Oxidative biochemical markers; clues to understanding aging in long-lived species

Experimental Gerontology

Volumn 36, Issue 4-6, 2001, Pages 619-640

  Floyd, R A ^a,b   West, M ^a   Hensley, K ^a  

^a OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^b UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

Aging and inflammation; Inflammatory stress; Mutated mitochondrial DNA; Oxidative damage; Oxidized proteins; Proinflammatory cytokines; Reactive oxygen species

Indexed keywords

ADENINE NUCLEOTIDE TRANSLOCASE; BIOCHEMICAL MARKER; CATALASE; CELL PROTEIN; CYTOCHROME C; CYTOKINE; FREE RADICAL; GLUTATHIONE PEROXIDASE; GROWTH FACTOR; MANGANESE; MITOCHONDRIAL DNA; MITOCHONDRIAL ENZYME; NITRIC OXIDE SYNTHASE; OXYGEN RADICAL; PEROXYNITRITE; PROTEINASE;

AGING; ALZHEIMER DISEASE; APOPTOSIS; CELL DAMAGE; CONFERENCE PAPER; ENZYME ACTIVITY; FIBROBLAST; HUMAN; INFLAMMATION; LIFESPAN; LIPID OXIDATION; LONGEVITY; MOUSE; NONHUMAN; OXIDATIVE STRESS; PIGEON; PRIORITY JOURNAL; PROTEIN DEFECT; PROTEIN DEGRADATION; RAT; SENESCENCE;

AGING; ANIMALS; BIOLOGICAL MARKERS; FREE RADICALS; HUMANS; LONGEVITY; MITOCHONDRIA; PROTEINS; REACTIVE OXYGEN SPECIES; RESEARCH;

NEXUS;

EID: 0035060368     PISSN: 05315565     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0531-5565(00)00231-X     Document Type: Conference Paper

References (87)

