Tocopherol (vitamin E) in Alzheimer's disease and other neurodegenerative disorders

CNS Drugs

Volumn 18, Issue 12, 2004, Pages 807-825

  Eerman, Karen ^a   Brodaty, Henry ^a,b  

^a PRINCE OF WALES HOSPITAL   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL;

ABDOMINAL CRAMP; ALZHEIMER DISEASE; ANTIOXIDANT ACTIVITY; BLEEDING; CLINICAL PRACTICE; CLINICAL TRIAL; DEGENERATIVE DISEASE; DIABETES MELLITUS; DIARRHEA; DIZZINESS; DOSE RESPONSE; DRUG EFFICACY; DRUG SAFETY; DRUG STRUCTURE; HEADACHE; HUMAN; HYPERCHOLESTEROLEMIA; INDIGESTION; META ANALYSIS; NEUROLOGIC DISEASE; OXIDATIVE STRESS; PARKINSON DISEASE; PRIORITY JOURNAL; REVIEW; SYNCOPE; SYSTEMATIC REVIEW; TARDIVE DYSKINESIA; VAGINA BLEEDING; VISUAL DISORDER; VITAMIN SUPPLEMENTATION;

ALZHEIMER DISEASE; ANIMALS; HUMANS; MODELS, BIOLOGICAL; NEURODEGENERATIVE DISEASES; TOCOPHEROLS;

EID: 6944229313     PISSN: 11727047     EISSN: None     Source Type: Journal    
DOI: 10.2165/00023210-200418120-00005     Document Type: Review

References (131)

1. Brodaty H, Sachdev PS. Drugs for the prevention and treatment of Alzheimer's disease. Med J Aust 1997; 167 (8): 447-9, 452
2. Brodaty H, Ames D, Boundy KL, et al. Pharmacological treatment of cognitive deficits in Alzheimer's disease. Med J Aust 2001; 175 (6): 324-9
3. Kappus H, Diplock AT. Tolerance and safety of vitamin E: a toxicological position report. Free Radic Biol Med 1992; 13 (1): 55-74
4. Tabet N, Birks J, Grimley Evans J. Vitamin E for Alzheimer's disease. Cochrane Database of Systematic Reviews 2000; (4): CD002854
5. Martin A, Janigian D, Shukitt-Hale B, et al. Effect of vitamin E intake on levels of vitamins E and C in the central nervous system and peripheral tissues: implications for health recommendations. Brain Res 1999; 845 (1); 50-9
6. Joseph JA, Denisova NA, Bielinski D, et al. Oxidative stress protection and vulnerability in aging: putative nutritional implications for intervention. Mech Ageing Dev 2000; 116 (2-3): 141-53
7. Meydani M. Vitamin E. Lancet 1995; 345 (8943): 170-5
8. Marcus R, Coulston AM. Fat soluble vitamins. In: Gilman AG, Rail TW, Nies AS, et al., editors. Goodman and Gilman's the pharmacological basis of therapeutics. 8th ed. New York: McGraw Hill Inc., 1992: 1566-99
9. Jiang Q, Christen S, Shigenaga MK, et al. Gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. Am J Clin Nutr 2001; 74 (6): 714-22
10. Traber MG, Sies H. Vitamin E in humans: demand and delivery. Annu Rev Nutr 1996; 16: 321-47
11. Eisai Co. Ltd. This is vitamin E [online]. Available from URL: http://www.eisai.co.jp/index-e.html. [Accessed 2003 May 30]
12. US Department of Health and Human Services, National Institutes of Health. Vitamin E [online]. Available from URL: http://www.nih.gov/. [Accessed 2003 May 20]
13. Weber P, Bendich A, Machlin LJ. Vitamin E and human health: rationale for determining recommended intake levels. Nutrition 1997; 13 (5): 450-60
14. Sokol RJ. The coming of age of vitamin E. Hepatology 1989; 9 (4): 649-53
15. Vatassery GT, Bauer T, Dysken M. High doses of vitamin E in the treatment of disorders of the central nervous system in the aged. Am J Clin Nutr 1999; 70 (5): 793-801
16. Vogel R. Antioxidants are useful in preventing cardiovascular disease: a debate. Pro antioxidants. Can J Cardiol 1999; 15 Suppl. B: 23B-5B
