Cellular memory and hematopoietic stem cell aging

Stem Cells

Volumn 24, Issue 5, 2006, Pages 1143-1149

  Kamminga, Leonie M ^a   De Haan, Gerald ^a  

^a UNIVERSITY MEDICAL CENTER GRONINGEN   (Netherlands)

Author keywords

Aging; Cellular memory; Chromatin; Epigenetics; Stem cells

Indexed keywords

CELL AGING; CHROMATIN ASSEMBLY AND DISASSEMBLY; CHROMATIN STRUCTURE; DNA DAMAGE; EPIGENETICS; GENETIC REGULATION; GENETIC TRANSCRIPTION; HEMATOPOIETIC STEM CELL; HISTONE CODE; HUMAN; NONHUMAN; OXIDATIVE STRESS; REVIEW; TELOMERE;

ANIMALS; CELL AGING; CHROMATIN; DNA DAMAGE; HEMATOPOIETIC STEM CELLS; HUMANS; MODELS, BIOLOGICAL; REPRESSOR PROTEINS;

EID: 33749047273     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1634/stemcells.2005-0345     Document Type: Review

References (104)

1. Ho AD. Kinetics and symmetry of divisions of hematopoietic stem cells. Exp Hematol 2005;33:1-8.
2. Chen J, Astle CM, Harrison DE. Development and aging of primitive hematopoietic stem cells in BALB/cBy mice. Exp Hematol 1999;27: 928-935.
3. Harrison DE, Astle CM, Stone M. Numbers and functions of transplantable primitive immunohematopoietic stem cells. Effects of age. J Immunol 1989;142:3833-3840.
4. Zhao Y, Lin Y, Zhan Y et al. Murine hematopoietic stem cell characterization and its regulation in BM transplantation. Blood 2000;96:3016-3022.
5. Chen J, Astle CM, Muller-Sieburg CE et al. Primitive hematopoietic stem cell function in vivo is uniquely high in the CXB-12 mouse strain. Blood 2000;96:4124-4131.
6. Harrison DE, Jordan CT, Zhong RK et al. Primitive hemopoietic stem cells: Direct assay of most productive populations by competitive repopulation with simple binomial, correlation and covariance calculations. Exp Hematol 1993;21:206-219.
7. Muller-Sieburg CE, Riblet R. Genetic control of the frequency of hematopoietic stem cells in mice: Mapping of a candidate locus to chromosome 1. J Exp Med 1996;183:1141-1150.
8. Spangrude GJ, Heimfeld S, Weissman IL. Purification and characterization of mouse hematopoietic stem cells. Science 1988;241:58-62.
9. Osawa M, Hanada K, Hamada H et al. Long-term lymphohematopoietic reconstitution by a single CD34-low/negative hematopoietic stem cell. Science 1996;273:242-245.
10. van Os R, Kamminga LM, de Haan G. Stem cell assays: Something old, something new, something borrowed. STEM CELLS 2004;22:1181-1190.
11. Coulombel L. Identification of hematopoietic stem/progenitor cells: Strength and drawbacks of functional assays. Oncogene 2004;23:7210-7222.
12. Harrison DE. Mouse erythropoietic stem cell lines function normally 100 months: Loss related to number of transplantations. Mech Ageing Dev 1979;9:427-433.
13. Van Zant G, de Haan G, Rich-Ivan N. Alternatives to stem cell renewal from a developmental viewpoint. Exp Hematol 1997;1997:187-192.
14. Siminovitch L, Till JE, McCullock EA. Decline in colony-forming ability of marrow cells subjected to serial transplantion into irradiated mice. J Cell Comp Physiol 1964;64:23.
15. Cudkowicz G, Upton AC, Shearer GM. Lymphocyte content and proliferative capacity of serially transplanted mouse bone marrow. Nature 1964;201:165.
16. Micklem HS, Ogden DA. Ageing of haematopoietic cell populations in the mouse. In: Cairnie AB, Lala PK, Osmond DG, eds. Stem Cells of Renewing Cell Populations. New York: Academic Press, Inc., 1976:331-341.
17. Ogden DA, Mickliem HS. The fate of serially transplanted bone marrowcell populations from young and old donors. Transplantation 1976;22:287-293.
18. Harrison DE, Astle CM, Delaittre JA. Loss of proliferative capacity in immunohemopoietic stem cells caused by serial transplantation rather than aging. J Exp Med 1978;147:1526-1531.
19. Hellman S, Botnick LE, Hannon EC et al. Proliferative capacity of murine hematopoietic stem cells. Proc Natl Acad Sci U S A 1978;75:490-494.
20. Ross EA, Anderson N, Micklem HS. Serial depletion and regeneration of the murine hematopoietic system. Implications for hematopoietic organization and the study of cellular aging. J Exp Med 1982;155:432-444.
