Genome instability, cancer and aging

Biochimica et Biophysica Acta - General Subjects

Volumn 1790, Issue 10, 2009, Pages 963-969

  Maslov, Alexander Y ^a   Vijg, Jan ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

Aging; Apoptosis; Cancer; DNA damage; Epimutation; Genome instability; Senescence; Stem cell

Indexed keywords

ATR PROTEIN; PROTEIN P53;

AGING; APOPTOSIS; CANCER RISK; CANCER STEM CELL; CARCINOGENESIS; CELL CYCLE ARREST; CELL DEGENERATION; CELL PROLIFERATION; DNA DAMAGE; DNA REPAIR; DNA SEQUENCE; DOUBLE STRANDED DNA BREAK; EPIGENETICS; GENE REARRANGEMENT; GENOMIC INSTABILITY; HEMATOPOIETIC STEM CELL; HUMAN; MITOCHONDRIAL GENOME; MUTAGENESIS; NEOPLASM; NEURAL STEM CELL; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; REVIEW; SENESCENCE; SOMATIC MUTATION; TRANSCRIPTION REGULATION;

AGING; ANIMALS; APOPTOSIS; DNA DAMAGE; GENOMIC INSTABILITY; HUMANS; MODELS, BIOLOGICAL; MUTATION; NEOPLASMS; STEM CELLS;

MAMMALIA;

EID: 69949085788     PISSN: 03044165     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbagen.2009.03.020     Document Type: Review

References (75)