17. Halliwell B. The antioxidant paradox. Lancet 2000 Apr 1; 355 (9210): 1179-80
18. Hercberg S, Galan P, Preziosi P. Antioxidant vitamins and cardiovascular disease: Dr Jekyll or Mr Hyde? Am J Public Health 1999; 89 (3): 289-91
19. Williamson KS, Gabbita SP, Mou S, et al. The nitration product 5-nitro-gamma-tocopherol is increased in the Alzheimer brain. Nitric Oxide 2002; 6 (2): 221-7
20. Grundman M. Vitamin E and Alzheimer disease: the basis for additional clinical trials. Am J Clin Nutr 2000; 71 (2): 630-636S
21. Delanty N, Dichter MA. Antioxidant therapy in neurologic disease. Arch Neurol 2000; 57 (9): 1265-70
22. Pitchumoni SS, Doraiswamy PM. Current status of antioxidant therapy for Alzheimer's Disease. J Am Geriatr Soc 1998; 46 (12): 1566-72
23. Sokol RJ. Vitamin E and neurologic deficits. Adv Pediatr 1990; 37: 119-48
24. Phelps DL. The role of vitamin E therapy in high risk neonates. Clin Perinatol 1988 Dec; 15 (4): 955-63
25. Zipursky A, Brown EJ, Watts J, et al. Oral vitamin E supplementation for the prevention of anaemia in premature infants: a controlled trial. Pediatrics 1987 Jan; 79 (1): 61-8
26. Bell EF, Filer Jnr LJ. The role of vitamin E in the nutrition of premature infants [review]. Am J Clin Nutr 1981 Mar; 34 (3): 414-22
27. Sano M, Ernesto C, Thomas RG, et al. A controlled trial of selegiline, alpha-tocopherol, or both as treatment for Alzheimer's disease: The Alzheimer's Disease Cooperative Study. N Engl J Med 1997; 336 (17): 1216-22
28. Impact of deprenyl and tocopherol treatment on Parkinson's disease in DATATOP patients requiring levodopa. Parkinson Study Group. Ann Neurol 1996; 39 (1): 37-45
29. Pappert EJ, Tangney CC, Goetz CG, et al. Alpha-tocopherol in the ventricular cerebrospinal fluid of Parkinson's disease patients: dose-response study and correlations with plasma levels. Neurology 1996; 47 (4): 1037-42
30. Fahn S. A pilot trial of high-dose alpha-tocopherol and ascorbate in early Parkinson's disease. Ann Neurol 1992; 32 Suppl.: S128-32
31. Anderson TW, Reid DB. A double-blind trial of vitamin E in angina pectoris. Am J Clin Nutr 1974; 27 (10): 1174-8
32. Corrigan JJ. The effect of vitamin E on warfarin-induced vitamin K deficiency. Ann N Y Acad Sci 1982; 393: 361-8
33. Bendich A, Machlin LJ. Safety of oral intake of vitamin E. Am J Clin Nutr 1988; 48 (3): 612-9
34. Pratico D, Delanty N. Oxidative injury in diseases of the central nervous system: focus on Alzheimer's disease. Am J Med 2000; 109 (7): 577-85
35. Behl C. Vitamin E and other antioxidants in neuroprotection. Int J Vitam Nutr Res 1999; 69 (3): 213-9
36. Floyd RA. Antioxidants, oxidative stress, and degenerative neurological disorders. Proc Soc Exp Biol Med 1999; 222 (3): 236-45
37. Engelhart MJ, Geerlings MI, Ruitenberg A, et al. Dietary intake of antioxidants and risk of Alzheimer disease. JAMA 2002; 287 (24): 3223-9
38. Good PF, Werner P, Hsu A, et al. Evidence of neuronal oxidative damage in Alzheimer's disease. Am J Pathol 1996; 149 (1): 21-8
39. Lohr JB, Kuczenski R, Niculescu A. Oxidative mechanisms and tardive dyskinesia. CNS Drugs 2003; 17 (1): 47-62
40. Floyd RA. Role of oxygen free radicals in carcinogenesis and brain ischemia. FASEB J 1990; 4 (9): 2587-97
