메뉴 건너뛰기




Volumn 41, Issue 12, 2009, Pages 2389-2397

The E2F family and the role of E2F1 in apoptosis

Author keywords

Apoptosis; Cancer cell; E2F; E2F1; Therapeutic target

Indexed keywords

BETA LAPACHONE; HISTONE DEACETYLASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LIGASE INHIBITOR; NUTLIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN BCL 2; PROTEIN KINASE B; PROTEIN P53; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1; UNCLASSIFIED DRUG;

EID: 70350270053     PISSN: 13572725     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biocel.2009.06.004     Document Type: Review
Times cited : (59)

References (94)
  • 1
    • 0029973557 scopus 로고    scopus 로고
    • Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors
    • Adams P.D., Sellers W.R., Sharma S.K., Wu A.D., Nalin C.M., and Kaelin Jr. W.G. Identification of a cyclin-cdk2 recognition motif present in substrates and p21-like cyclin-dependent kinase inhibitors. Mol Cell Biol 16 (1996) 6623-6633
    • (1996) Mol Cell Biol , vol.16 , pp. 6623-6633
    • Adams, P.D.1    Sellers, W.R.2    Sharma, S.K.3    Wu, A.D.4    Nalin, C.M.5    Kaelin Jr., W.G.6
  • 2
    • 58149382580 scopus 로고    scopus 로고
    • MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc
    • Aguda B.D., Kim Y., Piper-Hunter M.G., Friedman A., and Marsh C.B. MicroRNA regulation of a cancer network: consequences of the feedback loops involving miR-17-92, E2F, and Myc. Proc Natl Acad Sci USA 105 (2008) 19678-19683
    • (2008) Proc Natl Acad Sci USA , vol.105 , pp. 19678-19683
    • Aguda, B.D.1    Kim, Y.2    Piper-Hunter, M.G.3    Friedman, A.4    Marsh, C.B.5
  • 3
    • 0029050533 scopus 로고
    • Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis
    • Almasan A., Yin Y., Kelly R.E., Lee E.Y., Bradley A., Li W., et al. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry, activation of E2F-responsive genes, and apoptosis. Proc Natl Acad Sci USA 92 (1995) 5436-5440
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 5436-5440
    • Almasan, A.1    Yin, Y.2    Kelly, R.E.3    Lee, E.Y.4    Bradley, A.5    Li, W.6
  • 4
    • 34249303144 scopus 로고    scopus 로고
    • Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1
    • Ambrosini G., Sambol E.B., Carvajal D., Vassilev L.T., Singer S., and Schwartz G.K. Mouse double minute antagonist Nutlin-3a enhances chemotherapy-induced apoptosis in cancer cells with mutant p53 by activating E2F1. Oncogene 26 (2007) 3473-3481
    • (2007) Oncogene , vol.26 , pp. 3473-3481
    • Ambrosini, G.1    Sambol, E.B.2    Carvajal, D.3    Vassilev, L.T.4    Singer, S.5    Schwartz, G.K.6
  • 5
    • 0041624239 scopus 로고    scopus 로고
    • Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation
    • Ayyanathan K., Lechner M.S., Bell P., Maul G.G., Schultz D.C., Yamada Y., et al. Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: a mammalian cell culture model of gene variegation. Genes Dev 17 (2003) 1855-1869
    • (2003) Genes Dev , vol.17 , pp. 1855-1869
    • Ayyanathan, K.1    Lechner, M.S.2    Bell, P.3    Maul, G.G.4    Schultz, D.C.5    Yamada, Y.6
  • 6
    • 20344387475 scopus 로고    scopus 로고
    • Autophagy: dual roles in life and death?
