Genome instability: Cancer or aging?

Mechanisms of Ageing and Development

Volumn 128, Issue 7-8, 2007, Pages 466-468

  Vijg, Jan ^a   Dollé, Martijn E T ^b  

^a BUCK INSTITUTE FOR RESEARCH ON AGING   (United States)

^b NATIONAL INSTITUTE FOR PUBLIC HEALTH AND THE ENVIRONMENT   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

BETA GALACTOSIDASE;

AGING; ARTICLE; CANCER RISK; CHROMOSOME ANALYSIS; GENE MAPPING; GENE MUTATION; GENE TRANSLOCATION; GENOMIC INSTABILITY; HUMAN; PRIORITY JOURNAL;

AGING; ANIMALS; GENOMIC INSTABILITY; HUMANS; NEOPLASMS;

EID: 34547699363     PISSN: 00476374     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mad.2007.05.004     Document Type: Article

References (18)

1. Bailey K.J., Maslov A.Y., and Pruitt S.C. Accumulation of mutations and somatic selection in aging neural stem/progenitor cells. Aging Cell 3 (2004) 391-397
2. Campisi J. Cancer and ageing: rival demons?. Nat. Rev. Cancer 3 (2003) 339-349
3. Curtis H., and Crowley C. Chromosome aberrations in liver cells in relation to the somatic mutation theory of aging. Radiat. Res. 19 (1963) 337-344
4. Dollé M.E., and Vijg J. Genome dynamics in aging mice. Genome Res. 12 (2002) 1732-1738
5. Failla G. The aging process and carcinogenesis. Ann. NY Acad. Sci. 71 (1958) 1124-1135
6. Fraga M.F., Ballestar E., Paz M.F., Ropero S., Setien F., Ballestar M.L., Heine-Suner D., Cigudosa J.C., Urioste M., Benitez J., Boix-Chornet M., Sanchez-Aguilera A., Ling C., Carlsson E., Poulsen P., Vaag A., Stephan Z., Spector T.D., Wu Y.Z., Plass C., and Esteller M. Epigenetic differences arise during the lifetime of monozygotic twins. Proc. Natl. Acad. Sci. USA 102 (2005) 10604-10609
7. Gilbert N., Boyle S., Fiegler H., Woodfine K., Carter N.P., and Bickmore W.A. Chromatin architecture of the human genome: gene-rich domains are enriched in open chromatin fibers. Cell 118 (2004) 555-566
8. Jones I.M., Thomas C.B., Tucker B., Thompson C.L., Pleshanov P., Vorobtsova I., and Moore II D.H. Impact of age and environment on somatic mutation at the hprt gene of T lymphocytes in humans. Mutat. Res. 338 (1995) 129-139
9. Martin G.M., Ogburn C.E., Colgin L.M., Gown A.M., Edland S.D., and Monnat Jr. R.J. Somatic mutations are frequent and increase with age in human kidney epithelial cells. Hum. Mol. Genet. 5 (1996) 215-221
10. Maynard Smith J. A theory of ageing. Nature 184 (1959) 956-957
11. Muotri A.R., Chu V.T., Marchetto M.C., Deng W., Moran J.V., and Gage F.H. Somatic mosaicism in neuronal precursor cells mediated by L1 retrotransposition. Nature 435 (2005) 903-910
12. Ramsey M.J., Moore II D.H., Briner J.F., Lee D.A., Olsen L., Senft J.R., and Tucker J.D. The effects of age and lifestyle factors on the accumulation of cytogenetic damage as measured by chromosome painting. Mutat. Res. 338 (1995) 95-106
13. Rehen S.K., McConnell M.J., Kaushal D., Kingsbury M.A., Yang A.H., and Chun J. Chromosomal variation in neurons of the developing and adult mammalian nervous system. Proc. Natl. Acad. Sci. USA 98 (2001) 13361-13366
14. Rehen S.K., Yung Y.C., McCreight M.P., Kaushal D., Yang A.H., Almeida B.S., Kingsbury M.A., Cabral K.M., McConnell M.J., Anliker B., Fontanoz M., and Chun J. Constitutional aneuploidy in the normal human brain. J. Neurosci. 25 (2005) 2176-2180
15. Richardson C., and Jasin M. Frequent chromosomal translocations induced by DNA double-strand breaks. Nature 405 (2000) 697-700
16. Szilard L. On the nature of the aging process. Proc. Natl. Acad. Sci. USA 45 (1959) 30-45
17. Tucker J.D., Spruill M.D., Ramsey M.J., Director A.D., and Nath J. Frequency of spontaneous chromosome aberrations in mice: effects of age. Mutat. Res. 425 (1999) 135-141
18. Vijg J. Aging of the Genome (2007), Oxford University Press, Oxford