메뉴 건너뛰기




Volumn 9, Issue 2, 1998, Pages 113-118

E2F1-specific Induction of Apoptosis and p53 Accumulation, Which Is Blocked by Mdm2

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CELL CYCLE PROTEIN; DNA BINDING PROTEIN; E2F1 PROTEIN, RAT; MDM2 PROTEIN, RAT; NUCLEAR PROTEIN; ONCOPROTEIN; PROTEIN MDM2; PROTEIN P53; RETINOBLASTOMA BINDING PROTEIN 1; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR DP1; TRANSCRIPTION FACTOR E2F; TRANSCRIPTION FACTOR E2F1;

EID: 0031992159     PISSN: 10449523     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (191)

References (41)
  • 1
    • 0027497372 scopus 로고
    • The retinoblastoma protein as a transcriptional repressor
    • Helin, K., and Harlow, E. The retinoblastoma protein as a transcriptional repressor. Trends Cell Biol., 3: 43-46, 1993.
    • (1993) Trends Cell Biol. , vol.3 , pp. 43-46
    • Helin, K.1    Harlow, E.2
  • 2
    • 0026526437 scopus 로고
    • E2F: A link between the Rb tumor suppressor protein and viral oncoproteins
    • Washington DC
    • Nevins, J. R. E2F: a link between the Rb tumor suppressor protein and viral oncoproteins. Science (Washington DC), 258: 424-429, 1992.
    • (1992) Science , vol.258 , pp. 424-429
    • Nevins, J.R.1
  • 3
    • 0028267869 scopus 로고
    • DRTF1/E2F: An expanding family of heterodimeric transcription factors implicated in cell-cycle control
    • La Thangue, N. B. DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control. Trends Biochem. Sci., 19: 108-114, 1994.
    • (1994) Trends Biochem. Sci. , vol.19 , pp. 108-114
    • La Thangue, N.B.1
  • 4
    • 0029849620 scopus 로고    scopus 로고
    • Cancer cell cycles
    • Washington DC
    • Sherr, C. J. Cancer cell cycles. Science (Washington DC), 274: 1672-1677, 1996.
    • (1996) Science , vol.274 , pp. 1672-1677
    • Sherr, C.J.1
  • 5
    • 0030933277 scopus 로고    scopus 로고
    • Oncoprotein networks
    • Hunter, T. Oncoprotein networks. Cell, 88: 333-346, 1997.
    • (1997) Cell , vol.88 , pp. 333-346
    • Hunter, T.1
  • 6
    • 0027491775 scopus 로고
    • Expression of transcription factor E2F1 induces quiescent cells to enter S phase
    • Johnson, D. G., Schwarz, J. K., Cress, W. D., and Nevins, J. R. Expression of transcription factor E2F1 induces quiescent cells to enter S phase. Nature (Lond.), 365: 349-352, 1993.
    • (1993) Nature (Lond.) , vol.365 , pp. 349-352
    • Johnson, D.G.1    Schwarz, J.K.2    Cress, W.D.3    Nevins, J.R.4
  • 7
    • 0027947383 scopus 로고
    • Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis
    • Qin, X-Q., Livingston, D. M., Kaelin, W. G., and Adams, P. D. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc. Natl. Acad. Sci. USA. 91: 10918-10922, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 10918-10922
    • Qin, X.-Q.1    Livingston, D.M.2    Kaelin, W.G.3    Adams, P.D.4
  • 8
    • 0028360766 scopus 로고
    • Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation
    • Singh, P., Wong, S. W., and Hong, W. Overexpression of E2F-1 in rat embryo fibroblasts leads to neoplastic transformation. EMBO J., 13: 3329-3338, 1994.
    • (1994) EMBO J. , vol.13 , pp. 3329-3338
    • Singh, P.1    Wong, S.W.2    Hong, W.3
  • 10
    • 0028960617 scopus 로고
    • E2F1 Overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis
    • Kowalik, T. F., DeGregori, J., Schwarz, J. K., and Nevins, J. R. E2F1 Overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J. Virol., 69: 2491-2500, 1995.
    • (1995) J. Virol. , vol.69 , pp. 2491-2500
    • Kowalik, T.F.1    DeGregori, J.2    Schwarz, J.K.3    Nevins, J.R.4
  • 11
    • 0028222124 scopus 로고
    • p53 and E2F-1 cooperate to mediate apoptosis