    • Baehrecke E.H. Autophagy: dual roles in life and death?. Nat Rev Mol Cell Biol 6 (2005) 505-510
    • (2005) Nat Rev Mol Cell Biol , vol.6 , pp. 505-510
    • Baehrecke, E.H.1
  • 8
    • 0037448689 scopus 로고    scopus 로고
    • ATM is a target for positive regulation by E2F-1
    • Berkovich E., and Ginsberg D. ATM is a target for positive regulation by E2F-1. Oncogene 22 (2003) 161-167
    • (2003) Oncogene , vol.22 , pp. 161-167
    • Berkovich, E.1    Ginsberg, D.2
  • 10
    • 6444239416 scopus 로고    scopus 로고
    • E2F-1 transcription factor immunoexpression is inversely associated with tumor growth in colon adenocarcinomas
    • Bramis J., Zacharatos P., Papaconstantinou I., Kotsinas A., Sigala F., Korkolis D.P., et al. E2F-1 transcription factor immunoexpression is inversely associated with tumor growth in colon adenocarcinomas. Anticancer Res 24 (2004) 3041-3047
    • (2004) Anticancer Res , vol.24 , pp. 3041-3047
    • Bramis, J.1    Zacharatos, P.2    Papaconstantinou, I.3    Kotsinas, A.4    Sigala, F.5    Korkolis, D.P.6
  • 11
    • 0141707813 scopus 로고    scopus 로고
    • Emerging roles for E2F: beyond the G1/S transition and DNA replication
    • Cam H., and Dynlacht B.D. Emerging roles for E2F: beyond the G1/S transition and DNA replication. Cancer Cell 3 (2003) 311-316
    • (2003) Cancer Cell , vol.3 , pp. 311-316
    • Cam, H.1    Dynlacht, B.D.2
  • 12
    • 9744256274 scopus 로고    scopus 로고
    • Transcriptional regulation of AKT activation by E2F
    • Chaussepied M., and Ginsberg D. Transcriptional regulation of AKT activation by E2F. Mol Cell 16 (2004) 831-837
    • (2004) Mol Cell , vol.16 , pp. 831-837
    • Chaussepied, M.1    Ginsberg, D.2
  • 13
  • 14
    • 33947491578 scopus 로고    scopus 로고
    • E2F4 regulates a stable G2 arrest response to genotoxic stress in prostate carcinoma
    • Crosby M.E., Jacobberger J., Gupta D., Macklis R.M., and Almasan A. E2F4 regulates a stable G2 arrest response to genotoxic stress in prostate carcinoma. Oncogene 26 (2007) 1897-1909
    • (2007) Oncogene , vol.26 , pp. 1897-1909
    • Crosby, M.E.1    Jacobberger, J.2    Gupta, D.3    Macklis, R.M.4    Almasan, A.5
  • 15
    • 85047699682 scopus 로고    scopus 로고
    • Direct repression of the Mcl-1 promoter by E2F1
    • Croxton R., Ma Y., Song L., Haura E.B., and Cress W.D. Direct repression of the Mcl-1 promoter by E2F1. Oncogene 21 (2002) 1359-1369
    • (2002) Oncogene , vol.21 , pp. 1359-1369
    • Croxton, R.1    Ma, Y.2    Song, L.3    Haura, E.B.4    Cress, W.D.5
  • 16
    • 33750920705 scopus 로고    scopus 로고
    • Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis
    • DeGregori J., and Johnson D.G. Distinct and overlapping roles for E2F family members in transcription, proliferation and apoptosis. Curr Mol Med 6 (2006) 739-748
    • (2006) Curr Mol Med , vol.6 , pp. 739-748
    • DeGregori, J.1    Johnson, D.G.2
  • 17
    • 0029049577 scopus 로고
    • Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes
    • DeGregori J., Kowalik T., and Nevins J.R. Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes. Mol Cell Biol 15 (1995) 4215-4224
    • (1995) Mol Cell Biol , vol.15 , pp. 4215-4224
    • DeGregori, J.1    Kowalik, T.2    Nevins, J.R.3
  • 19
    • 18344393150 scopus 로고    scopus 로고
    • The E2F transcriptional network: old acquaintances with new faces
    • Dimova D.K., and Dyson N.J. The E2F transcriptional network: old acquaintances with new faces. Oncogene 24 (2005) 2810-2826
    • (2005) Oncogene , vol.24 , pp. 2810-2826
    • Dimova, D.K.1    Dyson, N.J.2
  • 20
    • 0037344006 scopus 로고    scopus 로고
    • E2F-1 overexpression sensitizes colorectal cancer cells to camptothecin
    • Dong Y.B., Yang H.L., and McMasters K.M. E2F-1 overexpression sensitizes colorectal cancer cells to camptothecin. Cancer Gene Ther 10 (2003) 168-178
    • (2003) Cancer Gene Ther , vol.10 , pp. 168-178
    • Dong, Y.B.1    Yang, H.L.2    McMasters, K.M.3
  • 21
    • 3042743989 scopus 로고    scopus 로고
    • Genotoxic stress induces expression of E2F4, leading to its association with p130 in prostate carcinoma cells
    • DuPree E.L., Mazumder S., and Almasan A. Genotoxic stress induces expression of E2F4, leading to its association with p130 in prostate carcinoma cells. Cancer Res 64 (2004) 4390-4393