1. Aging and proteolysis of oxidized proteins
2. Protein oxidation and enzyme activity decline in old brown Norway rats are reduced by dietary restriction
3. Inactivation of aconitase and oxoglutarate dehydrogenase in skeletal muscle in vitro by superoxide anions and/or nitric oxide
4. Localization at complex I and mechanism of the higher free radical production of brain nonsynaptic mitochondria in the short-lived rat than in the longevous pigeon
5. ADP-regulation of mitochondrial free radical production is different with complex I- or complex II-linked substrates: implications for the exercise paradox and brain hypermetabolism
6. 2 consumption can explain the simultaneous presence of high longevity and high aerobic metabolic rate in birds
7. Protein oxidation in aging disease, and oxidative stress
8. Mitochondria - the death signal integrators
9. Selective inactivation of the transacylase components of the 2-oxoacid dehydrogenase multienzyme complexes of Escherichia coli
10. Reversal of age-related increase in brain protein oxidation, decrease in enzyme activity, and loss in temporal and spacial memory by chronic administration of the spin-trapping compound N-tert-butyl-α-phenylnitrone
11. Aconitase is readily inactivated by peroxynitrite, but not by its precursor, nitric oxide
12. Tricarboxylic acid cycle flux and enzyme activities in the isolated working rat heart
13. Altered regulation of IL-6 production with normal aging
14. Effect of spin-trapping compound N-tert-butyl-α-phenylnitrone on protein oxidation and life span
15. Effect of age and caloric intake on protein oxidation in different brain regions and on behavioral functions of the mouse
16. The spin-trap N-tert-α-phenyl-butylnitrone prolongs the life span of the senescence-accelerated mouse
17. Interleukin-6 and aging: blood levels and mononuclear cell production increase with advancing aging and in vitro production is modifiable by dietary restriction
18. Genetics of aging
19. Facile detection of mitochondrial DNA mutations in tumors and bodily fluids
20. Role of oxygen free radicals in carcinogenesis and brain ischemia
21. Antioxidants, oxidative stress, and degenerative neurological disorders (44448)
22. Neuroinflammatory processes are important in neurodegenerative diseases: an hypothesis to explain the increased formation of reactive oxygen and nitrogen species as major factors involved in neurodegenerative disease development
23. Superoxide sensitivity of the Escherichia coli Aconitase
24. Oxygen poisoning and x-irradiation: a mechanism in common
25. Reduced activities of thiamine-dependent enzymes in the brains and peripheral tissues of patients with Alzheimer's disease
26. Activation of the cell death program by nitric oxide involves inhibition of the proteasome
27. Degradation of oxidized proteins in mammalian cells
28. Mitochondrial decay in hepatocytes from old rats: membrane potential declines, heterogeneity and oxidants increase
29. Acetyl-L-carnitine fed to old rats partially restores mitochondrial function and ambulatory activity
30. (R)-α-Lipoic acid-supplemented old rats have improved mitochondrial function, decreased oxidative damage, and increased metabolic rate
31. Aging: a theory based on free radical and radiation chemistry
32. Role of free radicals in mutation, cancer, aging, and the maintenance of life
33. The biologic clock: the mitochondria?
34. Electrochemical analysis of protein nitrotyrosine and dityrosine in the Alzheimer brain indicates region-specific accumulation
35. Interaction of α-phenyl-N-tert-butyl nitrone and alternative electron acceptors with complex I indicates a substrate reduction site upstream from the rotenone binding site
36. Determination of biological oxidative stress using high performance liquid chromatography with electrochemical detection (HPLC-ECD)
37. Measurement of 3-nitrotyrosine and 5-nitro-γ-tocopherol by high-performance liquid chromatography with electrochemical detection
38. Selective inactivation of α-ketoglutarate dehydrogenase and pyruvate dehydrogenase: reaction of lipoic acid with 4-hydroxy-2-nonenal
39. Biological tyrosine nitration: a pathophysiological function of nitric oxide and reactive oxygen species
40. Crystal structure of the truncated cubic core component of the Eschericha coli 2-oxoglutarate dehydrogenase multienzyme complex
41. Mitochondrial control of cell death
42. Relationship between mitochondrial superoxide and hydrogen peroxide production and longevity of mammalian species
43. Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria
44. Gene-expression profile of the ageing brain in mice
45. Cytochrome c release and apoptosis induced by mitochondrial targeting nuclear orphan receptor TR3
46. 2 production in pigeon heart mitochondria
47. Declines in mitochondrial respiration during cardiac reperfusion: age-dependent inactivation of α-ketoglutarate dehydrogenase
48. Relationship between enzymatic activity loss and post-translational protein modification in aging
49. Action of food restriction in delaying the aging process
50. Extension of life span with superoxide dismutase/catalase mimetics
51. Aging-dependent large accumulation of point mutations in the human mtDNA control region for replication
52. shc adaptor protein controls oxidative stress response and life span in mammals
53. Oxygen radical release in mitochondria: influence of age
54. A role of mixed-function oxidation reactions in the accumulation of altered enzyme forms during aging
55. Reactive oxygen species, mitochondria, apoptosis, and aging
56. Metabolic impairment induces oxidative stress, compromises inflammatory responses, and inactivates a key mitochondrial enzyme in microglia
57. The rate of free radical production as a determinant of the rate of aging: evidence from the comparative approach
58. Somatic mutations of the mitochondrial genome in human colorectal tumors
59. Comparative resistance of the 20S and 26S proteasome to oxidative stress
60. Purification of a liver alkaline protease, which degrades oxidatively, modified glutamine synthetase
61. Age-related activation of microglia and astrocytes: in vitro studies show persistent phenotypes of aging, increased proliferation, and resistance to down-regulation
62. Antioxidant treatment with phenyl-α-tert-butyl nitrone (PBN) improves the cognitive performance and survival of aging rats
63. A spin trap, N-tert-butyl-α-phenylnitrone extends the life span of mice
64. Causes, effects, and constraints in the genetics of human longevity
65. Genetics of survival
66. High levels of mitochondrial DNA deletions in skeletal muscle of old rhesus monkeys
67. Abnormality of the α-ketoglutarate dehydrogenase complex in fibroblasts from familial Alzheimer's disease
68. Oxidative damage and mitochondrial decay in aging
69. Oxidative stress, caloric restriction, and aging
70. An age-dependent release of matrix proteins from rat liver mitochondria
71. Minireview: protein modification in aging
72. Protein oxidation and aging
73. Mammalian α-K.E.T.O.acid dehydrogease complexes
74. Protein oxidation and loss of protease activity may lead to cataract formation in the aged lens
75. Poly-ADP ribose polymerase activates nuclear proteasome to degrade oxidatively damaged histones
76. Aging in rodent brain: alteration in astrocyte population
77. Mitochondrial genetics: a paradigm for aging and degenerative diseases
78. Review - mitochondrial DNA sequence variation in human evolution and disease
79. Apoptosis: a two-edged sword in aging
80. Increase of plasma IL-6 concentration with age in healthy subjects
81. The retardation of aging by caloric restriction: studies in rodents and primates
82. Modification of mitochondrial respiration by aging and dietary restriction
83. Mitochondrial adenine nucleotide translocase is modified oxidatively during aging
84. Oxidative damage during aging targets mitochondrial aconitase
85. Marked replicative advantage of human mtDNA carrying a point mutation that causes the MELAS encephalomyopathy
86. Caloric restriction of rehesus monkeys lowers oxidative damage in skeletal muscle