Medullary serotonin defects and respiratory dysfunction in sudden infant death syndrome

Respiratory Physiology and Neurobiology

Volumn 168, Issue 1-2, 2009, Pages 133-143

  Paterson, David S ^a   Hilaire, Gerard ^b   Weese Mayer, Debra E ^c  

^a BOSTON CHILDREN S HOSPITAL   (United States)

^b University of Mediterranée   (France)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Infant; Pregnancy; SIDS

Indexed keywords

ALCOHOL; CIGARETTE SMOKE; SEROTONIN;

ARTICLE; AUTONOMIC DYSFUNCTION; AUTONOMIC NERVOUS SYSTEM FUNCTION; BRAIN STEM; CHEMOSENSITIVITY; DNA POLYMORPHISM; FETUS DEVELOPMENT; GENETIC RISK; HUMAN; IMMUNOFLUORESCENCE TEST; NERVE CELL DIFFERENTIATION; NERVE CELL PLASTICITY; NONHUMAN; PATHOGENESIS; POSTNATAL DEVELOPMENT; PRENATAL EXPOSURE; PRIORITY JOURNAL; RECEPTOR BINDING; RESPIRATORY FAILURE; RESPIRATORY FUNCTION; RISK ASSESSMENT; SEROTONINERGIC NERVE CELL; SEX DIFFERENCE; SUDDEN INFANT DEATH SYNDROME;

ANIMALS; DISEASE MODELS, ANIMAL; FEMALE; HUMANS; INFANT; INFANT, NEWBORN; MEDULLA OBLONGATA; NEURONS; POLYMORPHISM, GENETIC; PREGNANCY; PRENATAL EXPOSURE DELAYED EFFECTS; RESPIRATION DISORDERS; SEROTONIN; SUDDEN INFANT DEATH;

EID: 69249205485     PISSN: 15699048     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.resp.2009.05.010     Document Type: Article

References (217)

1. Ahlgren S.C., and Bronner-Fraser M. Inhibition of sonic hedgehog signaling in vivo results in craniofacial neural crest cell death. Curr. Biol. 9 (1999) 1304-1314
2. Ahlgren S.C., Thakur V., and Bronner-Fraser M. Sonic hedgehog rescues cranial neural crest from cell death induced by ethanol exposure. Proc. Natl. Acad. Sci. U.S.A. 99 (2002) 10476-10481
3. Al-Zubaidy Z.A., Erickson R.L., and Greer J.J. Serotonergic and noradrenergic effects on respiratory neural discharge in the medullary slice preparation of neonatal rats. Pflugers Arch. 431 (1996) 942-949
4. Alm B., Wennergren G., Norvenius G., Skjaerven R., Oyen N., Helweg-Larsen K., Lagercrantz H., and Irgens L.M. Caffeine and alcohol as risk factors for sudden infant death syndrome. Nordic Epidemiological SIDS Study. Arch. Dis. Child. 81 (1999) 107-111
5. Anderson M.E., Johnson D.C., and Batal H.A. Sudden infant death syndrome and prenatal maternal smoking: rising attributed risk in the back to sleep era. BMC Med. 3 (2005) 4
6. Arango V., Underwood M.D., Gubbi A.V., and Mann J.J. Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Res. 688 (1995) 121-133
7. Arneil G.C., Brooke H., Gibson A.A., Harvie A., McIntosh H., and Patrick W.J. National post-perinatal infant mortality and cot death study, Scotland 1981-1982. Lancet 1 (1985) 740-743
8. Audero E., Coppi E., Mlinar B., Rossetti T., Caprioli A., Banchaabouchi M.A., Corradetti R., and Gross C. Sporadic autonomic dysregulation and death associated with excessive serotonin autoinhibition. Science 321 (2008) 130-133
9. Aznar S., Kostova V., Christiansen S.H., and Knudsen G.M. Alpha 7 nicotinic receptor subunit is present on serotonin neurons projecting to hippocampus and septum. Synapse 55 (2005) 196-200
10. Baker-Herman T.L., Fuller D.D., Bavis R.W., Zabka A.G., Golder F.J., Doperalski N.J., Johnson R.A., Watters J.J., and Mitchell G.S. BDNF is necessary and sufficient for spinal respiratory plasticity following intermittent hypoxia. Nat. Neurosci. 7 (2004) 48-55
11. Bayliss D.A., Cidlowski J.A., and Millhorn D.E. The stimulation of respiration by progesterone in ovariectomized cat is mediated by an estrogen-dependent hypothalamic mechanism requiring gene expression. Endocrinology 126 (1990) 519-527
12. Bayliss D.A., and Millhorn D.E. Central neural mechanisms of progesterone action: application to the respiratory system. J. Appl. Physiol. 73 (1992) 393-404
13. Beal S. Sudden infant death syndrome. Med. J. Aust. 2 (1972) 1223-1229
14. Bethea C.L., Lu N.Z., Gundlah C., and Streicher J.M. Diverse actions of ovarian steroids in the serotonin neural system. Front. Neuroendocrinol. 23 (2002) 41-100
15. Bitner R.S., and Nikkel A.L. Alpha-7 nicotinic receptor expression by two distinct cell types in the dorsal raphe nucleus and locus coeruleus of rat. Brain Res. 938 (2002) 45-54
16. Blair P.S., Fleming P.J., Bensley D., Smith I., Bacon C., Taylor E., Berry J., Golding J., and Tripp J. Smoking and the sudden infant death syndrome: results from 1993-1995 case-control study for confidential inquiry into stillbirths and deaths in infancy. Confidential Enquiry into Stillbirths and Deaths Regional Coordinators and Researchers. Br. Med. J. 313 (1996) 195-198
17. Blair P.S., Fleming P.J., Smith I.J., Platt M.W., Young J., Nadin P., Berry P.J., and Golding J. Babies sleeping with parents: case-control study of factors influencing the risk of the sudden infant death syndrome. CESDI SUDI research group. Br. Med. J. 319 (1999) 1457-1461
18. Blair P.S., Platt M.W., Smith I.J., and Fleming P.J. Sudden infant death syndrome and sleeping position in pre-term and low birth weight infants: an opportunity for targeted intervention. Arch. Dis. Child. 91 (2006) 101-106
19. Bou-Flores C., and Hilaire G. 5-Hydroxytryptamine(2A) and 5-hydroxytryptamine(1B) receptors are differently affected by the monoamine oxidase A-deficiency in the Tg8 transgenic mouse. Neurosci. Lett. 296 (2000) 141-144
