Epothilone analogues with benzimidazole and quinoline side chains: Chemical synthesis, antiproliferative activity, and interactions with tubulin

Chemistry - A European Journal

Volumn 15, Issue 39, 2009, Pages 10144-10157

  Dietrich, Silvia Anthoine ^a   Lindauer, Renate ^a   Stierlin, Claire ^a   Gertsch, Jürg ^a   Matesanz, Ruth ^b   Notararigo, Sara ^b   Díaz, José Fernando ^b   Altmann, Karl Heinz ^a  

^a ETH ZURICH   (Switzerland)

^b CENTRO DE INVESTIGACIONES BIOLÓGICAS   (Spain)

Author keywords

Antitumor agents epothilone; Microtubules natural products; Structure activity relationships; Total synthesis

Indexed keywords

ANTIPROLIFERATIVE ACTIVITIES; ANTITUMOR AGENTS EPOTHILONE; BENZIMIDAZOLES; CHEMICAL SYNTHESIS; EPOTHILONES; FUNCTIONALIZED; HUMAN CANCER CELLS; IN-VITRO; MICROTUBULES; MICROTUBULES NATURAL PRODUCTS; POTENT INHIBITION; PRODRUGS; SIDE CHAINS; STRUCTURE-ACTIVITY RELATIONSHIPS; TOTAL SYNTHESIS; TUBULIN POLYMERIZATION;

BEARINGS (STRUCTURAL); CELL MEMBRANES; CELL PROLIFERATION; CYTOTOXICITY; GROWTH KINETICS; TUMORS;

SYNTHESIS (CHEMICAL);

ANTINEOPLASTIC AGENT; BENZIMIDAZOLE DERIVATIVE; BIOLOGICAL PRODUCT; EPOTHILONE DERIVATIVE; QUINOLINE; QUINOLINE DERIVATIVE; TUBULIN;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; HUMAN; MALE; METABOLISM; MICROTUBULE; STEREOISOMERISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

ANTINEOPLASTIC AGENTS; BENZIMIDAZOLES; BIOLOGICAL PRODUCTS; CELL LINE, TUMOR; EPOTHILONES; HUMANS; MALE; MICROTUBULES; MOLECULAR STRUCTURE; QUINOLINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 70349689996     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.200901376     Document Type: Article

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