21. Harrison DE, Astle CM. Loss of stem cell repopulating ability upon transplantation. Effects of donor age, cell number, and transplantation procedure. J Exp Med 1982;156:1767-1779.
22. Iscove NN, Nawa K. Hematopoietic stem cells expand during serial transplantation in vivo without apparent exhaustion. Curr Biol 1997;7:805-808.
23. Harrison DE, Stone M, Astle CM. Effects of transplantation on the primitive immunohematopoietic stem cell. J Exp Med 1990;172:431-437.
24. Micklem HS, Ross E. Heterogeneity and ageing of haematopoietic stem cells. Ann Immunol (Paris) 1978;129:367-376.
25. Spangrude GJ, Brooks DM, Tumas DB. Long-term repopulation of irradiated mice with limiting numbers of purified hematopoietic stem cells: In vivo expansion of stem cell phenotype but not function. Blood 1995;85:1006-1016.
26. Kamminga LM, van Os R, Ausema A et al. Impaired hematopoietic stem cell functioning after serial transplantation and during normal aging. STEM CELLS 2005;23:82-92.
27. Gordon MY, Lewis JL, Marley SB et al. Stromal cells negatively regulate primitive haemopoietic progenitor cell activation via a phosphatidylinositol- anchored cell adhesion/signalling mechanism. Br J Haematol 1997;96:647-653.
28. Hackney JA, Charbord P, Brunk BP et al. A molecular profile of a hematopoietic stem cell niche. Proc Natl Acad Sci U S A 2002;99:13061-13066.
29. Walker JA, Lunch M, Silverman S et al. The Notch/Jagged pathway inhibits proliferation of human hematopoietic progenitors in vitro. STEM CELLS 1999;17:162-171.
30. Wilson JG. Adhesive interactions in hemopoiesis. Acta Haematologica 1997;97:6-12.
31. Yoder MC, Williams DA. Matrix molecule interactions with hematopoietic stem cells. Exp Hematol 1995;23:961-967.
32. Liang Y, Van Zant G, Szilvassy SJ. Effects of aging on the homing and engraftment of murine hematopoietic stem and progenitor cells. Blood 2005;106:1479-1487.
33. Calvi LM, Adams GB, Weibrecht KW et al. Osteoblastic cells regulate the haematopoietic stem cell niche. Nature 2003;425:841-846.
34. Chen J, Astle CM, Harrison DE. Genetic regulation of primitive hematopoietic stem cell senescence. Exp Hematol 2000;28:442-450.
35. de Haan G, Van Zant G. Dynamic changes in mouse hematopoietic stem cell numbers during aging. Blood 1999;93:3294-3301.
36. Sudo K, Ema H, Morita Y et al. Age-associated characteristics of murine hematopoietic stem cells. J Exp Med 2000;192:1273-1280.
37. Morrison SJ, Wandycz AM, Akashi K et al. The aging of hematopoietic stem cells. Nat Med 1996;2:1011-1016.
38. Kamminga LM, Akkerman I, Weersing E et al. Autonomous behavior of hematopoietic stem cells. Exp Hematol 2000;28:1451-1459.
39. Van Zant G, Holland BP, Eldridge PW et al. Genotype-restricted growth and aging patterns in hematopoietic stem cell populations of allophenic mice. J Exp Med 1990;171:1547-1565.
40. de Haan G, Nijhof W, Van Zant G. Mouse strain-dependent changes in frequency and proliferation of hematopoietic stem cells during aging: Correlation between lifespan and cycling activity. Blood 1997;89:1543-1550.
41. Roeder I, Kamminga LM, Braesel K et al. Competitive clonal hematopoiesis in mouse chimeras explained by a stochastic model of stem cell organization. Blood 2005;105:609-616.
42. Greider CW, Blackburn EH. Identification of a specific telomere terminal transferase activity in Tetrahymena extracts. Cell 1985;43:405-413.
43. Harley CB, Futcher AB, Greider CW. Telomeres shorten during ageing of human fibroblasts. Nature 1990;345:458-460.
44. Vaziri H, Dragowska W, Allsopp RC et al. Evidence for a mitotic clock in human hematopoietic stem cells: Loss of telomeric DNA with age. Proc Natl Acad Sci U S A 1994;91:9857-9860.
45. Allsopp RC, Cheshier S, Weissman IL. Telomere shortening accompanies increased cell cycle activity during serial transplantation of hematopoietic stem cells. J Exp Med 2001;193:917-924.
