SETDB1: A novel KAP-1-associated histone H3, lysine 9-specific methyltransferase that contributes to HP1-mediated silencing of euchromatic genes by KRAB zinc-finger proteins

Genes and Development

Volumn 16, Issue 8, 2002, Pages 919-932

  Schultz, David C ^a   Ayyanathan, Kasirajan ^b   Negorev, Dmitri ^a   Maul, Gerd G ^b   Rauscher III, Frank J ^b  

^a WISTAR INSTITUTE   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chromatin; Histone methylation; KRAB domain; SET domain

Indexed keywords

CHROMOSOME PROTEIN; HETEROCHROMATIN PROTEIN 1; HISTONE H3; HISTONE LYSINE METHYLTRANSFERASE; LYSINE; REPRESSOR PROTEIN; SETDB1 PROTEIN; UNCLASSIFIED DRUG; ZINC FINGER PROTEIN;

ACETYLATION; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; ENZYME ACTIVITY; EUCHROMATIN; GENE EXPRESSION REGULATION; GENE SILENCING; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN METHYLATION; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING;

ANIMALS; CELL LINE; CHROMOSOMAL PROTEINS, NON-HISTONE; DNA-BINDING PROTEINS; EUCHROMATIN; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE SILENCING; HISTONES; HUMANS; LYSINE; MACROMOLECULAR SUBSTANCES; METHYLATION; MICE; MOLECULAR SEQUENCE DATA; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN METHYLTRANSFERASES; PROTEIN STRUCTURE, TERTIARY; REPRESSOR PROTEINS; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY; TRANSCRIPTION FACTORS; TWO-HYBRID SYSTEM TECHNIQUES; ZINC FINGERS;

ANIMALIA; EUKARYOTA;

EID: 0037089626     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.973302     Document Type: Article

References (41)

1. Hormone-dependent tumor regression in vivo by an inducible transcriptional repressor directed at the PAX3-FKHR oncogene
2. Selective recognition of methylated lysine 9 on histone H3 by the HP1 chromo domain
3. An embarrassment of niches: The many covalent modifications of histones in transcriptional regulation
4. A family of chromatin remodeling factors related to Williams syndrome transcription factor
5. Differentially methylated forms of histone H3 show unique association patterns with inactive human X chromosomes
6. Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae
7. Solution structure of the PHD domain from the KAP-1 corepressor: Structural determinants for PHD, RING and LIM zinc-binding domains
8. Regulation of transcription by a protein methyltransferase
9. Signaling to chromatin through histone modifications
10. KAP1, a novel corepressor for the highly conserved KRAB repression domain
11. Assignment of a novel bifurcated SET domain gene, SETDB1, to human chromosome band lq21 by in situ hybridization and radiation hybrids
12. Methylation of histone H3 at Lys-9 is an early mark on the X chromosome during X inactivation
13. Structure of HP1 chromodomain bound to a lysine 9-methylated histone H3 tail
14. Specificity of the HP1 chromo domain for the methylated N-terminus of histone H3
15. BAP1: A novel ubiquitin hydrolase which binds to the BRCA1 RING finger and enhances BRCAl-mediated cell growth suppression
16. Translating the histone code
17. A homeotic mutation in the trithorax SET domain impedes histone binding
18. Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins
19. Molecular determinants for targeting heterochromatin protein 1-mediated gene silencing: Direct chromoshadow domain-KAP-1 corepressor interaction is essential
20. Correlation between histone lysine methylation and developmental changes at the chicken β-globin locus
21. Comparative analysis of KRAB zinc finger proteins in rodents and man: Evidence for several evolutionarily distinct subfamilies of KRAB zinc finger genes
22. Nuclear redistribution of BRCA1 during viral infection
23. COMPASS: A complex of proteins associated with a trithorax-related SET domain protein
24. Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly
25. Rb targets histone H3 methylation and HP1 to promoters
26. Set9, a novel histone H3 methyltransferase that facilitates transcription by precluding histone tail modifications required for heterochromatin formation
27. SET1, a yeast member of the trithorax family, functions in transcriptional silencing and diverse cellular processes
28. Transitions in distinct histone H3 methylation patterns at the heterochromatin domain boundaries
29. Analysis of chromatin structure by in vivo formaldehyde cross-linking
30. Biochemical analysis of the Kruppel-associated box (KRAB) transcriptional repression domain
31. Reconstitution of the KRAB-KAP-1 repressor complex: A model system for defining the molecular anatomy of RING-B box-coiled-coil domain-mediated protein-protein interactions
32. Loss of the suv39h histone methyltransferases impairs mammalian heterochromatin and genome stability
33. Regulation of chromatin structure by site-specific histone H3 methyltransferases
34. The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4
35. KAP-1 corepressor protein interacts and colocalizes with heretochromatic and euchromatic HP1 proteins: A potential role for Kruppel-associated box-zinc finger proteins in heterochromatin-mediated gene silencing
36. Targeting histone deacetylase complexes via KRAB-zinc finger proteins: The PHD and bromodomains of KAP-1 form a cooperative unit that recruits a novel isoform of the Mi-2α subunit of NuRD
37. The language of covalent histone modifications
38. Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena
39. Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3
40. A histone H3 methyltransferase controls DNA methylation in Neurospora crassa
41. ReCoGnizing methylated DNA