954.
13. Wang, X., and J. Han. 2000. Elucidating tumor necrosis factor signaling pathway using a functional gene identification approach. Immunol. Res. 21: 55-61.
14. Wang, X., K. Ono, S. O. Kim, V. Kravchenko, S. C. Lin, and J. Han. 2001. Metaxin is required for tumor necrosis factor-induced cell death. EMBO Rep. 2: 628-633.
15. Kim, S. O., S. D. Ha, S. Lee, S. Stanton, B. Beutler, and J. Han. 2007. Mutagenesis by retroviral insertion in chemical mutagen-generated quasi-haploid mammalian cells. BioTechniques 42: 493-501.
16. Roshy, S., B. F. Sloane, and K. Moin. 2003. Pericellular cathepsin B and malignant progression. Cancer Metastasis Rev. 22: 271-286.
17. Jane, D. T., L. DaSilva, J. Koblinski, M. Horwitz, B. F. Sloane, and M. J. Dufresne. 2002. Evidence for the involvement of cathepsin B in skeletal myoblast differentiation. J. Cell Biochem. 84: 520-531.
18. Balaji, K. N., N. Schaschke, W. Machleidt, M. Catalfamo, and P. A. Henkart. 2002. Surface cathepsin B protects cytotoxic lymphocytes from self-destruction after degranulation. J. Exp. Med. 196: 493-503.
19. Foghsgaard, L., U. Lademann, D. Wissing, B. Poulsen, and M. Jaattela. 2002. Cathepsin B mediates tumor necrosis factor-induced arachidonic acid release in tumor cells. J. Biol. Chem. 277: 39499-39506.
20. Hentze, H., X. Y. Lin, M. S. Choi, and A. G. Porter. 2003. Critical role for cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin nigericin. Cell Death Differ. 10: 956-968.
21. Szpaderska, A. M., and A. Frankfater. 2001. An intracellular form of cathepsin B contributes to invasiveness in cancer. Cancer Res. 61: 3493-3500.
22. Clemons-Miller, A. R., G. W. Cox, J. Suttles, and R. D. Stout. 2000. LPS stimulation of TNF-receptor deficient macrophages: a differential role for TNF α autocrine signaling in the induction of cytokine and nitric oxide production. Im-munobiology 202: 477-492.
23. Adami, C, M. J. Brunda, and A. V. Palleroni. 1993. In vivo immortalization of murine peritoneal macrophages: a new rapid and efficient method for obtaining maerophage cell lines. J. Leukocyte Biol. 53: 475-478.
24. Warren, M. K., and S. N. Vogel. 1985. Bone marrow-derived macrophages: development and regulation of differentiation markers by colony-stimulating factor and interferons. J. Immunol. 134: 982-989.
25. Ha, S. D., D. Ng, S. L. Pelech, and S. O. Kim. 2007. Critical role of the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase-3 signaling pathway in recovery from anthrax lethal toxin-induced cell cycle arrest and MEK cleavage in macrophages. J. Biol. Chem. 282: 36230-36239.
26. Kim, S. O., H. I. Sheikh, S. D. Ha, A. Martins, and G. Reid. 2006. G-CSF-mediated inhibition of JNK is a key mechanism for Lactobacillus rhamnosus-induced suppression of TNF production in macrophages. Cell Microbiol. 8: 1958-1971.
27. Shurety, W, J. K. Pagan, J. B. Prins, and J. L. Stow. 2001. Endocytosis of uncleaved tumor necrosis factor α in macrophages. Lab. Invest. 81: 107-117.
28. Buttle, D. J., M. Murata, C. G. Knight, and A. J. Barrett. 1992. CA074 methyl ester: a proinhibitor for intracellular cathepsin B. Arch. Biochem. Biophys. 299: 377-380.
29. McGrath, M. E. 1999. The lysosomal cysteine proteases. Annu. Rev. Biophys. Biomol Struct. 28: 181-204.
30. Mort J.-S., and D. J. Buttle. 1997. Cathepsin B. Int. J. Biochem. Cell Biol. 29: 715-720.
31. Benchoua, A., J. Braudeau, A. Reis, C. Couriaud, and B. Onteniente. 2004. Activation of proinfiammatory caspases by cathepsin B in focal cerebral ischemia. J. Cereb. Blood Flow Metab. 24: 1272-1279.