46. Samper E, Fernandez P, Eguia R et al. Long-term repopulating ability of telomerase-deficient murine hematopoietic stem cells. Blood 2002;99:2767-2775.
47. Allsopp RC, Morin GB, DePinho R et al. Telomerase is required to slow telomere shortening and extend replicative lifespan of HSCs during serial transplantation. Blood 2003;102:517-520.
48. Marrone A, Mason PJ. Dyskeratosis congenita. Cell Mol Life Sci 2003;60:507-517.
49. Mason PJ. Stem cells, telomerase and dyskeratosis congenita. Bioessays 2003;25:126-133.
50. Hande MP. DNA repair factors and telomere-chromosome integrity in mammalian cells. Cytogenet Genome Res 2004;104:116-122.
51. Allsopp RC, Morin GB, Horner JW et al. Effect of TERT overexpression on the long-term transplantation capacity of hematopoietic stem cells. Nat Med 2003;9:369-371.
52. Hoeijmakers JH. Genome maintenance mechanisms for preventing cancer. Nature 2001;411:366-374.
53. Mitchell JR, Hoeijmakers JH, Niedernhofer LJ. Divide and conquer: Nucleotide excision repair battles cancer and ageing. Curr Opin Cell Biol 2003;15:232-240.
54. Prasher JM, Lalai AS, Heijmans-Antonissen C et al. Reduced hematopoietic reserves in DNA interstrand crosslink repair-deficient Ercc1-/- mice. EMBO J 2005;24:861-871.
55. Smith JV, Heilbronn LK, Ravussin E. Energy restriction and aging. Curr Opin Clin Nutr Metab Care 2004;7:615-622.
56. Van Zant G, Liang Y. The role of stem cells in aging. Exp Hematol 2003;31:659-672.
57. Bokov A, Chaudhuri A, Richardson A. The role of oxidative damage and stress in aging. Mech Ageing Dev 2004;125:811-826.
58. Harper ME, Bevilacqua L, Hagopian K et al. Ageing, oxidative stress, and mitochondrial uncoupling. Acta Physiol Scand 2004;182:321-331.
59. Chen J, Astle CM, Harrison DE. Hematopoietic senescence is postponed and hematopoietic stem cell function is enhanced by dietary restriction. Exp Hematol 2003;31:1097-1103.
60. Ito K, Hirao A, Arai F et al. Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature 2004;431:997-1002.
61. Conboy IM, Conboy MJ, Wagers AJ et al. Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature 2005;433:760-764.
62. Nystrom T. Role of oxidative carbonylation in protein quality control and senescence. EMBO J 2005;24:1311-1317.
63. Oliver CN, Ahn BW, Moerman EJ et al. Age-related changes in oxidized proteins. J Biol Chem 1987;262:5488-5491.
64. Stadtman ER. Protein oxidation and aging. Science 1992;257:1220-1224.
65. Levine RL. Carbonyl modified proteins in cellular regulation, aging, and disease. Free Radic Biol Med 2002;32:790-796.
66. Yan LJ, Sohal RS. Mitochondrial adenine nucleotide translocase is modified oxidatively during aging. Proc Natl Acad Sci U S A 1998;95:12896-12901.
67. Yan LJ, Levine RL, Sohal RS. Oxidative damage during aging targets mitochondrial aconitase. Proc Natl Acad Sci U S A 1997;94:11168-11172.
68. Dalle-Donne I, Giustarini D, Colombo R et al. Protein carbonylation in human diseases. Trends Mol Med 2003;9:169-176.
69. Aguilaniu H, Gustafsson L, Rigoulet M et al. Asymmetric inheritance of oxidatively damaged proteins during cytokinesis. Science 2003;299:1751-1753.
70. Tagoh H, Melnik S, Lefevre P et al. Dynamic reorganization of chromatin structure and selective DNA demethylation prior to stable enhancer complex formation during differentiation of primary hematopoietic cells in vitro. Blood 2004;103:2950-2955.
71. Ringrose L, Paro R. Epigenetic regulation of cellular memory by the Polycomb and Trithorax group proteins. Annu Rev Genet 2004;38:413-443.
72. Wolffe AP, Hayes JJ. Chromatin disruption and modification. Nucleic Acids Res 1999;27:711-720.
73. Luger K, Richmond TJ. The histone tails of the nucleosome. Curr Opin Genet Dev 1998;8:140-146.
74. Wolffe AP, Guschin D. Review: Chromatin structural features and targets that regulate transcription. J Struct Biol 2000;129:102-122.
75. Wu J, Grunstein M. 25 years after the nucleosome model: Chromatin modifications. Trends Biochem Sci 2000;25:619-623.