41. Schippling S, Kontush A, Arlt S, et al. Increased lipoprotein oxidation in Alzheimer's disease. Free Radic Biol Med 2000; 28 (3): 351-60
42. Varadarajan S, Yatin S, Aksenova M, et al. Review: Alzheimer's amyloid beta-peptide-associated free radical oxidative stress and neurotoxicity. J Struct Biol 2000; 130 (2-3): 184-208
43. Harman D. Aging: a theory based on free radical and radiation chemistry. J Gerontol 1956; 11: 131-5
44. Wolf R, Wolf D, Ruocco V. Vitamin E: the radical protector. J Eur Acad Dermatol Venereol 1998; 10 (2): 103-17
45. Gale CR. Dietary antioxidants and dementia. Int Psychogeriatr 2001; 13 (3): 259-62
46. Darley-Usmar V, Wiseman H, Halliwell B. Nitric oxide and oxygen radicals: a question of balance. FEBS Lett 1995; 369 (2-3): 131-5
47. Cassarino DS, Bennett JP. An evaluation of the role of mitochondria in neurodegenerative diseases: mitochondrial mutations and oxidative pathology, protective nuclear responses, and cell death in neurodegeneration. Brain Res Brain Res Rev 1999; 29 (1): 1-25
48. Rottkamp CA, Nunomura A, Hirai K, et al. Will antioxidants fulfil their expectations for the treatment of Alzheimer's disease? Mech Ageing Dev 2000; 116 (2-3): 169-79
49. Butterfield DA. β-Amyloid-associated free radical oxidative stress and neurotoxicity: implications for Alzheimer's disease. Chem Res Toxicol 1997; 10 (5): 495-506
50. Gasic-Milenkovic J, Loske C, Munch G. Advanced glycation endproducts cause lipid peroxidation in the human neuronal cell line SH-SY5Y. J Alzheimers Dis 2003; 5 (1): 25-30
51. McIntosh LJ, Trush MA, Troncoso JC. Increased susceptibility of Alzheimer's disease temporal cortex to oxygen free radical-mediated processes. Free Radic Biol Med 1997; 23 (2): 183-90
52. Floyd RA, West M, Hensley K. Oxidative biochemical markers: clues to understanding aging in long-lived species. Exp Gerontol 2001; 36: 619-40
53. Altavilla D, Deodato B, Campo GM, et al. IRFI 042, a novel dual vitamin E-like antioxidant, inhibits activation of nuclear factor-kappaB and reduces the inflammatory response in myocardial ischemia-reperfusion injury. Cardiovasc Res 2000; 47 (3): 515-28
54. Behl C. Vitamin E protects neurons against oxidative cell death in vitro more effectively than 17-beta estradiol and induces the activity of the transcription factor NF-kappaB. J Neural Transm 2000; 107 (4): 393-407
55. Melton L. Oestrogen shields brain from ageing. Lancet 1999; 354 (9184): 1099
56. Vatassery GT. Vitamin E and other endogenous antioxidants in the central nervous system. Geriatrics 1998; 53 Suppl. 1:S25-7
57. Abd el-Fattah AA, al-Yousef HM, al-Bekairi AM, et al. Vitamin E protects the brain against oxidative injury stimulated by excessive aluminium intake. Biochem Mol Biol Int 1998; 46 (6): 1175-80
58. Bagchi D, Garg A, Krohn RL, et al. Protective effects of grape seed proanthocyanidins and selected antioxidants against TPA-induced hepatic and brain lipid peroxidation and DNA fragmentation, and peritoneal macrophage activation in mice. Gen Pharmacol 1998; 30 (5): 771-6
59. Inci S, Ozcan OE, Kilinc K. Time-level relationship for lipid peroxidation and the protective effect of alpha-tocopherol in experimental mild and severe brain injury. Neurosurgery 1998; 43 (2): 330-5
