A single tyrosine residue in the membrane-proximal domain of the granulocyte-macrophage colony-stimulating factor, interleukin (IL)-3, and IL- 5 receptor common β-chain is necessary and sufficient for high affinity binding and signaling by all three ligands

Journal of Biological Chemistry

Volumn 271, Issue 42, 1996, Pages 25999-26006

  Woodcock, Joanna M ^a   Bagley, Christopher J ^a,b   Zacharakis, Betty ^a   Lopez, Angel F ^a  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

^b UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR RECEPTOR; GROWTH HORMONE RECEPTOR; INTERLEUKIN 3 RECEPTOR; INTERLEUKIN 5 RECEPTOR; PROLACTIN RECEPTOR; RECEPTOR SUBUNIT; RECOMBINANT GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; RECOMBINANT INTERLEUKIN 3;

AMINO ACID SUBSTITUTION; ARTICLE; BETA CHAIN; BINDING AFFINITY; HUMAN; HUMAN CELL; HYDROPHOBICITY; IMMUNOMODULATION; MEMBRANE BINDING; MOLECULAR MODEL; PRIORITY JOURNAL; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ALANINE; AMINO ACID SEQUENCE; ANIMALS; COS CELLS; DNA-BINDING PROTEINS; HUMANS; INTERLEUKIN-3; INTERLEUKIN-5; JURKAT CELLS; MILK PROTEINS; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PROTEIN CONFORMATION; RECEPTORS, GRANULOCYTE-MACROPHAGE COLONY-STIMULATING FACTOR; RECEPTORS, INTERLEUKIN; RECEPTORS, INTERLEUKIN-3; RECEPTORS, INTERLEUKIN-5; SIGNAL TRANSDUCTION; STAT5 TRANSCRIPTION FACTOR; STRUCTURE-ACTIVITY RELATIONSHIP; TRANS-ACTIVATORS; TYROSINE;

EID: 0029860206     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.271.42.25999     Document Type: Article

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