20. Bou-Flores C., Lajard A.M., Monteau R., De Maeyer E., Seif I., Lanoir J., and Hilaire G. Abnormal phrenic motoneuron activity and morphology in neonatal monoamine oxidase A-deficient transgenic mice: possible role of a serotonin excess. J. Neurosci. 20 (2000) 4646-4656
21. Bradley S.R., Pieribone V.A., Wang W., Severson C.A., Jacobs R.A., and Richerson G.B. Chemosensitive serotonergic neurons are closely associated with large medullary arteries. Nat. Neurosci. 5 (2002) 401-402
22. Bras H., Gaytan S.P., Portalier P., Zanella S., Pasaro R., Coulon P., and Hilaire G. Prenatal activation of 5-HT2A receptor induces expression of 5-HT1B receptor in phrenic motoneurons and alters the organization of their premotor network in newborn mice. Eur. J. Neurosci. 28 (2008) 1097-1107
23. Brooke H., Gibson A., Tappin D., and Brown H. Case-control study of sudden infant death syndrome in Scotland, 1992-1995. Br. Med. J. 314 (1997) 1516-1520
24. Brown J.W., Sirlin E.A., Benoit A.M., Hoffman J.M., and Darnall R.A. Activation of 5-HT1A receptors in medullary raphe disrupts sleep and decreases shivering during cooling in the conscious piglet. Am. J. Physiol. Regul. Integr. Comp. Physiol. 294 (2008) R884-R894
25. Burnet H., Bevengut M., Chakri F., Bou-Flores C., Coulon P., Gaytan S., Pasaro R., and Hilaire G. Altered respiratory activity and respiratory regulations in adult monoamine oxidase A-deficient mice. J. Neurosci. 21 (2001) 5212-5221
26. Butkevich I.P., Khozhai L.I., Mikhailenko V.A., and Otellin V.A. Decreased serotonin level during pregnancy alters morphological and functional characteristics of tonic nociceptive system in juvenile offspring of the rat. Reprod. Biol. Endocrinol. 1 (2003) 96
27. Cann-Moisan C., Girin E., Giroux J.D., Le Bras P., and Caroff J. Changes in cerebrospinal fluid monoamine metabolites, tryptophan, and gamma-aminobutyric acid during the 1st year of life in normal infants. comparison with victims of sudden infant death syndrome. Biol. Neonate 75 (1999) 152-159
28. Cao Y., Matsuyama K., Fujito Y., and Aoki M. Involvement of medullary GABAergic and serotonergic raphe neurons in respiratory control: electrophysiological and immunohistochemical studies in rats. Neurosci. Res. 56 (2006) 322-331
29. Cases O., Seif I., Grimsby J., Gaspar P., Chen K., Pournin S., Muller U., Aguet M., Babinet C., Shih J.C., et al. Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science 268 (1995) 1763-1766
30. Connelly C.A., Ellenberger H.H., and Feldman J.L. Are there serotonergic projections from raphe and retrotrapezoid nuclei to the ventral respiratory group in the rat?. Neurosci. Lett. 105 (1989) 34-40
31. Corcoran A.E., Hodges M.R., Wu Y., Wang W., Wylie C.J., Deneris E.S., and Richerson G.B. Medullary serotonin neurons and central CO(2) chemoreception. Respir. Physiol. Neurobiol. 168 (2009) 49-58
32. Cucchiaro G., and Commons K.G. Alpha 4 nicotinic acetylcholine receptor subunit links cholinergic to brainstem monoaminergic neurotransmission. Synapse 49 (2003) 195-205
33. Dahlstrom A., and Fuxe K. Localization of monoamines in the lower brain stem. Experientia 20 (1964) 398-399
34. Darnall R.A., Harris M.B., Gill W.H., Hoffman J.M., Brown J.W., and Niblock M.M. Inhibition of serotonergic neurons in the nucleus paragigantocellularis lateralis fragments sleep and decreases rapid eye movement sleep in the piglet: implications for sudden infant death syndrome. J. Neurosci. 25 (2005) 8322-8332
35. Dergacheva O., Kamendi H., Wang X., Pinol R.M., Frank J., Jameson H., Gorini C., and Mendelowitz D. The role of 5-HT3 and other excitatory receptors in central cardiorespiratory responses to hypoxia: implications for sudden infant death syndrome. Pediatr. Res. 65 (2009) 625-630
36. Di Pasquale E., Morin D., Monteau R., and Hilaire G. Serotonergic modulation of the respiratory rhythm generator at birth: an in vitro study in the rat. Neurosci. Lett. 143 (1992) 91-95
37. Dillon K.A., Gross-Isseroff R., Israeli M., and Biegon A. Autoradiographic analysis of serotonin 5-HT1A receptor binding in the human brain postmortem: effects of age and alcohol. Brain Res. 554 (1991) 56-64
38. Druse M.J., and Paul L.H. Effects of in utero ethanol exposure on serotonin uptake in cortical regions. Alcohol 5 (1988) 455-459
39. Druse M.J., Tajuddin N.F., Gillespie R.A., Dickson E., Atieh M., Pietrzak C.A., and Le P.T. The serotonin-1A agonist ipsapirone prevents ethanol-associated death of total rhombencephalic neurons and prevents the reduction of fetal serotonin neurons. Brain Res. Dev. 150 (2004) 79-88
40. Duncan J.R., Paterson D.S., and Kinney H.C. The development of nicotinic receptors in the human medulla oblongata: inter-relationship with the serotonergic system. Auton. Neurosci. 144 (2008) 61-75
41. Duncan J.R., Randall L.L., Belliveau R.A., Trachtenberg F.L., Randall B., Habbe D., Mandell F., Welty T.K., Iyasu S., and Kinney H.C. The effect of maternal smoking and drinking during pregnancy upon (3)H-nicotine receptor brainstem binding in infants dying of the sudden infant death syndrome: initial observations in a high risk population. Brain Pathol. 18 (2008) 21-31