    • Wu, X., and Levine, A. J. p53 and E2F-1 cooperate to mediate apoptosis. Proc. Natl. Acad. Sci. USA, 91: 3602-3606, 1994.
    • (1994) Proc. Natl. Acad. Sci. USA , vol.91 , pp. 3602-3606
    • Wu, X.1    Levine, A.J.2
  • 12
    • 0028061670 scopus 로고
    • Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis
    • Shan, B., and Lee, W-H. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol. Cell. Biol., 14: 8166-8173, 1994.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 8166-8173
    • Shan, B.1    Lee, W.-H.2
  • 15
    • 0027262606 scopus 로고
    • Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis
    • Lowe, S. W., and Ruley, H. E. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis. Genes Dev., 7: 535-545, 1993.
    • (1993) Genes Dev. , vol.7 , pp. 535-545
    • Lowe, S.W.1    Ruley, H.E.2
  • 17
    • 0030739355 scopus 로고    scopus 로고
    • Induction of DNA synthesis and apoptosis are separable functions of E2F-1
    • Phillips, A. C., Bates, S., Ryan, K. M., Helin, K., and Vousden, K. H. Induction of DNA synthesis and apoptosis are separable functions of E2F-1. Genes Dev., 11: 1853-1863, 1997.
    • (1997) Genes Dev. , vol.11 , pp. 1853-1863
    • Phillips, A.C.1    Bates, S.2    Ryan, K.M.3    Helin, K.4    Vousden, K.H.5
  • 18
    • 0030850752 scopus 로고    scopus 로고
    • E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction
    • Hsieh, J-K., Fredersdorf, S., Kouzarides, T., Martin, K., and Lu, X. E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction. Genes Dev., 11: 1840-1852, 1997.
    • (1997) Genes Dev. , vol.11 , pp. 1840-1852
    • Hsieh, J.-K.1    Fredersdorf, S.2    Kouzarides, T.3    Martin, K.4    Lu, X.5
  • 19
    • 0028938734 scopus 로고
    • p53-dependent growth arrest of REF52 cells containing newly amplified DNA
    • Ishizaka, Y., Chernov, M. V., Burns, C. M., and Stark, G. R. p53-dependent growth arrest of REF52 cells containing newly amplified DNA. Proc. Natl. Acad. Sci. USA, 92: 3224-3228, 1995.
    • (1995) Proc. Natl. Acad. Sci. USA , vol.92 , pp. 3224-3228
    • Ishizaka, Y.1    Chernov, M.V.2    Burns, C.M.3    Stark, G.R.4
  • 20
    • 0025969355 scopus 로고
    • Mutant p53 tumor suppressor alleles release ras-induced cell cycle growth arrest
    • Hicks, G. G., Egan, S. E., Greenberg, A. H., and Mowat, M. Mutant p53 tumor suppressor alleles release ras-induced cell cycle growth arrest. Mol. Cell. Biol., 11: 1344-1352, 1991.
    • (1991) Mol. Cell. Biol. , vol.11 , pp. 1344-1352
    • Hicks, G.G.1    Egan, S.E.2    Greenberg, A.H.3    Mowat, M.4
  • 21
    • 0013568829 scopus 로고
    • Regulation of transcription functions of the p53 tumour suppressor by the mdm-2 oncogene
    • Chen, J. D., Lin, J. Y., and Levine, A. J. Regulation of transcription functions of the p53 tumour suppressor by the mdm-2 oncogene. Mol. Med., 1: 141-152, 1995.
    • (1995) Mol. Med. , vol.1 , pp. 141-152
    • Chen, J.D.1    Lin, J.Y.2    Levine, A.J.3
  • 22
    • 0029913730 scopus 로고    scopus 로고
    • mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein
    • Chen, J., Wu, X., Lin, J., and Levine, A. J. mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein. Mol. Cell. Biol., 16: 2445-2452, 1996.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 2445-2452
    • Chen, J.1    Wu, X.2    Lin, J.3    Levine, A.J.4
  • 23
    • 0028834902 scopus 로고
    • Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53
    • Jones, S. N., Roe, A. E., Donehower, L. A., and Bradley, A. Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53. Nature (Lond.), 378: 206-208, 1995.
    • (1995) Nature (Lond.) , vol.378 , pp. 206-208
    • Jones, S.N.1    Roe, A.E.2    Donehower, L.A.3    Bradley, A.4
  • 24
    • 0028823020 scopus 로고
    • Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
    • Montes de Oca Luna, R., Wagner, D. S., and Lozano, G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature (Lond.), 378: 203-206, 1995.
    • (1995) Nature (Lond.) , vol.378 , pp. 203-206
    • Montes De Oca Luna, R.1    Wagner, D.S.2    Lozano, G.3
  • 25
    • 0030046508 scopus 로고    scopus 로고
    • Life, death, and the pursuit of apoptosis
    • White, E. Life, death, and the pursuit of apoptosis. Genes Dev., 10: 1-15, 1996.
    • (1996) Genes Dev. , vol.10 , pp. 1-15
    • White, E.1
  • 27
    • 0030905284 scopus 로고    scopus 로고
    • Mdm2 promotes the rapid degradation of p53
    • Haupt, Y., Maya, R., Kazaz, A., and Oren, M. Mdm2 promotes the rapid degradation of p53. Nature (Lond.), 387: 296-299, 1997.
    • (1997) Nature (Lond.) , vol.387 , pp. 296-299
    • Haupt, Y.1    Maya, R.2    Kazaz, A.3    Oren, M.4
  • 28
    • 0027358723 scopus 로고
    • The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53
    • Scheffner, M., Huibregtse, J. M., Vierstra, R. D., and Howley, P. M. The HPV-16 E6 and E6-AP complex functions as a ubiquitin-protein ligase in the ubiquitination of p53. Cell, 75: 495-505, 1993.
    • (1993) Cell , vol.75 , pp. 495-505
    • Scheffner, M.1    Huibregtse, J.M.2    Vierstra, R.D.3    Howley, P.M.4
  • 29
    • 0029615315 scopus 로고
    • Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1
    • O'Connor, D. J., Lam, E. W. F., Griffin, S., Zhong, S., Leighton, L. C., Burbidge, S. A., and Lu, X. Physical and functional interactions between p53 and cell cycle co-operating transcription factors, E2F1 and DP1. EMBO J. 14: 6184-6192, 1995.
    • (1995) EMBO J. , vol.14 , pp. 6184-6192
    • O'Connor, D.J.1    Lam, E.W.F.2    Griffin, S.3    Zhong, S.4    Leighton, L.C.5    Burbidge, S.A.6    Lu, X.7
  • 34
    • 0029819994 scopus 로고    scopus 로고
    • PRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis
    • Zacksenhaus, E., Jiang, Z., Chung, D., Marth, J. D., Phillips, R. A., and Gallie, B. L. pRb controls proliferation, differentiation, and death of skeletal muscle cells and other lineages during embryogenesis. Genes Dev., 10: 3051-3064, 1996.
    • (1996) Genes Dev. , vol.10 , pp. 3051-3064
    • Zacksenhaus, E.1    Jiang, Z.2    Chung, D.3    Marth, J.D.4    Phillips, R.A.5    Gallie, B.L.6
  • 35
    • 0027934570 scopus 로고
    • p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens
    • Morgenbessen, S. D., Williams, B. O., Jacks, T., and DePincho, R. A. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature (Lond.), 371: 72-74, 1994.
    • (1994) Nature (Lond.) , vol.371 , pp. 72-74
    • Morgenbessen, S.D.1    Williams, B.O.2    Jacks, T.3    DePincho, R.A.4
  • 39
  • 40
    • 0027367144 scopus 로고
    • Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F
    • Ivey-Hoyle, M., Conroy, R., Huber, H. E., Goodhart, P. J., Oliff, A., and Heimbrook, D. C. Cloning and characterization of E2F-2, a novel protein with the biochemical properties of transcription factor E2F. Mol. Cell. Biol., 13: 7802-7812, 1993.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 7802-7812
    • Ivey-Hoyle, M.1    Conroy, R.2    Huber, H.E.3    Goodhart, P.J.4    Oliff, A.5    Heimbrook, D.C.6
  • 41
    • 0029868367 scopus 로고    scopus 로고
    • A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation
    • Ikeda, M-A., Jakoi, L., and Nevins, J. R. A unique role for the Rb protein in controlling E2F accumulation during cell growth and differentiation. Proc. Natl. Acad. Sci. USA, 93: 3215-3220, 1996.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 3215-3220
    • Ikeda, M.-A.1    Jakoi, L.2    Nevins, J.R.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.