1. de Duve C. The onset of selection. Nature 433 (2005) 581-582
2. Friedberg E.C., Walker G.R., Siede W., Wood R.D., Schultz R.A., and Ellenberger T. DNA Repair and Mutagenesis. 2nd ed. (2006), ASM Press, Washington
3. Charlesworth B. Fisher, Medawar, Hamilton and the evolution of aging. Genetics 156 (2000) 927-931
4. Kirkwood T.B. Evolution of ageing. Nature 270 (1977) 301-304
5. Vijg J. Aging of the Genome (2007), Oxford University Press, New York
6. Khrapko K., and Vijg J. Mitochondrial DNA mutations and aging: devils in the details?. Trends Genet. 25 (2009) 91-98
7. Lindahl T. Instability and decay of the primary structure of DNA. Nature 362 (1993) 709-715
8. Collins A.R., Cadet J., Moller L., Poulsen H.E., and Vina J. Are we sure we know how to measure 8-oxo-7,8-dihydroguanine in DNA from human cells?. Arch. Biochem. Biophys. 423 (2004) 57-65
9. Muller H.J. Artificial transmutation of the gene. Science 66 (1927) 84-87
10. Henshaw P.S., Riley E.F., and Stapleton G.E. The biologic effects of pile radiations. Radiology 49 (1947) 349-364
11. Failla G. The aging process and cancerogenesis. Ann. N.Y. Acad. Sci. 71 (1958) 1124-1140
12. Szilard L. On the nature of the aging process. Proc. Natl. Acad. Sci. U. S. A. 45 (1959) 30-45
13. Maynard Smith J. Review lectures on senescence. I. The causes of ageing. Proc. Roy. Soc. B. 157 (1962) 115-127
14. Russell L.B., Selby P.B., von Halle E., Sheridan W., and Valcovic L. Use of the mouse spot test in chemical mutagenesis: interpretation of past data and recommendations for future work. Mutat. Res. 86 (1981) 355-379
15. Kaya B., Marcos R., Yanikoglu A., and Creus A. Evaluation of the genotoxicity of four herbicides in the wing spot test of Drosophila melanogaster using two different strains. Mutat. Res. 557 (2004) 53-62
16. Rehen S.K., Yung Y.C., McCreight M.P., et al. Constitutional aneuploidy in the normal human brain. J. Neurosci. 25 (2005) 2176-2180
17. Martin G.M., Ogburn C.E., Colgin L.M., Gown A.M., Edland S.D., and Monnat Jr. R.J. Somatic mutations are frequent and increase with age in human kidney epithelial cells. Hum. Mol. Genet. 5 (1996) 215-221
18. Boerrigter M.E., Dolle M.E., Martus H.J., Gossen J.A., and Vijg J. Plasmid-based transgenic mouse model for studying in vivo mutations. Nature 377 (1995) 657-659
19. Vijg J., and Dollé M.E. Large genome rearrangements as a primary cause of aging. Mech. Ageing Dev. 123 (2002) 907-915
20. Dollé M.E., and Vijg J. Genome dynamics in aging mice. Genome Res. 12 (2002) 1732-1738
21. Fraga M.F., Ballestar E., Paz M.F., et al. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci. U. S. A. 102 (2005) 10604-10609
22. Issa J.P. Age-related epigenetic changes and the immune system. Clin. Immunol. 109 (2003) 103-108
23. Slagboom P.E., and Vijg J. The dynamics of genome organization and expression during the aging process. Ann. N.Y. Acad. Sci. 673 (1992) 58-69
24. Issa J.P., Ottaviano Y.L., Celano P., Hamilton S.R., Davidson N.E., and Baylin S.B. Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat. Genet. 7 (1994) 536-540
25. Kastan M.B., Gowans B.J., and Lieberman M.W. Methylation of deoxycytidine incorporated by excision-repair synthesis of DNA. Cell 30 (1982) 509-516
26. Groth A., Rocha W., Verreault A., and Almouzni G. Chromatin challenges during DNA replication and repair. Cell 128 (2007) 721-733
27. Chakalova L., Debrand E., Mitchell J.A., Osborne C.S., and Fraser P. Replication and transcription: shaping the landscape of the genome. Nat. Rev. Genet. 6 (2005) 669-677
28. Oberdoerffer P., Michan S., McVay M., et al. SIRT1 redistribution on chromatin promotes genomic stability but alters gene expression during aging. Cell 135 (2008) 907-918
29. Bahar R., Hartmann C.H., Rodriguez K.A., et al. Increased cell-to-cell variation in gene expression in ageing mouse heart. Nature 441 (2006) 1011-1014
30. Finch C.E., and Kirkwood T.B. Chance, Development, and Aging (1999), Oxford University Press, Oxford
31. Fraser H.B., Hirsh A.E., Giaever G., Kumm J., and Eisen M.B. Noise minimization in eukaryotic gene expression. PLoS Biol. 2 (2004) e137
32. Gavrilov L.A., and Gavrilova N.S. The reliability theory of aging and longevity. J. Theor. Biol. 213 (2001) 527-545
33. Kirkwood T.B., and Austad S.N. Why do we age?. Nature 408 (2000) 233-238
34. Bergman A., Atzmon G., Ye K., MacCarthy T., and Barzilai N. Buffering mechanisms in aging: a systems approach toward uncovering the genetic component of aging. PLoS Comput. Biol. 3 (2007) e170
35. Gavrilov L.A., and Gavrilova N.S. The reliability-engineering approach to the problem of biological aging. Ann. N.Y. Acad. Sci. 1019 (2004) 509-512
36. Young H.E., Duplaa C., Romero-Ramos M., et al. Adult reserve stem cells and their potential for tissue engineering. Cell Biochem. Biophys. 40 (2004) 1-80
37. Campisi J. Cancer and ageing: rival demons?. Nat. Rev. Cancer 3 (2003) 339-349
38. Campisi J. Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell 120 (2005) 513-522
39. Hasty P., Campisi J., Hoeijmakers J., van Steeg H., and Vijg J. Aging and genome maintenance: lessons from the mouse?. Science 299 (2003) 1355-1359