    • (2004) Cancer Res , vol.64 , pp. 4390-4393
    • DuPree, E.L.1    Mazumder, S.2    Almasan, A.3
  • 22
    • 0032146274 scopus 로고    scopus 로고
    • The regulation of E2F by pRB-family proteins
    • Dyson N. The regulation of E2F by pRB-family proteins. Genes Dev 12 (1998) 2245-2262
    • (1998) Genes Dev , vol.12 , pp. 2245-2262
    • Dyson, N.1
  • 24
    • 3042723615 scopus 로고    scopus 로고
    • HDAC inhibitors trigger apoptosis in HPV-positive cells by inducing the E2F-p73 pathway
    • Finzer P., Krueger A., Stohr M., Brenner D., Soto U., Kuntzen C., et al. HDAC inhibitors trigger apoptosis in HPV-positive cells by inducing the E2F-p73 pathway. Oncogene 23 (2004) 4807-4817
    • (2004) Oncogene , vol.23 , pp. 4807-4817
    • Finzer, P.1    Krueger, A.2    Stohr, M.3    Brenner, D.4    Soto, U.5    Kuntzen, C.6
  • 25
    • 52949111487 scopus 로고    scopus 로고
    • CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity
    • Firestein R., Bass A.J., Kim S.Y., Dunn I.F., Silver S.J., Guney I., et al. CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. Nature 455 (2008) 547-551
    • (2008) Nature , vol.455 , pp. 547-551
    • Firestein, R.1    Bass, A.J.2    Kim, S.Y.3    Dunn, I.F.4    Silver, S.J.5    Guney, I.6
  • 26
    • 2942722811 scopus 로고    scopus 로고
    • Molecular mechanisms of E2F-dependent activation and pRB-mediated repression
    • Frolov M.V., and Dyson N.J. Molecular mechanisms of E2F-dependent activation and pRB-mediated repression. J Cell Sci 117 (2004) 2173-2181
    • (2004) J Cell Sci , vol.117 , pp. 2173-2181
    • Frolov, M.V.1    Dyson, N.J.2
  • 27
    • 0031749470 scopus 로고    scopus 로고
    • Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo
    • Fueyo J., Gomez-Manzano C., Yung W.K., Liu T.J., Alemany R., McDonnell T.J., et al. Overexpression of E2F-1 in glioma triggers apoptosis and suppresses tumor growth in vitro and in vivo. Nat Med 4 (1998) 685-690
    • (1998) Nat Med , vol.4 , pp. 685-690
    • Fueyo, J.1    Gomez-Manzano, C.2    Yung, W.K.3    Liu, T.J.4    Alemany, R.5    McDonnell, T.J.6
  • 28
    • 37349070024 scopus 로고    scopus 로고
    • An E2F1-dependent gene expression program that determines the balance between proliferation and cell death
    • Hallstrom T.C., Mori S., and Nevins J.R. An E2F1-dependent gene expression program that determines the balance between proliferation and cell death. Cancer Cell 13 (2008) 11-22
    • (2008) Cancer Cell , vol.13 , pp. 11-22
    • Hallstrom, T.C.1    Mori, S.2    Nevins, J.R.3
  • 29
    • 0141814666 scopus 로고    scopus 로고
    • Specificity in the activation and control of transcription factor E2F-dependent apoptosis
    • Hallstrom T.C., and Nevins J.R. Specificity in the activation and control of transcription factor E2F-dependent apoptosis. Proc Natl Acad Sci USA 100 (2003) 10848-10853
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 10848-10853
    • Hallstrom, T.C.1    Nevins, J.R.2
  • 30
    • 33644776551 scopus 로고    scopus 로고
    • Jab1 is a specificity factor for E2F1-induced apoptosis
    • Hallstrom T.C., and Nevins J.R. Jab1 is a specificity factor for E2F1-induced apoptosis. Genes Dev 20 (2006) 613-623
    • (2006) Genes Dev , vol.20 , pp. 613-623
    • Hallstrom, T.C.1    Nevins, J.R.2
  • 31
    • 0031886093 scopus 로고    scopus 로고
    • Regulation of cell proliferation by the E2F transcription factors
    • Helin K. Regulation of cell proliferation by the E2F transcription factors. Curr Opin Genet Dev 8 (1998) 28-35
    • (1998) Curr Opin Genet Dev , vol.8 , pp. 28-35
    • Helin, K.1
  • 33
    • 17144371342 scopus 로고    scopus 로고
    • Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F
    • Hershko T., Chaussepied M., Oren M., and Ginsberg D. Novel link between E2F and p53: proapoptotic cofactors of p53 are transcriptionally upregulated by E2F. Cell Death Differ 12 (2005) 377-383
    • (2005) Cell Death Differ , vol.12 , pp. 377-383
    • Hershko, T.1    Chaussepied, M.2    Oren, M.3    Ginsberg, D.4
  • 35
    • 0033941117 scopus 로고    scopus 로고
    • Thymidylate synthase expression correlates closely with E2F1 expression in colon cancer
    • Kasahara M., Takahashi Y., Nagata T., Asai S., Eguchi T., Ishii Y., et al. Thymidylate synthase expression correlates closely with E2F1 expression in colon cancer. Clin Cancer Res 6 (2000) 2707-2711