42. Emery M.J., Hlastala M.P., and Matsumoto A.M. Depression of hypercapnic ventilatory drive by testosterone in the sleeping infant primate. J. Appl. Physiol. 76 (1994) 1786-1793
43. Emery M.J., Krous H.F., Nadeau-Manning J.M., Marck B.T., and Matsumoto A.M. Serum testosterone and estradiol in sudden infant death. J. Pediatr. 147 (2005) 586-591
44. Erickson J.T., Shafer G., Rossetti M.D., Wilson C.G., and Deneris E.S. Arrest of 5HT neuron differentiation delays respiratory maturation and impairs neonatal homeostatic responses to environmental challenges. Respir. Physiol. Neurobiol. 159 (2007) 85-101
45. Faber K.M., and Haring J.H. Synaptogenesis in the postnatal rat fascia dentata is influenced by 5-HT1a receptor activation. Brain Res. Dev. 114 (1999) 245-252
46. Feldman J.L., Mitchell G.S., and Nattie E.E. Breathing: rhythmicity, plasticity, chemosensitivity. Annu. Rev. Neurosci. 26 (2003) 239-266
47. Ferrari P.F., Lowther S., Tidbury H., Greengrass P., Wilson C.A., and Horton R.W. The influence of gender and age on neonatal rat hypothalamic 5-HT1A and 5-HT2A receptors. Cell. Mol. Neurobiol. 19 (1999) 775-784
48. Filiano J.J., Choi J.C., and Kinney H.C. Candidate cell populations for respiratory chemosensitive fields in the human infant medulla. J. Comp. Neurol. 293 (1990) 448-465
49. Filiano J.J., and Kinney H.C. A perspective on neuropathologic findings in victims of the sudden infant death syndrome: the triple-risk model. Biol. Neonate 65 (1994) 194-197
50. Filonzi L., Magnani C., Lavezzi A.M., Rindi G., Parmigiani S., Bevilacqua G., Matturri L., and Marzano F.N. Association of dopamine transporter and monoamine oxidase molecular polymorphisms with sudden infant death syndrome and stillbirth: new insights into the serotonin hypothesis. Neurogenetics 10 (2009) 65-72
51. Fleming P.J., Blair P.S., Bacon C., Bensley D., Smith I., Taylor E., Berry J., Golding J., and Tripp J. Environment of infants during sleep and risk of the sudden infant death syndrome: results of 1993-1995 case-control study for confidential inquiry into stillbirths and deaths in infancy. Confidential Enquiry into Stillbirths and Deaths Regional Coordinators and Researchers. Br. Med. J. 313 (1996) 191-195
52. Fleming P.J., Gilbert R., Azaz Y., Berry P.J., Rudd P.T., Stewart A., and Hall E. Interaction between bedding and sleeping position in the sudden infant death syndrome: a population based case-control study [see comments]. Br. Med. J. 301 (1990) 85-89
53. Fogel R.B., Malhotra A., Pillar G., Edwards J.K., Beauregard J., Shea S.A., and White D.P. Genioglossal activation in patients with obstructive sleep apnea versus control subjects. Mechanisms of muscle control. Am. J. Respir. Crit. Care Med. 164 (2001) 2025-2030
54. Forest M.G., de Peretti E., and Bertrand J. Testicular and adrenal androgens and their binding to plasma proteins in the perinatal period: developmental patterns of plasma testosterone, 4-androstenedione, dehydroepiandrosterone and its sulfate in premature and small for date infants as compared with that of full-term infants. J. Steroid Biochem. 12 (1980) 25-36
55. Froggatt P., Lynas M.A., and Marshall T.K. Sudden death in babies: epidemiology. Am. J. Cardiol. 22 (1968) 457-468
56. Fuller D.D., Zabka A.G., Baker T.L., and Mitchell G.S. Phrenic long-term facilitation requires 5-HT receptor activation during but not following episodic hypoxia. J. Appl. Physiol. 90 (2001) 2001-2006 (discussion 2000)
57. Gaspar P., Cases O., and Maroteaux L. The developmental role of serotonin: news from mouse molecular genetics. Nat. Rev. Neurosci. 4 (2003) 1002-1012
58. Greenberg B.D., Tolliver T.J., Huang S.J., Li Q., Bengel D., and Murphy D.L. Genetic variation in the serotonin transporter promoter region affects serotonin uptake in human blood platelets. Am. J. Med. Genet. 88 (1999) 83-87
59. Gunther S., Maroteaux L., and Schwarzacher S.W. Endogenous 5-HT2B receptor activation regulates neonatal respiratory activity in vitro. J. Neurobiol. 66 (2006) 949-961
60. Guyenet P.G., Bayliss D.A., Mulkey D.K., Stornetta R.L., Moreira T.S., and Takakura A.T. The retrotrapezoid nucleus and central chemoreception. Adv. Exp. Med. Biol. 605 (2008) 327-332
61. Guyenet P.G., Bayliss D.A., Stornetta R.L., Fortuna M.G., Abbott S.B.G., and DePuy S.D. Retrotrapezoid nucleus, respiratory chemosensitivity and breathing automaticity. Respir. Physiol. Neurobiol. 168 (2009) 59-68
62. Haglund B. Cigarette smoking and sudden infant death syndrome: some salient points in the debate. Acta Paediatr. Suppl. 82 Suppl. 389 (1993) 37-39
63. Hauck F.R., Herman S.M., Donovan M., Iyasu S., Merrick Moore C., Donoghue E., Kirschner R.H., and Willinger M. Sleep environment and the risk of sudden infant death syndrome in an urban population: the Chicago Infant Mortality Study. Pediatrics 111 (2003) 1207-1214
64. Haydon P.G., McCobb D.P., and Kater S.B. The regulation of neurite outgrowth, growth cone motility, and electrical synaptogenesis by serotonin. J. Neurobiol. 18 (1987) 197-215
65. Heils A., Mossner R., and Lesch K.P. The human serotonin transporter gene polymorphism-basic research and clinical implications. J. Neural Transm. 104 (1997) 1005-1014
