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Angewandte Chemie - International Edition

Volumn 46, Issue 11, 2007, Pages 1864-1868

Structural basis of the activity of the microtubule-stabilizing agent epothilone a studied by NMR spectroscopy in solution

(7) Reese, Marcel a Sánchez Pedregal, Víctor M a,d Kubicek, Karel a Meiler, Jens b Blommers, Marcel J J c Griesinger, Christian a Carlomagno, Teresa a

a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY (Germany)

b VANDERBILT UNIVERSITY SCHOOL OF MEDICINE (United States)

c NOVARTIS PHARMA AG (Switzerland)

d UNIVERSITY OF SANTIAGO DE COMPOSTELA (Spain)

Author keywords

Epothilones; NMR spectroscopy; Structure elucidation; Structure activity relationships; Tubulins

Indexed keywords

MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

EPOTHILONES; MUTANT TUBULINS; PHARMACOPHORE;

CYTOTOXICITY;

ANTINEOPLASTIC AGENT; EPOTHILONE A; EPOTHILONE DERIVATIVE; MAGNESIUM; TUBULIN;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECT; GENETICS; MICROTUBULE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; SOLUTION AND SOLUBILITY; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; EPOTHILONES; MAGNESIUM; MAGNETIC RESONANCE SPECTROSCOPY; MICROTUBULES; MODELS, MOLECULAR; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 34249666266 PISSN: 14337851 EISSN: None Source Type: Journal
DOI: 10.1002/anie.200604505 Document Type: Article

Times cited : (74)

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