76. Workman JL, Kingston RE. Alteration of nucleosome structure as a mechanism of transcriptional regulation. Annu Rev Biochem 1998;67:545-579.
77. Kornberg RD, Lorch Y. Chromatin-modifying and -remodeling complexes. Curr Opin Genet Dev 1999;9:148-151.
78. Rice JC, Allis CD. Histone methylation versus histone acetylation: New insights into epigenetic regulation. Curr Opin Cell Biol 2001;13:263-273.
79. Lund AH, van Lohuizen M. Polycomb complexes and silencing mechanisms. Curr Opin Cell Biol 2004;16:239-246.
80. Kajiume T, Ninomiya Y, Ishihara H et al. Polycomb group gene mel-18 modulates the self-renewal activity and cell cycle status of hematopoietic stem cells. Exp Hematol 2004;32:571-578.
81. Ohta H, Sawada A, Kim JY et al. Polycomb group gene rae28 is required for sustaining activity of hematopoietic stem cells. J Exp Med 2002;195:759-770.
82. Park IK, Qian D, Kiel M et al. Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature 2003;423:302-305.
83. Jacobs JJ, Kieboom K, Marino S et al. The oncogene and Polycomb-group gene bmi-1 regulates cell proliferation and senescence through the ink4a locus. Nature 1999;397:164-168.
84. Lessard J, Schumacher A, Thorsteinsdottir U et al. Functional antagonism of the Polycomb-Group genes eed and Bmi1 in hemopoietic cell proliferation. Genes Dev 1999;13:2691-2703.
85. Collins RT, Furukawa T, Tanese N et al. Osa associates with the Brahma chromatin remodeling complex and promotes the activation of some target genes. EMBO J 1999;18:7029-7040.
86. Smith ST, Petruk S, Sedkov Y et al. Modulation of heat shock gene expression by the TAC1 chromatin-modifying complex. Nat Cell Biol 2004;6:162-167.
87. Simon JA, Tamkun JW. Programming off and on states in chromatin: Mechanisms of Polycomb and trithorax group complexes. Curr Opin Genet Dev 2002;12:210-218.
88. Lund AH, van Lohuizen M. Epigenetics and cancer. Genes Dev 2004;18:2315-2335.
89. Milne TA, Briggs SD, Brock HW et al. MLL targets SET domain methyltransferase activity to Hox gene promoters. Mol Cell 2002;10:1107-1117.
90. Nakamura T, Mori T, Tada S et al. ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol Cell 2002;10:1119-1128.
91. Djabali M, Selleri L, Parry P et al. A trithorax-like gene is interrupted by chromosome 11q23 translocations in acute leukaemias. Nat Genet 1992;2:113-118.
92. Gu Y, Nakamura T, Alder H et al. The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene. Cell 1992;71:701-708.
93. Tkachuk DC, Kohler S, Cleary ML. Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias. Cell 1992;71:691-700.
94. Ernst P, Fisher JK, Avery W et al. Definitive hematopoiesis requires the mixed-lineage leukemia gene. Dev Cell 2004;6:437-443.
95. Verdel A, Jia S, Gerber S et al. RNAi-mediated targeting of heterochromatin by the RITS complex. Science 2004;303:672-676.
96. Pasquinelli AE, Hunter S, Bracht J. MicroRNAs: A developing story. Curr Opin Genet Dev 2005;15:200-205.
97. Chen CZ, Li L, Lodish HF et al. MicroRNAs modulate hematopoietic lineage differentiation. Science 2004;303:83-86.
98. Imai S, Kitano H. Heterochromatin islands and their dynamic reorganization: A hypothesis for three distinctive features of cellular aging. Exp Gerontol 1998;33:555-570.
99. Villeponteau B. The heterochromatin loss model of aging. Exp Gerontol 1997;32:383-394.
100. Enver T, Greaves M. Loops, lineage, and leukemia. Cell 1998;94:9-12.
101. Terskikh AV, Miyamoto T, Chang C et al. Gene expression analysis of purified hematopoietic stem cells and committed progenitors. Blood 2003;102:94-101.
102. Akashi K, He X, Chen J et al. Transcriptional accessibility for genes of multiple tissues and hematopoietic lineages is hierarchically controlled during early hematopoiesis. Blood 2003;101:383-389.
103. Rossi DJ, Bryder D, Zahn JM et al. Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A 2005;102:9194-9199.
104. Cowan CA, Atienza J, Melton DA et al. Nuclear reprogramming of somatic cells after fusion with human embryonic stem cells. Science 2005;309:1369-1373.