Nf1 and Gmcsf interact in myeloid leukemogenesis

Molecular Cell

Volumn 5, Issue 1, 2000, Pages 189-195

  Birnbaum, Ron A ^a   O'Marcaigh, Aengus ^a,e   Wardak, Zabihullah ^a   Zhang, You Yan ^b   Dranoff, Glenn ^c   Jacks, Tyler ^d   Clapp, D Wade ^b   Shannon, Kevin M ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b INDIANA UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e OUR LADY S CHILDREN S HOSPITAL   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GUANOSINE TRIPHOSPHATASE ACTIVATING PROTEIN; NEUROFIBROMIN;

ADOPTIVE TRANSFER; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; FETUS CELL; GENETIC ENGINEERING; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HYPERSENSITIVITY; LEUKEMOGENESIS; LIVER CELL; MOUSE; MOUSE MUTANT; MYELOMONOCYTIC LEUKEMIA; MYELOPROLIFERATIVE DISORDER; NONHUMAN; TUMOR SUPPRESSOR GENE;

ANIMALIA; MURINAE;

EID: 0033982718     PISSN: 10972765     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1097-2765(00)80415-3     Document Type: Article

References (40)

1. Arico, M., Biondi, A., and Pui, C.-H. (1997). Juvenile myelomonocytic leukemia. Blood 90, 479-488.
2. Bagley, C.J., Woodcock, J.M., Stomski, F.C., and Lopez, A.F. (1997). The structural and functional basis of cytokine receptor activation: lessons from the common beta subunit of the granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 receptors. Blood 89, 1471-1482.
3. Bernards, A. (1995). Neurofibromatosis type 1 and Ras-mediated signaling: filling in the GAPs. Biochim. Biophys. Acta 1242, 43-59.
4. Boguski, M., and McCormick, F. (1993). Proteins regulating Ras and its relatives. Nature 366, 643-653.
5. Bollag, G., Clapp, D.W., Shih, S., Adler, F., Zhang, Y., Thompson, P., Lange, B.J., Freedman, M.H., McCormick, F., Jacks, T., and Shannon, K. (1996). Loss of NF1 results in activation of the Ras signaling pathway and leads to aberrant growth in murine and human hematopoietic cells. Nat. Genet. 12, 144-148.
6. Bos, J.L. (1989). ras oncogenes in human cancer: a review. Cancer Res. 49, 4682-4689.
7. Bourne, H.R., Sanders, D.A., and McCormick, F. (1990). The GTPase superfamily: a conserved switch for diverse cell functions. Nature 348, 125-132.
8. Brannan, C.I., Perkins, A.S., Vogel, K.S., Ratner, N., Nordlund, M.L., Reid, S.W., Buchberg, A.M., Jenkins, N., Parada, L., and Copeland, N. (1994). Targeted disruption of the neurofibromatosis type 1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev. 8, 1019-1029.
9. Chin, L., Tam, A., Pomerantz, J., Wong, M., Holash, J., Bardeesy, N., Shen, Q., O'Hagan, R., Pantginis, J., Zhou, H., et al. (1999). Essential role for oncogenic Ras in tumour maintenance. Nature 400, 468-472.
10. D'Andrea, R.J., Harrison-Findik, D., Butcher, C.M., Finnie, J., Blumbergs, P., Bartley, P., McCormack, M., Jones, K., Rowland, R., Gonda, T.J., and Vadas, M.A. (1998). Dysregulated hematopoiesis and a progressive neurological disorder induced by expression of an activated form of the human common beta chain in transgenic mice. J. Clin. Invest. 102, 1951-1960.
11. Downward, J. (1990). The ras superfamily of small GTP-binding proteins. Trends Biochem. Sci. 15, 469-472.