    • (2000) Clin Cancer Res , vol.6 , pp. 2707-2711
    • Kasahara, M.1    Takahashi, Y.2    Nagata, T.3    Asai, S.4    Eguchi, T.5    Ishii, Y.6
  • 36
    • 0037901839 scopus 로고    scopus 로고
    • Transcription of mouse DNA methyltransferase 1 (Dnmt1) is regulated by both E2F-Rb-HDAC-dependent and -independent pathways
    • Kimura H., Nakamura T., Ogawa T., Tanaka S., and Shiota K. Transcription of mouse DNA methyltransferase 1 (Dnmt1) is regulated by both E2F-Rb-HDAC-dependent and -independent pathways. Nucleic Acids Res 31 (2003) 3101-3113
    • (2003) Nucleic Acids Res , vol.31 , pp. 3101-3113
    • Kimura, H.1    Nakamura, T.2    Ogawa, T.3    Tanaka, S.4    Shiota, K.5
  • 37
    • 51649088367 scopus 로고    scopus 로고
    • E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines
    • Kitagawa M., Aonuma M., Lee S.H., Fukutake S., and McCormick F. E2F-1 transcriptional activity is a critical determinant of Mdm2 antagonist-induced apoptosis in human tumor cell lines. Oncogene 27 (2008) 5303-5314
    • (2008) Oncogene , vol.27 , pp. 5303-5314
    • Kitagawa, M.1    Aonuma, M.2    Lee, S.H.3    Fukutake, S.4    McCormick, F.5
  • 38
    • 0022454147 scopus 로고
    • Identification of a cellular transcription factor involved in E1A trans-activation
    • Kovesdi I., Reichel R., and Nevins J.R. Identification of a cellular transcription factor involved in E1A trans-activation. Cell 45 (1986) 219-228
    • (1986) Cell , vol.45 , pp. 219-228
    • Kovesdi, I.1    Reichel, R.2    Nevins, J.R.3
  • 39
    • 0031992159 scopus 로고    scopus 로고
    • E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2
    • Kowalik T.F., DeGregori J., Leone G., Jakoi L., and Nevins J.R. E2F1-specific induction of apoptosis and p53 accumulation, which is blocked by Mdm2. Cell Growth Differ 9 (1998) 113-118
    • (1998) Cell Growth Differ , vol.9 , pp. 113-118
    • Kowalik, T.F.1    DeGregori, J.2    Leone, G.3    Jakoi, L.4    Nevins, J.R.5
  • 40
    • 0028362359 scopus 로고
    • Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase
    • Krek W., Ewen M.E., Shirodkar S., Arany Z., Kaelin Jr. W.G., and Livingston D.M. Negative regulation of the growth-promoting transcription factor E2F-1 by a stably bound cyclin A-dependent protein kinase. Cell 78 (1994) 161-172
    • (1994) Cell , vol.78 , pp. 161-172
    • Krek, W.1    Ewen, M.E.2    Shirodkar, S.3    Arany, Z.4    Kaelin Jr., W.G.5    Livingston, D.M.6
  • 41
    • 0029559027 scopus 로고
    • Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint
    • Krek W., Xu G., and Livingston D.M. Cyclin A-kinase regulation of E2F-1 DNA binding function underlies suppression of an S phase checkpoint. Cell 83 (1995) 1149-1158
    • (1995) Cell , vol.83 , pp. 1149-1158
    • Krek, W.1    Xu, G.2    Livingston, D.M.3
  • 42
    • 23744507860 scopus 로고    scopus 로고
    • E2F1 is crucial for E2F-dependent apoptosis
    • Lazzerini Denchi E., and Helin K. E2F1 is crucial for E2F-dependent apoptosis. EMBO Rep 6 (2005) 661-668
    • (2005) EMBO Rep , vol.6 , pp. 661-668
    • Lazzerini Denchi, E.1    Helin, K.2
  • 43
    • 37749005850 scopus 로고    scopus 로고
    • Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development
    • Li J., Ran C., Li E., Gordon F., Comstock G., Siddiqui H., et al. Synergistic function of E2F7 and E2F8 is essential for cell survival and embryonic development. Dev Cell 14 (2008) 62-75
    • (2008) Dev Cell , vol.14 , pp. 62-75
    • Li, J.1    Ran, C.2    Li, E.3    Gordon, F.4    Comstock, G.5    Siddiqui, H.6
  • 44
    • 0344406759 scopus 로고    scopus 로고
    • Selective killing of cancer cells by beta-lapachone: direct checkpoint activation as a strategy against cancer
    • Li Y., Sun X., LaMont J.T., Pardee A.B., and Li C.J. Selective killing of cancer cells by beta-lapachone: direct checkpoint activation as a strategy against cancer. Proc Natl Acad Sci USA 100 (2003) 2674-2678
    • (2003) Proc Natl Acad Sci USA , vol.100 , pp. 2674-2678
    • Li, Y.1    Sun, X.2    LaMont, J.T.3    Pardee, A.B.4    Li, C.J.5
  • 45
    • 0035878122 scopus 로고    scopus 로고
    • Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation
    • Lin W.C., Lin F.T., and Nevins J.R. Selective induction of E2F1 in response to DNA damage, mediated by ATM-dependent phosphorylation. Genes Dev 15 (2001) 1833-1844
    • (2001) Genes Dev , vol.15 , pp. 1833-1844
    • Lin, W.C.1    Lin, F.T.2    Nevins, J.R.3
  • 46
    • 1842831271 scopus 로고    scopus 로고
    • TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival
    • Liu K., Luo Y., Lin F.T., and Lin W.C. TopBP1 recruits Brg1/Brm to repress E2F1-induced apoptosis, a novel pRb-independent and E2F1-specific control for cell survival. Genes Dev 18 (2004) 673-686
    • (2004) Genes Dev , vol.18 , pp. 673-686
    • Liu, K.1    Luo, Y.2    Lin, F.T.3    Lin, W.C.4
  • 47
    • 33750209770 scopus 로고    scopus 로고
    • Regulation of TopBP1 oligomerization by Akt/PKB for cell survival
    • Liu K., Paik J.C., Wang B., Lin F.T., and Lin W.C. Regulation of TopBP1 oligomerization by Akt/PKB for cell survival. EMBO J 25 (2006) 4795-4807
    • (2006) EMBO J , vol.25 , pp. 4795-4807
    • Liu, K.1    Paik, J.C.2    Wang, B.3    Lin, F.T.4    Lin, W.C.5
  • 48
    • 0030053130 scopus 로고    scopus 로고
    • Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression
    • Lukas J., Petersen B.O., Holm K., Bartek J., and Helin K. Deregulated expression of E2F family members induces S-phase entry and overcomes p16INK4A-mediated growth suppression. Mol Cell Biol 16 (1996) 1047-1057
    • (1996) Mol Cell Biol , vol.16 , pp. 1047-1057
    • Lukas, J.1    Petersen, B.O.2    Holm, K.3    Bartek, J.4    Helin, K.5
  • 51
    • 44849093460 scopus 로고    scopus 로고
    • TopBP1 activates ATR through ATRIP and a PIKK regulatory domain
    • Mordes D.A., Glick G.G., Zhao R., and Cortez D. TopBP1 activates ATR through ATRIP and a PIKK regulatory domain. Genes Dev 22 (2008) 1478-1489
    • (2008) Genes Dev , vol.22 , pp. 1478-1489
    • Mordes, D.A.1    Glick, G.G.2    Zhao, R.3    Cortez, D.4
  • 53
    • 52949093102 scopus 로고    scopus 로고
    • E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8
    • Morris E.J., Ji J.Y., Yang F., Di Stefano L., Herr A., Moon N.S., et al. E2F1 represses beta-catenin transcription and is antagonized by both pRB and CDK8. Nature 455 (2008) 552-556
    • (2008) Nature , vol.455 , pp. 552-556
    • Morris, E.J.1    Ji, J.Y.2    Yang, F.3    Di Stefano, L.4    Herr, A.5    Moon, N.S.6
  • 54
    • 33751363564 scopus 로고    scopus 로고
    • Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo
    • Morris E.J., Michaud W.A., Ji J.Y., Moon N.S., Rocco J.W., and Dyson N.J. Functional identification of Api5 as a suppressor of E2F-dependent apoptosis in vivo. PLoS Genet 2 (2006) e196
    • (2006) PLoS Genet , vol.2
    • Morris, E.J.1    Michaud, W.A.2    Ji, J.Y.3    Moon, N.S.4    Rocco, J.W.5    Dyson, N.J.6
  • 56
    • 0035265832 scopus 로고    scopus 로고
    • The C. elegans E2F- and DP-related proteins are required for embryonic asymmetry and negatively regulate Ras/MAPK signaling
    • Page B.D., Guedes S., Waring D., and Priess J.R. The C. elegans E2F- and DP-related proteins are required for embryonic asymmetry and negatively regulate Ras/MAPK signaling. Mol Cell 7 (2001) 451-460
    • (2001) Mol Cell , vol.7 , pp. 451-460
    • Page, B.D.1    Guedes, S.2    Waring, D.3    Priess, J.R.4
  • 57
    • 0038142184 scopus 로고    scopus 로고
    • Differential regulation of E2F1 apoptotic target genes in response to DNA damage
    • Pediconi N., Ianari A., Costanzo A., Belloni L., Gallo R., Cimino L., et al. Differential regulation of E2F1 apoptotic target genes in response to DNA damage. Nat Cell Biol 5 (2003) 552-558
    • (2003) Nat Cell Biol , vol.5 , pp. 552-558
    • Pediconi, N.1    Ianari, A.2    Costanzo, A.3    Belloni, L.4    Gallo, R.5    Cimino, L.6
  • 58
    • 0033231615 scopus 로고    scopus 로고
    • E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways
    • Phillips A.C., Ernst M.K., Bates S., Rice N.R., and Vousden K.H. E2F-1 potentiates cell death by blocking antiapoptotic signaling pathways. Mol Cell 4 (1999) 771-781
    • (1999) Mol Cell , vol.4 , pp. 771-781
    • Phillips, A.C.1    Ernst, M.K.2    Bates, S.3    Rice, N.R.4    Vousden, K.H.5
  • 59
    • 54049120956 scopus 로고    scopus 로고
    • E2F-at the crossroads of life and death
    • Polager S., and Ginsberg D. E2F-at the crossroads of life and death. Trends Cell Biol 18 (2008) 528-535
