Pd(0)/Cu(I)-mediated direct arylation of 2′-deoxyadenosines: Mechanistic role of Cu(I) and reactivity comparisons with related purine nucleosides

Journal of Organic Chemistry

Volumn 74, Issue 16, 2009, Pages 5810-5821

  Storr, Thomas E ^a   Baumann, Christoph G ^a   Thatcher, Robert J ^a   De Ornellas, Sara ^a   Whitwood, Adrian C ^a   Fairlamb, Ian J S ^a  

^a UNIVERSITY OF YORK   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ACIDS; AMINES; BINDING ENERGY; BIOMOLECULES; CATALYSIS; CESIUM; CONFORMATIONS; COPPER; PALLADIUM; SINGLE CRYSTALS; SYNTHESIS (CHEMICAL);

ACID ADDITIVES; ARYL IODIDES; ARYLATIONS; ARYLBORONIC ACIDS; BINDING AFFINITIES; CATALYST SYSTEM; CESIUM CARBONATES; CHEMICAL EQUATIONS; CONFORMATIONAL PREFERENCES; DEGLYCOSYLATION; DEOXYADENOSINE; GOOD YIELD; GUANOSINES; IN-SITU; INHIBITORY EFFECT; KEY COMPONENT; MANDATORY REQUIREMENT; PREFERRED SOLUTIONS; PYRIDYL GROUPS; PYRIDYL NITROGEN ATOMS; REACTION OPTIMIZATION; SECONDARY AMINES; SINGLE CRYSTAL X-RAY DIFFRACTION; STATE-EQUILIBRIUM; SUZUKI CROSS COUPLING; SYNTHETIC PROTOCOLS;

AROMATIC COMPOUNDS;

ADENOSINE; CUPROUS ION; DEOXYADENOSINE DERIVATIVE; IMIDAZOLE DERIVATIVE; NITROGEN; PALLADIUM; PIPERIDINE; PURINE NUCLEOSIDE DERIVATIVE; 2'-DEOXYADENOSINE; AMINE; COPPER; IODOBENZENE;

ARTICLE; ARYLATION; CARBON NUCLEAR MAGNETIC RESONANCE; CATALYST; CONFORMATION; DRUG STRUCTURE; DRUG SYNTHESIS; HYDROGEN BOND; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; X RAY DIFFRACTION; CATALYSIS; CHEMICAL STRUCTURE; CHEMISTRY; COMPARATIVE STUDY; X RAY CRYSTALLOGRAPHY;

AMINES; CATALYSIS; COPPER; CRYSTALLOGRAPHY, X-RAY; DEOXYADENOSINES; IODOBENZENES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PALLADIUM;

EID: 70349085376     PISSN: 00223263     EISSN: None     Source Type: Journal    
DOI: 10.1021/jo9012282     Document Type: Article

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