40. Hasty P., and Vijg J. Accelerating aging by mouse reverse genetics: a rational approach to understanding longevity. Aging Cell 3 (2004) 55-65
41. Vijg J., and Dolle M.E. Genome instability: cancer or aging?. Mech. Ageing Dev. 128 (2007) 466-468
42. Cairns J. Somatic stem cells and the kinetics of mutagenesis and carcinogenesis. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 10567-10570
43. Maslov A.Y., Barone T.A., Plunkett R.J., and Pruitt S.C. Neural stem cell detection, characterization, and age-related changes in the subventricular zone of mice. J. Neurosci. 24 (2004) 1726-1733
44. Bailey K.J., Maslov A.Y., and Pruitt S.C. Accumulation of mutations and somatic selection in aging neural stem/progenitor cells. Aging Cell 3 (2004) 391-397
45. Shao C., Deng L., Henegariu O., et al. Mitotic recombination produces the majority of recessive fibroblast variants in heterozygous mice. Proc. Natl. Acad. Sci. U. S. A. 96 (1999) 9230-9235
46. Rossi D.J., Bryder D., Seita J., Nussenzweig A., Hoeijmakers J., and Weissman L. Deficiencies in DNA damage repair limit the function of haematopoietic stem cells with age. Nature 447 (2007) 725-729
47. Harrison D.E. Mouse erythropoietic stem cell lines function normally 100 months: loss related to number of transplantations. Mech. Ageing Dev. 9 (1979) 427-433
48. Kamminga L.M., and de Haan G. Cellular memory and hematopoietic stem cell aging. Stem Cells 24 (2006) 1143-1149
49. Chambers S.M., Shaw C.A., Gatza C., Fisk C.J., Donehower L.A., and Goodell M.A. Aging hematopoietic stem cells decline in function and exhibit epigenetic dysregulation. PLoS Biol. 5 (2007) e201
50. Rando T.A. Stem cells, ageing and the quest for immortality. Nature 441 (2006) 1080-1086
51. Conboy I.M., Conboy M.J., Smythe G.M., and Rando T.A. Notch-mediated restoration of regenerative potential to aged muscle. Science 302 (2003) 1575-1577
52. Conboy I.M., and Rando T.A. Aging, stem cells and tissue regeneration: lessons from muscle. Cell Cycle 4 (2005) 407-410
53. Carlson B.M., and Faulkner J.A. Muscle transplantation between young and old rats: age of host determines recovery. Am. J. Physiol. 256 (1989) C1262-1266
54. Zacks S.I., and Sheff M.F. Age-related impeded regeneration of mouse minced anterior tibial muscle. Muscle Nerve 5 (1982) 152-161
55. Conboy I.M., Conboy M.J., Wagers A.J., Girma E.R., Weissman I.L., and Rando T.A. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 433 (2005) 760-764
56. Bortoli S., Renault V., Eveno E., Auffray C., Butler-Browne G., and Pietu G. Gene expression profiling of human satellite cells during muscular aging using cDNA arrays. Gene 321 (2003) 145-154
57. Collins C.J., and Sedivy J.M. Involvement of the INK4a/Arf gene locus in senescence. Aging Cell 2 (2003) 145-150
58. Janzen V., Forkert R., Fleming H.E., et al. Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a. Nature 443 (2006) 421-426
59. Molofsky A.V., Slutsky S.G., Joseph N.M., et al. Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing. Nature 443 (2006) 448-452
60. Krishnamurthy J., Ramsey M.R., Ligon K.L., et al. p16INK4a induces an age-dependent decline in islet regenerative potential. Nature 443 (2006) 453-457
61. Sharpless N.E., Bardeesy N., Lee K.H., et al. Loss of p16Ink4a with retention of p19Arf predisposes mice to tumorigenesis. Nature 413 (2001) 86-91
62. Harding C., Pompei F., Lee E.E., and Wilson R. Cancer suppression at old age. Cancer Res. 68 (2008) 4465-4478
63. Tyner S.D., Venkatachalam S., Choi J., et al. p53 mutant mice that display early ageing-associated phenotypes. Nature 415 (2002) 45-53
64. K.W. Kinzler, B. Vogelstein, Cancer-susceptibility genes. Gatekeepers and caretakers, Nature 386 (1997) 761, 763.
65. Harris S.L., and Levine A.J. The p53 pathway: positive and negative feedback loops. Oncogene 24 (2005) 2899-2908
66. Donehower L.A., Harvey M., Slagle B.L., et al. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours. Nature 356 (1992) 215-221
67. Ruzankina Y., Pinzon-Guzman C., Asare A., et al. Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. Cell Stem Cell 1 (2007) 113-126
68. Cimprich K.A., and Cortez D. ATR: an essential regulator of genome integrity. Nat. Rev. Mol. Cell Biol. 9 (2008) 616-627
69. Brown E.J., and Baltimore D. Essential and dispensable roles of ATR in cell cycle arrest and genome maintenance. Genes Dev. 17 (2003) 615-628
70. Cortez D., Guntuku S., Qin J., and Elledge S.J. ATR and ATRIP: partners in checkpoint signaling. Science 294 (2001) 1713-1716
71. de Klein A., Muijtjens M., van Os R., et al. Targeted disruption of the cell-cycle checkpoint gene ATR leads to early embryonic lethality in mice. Curr. Biol. 10 (2000) 479-482
72. Brown E.J., and Baltimore D. ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev. 14 (2000) 397-402
73. Sharpless N.E., and DePinho R.A. How stem cells age and why this makes us grow old. Nat. Rev. Mol. Cell Biol. 8 (2007) 703-713
74. Zhuravlev Y.N., and Avetisov V.A. The definition of life in the context of its origin. Biogeosciences (2006) 281-291
75. Sheckley R. Pilgrimage to Earth (1978), Ace Books