Regulated recruitment of HP1 to a euchromatic gene induces mitotically heritable, epigenetic gene silencing: A mammalian cell culture model of gene variegation

Genes and Development

Volumn 17, Issue 15, 2003, Pages 1855-1869

  Ayyanathan, Kasirajan ^a   Lechner, Mark S ^a,b   Bell, Peter ^a   Maul, Gerd G ^a   Schultz, David C ^c   Yamada, Yoshihiko ^d   Tanaka, Kazuhiro ^d   Torigoe, Kiyoyuki ^d   Rauscher III, Frank J ^a  

^a WISTAR INSTITUTE   (United States)

^b DREXEL UNIVERSITY   (United States)

^c CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

Gene silencing; Heterochromatin; HP1; KAP1; KRAB domain; Position effect variegation

Indexed keywords

HETEROCHROMATIN PROTEIN 1; HORMONE; LYSINE; M PROTEIN; METHYLTRANSFERASE; PROTEIN; PROTEIN KAP 1; PROTEIN KRAB; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ARTICLE; CELL CLONE; CELL CULTURE; CHROMATIN STRUCTURE; CONTROLLED STUDY; DROSOPHILA; EUCHROMATIN; GENE EXPRESSION; GENE INDUCTION; GENE LOCATION; GENE LOCUS; GENE SILENCING; HETEROCHROMATIN; MAMMAL CELL; METHYLATION; MITOSIS RATE; MODEL; MOLECULAR CLONING; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN DOMAIN; PROTEIN SYNTHESIS; REGULATORY MECHANISM; TRANSGENE;

3T3 CELLS; AMINO ACID MOTIFS; ANIMALS; CELL CULTURE TECHNIQUES; CELL LINE; CHROMATIN; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA METHYLATION; ENDONUCLEASES; GENE SILENCING; GENES, REPORTER; HISTONES; HYDROXYTESTOSTERONES; IN SITU HYBRIDIZATION, FLUORESCENCE; LUCIFERASES; LYSINE; MICE; MICROSCOPY, FLUORESCENCE; MITOSIS; MODELS, GENETIC; PLASMIDS; PRECIPITIN TESTS; PROMOTER REGIONS (GENETICS); PROTEIN STRUCTURE, TERTIARY; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TIME FACTORS; TRANSFECTION; TRANSGENES; ZINC FINGERS;

ANIMALIA; MAMMALIA;

EID: 0041624239     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1102803     Document Type: Article

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