    • (2008) Trends Cell Biol , vol.18 , pp. 528-535
    • Polager, S.1    Ginsberg, D.2
  • 60
    • 49649121765 scopus 로고    scopus 로고
    • E2F1 regulates autophagy and the transcription of autophagy genes
    • Polager S., Ofir M., and Ginsberg D. E2F1 regulates autophagy and the transcription of autophagy genes. Oncogene 27 (2008) 4860-4864
    • (2008) Oncogene , vol.27 , pp. 4860-4864
    • Polager, S.1    Ofir, M.2    Ginsberg, D.3
  • 61
    • 0032549704 scopus 로고    scopus 로고
    • The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53
    • Pomerantz J., Schreiber-Agus N., Liegeois N.J., Silverman A., Alland L., Chin L., et al. The Ink4a tumor suppressor gene product, p19Arf, interacts with MDM2 and neutralizes MDM2's inhibition of p53. Cell 92 (1998) 713-723
    • (1998) Cell , vol.92 , pp. 713-723
    • Pomerantz, J.1    Schreiber-Agus, N.2    Liegeois, N.J.3    Silverman, A.4    Alland, L.5    Chin, L.6
  • 62
  • 63
    • 34247882638 scopus 로고    scopus 로고
    • E2F1 death pathways as targets for cancer therapy
    • Putzer B.M. E2F1 death pathways as targets for cancer therapy. J Cell Mol Med 11 (2007) 239-251
    • (2007) J Cell Mol Med , vol.11 , pp. 239-251
    • Putzer, B.M.1
  • 64
    • 0027947383 scopus 로고
    • Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
    • Qin X.Q., Livingston D.M., Kaelin Jr. W.G., and Adams P.D. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci USA 91 (1994) 10918-10922
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 10918-10922
    • Qin, X.Q.1    Livingston, D.M.2    Kaelin Jr., W.G.3    Adams, P.D.4
  • 65
    • 0033919595 scopus 로고    scopus 로고
    • DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters
    • Robertson K.D., Ait-Si-Ali S., Yokochi T., Wade P.A., Jones P.L., and Wolffe A.P. DNMT1 forms a complex with Rb, E2F1 and HDAC1 and represses transcription from E2F-responsive promoters. Nat Genet 25 (2000) 338-342
    • (2000) Nat Genet , vol.25 , pp. 338-342
    • Robertson, K.D.1    Ait-Si-Ali, S.2    Yokochi, T.3    Wade, P.A.4    Jones, P.L.5    Wolffe, A.P.6
  • 66
    • 30844469526 scopus 로고    scopus 로고
    • E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIP(short)
    • Salon C., Eymin B., Micheau O., Chaperot L., Plumas J., Brambilla C., et al. E2F1 induces apoptosis and sensitizes human lung adenocarcinoma cells to death-receptor-mediated apoptosis through specific downregulation of c-FLIP(short). Cell Death Differ 13 (2006) 260-272
    • (2006) Cell Death Differ , vol.13 , pp. 260-272
    • Salon, C.1    Eymin, B.2    Micheau, O.3    Chaperot, L.4    Plumas, J.5    Brambilla, C.6
  • 67
    • 0037089626 scopus 로고    scopus 로고
    • SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins
    • Schultz D.C., Ayyanathan K., Negorev D., Maul G.G., and Rauscher III F.J. SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins. Genes Dev 16 (2002) 919-932
    • (2002) Genes Dev , vol.16 , pp. 919-932
    • Schultz, D.C.1    Ayyanathan, K.2    Negorev, D.3    Maul, G.G.4    Rauscher III, F.J.5
  • 68
    • 0028873133 scopus 로고
    • Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression
    • Schwarz J.K., Bassing C.H., Kovesdi I., Datto M.B., Blazing M., George S., et al. Expression of the E2F1 transcription factor overcomes type beta transforming growth factor-mediated growth suppression. Proc Natl Acad Sci USA 92 (1995) 483-487
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 483-487
    • Schwarz, J.K.1    Bassing, C.H.2    Kovesdi, I.3    Datto, M.B.4    Blazing, M.5    George, S.6
  • 69
    • 0001510491 scopus 로고    scopus 로고
    • The RB and p53 pathways in cancer
    • Sherr C.J., and McCormick F. The RB and p53 pathways in cancer. Cancer Cell 2 (2002) 103-112
    • (2002) Cancer Cell , vol.2 , pp. 103-112
    • Sherr, C.J.1    McCormick, F.2
  • 71
    • 33646047403 scopus 로고    scopus 로고
    • E2F1-induced apoptosis: turning killers into therapeutics
    • Stanelle J., and Putzer B.M. E2F1-induced apoptosis: turning killers into therapeutics. Trends Mol Med 12 (2006) 177-185
    • (2006) Trends Mol Med , vol.12 , pp. 177-185
    • Stanelle, J.1    Putzer, B.M.2
  • 72
    • 0036897835 scopus 로고    scopus 로고
    • A revised picture of the E2F transcriptional network and RB function