32. Morland, B., and A. Pedersen. 1979. Cathepsin B activity in stimulated mouse peritoneal macrophages. Lab. Invest. 41: 379-384.
33. Li, Q., W. A. Falkler, Jr., and C. T. Bever, Jr. 1997. Endotoxin induces increased intracellular cathepsin B activity in THP-1 cells. Immunopharmacol. Immuno-toxicol. 19: 215-237.
34. Li, Q., and C. T. Bever, Jr. 1997. Interferon-γ induced increases in intracellular cathepsin B activity in THP-1 cells are dependent on RNA transcription. J. Neuroimmunol. 74: 77-84.
35. Di Piazza, M., C. Mader, K. Geletneky, Y. C. M. Herrero, E. Weber, J. Schlehofer, L. Deleu, and J. Rommelaere. 2007. Cytosolic activation of cathepsins mediates parvovirus H-I-induced killing of cisplatin and TRAIL-resistant glioma cells. J. Virol. 81: 4186-4198.
36. Shurety, W., A. Merino-Trigo, D. Brown, D. A. Hume, and J. L. Stow. 2000. Localization and post-Golgi trafficking of tumor necrosis factorαin macrophages. J. Interferon Cytokine Res. 20: 427-438.
37. Murray, R. Z., F. G. Wylie, T. Khromykh, D. A. Hume, and J. L. Stow. 2005. Syntaxin 6 and Vtilb form a novel SNARE complex, which is up-regulated in activated macrophages to facilitate exocytosis of tumor necrosis factor α. J. Biol. Chem. 280: 10478-10483.
38. Pagan, J. K., F. G. Wylie, S. Joseph, C. Widberg, N. J. Bryant, D. E. James, and J. L. Stow. 2003. The t-SNARE syntaxin 4 is regulated during macrophage activation to function in membrane traffic and cytokine secretion. Curr. Biol. 13: 156-160.
39. Goulet, B., A. Baruch, N. S. Moon, M. Poirier, L. L. Sansregret, A. Erickson, M. Bogyo, and A. Nepveu. 2004. A cathepsin L isoform that is devoid of a signal peptide localizes to the nucleus in S phase and processes the CDP/Cux transcription factor. Mol. Cell 14: 207-219.
40. Riccio, M., R. Di Giaimo, S. Pianetti, P. P. Palmieri, M. Melli, and S. Santi. 2001. Nuclear localization of cystatin B, the cathepsin inhibitor implicated in myoclonus epilepsy (EPM1). Exp. Cell Res. 262: 84-94.
41. Pizzomo, M. C. 2001. Nuclear cathepsin B-Iike protease cleaves transcription factor YY1 in differentiated cells. Biochim. Biophys. Acta 1536: 31-42.
42. Jutras, I., and T. L. Reudelhuber. 1999. Prorenin processing by cathepsin B in vitro and in transfected cells. FEBS Lett. 443: 48-52.
43. Dunn, A. D., and J. T. Dunn. 1988. Cysteine proteinases from human thyroids and their actions on thyroglobulin. Endocrinology 123: 1089-1097.
44. Hill, P. A., D. J. Buttle, S. J. Jones, A. Boyde, M. Murata, J. J. Reynolds, and M. C. Meikle. 1994. Inhibition of bone resorption by selective inactivators of cysteine proteinases. J. Cell. Biochem. 56: 118-130.
45. Schotte, P., R. Schauvliege, S. Janssens, and R. Beyaert. 2001. The cathepsin B inhibitor z-FA.fmk inhibits cytokine production in macrophages stimulated by lipopolysaccharide. J. Biol. Chem. 276: 21153-21157.
46. Frlan, R., and S. Gobec. 2006. Inhibitors of cathepsin B. Curr. Sled. Chem. 13: 2309-2327.
47. Yan, S., and B. F. Sloane. 2003. Molecular regulation of human cathepsin B: implication in pathologies. Biol. Chem. 384: 845-854.