60. Giray B, Gurbay A, Hincal F. Cypermethrin-induced oxidative stress in rat brain and liver is prevented by vitamin E or allopurinol. Toxicol Lett 2001; 118 (3): 139-46
61. Tagami M, Ikeda K, Yamagata K, et al. Vitamin E prevents apoptosis in hippocampal neurons caused by cerebral ischemia and reperfusion in stroke-prone spontaneously hypertensive rats. Lab Invest 1999; 79 (5): 609-15
62. Urano S, Asai Y, Makabe S, et al. Oxidative injury of synapse and alteration of antioxidative defense systems in rats, and its prevention by vitamin E. Eur J Biochem 1997; 245 (1): 64-70
63. Hara H, Kato H, Kogure K. Protective effect of alpha-tocopherol on ischemic neuronal damage in the gerbil hippocampus. Brain Res 1990; 510 (2): 335-8
64. Sohal RS, Brunt UT. Lipofuscin as an indicator of oxidative stress and aging [review]. Adv Exp Med Biol 1989; 266: 17-26
65. Monji A, Morimoto N, Okuyama I, et al. Effect of dietary vitamin E on lipofuscin accumulation with age in the rat brain. Brain Res 1994; 634 (1): 62-8
66. O'Donnell E, Lynch MA. Dietary antioxidant supplementation reverses age-related neuronal changes. Neurobiol Aging 1998; 19 (5): 461-7
67. Koppal T, Subramaniam R, Drake J, et al. Vitamin E protects against Alzheimer's amyloid peptide (25-35)-induced changes in neocortical synaptosomal membrane lipid structure and composition. Brain Res 1998; 786 (1-2): 270-3
68. Escames G, Guerrero JM, Reiter RJ, et al. Melatonin and vitamin E limit nitric oxide-induced lipid peroxidation in rat brain homogenates. Neurosci Lett 1997; 230 (3): 147-50
69. Post A, Holsboer F, Behl C. Induction of NF-kappaB activity during haloperidol-induced oxidative toxicity in clonal hippocampal cells: suppression of NF-kappaB and neuroprotection by antioxidants. J Neurosci 1998; 18 (20): 8236-46
70. Dillard CJ, Dumelin EE, Tappel AL. Effect of dietary vitamin E on expiration of pentane and ethane by the rat. Lipids 1977; 12 (1): 109-14
71. Dillard CJ, Litov RE, Tappel AL. Effects of dietary vitamin E, selenium, and polyunsaturated fats on in vivo lipid peroxidation in the rat as measured by pentane production. Lipids 1978; 13 (6): 396-402
72. Yamada K, Tanaka T, Han D, et al. Protective effects of idebenone and alpha-tocopherol on beta-amyloid- (1-42)-induced learning and memory deficits in rats: implication of oxidative stress in beta-amyloid-induced neurotoxicity in vivo. Eur J Neurosci 1999; 11 (1): 83-90
73. Socci DJ, Crandall BM, Arendash GW. Chronic antioxidant treatment improves the cognitive performance of aged rats. Brain Res 1995; 693 (1-2): 88-94
74. Guerrero AL, Dorado-Martinez C, Rodriguez A, et al. Effects of vitamin E on ozone-induced memory deficits and lipid peroxidation in rats. Neuroreport 1999; 10 (8): 1689-92
75. Yatin SM, Aksenov M, Butterfield DA. The antioxidant vitamin E modulates amyloid beta-peptide-induced creatine kinase activity inhibition and increased protein oxidation: implications for the free radical hypothesis of Alzheimer's disease. Neurochem Res 1999; 24 (3): 427-35
76. Yao ZX, Drieu K, Szweda LI, et al. Free radicals and lipid peroxidation do not mediate beta-amyloid-induced neuronal cell death. Brain Res 1999; 847 (2): 203-10
