Characterization of Glu350 as a critical residue involved in the N- terminal amine binding site of aminopeptidase N (EC 3.4.11.2): Insights into its mechanism of action

Biochemistry

Volumn 37, Issue 2, 1998, Pages 686-692

  Luciani, Nathalie ^a   Marie Claire, Cynthia ^a   Ruffet, Emmanuel ^a   Beaumont, Ann ^a   Roques, Bernard P ^a   Fournié Zaluski, Marie Claude ^a  

^a Laboratoire de Pharmacochimie   (France)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; MICROSOMAL AMINOPEPTIDASE; PEPTIDASE; THERMOLYSIN; EXOPEPTIDASE; GLUTAMIC ACID; PEPTIDE HYDROLASE; PROTEINASE INHIBITOR; RECOMBINANT PROTEIN;

ARTICLE; BINDING SITE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME KINETICS; HYDROLYSIS; ISOTOPE LABELING; MICHAELIS MENTEN KINETICS; NONHUMAN; PLASMID; PRIORITY JOURNAL; SITE DIRECTED MUTAGENESIS; AMINO ACID SEQUENCE; ANIMAL; CELL STRAIN COS1; CHEMICAL MODEL; COMPARATIVE STUDY; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; PROTEIN BINDING; SEQUENCE HOMOLOGY; SWINE;

AMINO ACID SEQUENCE; ANIMALS; ANTIGENS, CD13; BINDING SITES; COS CELLS; EXOPEPTIDASES; GLUTAMIC ACID; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; MUTATION; PEPTIDE HYDROLASES; PROTEASE INHIBITORS; PROTEIN BINDING; RECOMBINANT PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SWINE;

EID: 0032512368     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi971705p     Document Type: Article

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