12. Doyle, S.E., and Gasson, J.C. (1998). Characterization of the role of the human granulocyte-macrophage colony-stimulating factor receptor alpha subunit in the activation of JAK2 and STAT5. Blood 92, 867-876.
13. Dranoff, G., Crawford, A., Sadelain, M., Ream., B., Rashid, A., Bronson, R., Dickersin, R., Bachurski, C., Mark, E., Jeffrey, W., and Mulligan, R. (1994). Involvement of GM-CSF in pulmonary homeostasis. Science 264, 713-716.
14. Emanuel, P.D., Bates, L.J., Castleberry, R.P., Gualtieri, R.J., and Zuckerman, K.S. (1991). Selective hypersensitivity to granulocyte-macrophage colony stimulating factor by juvenile chronic myeloid leukemia hematopoietic progenitors. Blood 77, 925-929.
15. Emanuel, P.D., Shannon, K.M., and Castleberry, R.P. (1996). Juvenile myelomonocytic leukemia: molecular understanding and prospects for therapy. Mol. Med. Today 2, 468-475.
16. Evans, C.A., Pierce, A., Winter, S.A., Spooncer, E., Heyworth, C.M., and Whetton, A.D. (1999). Activation of granulocyte-macrophage colony-stimulating factor and interleukin-3 receptor subunits in a multipotential hematopoietic progenitor cell line leads to differential effects on development. Blood 94, 1504-1514.
17. Felsher, D.W., and Bishop, J.M. (1999). Reversible tumorigenesis by MYC in hematopoietic lineages. Mol. Cell 4, 199-207.
18. Frankel, A.E., Lilly, M., Kreitman, R., Hogge, D., Beran, M., Freedman, M.H., Emanuel, P.D., McLain, C., Hall, P., Tagge, E., et al. (1998). Diphtheria toxin fused to granulocyte-macrophage colony-stimulating factor is toxic to blasts from patients with juvenile myelomonocytic leukemia and chronic myelomonocytic leukemia. Blood 92, 4279-4286.
19. Hall, A. (1992). Signal transduction through small GTPases - a tale of two GAPs. Cell 69, 389-391.
20. Iversen, P., Rodwell, R.L., Pitcher, L., Taylor, K.M., and Lopez, A.F. (1996). Inhibition of proliferation and induction of apoptosis in JMML cells by the granulocyte-macrophage colony-stimulating factor analogue E21R. Blood 88, 2634-2639.
21. Iversen, P.O., Lewis, I.D., Turczynowicz, S., Hasle, H., Niemeyer, C., Schmiegelow, K., Bastiras, S., Biondi, A., Hughes, T.P., and Lopez, A.F. (1997). Inhibition of granulocyte-macrophage colony-stimulating factor prevents dissemination and induces remission of juvenile myelomonocytic leukemia in engrafted immunodeficient mice. Blood 90, 4910-4917.
22. Jacks, T., Shih, S., Schmitt, E.M., Bronson, R.T., Bernards, A., and Weinberg, R.A. (1994). Tumorigenic and developmental consequences of a targeted Nf1 mutation in the mouse. Nat. Genet. 7, 353-361.
23. Johnson, G.R., Gonda, T.J., Metcalf, D., Hariharan, K., and Cory, S. (1989). A lethal myeloproliferative syndrome in mice transplanted with bone marrow cells infected with a retrovirus expressing granulocyte-macrophage colony stimulating factor. EMBO J. 8, 441-448.
24. ras. Blood 84, 3435-3439.
25. Lang, R., Metcalf, D., Cuthbertson, R., Lyons, I., Stanley, E., Kelso, A., Kannourakis, G., Williamson, D., Klintworth, G., Gonda, T., and Dunn, A. (1987). Transgenic mice expressing a hematopoietic growth factor gene (GM-CSF) develop accumulations of macrophages, blindness, and a fatal syndrome of tissue damage. Cell 51, 675-686.
26. Largaespada, D.A., Brannan, C.I., Jenkins, N.A., and Copeland, N.G. (1996). Nf1 deficiency causes Ras-mediated granulocyte-macrophage colony stimulating factor hypersensitivity and chronic my-eloid leukemia. Nat. Genet. 12, 137-143.