66. Hendricks T., Francis N., Fyodorov D., and Deneris E.S. The ETS domain factor Pet-1 is an early and precise marker of central serotonin neurons and interacts with a conserved element in serotonergic genes. J. Neurosci. 19 (1999) 10348-10356
67. Hendricks T.J., Fyodorov D.V., Wegman L.J., Lelutiu N.B., Pehek E.A., Yamamoto B., Silver J., Weeber E.J., Sweatt J.D., and Deneris E.S. Pet-1 ETS gene plays a critical role in 5-HT neuron development and is required for normal anxiety-like and aggressive behavior. Neuron 37 (2003) 233-247
68. Hilaire G., Morin D., Lajard A.M., and Monteau R. Changes in serotonin metabolism may elicit obstructive apnoea in the newborn rat. J. Physiol. 466 (1993) 367-381
69. Hodges M.R., and Richerson G.B. Contributions of 5-HT neurons to respiratory control: neuromodulatory and trophic effects. Respir. Physiol. Neurobiol. 164 (2008) 222-232
70. Hodges M.R., Tattersall G.J., Harris M.B., McEvoy S.D., Richerson D.N., Deneris E.S., Johnson R.L., Chen Z.F., and Richerson G.B. Defects in breathing and thermoregulation in mice with near-complete absence of central serotonin neurons. J. Neurosci. 28 (2008) 2495-2505
71. Hoffman H.J., and Hillman L.S. Epidemiology of the sudden infant death syndrome: maternal, neonatal, and postneonatal risk factors. Clin. Perinatol. 19 (1992) 717-737
72. Hoffman J.M., Brown J.W., Sirlin E.A., Benoit A.M., Gill W.H., Harris M.B., and Darnall R.A. Activation of 5-HT1A receptors in the paragigantocellularis lateralis decreases shivering during cooling in the conscious piglet. Am. J. Physiol. Regul. Integr. Comp. Physiol. 293 (2007) R518-R527
73. Holtman Jr. J.R. Immunohistochemical localization of serotonin- and substance P-containing fibers around respiratory muscle motoneurons in the nucleus ambiguus of the cat. Neuroscience 26 (1988) 169-178
74. Holtman Jr. J.R., Dick T.E., and Berger A.J. Involvement of serotonin in the excitation of phrenic motoneurons evoked by stimulation of the raphe obscurus. J. Neurosci. 6 (1986) 1185-1193
75. Holtman Jr. J.R., Dick T.E., and Berger A.J. Serotonin-mediated excitation of recurrent laryngeal and phrenic motoneurons evoked by stimulation of the raphe obscurus. Brain Res. 417 (1987) 12-20
76. Holtman Jr. J.R., and King K.A. Effect of activation of 5-HT1A receptors at the ventral medulla on phrenic nerve activity. Eur. J. Pharmacol. 253 (1994) 307-310
77. Hornung J.P. The human raphe nuclei and the serotonergic system. J. Chem. Neuroanat. 26 (2003) 331-343
78. Hunt C.E. Abnormal hypercarbic and hypoxic sleep arousal responses in Near-Miss SIDS infants. Pediatr. Res. 15 (1981) 1462-1464
79. Hunt C.E., McCulloch K., and Brouillette R.T. Diminished hypoxic ventilatory responses in near-miss sudden infant death syndrome. J. Appl. Physiol.: Respir. Environ. Exercise Physiol. 50 (1981) 1313-1317
80. Ivgy-May N., Tamir H., and Gershon M.D. Synaptic properties of serotonergic growth cones in developing rat brain. J. Neurosci. 14 (1994) 1011-1029
81. Iyasu S., Randall L.L., Welty T.K., Hsia J., Kinney H.C., Mandell F., McClain M., Randall B., Habbe D., Wilson H., and Willinger M. Risk factors for sudden infant death syndrome among northern plains Indians. JAMA 288 (2002) 2717-2723
82. Iyo A.H., Porter B., Deneris E.S., and Austin M.C. Regional distribution and cellular localization of the ETS-domain transcription factor, FEV, mRNA in the human postmortem brain. Synapse 57 (2005) 223-228
83. Jacobs B.L., and Azmitia E.C. Structure and function of the brain serotonin system. Physiol. Rev. 72 (1992) 165-229
84. Johns J.M., Lubin D.A., Lieberman J.A., and Lauder J.M. Developmental effects of prenatal cocaine exposure on 5-HT1A receptors in male and female rat offspring. Dev. Neurosci. 24 (2002) 522-530
85. Kamendi H.W., Cheng Q., Dergacheva O., Gorini C., Jameson H.S., Wang X., McIntosh J.M., and Mendelowitz D. Abolishment of serotonergic neurotransmission to cardiac vagal neurons during and after hypoxia and hypercapnia with prenatal nicotine exposure. J. Neurophysiol. 101 (2009) 1141-1150
86. Kelly D.H., and Shannon D.C. Periodic breathing in infants with near-miss sudden infant death syndrome. Pediatrics 63 (1979) 355-360
87. Kenny P.J., File S.E., and Rattray M. Nicotine regulates 5-HT(1A) receptor gene expression in the cerebral cortex and dorsal hippocampus. Eur. J. Neurosci. 13 (2001) 1267-1271
88. Kim J.A., and Druse M.J. Protective effects of maternal buspirone treatment on serotonin reuptake sites in ethanol-exposed offspring. Brain Res. Dev. 92 (1996) 190-198
89. King J.A., Davila-Garcia M., Azmitia E.C., and Strand F.L. Differential effects of prenatal and postnatal ACTH or nicotine exposure on 5-HT high affinity uptake in the neonatal rat brain. Int. J. Dev. Neurosci. 9 (1991) 281-286
90. Kinney H.C., Belliveau R.A., Trachtenberg F.L., Rava L.A., and Paterson D.S. The development of the medullary serotonergic system in early human life. Auton. Neurosci. 132 (2007) 81-102