77. Kolsch H, Ludwig M, Lutjohann D, et al. Neurotoxicity of 24-hydroxycholesterol, an important cholesterol elimination product of the brain, may be prevented by vitamin E and estradiol-17beta. J Neural Transm 2001; 108 (4); 475-88
78. Subbarao KV, Richardson JS, Ang LC. Autopsy samples of Alzheimer's cortex show increased peroxidation in vitro. J Neurochem 1990; 55 (1): 342-5
79. Hensley K, Hall N, Subramaniam R, et al. Brain regional correspondence between Alzheimer's disease histopathology and biomarkers of protein oxidation. J Neurochem 1995; 65 (5): 2146-56
80. Adams JD, Klaidman LK, Odunze IN, et al. Alzheimer's and Parkinson's disease: brain levels of glutathione, glutathione disulfide, and vitamin E. Mol Chem Neuropathol 1991; 14 (3): 213-26
81. Metcalfe T, Bowen DM, Muller DP. Vitamin E concentrations in human brain of patients with Alzheimer's disease, fetuses with Down's syndrome, centenarians, and controls. Neurochem Res 1989; 14 (12): 1209-12
82. Jeandel C, Nicolas MB, Dubois F, et al. Lipid peroxidation and free radical scavengers in Alzheimer's disease. Gerontology 1989; 35 (5-6): 275-82
83. Riviere S, Birlouez-Aragon I, Nourhashemi F, et al. Low plasma vitamin C in Alzheimer patients despite an adequate diet. Int J Geriatr Psychiatry 1998; 13 (11): 749-54
84. Zaman Z, Roche S, Fielden P, et al. Plasma concentrations of vitamins A and E and carotenoids in Alzheimer's disease. Age Ageing 1992; 21 (2): 91-4
85. Tohgi H, Abe T, Nakanishi M, et al. Concentrations of alpha-tocopherol and its quinone derivative in cerebrospinal fluid from patients with vascular dementia of the Binswanger type and Alzheimer type dementia. Neurosci Lett 1994; 174 (1): 73-6
86. Jimenez-Jimenez FJ, de Bustos F, Molina JA, et al. Cerebrospinal fluid levels of alpha-tocopherol (vitamin E) in Alzheimer's disease. J Neural Transm 1997; 104 (6-7): 703-10
87. Jama JW, Launer LJ, Witteman JC, et al. Dietary antioxidants and cognitive function in a population-based sample of older persons: The Rotterdam Study. Am J Epidemiol 1996; 144 (3): 275-80
88. Perkins AJ, Hendrie HC, Callahan CM, et al. Association of antioxidants with memory in a multiethnic elderly sample using the Third National Health and Nutrition Examination Survey. Am J Epidemiol 1999; 150 (1): 37-44
89. Kalmijn S, Feskens EJ, Launer LJ, et al. Polyunsaturated fatty acids, antioxidants, and cognitive function in very old men. Am J Epidemiol 1997; 145 (1): 33-41
90. Morris MC, Beckett LA, Scherr PA, et al. Vitamin E and vitamin C supplement use and risk of incident Alzheimer disease. Alzheimer Dis Assoc Disord 1998; 12 (3): 121-6
91. Masaki KH, Losonczy KG, Izmirlian G, et al. Association of vitamin E and C supplement use with cognitive function and dementia in elderly men. Neurology 2000; 54 (6): 1265-72
92. Morris MC, Evans DA, Bienias JL, et al. Dietary intake of antioxidant nutrients and the risk of incident Alzheimer disease in a biracial community study. JAMA 2002; 287 (24): 3230-7
93. Morris MC, Evans DA, Bienias JL, et al. Vitamin E and cognitive decline in older persons. Arch Neurol 2002; 59 (7): 1125-32
94. Luchsinger JA, Tang MX, Shea S, et al. Antioxidant vitamin intake and risk of Alzheimer disease. Arch Neurol 2003; 60 (2): 203-8