27. Mahgoub, N., Taylor, B.R., Gratiot, M., Kohl, N.E., Gibbs, J.B., Jacks, T., and Shannon, K.M. (1999). In vitro and in vivo effects of a farnesyltransferase inhibitor on Nf1-deficient hematopoietic cells. Blood 94, 2469-2476.
28. Metcalf, D., Begley, C., Williamson, D., Nice, E., DeLamarater, J., Mermod, J.-J., Thatcher, D., and Schmidt, A. (1987). Hemopoietic responses in mice injected with purified recombinant murine GM-CSF. Exp. Hematol. 15, 1-9.
29. Miles, D.K., Freedman, M.H., Stephens, K., Pallavicini, M., Sievers, E., Weaver, M., Grunberger, T., Thompson, P., and Shannon, K.M. (1996). Patterns of hematopoietic lineage involvement in children with neurofibromatosis, type 1, and malignant myeloid disorders. Blood 88, 4314-4320.
30. Nemunaitis, J., and Singer, J.W. (1993). The use of recombinant human granulocyte macrophage colony-stimulating factor in autologous and allogeneic bone marrow transplantation. Cancer Invest. 11, 224-228.
31. Nishinakamura, R., Nakayama, N., Hirabayashi, Y., Inoue, T., Aud, D., McNeil, T., Azuma, S., Yoshida, S., Toyoda, Y., Arai, K., et al. (1995). Mice deficienct for the IL-3/GM-CSF/IL-5 βc receptor exhibit lung pathology and impaired immune response, while βIL3 receptor-deficienct mice are normal. Immunity 2, 211-222.
32. Robb, L., Drinkwater, C.C., Metcalf, D., Li, R., Kontgen, F., Nicola, N.A., and Begley, C.G. (1995). Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5. Proc. Natl. Acad. Sci. USA 92, 9565-9569.
33. Rodenhuis, S. (1992). ras and human tumors. Semin. Cancer Biol. 3, 241-247.
34. Satoh, T., Nakafuku, M., Miyajima, A., and Kaziro, Y. (1991). Involvement of ras p21 protein in signal-transduction pathways from interleukin 2, interleukin 3, and granulocyte/macrophage colony-stimulating factor, but not from interleukin 4. Proc. Natl. Acad. Sci. USA 88, 3314-3318.
35. Shannon, K.M., O'Connell, P., Martin, G.A., Paderanga, D., Olson, K., Dinndorf, P., and McCormick, F. (1994). Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders. N. Engl. J. Med. 330, 597-601.
36. Side, L.E., and Shannon, K.M. (1998). The NF1 gene as a tumor suppressor. In Neurofibromatosis Type 1, M. Upashyaya and D.N. Cooper, eds. (Oxford, UK: Bios Scientific Publishers), pp. 133-152.
37. Side, L., Taylor, B., Cayouette, M., Connor, E., Thompson, P., Luce, M., and Shannon, K. (1997). Homozygous inactivation of the NF1 gene in bone marrow cells from children with neurofibromatosis type 1 and malignant myeloid disorders. N Engl J Med 336, 1713-1720.
38. Wittinghofer, A. (1998). Signal transduction via Ras. Biol. Chem. 379, 933-937.
39. Woodcock, J.M., McClure, B.J., Stomski, F.C., Elliott, M.J., Bagley, C.J., and Lopez, A.F. (1997). The human granulocyte-macrophage colony-stimulating factor (GM-CSF) receptor exists as a preformed receptor complex that can be activated by GM-CSF, interleukin-3, or interleukin-5. Blood 90, 3005-3017.
40. Zhang, Y., Vik, T.A., Ryder, J.W., Srour, E.F., Jacks, T., Shannon, K., and Clapp, D.W. (1998). Nf1 regulates hematopoietic progenitor cell growth and Ras signaling in response to multiple cytokines. J. Exp. Med. 187, 1893-1902.