The high-resolution solution structure of epothilone A bound to tuhulin: An understanding of the structure-activity relationships for a powerful class of antitumor agents

Angewandte Chemie - International Edition

Volumn 42, Issue 22, 2003, Pages 2511-2515

  Carlomagno, Teresa ^a   Blommers, Marcel J J ^b   Meiler, Jens ^a,d   Jahnke, Wolfgang ^b   Schupp, Thomas ^b   Petersen, Frank ^b   Schinzer, Dieter ^c   Altmann, Karl Heinz ^b   Griesinger, Christian ^a  

^a MAX PLANCK INSTITUTE FOR BIOPHYSICAL CHEMISTRY   (Germany)

^b NOVARTIS PHARMA AG   (Switzerland)

^c OTTO VON GUERICKE UNIVERSITY   (Germany)

^d UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Natural products; NMR spectroscopy; Structure

Indexed keywords

CHEMICAL MODIFICATION; CONFORMATIONS; MOLECULAR STRUCTURE; TUMORS; X RAY CRYSTALLOGRAPHY;

ANTITUMOR AGENTS;

KETONES;

ANTINEOPLASTIC AGENT; EPOTHILONE A; TUBULIN;

ARTICLE; CHEMICAL MODIFICATION; CORRELATION ANALYSIS; DRUG CONFORMATION; DRUG PROTEIN BINDING; DRUG STRUCTURE; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANIMALS; ANTINEOPLASTIC AGENTS; CATTLE; EPOTHILONES; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; SOLUTIONS; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 0038339605     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200351276     Document Type: Article

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