    • Stevaux O., and Dyson N.J. A revised picture of the E2F transcriptional network and RB function. Curr Opin Cell Biol 14 (2002) 684-691
    • (2002) Curr Opin Cell Biol , vol.14 , pp. 684-691
    • Stevaux, O.1    Dyson, N.J.2
  • 73
    • 0037445901 scopus 로고    scopus 로고
    • E2F and cell cycle control: a double-edged sword
    • Stevens C., and La Thangue N.B. E2F and cell cycle control: a double-edged sword. Arch Biochem Biophys 412 (2003) 157-169
    • (2003) Arch Biochem Biophys , vol.412 , pp. 157-169
    • Stevens, C.1    La Thangue, N.B.2
  • 74
    • 0038752083 scopus 로고    scopus 로고
    • Chk2 activates E2F-1 in response to DNA damage
    • Stevens C., Smith L., and La Thangue N.B. Chk2 activates E2F-1 in response to DNA damage. Nat Cell Biol 5 (2003) 401-409
    • (2003) Nat Cell Biol , vol.5 , pp. 401-409
    • Stevens, C.1    Smith, L.2    La Thangue, N.B.3
  • 75
    • 33744539154 scopus 로고    scopus 로고
    • Apoptosis signal-regulating kinase 1 is a direct target of E2F1 and contributes to histone deacetylase inhibitor-induced apoptosis through positive feedback regulation of E2F1 apoptotic activity
    • Tan J., Zhuang L., Jiang X., Yang K.K., Karuturi K.M., and Yu Q. Apoptosis signal-regulating kinase 1 is a direct target of E2F1 and contributes to histone deacetylase inhibitor-induced apoptosis through positive feedback regulation of E2F1 apoptotic activity. J Biol Chem 281 (2006) 10508-10515
    • (2006) J Biol Chem , vol.281 , pp. 10508-10515
    • Tan, J.1    Zhuang, L.2    Jiang, X.3    Yang, K.K.4    Karuturi, K.M.5    Yu, Q.6
  • 76
    • 0036279279 scopus 로고    scopus 로고
    • E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination
    • Tanaka H., Matsumura I., Ezoe S., Satoh Y., Sakamaki T., Albanese C., et al. E2F1 and c-Myc potentiate apoptosis through inhibition of NF-kappaB activity that facilitates MnSOD-mediated ROS elimination. Mol Cell 9 (2002) 1017-1029
    • (2002) Mol Cell , vol.9 , pp. 1017-1029
    • Tanaka, H.1    Matsumura, I.2    Ezoe, S.3    Satoh, Y.4    Sakamaki, T.5    Albanese, C.6
  • 77
    • 0035852632 scopus 로고    scopus 로고
    • The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex
    • Trimarchi J.M., Fairchild B., Wen J., and Lees J.A. The E2F6 transcription factor is a component of the mammalian Bmi1-containing polycomb complex. Proc Natl Acad Sci USA 98 (2001) 1519-1524
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 1519-1524
    • Trimarchi, J.M.1    Fairchild, B.2    Wen, J.3    Lees, J.A.4
  • 79
    • 0032159103 scopus 로고    scopus 로고
    • Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos
    • Tsai K.Y., Hu Y., Macleod K.F., Crowley D., Yamasaki L., and Jacks T. Mutation of E2f-1 suppresses apoptosis and inappropriate S phase entry and extends survival of Rb-deficient mouse embryos. Mol Cell 2 (1998) 293-304
    • (1998) Mol Cell , vol.2 , pp. 293-304
    • Tsai, K.Y.1    Hu, Y.2    Macleod, K.F.3    Crowley, D.4    Yamasaki, L.5    Jacks, T.6
  • 80
    • 10644270921 scopus 로고    scopus 로고
    • p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2
    • Urist M., Tanaka T., Poyurovsky M.V., and Prives C. p73 induction after DNA damage is regulated by checkpoint kinases Chk1 and Chk2. Genes Dev 18 (2004) 3041-3054
    • (2004) Genes Dev , vol.18 , pp. 3041-3054
    • Urist, M.1    Tanaka, T.2    Poyurovsky, M.V.3    Prives, C.4
  • 81
    • 10744221485 scopus 로고    scopus 로고
    • In vivo activation of the p53 pathway by small-molecule antagonists of MDM2
    • Vassilev L.T., Vu B.T., Graves B., Carvajal D., Podlaski F., Filipovic Z., et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303 (2004) 844-848
    • (2004) Science , vol.303 , pp. 844-848
    • Vassilev, L.T.1    Vu, B.T.2    Graves, B.3    Carvajal, D.4    Podlaski, F.5    Filipovic, Z.6
  • 82
    • 0344931628 scopus 로고    scopus 로고
    • CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase
    • Vigo E., Muller H., Prosperini E., Hateboer G., Cartwright P., Moroni M.C., et al. CDC25A phosphatase is a target of E2F and is required for efficient E2F-induced S phase. Mol Cell Biol 19 (1999) 6379-6395
    • (1999) Mol Cell Biol , vol.19 , pp. 6379-6395
    • Vigo, E.1    Muller, H.2    Prosperini, E.3    Hateboer, G.4    Cartwright, P.5    Moroni, M.C.6