91. Kinney H.C., Myers M.M., Belliveau R.A., Randall L.L., Trachtenberg F.L., Fingers S.T., Youngman M., Habbe D., and Fifer W.P. Subtle autonomic and respiratory dysfunction in sudden infant death syndrome associated with serotonergic brainstem abnormalities: a case report. J. Neuropathol. Exp. Neurol. 64 (2005) 689-694
92. Kinney H.C., and Paterson D.S. Sudden infant death syndrome. In: Golden J., and Harding B. (Eds). Pathology and Genetics: Developmental Neuropathology (2004), Neuropath Press, Basel
93. Kinney H.C., Randall L.L., Sleeper L.A., Willinger M., Belliveau R.A., Zec N., Rava L.A., Dominici L., Iyasu S., Randall B., Habbe D., Wilson H., Mandell F., McClain M., and Welty T.K. Serotonergic brainstem abnormalities in northern plains Indians with the sudden infant death syndrome. J. Neuropathol. Exp. Neurol. 62 (2003) 1178-1191
94. Klug M.G., Burd L., Kerbeshian J., Benz B., and Martsolf J.T. A comparison of the effects of parental risk markers on pre- and perinatal variables in multiple patient cohorts with fetal alcohol syndrome, autism, Tourette syndrome, and sudden infant death syndrome: an enviromic analysis. Neurotoxicol. Teratol. 25 (2003) 707-717
95. Kondoh M., Shiga T., and Okado N. Regulation of dendrite formation of Purkinje cells by serotonin through serotonin1A and serotonin2A receptors in culture. Neurosci. Res. 48 (2004) 101-109
96. Lajard A.M., Bou C., Monteau R., and Hilaire G. Serotonin levels are abnormally elevated in the fetus of the monoamine oxidase-A-deficient transgenic mouse. Neurosci. Lett. 261 (1999) 41-44
97. Lalley P.M., Bischoff A.M., and Richter D.W. 5-HT-1A receptor-mediated modulation of medullary expiratory neurones in the cat. J. Physiol. 476 (1994) 117-130
98. Lalley P.M., Bischoff A.M., Schwarzacher S.W., and Richter D.W. 5-HT2 receptor-controlled modulation of medullary respiratory neurones in the cat. J. Physiol. 487 Pt 3 (1995) 653-661
99. Lauder J.M. Neurotransmitters as morphogens. Prog. Brain Res. 73 (1988) 365-387
100. Lauder J.M. Ontogeny of the serotonergic system in the rat: serotonin as a developmental signal. Ann. NY Acad. Sci. 600 (1990) 297-313 (discussion 314)
101. Lavezzi, A.M., Casale, V., Oneda, R., Weese-Mayer, D.E., Matturri, L., 2009. Sudden infant death syndrome and sudden intrauterine unexplained death: correlation between hypoplasia of raphe nuclei and serotonin transporter gene promoter polymorphism. Pediatr. Res.
102. Lephart E.D., Lund T.D., and Horvath T.L. Brain androgen and progesterone metabolizing enzymes: biosynthesis, distribution and function. Brain Res. Rev. 37 (2001) 25-37
103. Lesch K.P., and Mossner R. Genetically driven variation in serotonin uptake: is there a link to affective spectrum, neurodevelopmental, and neurodegenerative disorders?. Biol. Psychiatry 44 (1998) 179-192
104. Li A., and Nattie E. Serotonin transporter knockout mice have a reduced ventilatory response to hypercapnia (predominantly in males) but not to hypoxia. J. Physiol. 586 (2008) 2321-2329
105. Liu P.Y., Yee B., Wishart S.M., Jimenez M., Jung D.G., Grunstein R.R., and Handelsman D.J. The short-term effects of high-dose testosterone on sleep, breathing, and function in older men. J. Clin. Endocrinol. Metab. 88 (2003) 3605-3613
106. Liu Q., and Wong-Riley M.T. Postnatal developmental expressions of neurotransmitters and receptors in various brain stem nuclei of rats. J. Appl. Physiol. 98 (2005) 1442-1457
107. Luo X., Persico A.M., and Lauder J.M. Serotonergic regulation of somatosensory cortical development: lessons from genetic mouse models. Dev. Neurosci. 25 (2003) 173-183
108. MacDorman M.F., Cnattingius S., Hoffman H.J., Kramer M.S., and Haglund B. Sudden infant death syndrome and smoking in the United States and Sweden. Am. J. Epidemiol. 146 (1997) 249-257
109. Machaalani R., Say M., and Waters K.A. Serotoninergic receptor 1A in the sudden infant death syndrome brainstem medulla and associations with clinical risk factors. Acta Neuropathol. 117 (2009) 257-265
110. Mahamed S., and Mitchell G.S. Is there a link between intermittent hypoxia-induced respiratory plasticity and obstructive sleep apnoea?. Exp. Physiol. 92 (2007) 27-37
111. Mahamed S., and Mitchell G.S. Simulated apnoeas induce serotonin-dependent respiratory long-term facilitation in rats. J. Physiol. 586 (2008) 2171-2181
112. Maher B.S., Marazita M.L., Rand C., Zhou L., Berry-Kravis E.M., and Weese-Mayer D.E. 3′ UTR polymorphism of the serotonin transporter gene and sudden infant death syndrome: haplotype analysis. Am. J. Med. Genet. A 140 (2006) 1453-1457
113. Manaker S., and Tischler L.J. Origin of serotoninergic afferents to the hypoglossal nucleus in the rat. J. Comp. Neurol. 334 (1993) 466-476
114. Manzke T., Guenther U., Ponimaskin E.G., Haller M., Dutschmann M., Schwarzacher S., and Richter D.W. 5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia. Science 301 (2003) 226-229
115. Manzke T., Preusse S., Hulsmann S., and Richter D.W. Developmental changes of serotonin 4(a) receptor expression in the rat pre-Botzinger complex. J. Comp. Neurol. 506 (2008) 775-790
116. Mathews, T.J., MacDorman, M.F., Menaker, F., 2002. Infant mortality statistics form the 1999 period linked birth/infant death data set. National Center for Health Statistics, Hyattsville, MD. http://www.cdc.gov/nchs/.