95. Grodstein F, Chen J, Willett WC. High-dose antioxidant supplements and cognitive function in community-dwelling elderly women. Am J Clin Nutr 2003; 77 (4); 975-84
96. Corrigan FM, Van Rhijn A, Horrobin DF. Essential fatty acids in Alzheimer's disease. Ann N Y Acad Sci 1991; 640: 250-2
97. MRC/BHF Heart Protection Study of antioxidant vitamin supplementation in 20,536 high-risk individuals: a randomised placebo-controlled trial. Heart Protection Study Collaborative Group. Lancet 2002; 360 (9326): 23-33
98. Jenner P, Olanow CW. Oxidative stress and the pathogenesis of Parkinson's disease. Neurology 1996; 47 (6 Suppl. 3): S161-70
99. Martignoni E, Blandini F, Godi L, et al. Peripheral markers of oxidative stress in Parkinson's disease, the role of L-DOPA. Free Radic Biol Med 1999; 27 (3-4): 428-37
100. Hildick-Smith M. Parkinson's disease. In: Pathy MSJ, editor. Principles and practice of geriatric medicine. 2nd ed. Chichester: John Wiley & Sons Ltd, 1991
101. Langsten JW, Langsten EB, Irwin I. MPTP-induced parkinsonism in human and non-human primates: clinical and experimental aspects. Acta Neurol Scand Suppl 1984; 100: 49-54
102. de Rijk MC, Breteler MM, den Breeijen JH, et al. Dietary antioxidants and Parkinson disease: The Rotterdam Study. Arch Neurol 1997; 54 (6): 762-5
103. Golbe LI, Farrell TM, Davis PH. Case-control study of early life dietary factors in Parkinson's disease. Arch Neurol 1988; 45 (12): 1350-3
104. Hellenbrand W, Boeing H, Robra BP, et al. Diet and Parkinson's disease: II. a possible role for the past intake of specific nutrients: results from a self-administered food-frequency questionnaire in a case-control study. Neurology 1996; 47 (3): 644-50
105. Scheider WL, Hershey LA, Vena JE, et al. Dietary antioxidants and other dietary factors in the etiology of Parkinson's disease. Mov Disord 1997; 12 (2): 190-6
106. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. The Parkinson Study Group. N Engl J Med 1993 Jan 21; 328 (3): 176-83
107. Morens DM, Grandinetti A, Waslien CI, et al. Case-control study of idiopathic Parkinson's disease and dietary vitamin E intake. Neurology 1996; 46 (5): 1270-4
108. Logroscino G, Marder K, Cote L, et al. Dietary lipids and antioxidants in Parkinson's disease: a population-based, case-control study. Ann Neurol 1996; 39 (1): 89-94
109. Zhang SM, Hernan MA, Chen H, et al. Intakes of vitamins E and C, carotenoids, vitamin supplements, and PD risk. Neurology 2002; 59 (8): 1161-9
110. Lohr JB, Caligiuri MP. A double-blind placebo-controlled study of vitamin E treatment of tardive dyskinesia. J Clin Psychiatry 1996; 57 (4): 167-73
111. Adler LA, Edson R, Lavori P, et al. Long-term treatment effects of vitamin E for tardive dyskinesia. Biol Psychiatry 1998; 43 (12): 868-72
112. Dannon PN, Grunhaus L, Iancu I, et al. Vitamin E treatment in tardive dystonia. Clin Neuropharmacol 1997; 20 (5): 434-7
113. Dorfman-Etrog P, Hermesh H, Prilipko L, et al. The effect of vitamin E addition to acute neuroleptic treatment on the emergence of extrapyramidal side effects in schizophrenic patients: an open label study. Eur Neuropsychopharmacol 1999; 9 (6): 475-7
114. Lohr JB, Cadet JL, Lohr MA, et al. Vitamin E in the treatment of tardive dyskinesia: the possible involvement of free radical mechanisms. Schizophr Bull 1988; 14 (2): 291-6