  • 83
    • 0036674617 scopus 로고    scopus 로고
    • Live or let die: the cell's response to p53
    • Vousden K.H., and Lu X. Live or let die: the cell's response to p53. Nat Rev Cancer 2 (2002) 594-604
    • (2002) Nat Rev Cancer , vol.2 , pp. 594-604
    • Vousden, K.H.1    Lu, X.2
  • 84
    • 33748200050 scopus 로고    scopus 로고
    • Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage
    • Wang C., Chen L., Hou X., Li Z., Kabra N., Ma Y., et al. Interactions between E2F1 and SirT1 regulate apoptotic response to DNA damage. Nat Cell Biol 8 (2006) 1025-1031
    • (2006) Nat Cell Biol , vol.8 , pp. 1025-1031
    • Wang, C.1    Chen, L.2    Hou, X.3    Li, Z.4    Kabra, N.5    Ma, Y.6
  • 85
    • 25144496653 scopus 로고    scopus 로고
    • MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation
    • Wang C., Ivanov A., Chen L., Fredericks W.J., Seto E., Rauscher III F.J., et al. MDM2 interaction with nuclear corepressor KAP1 contributes to p53 inactivation. EMBO J 24 (2005) 3279-3290
    • (2005) EMBO J , vol.24 , pp. 3279-3290
    • Wang, C.1    Ivanov, A.2    Chen, L.3    Fredericks, W.J.4    Seto, E.5    Rauscher III, F.J.6
  • 86
    • 35649016616 scopus 로고    scopus 로고
    • Regulation of E2F1 function by the nuclear corepressor KAP1
    • Wang C., Rauscher III F.J., Cress W.D., and Chen J. Regulation of E2F1 function by the nuclear corepressor KAP1. J Biol Chem 282 (2007) 29902-29909
    • (2007) J Biol Chem , vol.282 , pp. 29902-29909
    • Wang, C.1    Rauscher III, F.J.2    Cress, W.D.3    Chen, J.4
  • 87
    • 0035936113 scopus 로고    scopus 로고
    • The E2F1-3 transcription factors are essential for cellular proliferation
    • Wu L., Timmers C., Maiti B., Saavedra H.I., Sang L., Chong G.T., et al. The E2F1-3 transcription factors are essential for cellular proliferation. Nature 414 (2001) 457-462
    • (2001) Nature , vol.414 , pp. 457-462
    • Wu, L.1    Timmers, C.2    Maiti, B.3    Saavedra, H.I.4    Sang, L.5    Chong, G.T.6
  • 88
    • 0028222124 scopus 로고
    • p53 and E2F-1 cooperate to mediate apoptosis
    • Wu X., and Levine A.J. p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci USA 91 (1994) 3602-3606
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3602-3606
    • Wu, X.1    Levine, A.J.2
  • 89
    • 0028945789 scopus 로고
    • Multiple members of the E2F transcription factor family are the products of oncogenes
    • Xu G., Livingston D.M., and Krek W. Multiple members of the E2F transcription factor family are the products of oncogenes. Proc Natl Acad Sci USA 92 (1995) 1357-1361
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 1357-1361
    • Xu, G.1    Livingston, D.M.2    Krek, W.3
  • 90
    • 0028019279 scopus 로고
    • Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation
    • Xu M., Sheppard K.A., Peng C.Y., Yee A.S., and Piwnica-Worms H. Cyclin A/CDK2 binds directly to E2F-1 and inhibits the DNA-binding activity of E2F-1/DP-1 by phosphorylation. Mol Cell Biol 14 (1994) 8420-8431
    • (1994) Mol Cell Biol , vol.14 , pp. 8420-8431
    • Xu, M.1    Sheppard, K.A.2    Peng, C.Y.3    Yee, A.S.4    Piwnica-Worms, H.5
  • 92
    • 0242484074 scopus 로고    scopus 로고
    • Adenovirus-mediated E2F-1 gene transfer inhibits MDM2 expression and efficiently induces apoptosis in MDM2-overexpressing tumor cells
    • Yang H.L., Dong Y.B., Elliott M.J., Liu T.J., Atienza Jr. C., Stilwell A., et al. Adenovirus-mediated E2F-1 gene transfer inhibits MDM2 expression and efficiently induces apoptosis in MDM2-overexpressing tumor cells. Clin Cancer Res 5 (1999) 2242-2250
    • (1999) Clin Cancer Res , vol.5 , pp. 2242-2250
    • Yang, H.L.1    Dong, Y.B.2    Elliott, M.J.3    Liu, T.J.4    Atienza Jr., C.5    Stilwell, A.6
  • 94
    • 27644556419 scopus 로고    scopus 로고
    • Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim
    • Zhao Y., Tan J., Zhuang L., Jiang X., Liu E.T., and Yu Q. Inhibitors of histone deacetylases target the Rb-E2F1 pathway for apoptosis induction through activation of proapoptotic protein Bim. Proc Natl Acad Sci USA 102 (2005) 16090-16095
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 16090-16095
    • Zhao, Y.1    Tan, J.2    Zhuang, L.3    Jiang, X.4    Liu, E.T.5    Yu, Q.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.