117. Matsumoto A.M., Sandblom R.E., Schoene R.B., Lee K.A., Giblin E.C., Pierson D.J., and Bremner W.J. Testosterone replacement in hypogonadal men: effects on obstructive sleep apnoea, respiratory drives, and sleep. Clin. Endocrinol. (Oxf.) 22 (1985) 713-721
118. Maurer P., Rorive S., de Kerchove d'Exaerde A., Schiffmann S.N., Salmon I., and de Launoit Y. The Ets transcription factor Fev is specifically expressed in the human central serotonergic neurons. Neurosci. Lett. 357 (2004) 215-218
119. Mazer C., Muneyyirci J., Taheny K., Raio N., Borella A., and Whitaker-Azmitia P. Serotonin depletion during synaptogenesis leads to decreased synaptic density and learning deficits in the adult rat: a possible model of neurodevelopmental disorders with cognitive deficits. Brain Res. 760 (1997) 68-73
120. McKay L.C., Janczewski W.A., and Feldman J.L. Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons. Nat. Neurosci. 8 (2005) 1142-1144
121. 2 response in newborn piglets. J. Appl. Physiol. 96 (2004) 1909-1919
122. Millar W.J., and Hill G.B. Prevalence of and risk factors for sudden infant death syndrome in Canada. CMAJ 149 (1993) 629-635
123. Millhorn D.E., and Eldridge F.L. Role of ventrolateral medulla in regulation of respiratory and cardiovascular systems. J. Appl. Physiol. 61 (1986) 1249-1263
124. Mitchell E.A. Sudden infant death syndrome: should bed sharing be discouraged?. Arch. Pediatr. Adolesc. Med. 161 (2007) 305-306
125. Mitchell E.A., and Milerad J. Smoking and the sudden infant death syndrome. Rev. Environ. Health 21 (2006) 81-103
126. Mitchell G.S., Baker T.L., Nanda S.A., Fuller D.D., Zabka A.G., Hodgeman B.A., Bavis R.W., Mack K.J., and Olson Jr. E.B. Invited review: intermittent hypoxia and respiratory plasticity. J. Appl. Physiol. 90 (2001) 2466-2475
127. Morin D., Hennequin S., Monteau R., and Hilaire G. Depressant effect of raphe stimulation on inspiratory activity of the hypoglossal nerve: in vitro study in the newborn rat. Neurosci. Lett. 116 (1990) 299-303
128. Morin D., Monteau R., and Hilaire G. 5-Hydroxytryptamine modulates central respiratory activity in the newborn rat: an in vitro study. Eur. J. Pharmacol. 192 (1991) 89-95
129. Morin D., Monteau R., and Hilaire G. Serotonin and cervical respiratory motoneurones: intracellular study in the newborn rat brainstem-spinal cord preparation. Exp. Brain Res. 84 (1991) 229-232
130. Morley M.E., Rand C.M., Berry-Kravis E.M., Zhou L., Fan W., and Weese-Mayer D.E. Genetic variation in the HTR1A gene and sudden infant death syndrome. Am. J. Med. Genet. A 146 (2008) 930-933
131. Mulkey D.K., Rosin D.L., West G., Takakura A.C., Moreira T.S., Bayliss D.A., and Guyenet P.G. Serotonergic neurons activate chemosensitive retrotrapezoid nucleus neurons by a pH-independent mechanism. J. Neurosci. 27 (2007) 14128-14138
132. Mulkey D.K., Stornetta R.L., Weston M.C., Simmons J.R., Parker A., Bayliss D.A., and Guyenet P.G. Respiratory control by ventral surface chemoreceptor neurons in rats. Nat. Neurosci. 7 (2004) 1360-1369
133. Muneoka K., Ogawa T., Kamei K., Mimura Y., Kato H., and Takigawa M. Nicotine exposure during pregnancy is a factor which influences serotonin transporter density in the rat brain. Eur. J. Pharmacol. 411 (2001) 279-282
134. Muneoka K., Ogawa T., Kamei K., Muraoka S., Tomiyoshi R., Mimura Y., Kato H., Suzuki M.R., and Takigawa M. Prenatal nicotine exposure affects the development of the central serotonergic system as well as the dopaminergic system in rat offspring: involvement of route of drug administrations. Brain Res. Dev. 102 (1997) 117-126
135. Nakajima K., Matsuyama K., and Mori S. Prenatal administration of para-chlorophenylalanine results in suppression of serotonergic system and disturbance of swimming movements in newborn rats. Neurosci. Res. 31 (1998) 155-169
136. Nakamura K., and Hasegawa H. Developmental role of tryptophan hydroxylase in the nervous system. Mol. Neurobiol. 35 (2007) 45-54
137. Narita N., Narita M., Takashima S., Nakayama M., Nagai T., and Okado N. Serotonin transporter gene variation is a risk factor for sudden infant death syndrome in the Japanese population. Pediatrics 107 (2001) 690-692
138. Nattie E.E., Li A., Richerson G., and Lappi D.A. Medullary serotonergic neurones and adjacent neurones that express neurokinin-1 receptors are both involved in chemoreception in vivo. J. Physiol. 556 (2004) 235-253
139. Nonnis Marzano F., Maldini M., Filonzi L., Lavezzi A.M., Parmigiani S., Magnani C., Bevilacqua G., and Matturri L. Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome. Genomics 91 (2008) 485-491
140. O'Mara L. Review: bed sharing between parents and infants exposed to smoke may increase the risk of sudden infant death syndrome. Evid. Based Nurs. 10 (2007) 119
141. Ogilvie A.D., Battersby S., Bubb V.J., Fink G., Harmar A.J., Goodwim G.M., and Smith C.A. Polymorphism in serotonin transporter gene associated with susceptibility to major depression. Lancet 347 (1996) 731-733
142. Onimaru H., Shamoto A., and Homma I. Modulation of respiratory rhythm by 5-HT in the brainstem-spinal cord preparation from newborn rat. Pflugers Arch. 435 (1998) 485-494
143. Onimaru H., Ikeda K., and Kawakami K. Phox2b, RTN/pFRG neurons and respiratory rhythmogenesis. Respir. Physiol. Neurobiol. 168 (2009) 13-18