115. Boomershine KH, Shelton PS, Boomershine JE. Vitamin E in the treatment of tardive dyskinesia. Ann Pharmacother 1999; 33 (11): 1195-202
116. Scares KV, McGrath JJ. Vitamin E for neuroleptic-induced tardive dyskinesia. [update of Cochrane Database Syst Rev 2000; (2):CD000209; PMID: 10796508]. Cochrane Database of Systematic Reviews 2001; (4): CD000209
117. Scares KV, McGrath JJ. Vitamin E for neuroleptic-induced tardive dyskinesia. [update of Cochrane Database Syst Rev 2000; (2):CD000209; PMID: 10796508]. Cochrane Database of Systematic Reviews 2001; (4): CD000209
118. Barak Y, Swartz M, Shamir E, et al. Vitamin E (alpha-tocopherol) in the treatment of tardive dyskinesia: a statistical meta-analysis. Ann Clin Psychiatry 1998; 10 (3): 101-5
119. Dorevitch A, Lerner V, Shalfman M, et al. Lack of effect of vitamin E on serum creatine phosphokinase in patients with long-term tardive dyskinesia. Int Clin Psychopharmacol 1997; 12 (3): 171-3
120. Adler LA, Rotrosen J, Edson R, et al. Vitamin E treatment for tardive dyskinesia. Arch Gen Psychiatry 1999 Sep; 56 (9): 836-41
121. Apostolski S, Marinkovic Z, Nikolic A, et al. Glutathione peroxidase in amyotrophic lateral sclerosis: the effects of selenium supplementation. J Environ Pathol Toxicol Oncol 1998; 17 (3-4): 325-9
122. Oteiza PI, Uchitel OD, Carrasquedo F, et al. Evaluation of antioxidants, protein, and lipid oxidation products in blood from sporadic amyotrophic lateral sclerosis patients. Neurochem Res 1997; 22 (4): 535-9
123. Eisen A, Weber M. Treatment of amyotrophic lateral sclerosis. Drugs Aging 1999; 14 (3): 173-96
124. Santavuori P, Heiskala H, Autti T, et al. Comparison of the clinical courses in patients with juvenile neuronal ceroid lipofuscinosis receiving antioxidant treatment and those without antioxidant treatment. Adv Exp Med Biol 1989; 266: 273-82
125. Peyser CE, Folstein M, Chase GA, et al. Trial of d-alpha-tocopherol in Huntington's disease. Am J Psychiatry 1995; 152 (12): 1771-5
126. Doody RS, Stevens JC, Beck C, et al. Practice parameter: management of dementia (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology. Neurology 2001; 56 (9): 1154-66
127. Practice guideline for the treatment of patients with Alzheimer's disease and other dementias of late life. American Psychiatric Association [published erratum appears in Am J Psychiatry 1997 Aug; 154 (8): 1180]. Am J Psychiatry 1997; 154 (5 Suppl.): 1-39
128. Practice guideline for the treatment of patients with Alzheimer's disease and other dementias of late life. American Psychiatric Association [published erratum appears in Am J Psychiatry 1997 Aug; 154 (8): 1180]. Am J Psychiatry 1997; 154 (5 Suppl.): 1-39
129. Alzheimer Research Forum. Alpha-tocopherol (vitamin E) [online]. Available from URL: http://www.alzforum.org/dis/tre/drt/vitamine.asp. [Accessed 2002 October 15]
130. Haan MN. Can vitamin supplements prevent cognitive decline and dementia in old age? Am J Clin Nutr 2003; 77 (4): 762-3
131. Zandi PP, Anthony JC, Khachaturian AS, et al. Reduced risk of Alzheimer's disease in users of antioxidant vitamin supplements. The Cache County Study. Arch Neurol 2004; 61 (1): 82-8