144. Opdal S.H., Vege A., and Rognum T.O. Serotonin transporter gene variation in sudden infant death syndrome. Acta Paediatr. 97 (2008) 861-865
145. Ozawa Y., and Okado N. Alteration of serotonergic receptors in the brain stems of human patients with respiratory disorders. Neuropediatrics 33 (2002) 142-149
146. Ozawa Y., and Takashima S. Developmental neurotransmitter pathology in the brainstem of sudden infant death syndrome: a review and sleep position. Forensic Sci. Int. 130 Suppl. (2002) S53-S59
147. Panigrahy A., Filiano J., Sleeper L.A., Mandell F., Valdes-Dapena M., Krous H.F., Rava L.A., Foley E., White W.F., and Kinney H.C. Decreased serotonergic receptor binding in rhombic lip-derived regions of the medulla oblongata in the sudden infant death syndrome. J. Neuropathol. Exp. Neurol. 59 (2000) 377-384
148. Parsey R.V., Oquendo M.A., Simpson N.R., Ogden R.T., Van Heertum R., Arango V., and Mann J.J. Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635. Brain Res. 954 (2002) 173-182
149. Paterson D.S., Belliveau R.A., Trachtenberg F., and Kinney H.C. Differential development of 5-HT receptor and the serotonin transporter binding in the human infant medulla. J. Comp. Neurol. 472 (2004) 221-231
150. Paterson D.S., and Darnall R. 5-HT2A receptors are concentrated in regions of the human infant medulla involved in respiratory and autonomic control. Auton. Neurosci. 147 (2009) 48-55
151. Paterson D.S., Thompson E.G., and Kinney H.C. Serotonergic and glutamatergic neurons at the ventral medullary surface of the human infant: Observations relevant to central chemosensitivity in early human life. Auton. Neurosci. 124 (2006) 112-124
152. Paterson D.S., Trachtenberg F.L., Thompson E.G., Belliveau R.A., Beggs A.H., Darnall R., Chadwick A.E., Krous H.F., and Kinney H.C. Multiple serotonergic brainstem abnormalities in sudden infant death syndrome. JAMA 296 (2006) 2124-2132
153. Pelayo R., Owens J., Mindell J., and Sheldon S. Bed sharing with unimpaired parents is not an important risk for sudden infant death syndrome: to the editor. Pediatrics 117 (2006) 993-994 (author reply 994-996)
154. Pena F., and Ramirez J.M. Endogenous activation of serotonin-2A receptors is required for respiratory rhythm generation in vitro. J. Neurosci. 22 (2002) 11055-11064
155. Penatti E.M., Berniker A.V., Kereshi B., Cafaro C., Kelly M.L., Niblock M.M., Gao H.G., Kinney H.C., Li A., and Nattie E.E. Ventilatory response to hypercapnia and hypoxia after extensive lesion of medullary serotonergic neurons in newborn conscious piglets. J. Appl. Physiol. 101 (2006) 1177-1188
156. Peterson B.A., and Kennedy B.J. Aging and cancer management. Part I: Clinical observations. CA Cancer J. Clin. 29 (1979) 322-332
157. Pfaar H., von Holst A., Vogt Weisenhorn D.M., Brodski C., Guimera J., and Wurst W. mPet-1, a mouse ETS-domain transcription factor, is expressed in central serotonergic neurons. Dev. Genes Evol. 212 (2002) 43-46
158. Pickett C.K., Regensteiner J.G., Woodard W.D., Hagerman D.D., Weil J.V., and Moore L.G. Progestin and estrogen reduce sleep-disordered breathing in postmenopausal women. J. Appl. Physiol. 66 (1989) 1656-1661
159. Pilowsky P.M., de Castro D., Llewellyn-Smith I., Lipski J., and Voss M.D. Serotonin immunoreactive boutons make synapses with feline phrenic motoneurons. J. Neurosci. 10 (1990) 1091-1098
160. Popa D., Lena C., Fabre V., Prenat C., Gingrich J., Escourrou P., Hamon M., and Adrien J. Contribution of 5-HT2 receptor subtypes to sleep-wakefulness and respiratory control, and functional adaptations in knock-out mice lacking 5-HT2A receptors. J. Neurosci. 25 (2005) 11231-11238
161. Ptak K., Burnet H., Blanchi B., Sieweke M., De Felipe C., Hunt S.P., Monteau R., and Hilaire G. The murine neurokinin NK1 receptor gene contributes to the adult hypoxic facilitation of ventilation. Eur. J. Neurosci. 16 (2002) 2245-2252
162. Ptak K., Yamanishi T., Aungst J., Milescu L.S., Zhang R., Richerson G.B., and Smith J.C. Raphe neurons stimulate respiratory circuit activity by multiple mechanisms via endogenously released serotonin and substance P. J. Neurosci. 29 (2009) 3720-3737
163. Qin Z., Wu Z.H., and Wang X.F. 5-HT(1A) receptors are involved in the modulation of respiratory rhythmical discharge activity in the medulla oblongata slice preparation of neonatal rats. Sheng Li Xue Bao 59 (2007) 293-298
164. Rand C.M., Berry-Kravis E.M., Fan W., and Weese-Mayer D.E. HTR2A variation and sudden infant death syndrome: a case-control analysis. Acta Paediatr. 98 (2009) 58-61
165. Rand C.M., Berry-Kravis E.M., Zhou L., Fan W., and Weese-Mayer D.E. Sudden infant death syndrome: rare mutation in the serotonin system FEV gene. Pediatr. Res. 62 (2007) 180-182
166. Real C., Popa D., Seif I., Callebert J., Launay J.M., Adrien J., and Escourrou P. Sleep apneas are increased in mice lacking monoamine oxidase A. Sleep 30 (2007) 1295-1302
167. Regensteiner J.G., McCullough R.G., McCullough R.E., Pickett C.K., and Moore L.G. Combined effects of female hormones and exercise on hypoxic ventilatory response. Respir. Physiol. 82 (1990) 107-114
168. Richerson G.B. Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis. Nat. Rev. Neurosci. 5 (2004) 449-461
169. Richerson G.B., Wang W., Tiwari J., and Bradley S.R. Chemosensitivity of serotonergic neurons in the rostral ventral medulla. Respir. Physiol. 129 (2001) 175-189
170. Richter D.W., Schmidt-Garcon P., Pierrefiche O., Bischoff A.M., and Lalley P.M. Neurotransmitters and neuromodulators controlling the hypoxic respiratory response in anaesthetized cats [see comments]. J. Physiol. 514 (1999) 567-578
171. Sari Y., Powrozek T., and Zhou F.C. Alcohol deters the outgrowth of serotonergic neurons at midgestation. J. Biomed. Sci. 8 (2001) 119-125
172. Sawaguchi T., Patricia F., Kadhim H., Groswasser J., Sottiaux M., Nishida H., and Kahn A. The correlation between serotonergic neurons in the brainstem and sleep apnea in SIDS victims. Early Hum. Dev. 75 Suppl (2003) S31-40
173. Schoendorf K.C., and Kiely J.L. Relationship of sudden infant death syndrome to maternal smoking during and after pregnancy. Pediatrics 90 (1992) 905-908
174. Schwarzacher S.W., Pestean A., Gunther S., and Ballanyi K. Serotonergic modulation of respiratory motoneurons and interneurons in brainstem slices of perinatal rats. Neuroscience 115 (2002) 1247-1259
175. Scragg R., Mitchell E.A., Taylor B.J., Stewart A.W., Ford R.P., Thompson J.M., Allen E.M., and Becroft D.M. Bed sharing, smoking, and alcohol in the sudden infant death syndrome. New Zealand Cot Death Study Group. Br. Med. J. 307 (1993) 1312-1318
176. Shannon D.C., Kelly D.H., and O'Connell K. Abnormal regulation of ventilation in infants at risk for sudden-infant-death syndrome. New Engl. J. Med. 297 (1977) 747-750
177. Slotkin T.A., MacKillop E.A., Rudder C.L., Ryde I.T., Tate C.A., and Seidler F.J. Permanent, sex-selective effects of prenatal or adolescent nicotine exposure, separately or sequentially, in rat brain regions: indices of cholinergic and serotonergic synaptic function, cell signaling, and neural cell number and size at 6 months of age. Neuropsychopharmacology 32 (2007) 1082-1097
178. Slotkin T.A., Pinkerton K.E., and Seidler F.J. Perinatal environmental tobacco smoke exposure in rhesus monkeys: critical periods and regional selectivity for effects on brain cell development and lipid peroxidation. Environ. Health Perspect. 114 (2006) 34-39
179. Slotkin T.A., Ryde I.T., Tate C.A., and Seidler F.J. Lasting effects of nicotine treatment and withdrawal on serotonergic systems and cell signaling in rat brain regions: separate or sequential exposure during fetal development and adulthood. Brain Res. Bull. 73 (2007) 259-272
180. Slotkin T.A., and Seidler F.J. Cholinergic receptor subtypes in the olfactory bulbectomy model of depression. Brain Res. Bull. 68 (2006) 341-345
181. Slotkin T.A., Tate C.A., Cousins M.M., and Seidler F.J. Prenatal nicotine exposure alters the responses to subsequent nicotine administration and withdrawal in adolescence: serotonin receptors and cell signaling. Neuropsychopharmacology 31 (2006) 2462-2475
182. Smith J.C., Morrison D.E., Ellenberger H.H., Otto M.R., and Feldman J.L. Brainstem projections to the major respiratory neuron populations in the medulla of the cat. J. Comp. Neurol. 281 (1989) 69-96
183. Sparks D.L., and Hunsaker J.C.d. Sudden infant death syndrome: altered aminergic-cholinergic synaptic markers in hypothalamus. J. Child Neurol. 6 (1991) 335-339
184. St-John W.M., and Leiter J.C. Maintenance of gasping and restoration of eupnea after hypoxia is impaired following blockers of alpha1-adrenergic receptors and serotonin 5-HT2 receptors. J. Appl. Physiol. 104 (2008) 665-673
185. Steinbusch H.W. Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience 6 (1981) 557-618
186. Steinbusch H.W., Verhofstad A.A., Penke B., Varga J., and Joosten H.W. Immunohistochemical characterization of monoamine-containing neurons in the central nervous system by antibodies to serotonin and noradrenalin. A study in the rat and the lamprey (Lampetra fluviatilis). Acta Histochem. Suppl. 24 (1981) 107-122
187. Steinschneider A. Prolonged sleep apnea and respiratory instability: a discriminative study. Pediatrics 59 Suppl. (1977) 962-970
188. Stewart A.M. Infant leukaemias and cot deaths. Br. Med. J. 2 (1975) 605-607
189. Stewart A.M. Cot deaths. Nurs. Mirror Midwives J. 141 (1975) 57-58
190. Stoffel-Wagner B. Neurosteroid metabolism in the human brain. Eur. J. Endocrinol. 145 (2001) 669-679
191. Tapanainen J., Kellokumpu-Lehtinen P., Pelliniemi L., and Huhtaniemi I. Age-related changes in endogenous steroids of human fetal testis during early and midpregnancy. J. Clin. Endocrinol. Metab. 52 (1981) 98-102
192. Tappin D., Brooke H., and Ecob R. Bedsharing and sudden infant death syndrome (SIDS) in Scotland, UK. Lancet 363 (2004) 994
193. Tappin D., Ecob R., and Brooke H. Bedsharing, roomsharing, and sudden infant death syndrome in Scotland: a case-control study. J. Pediatr. 147 (2005) 32-37
194. Taylor N.C., Li A., and Nattie E.E. Medullary serotonergic neurones modulate the ventilatory response to hypercapnia, but not hypoxia in conscious rats. J. Physiol. 566 (2005) 543-557
195. Törk I., and Hornung J.-P. Raphe nuclei and the serotonergic system. In: Paxinos G. (Ed). The Human Nervous System (1990), Academic Press, San Diego, CA 1001-1022
196. Tryba A.K., Pena F., and Ramirez J.M. Gasping activity in vitro: a rhythm dependent on 5-HT2A receptors. J. Neurosci. 26 (2006) 2623-2634
197. Valic M., Pecotic R., and Dogas Z. Phrenic nerve activity is enhanced by 5-HT1A receptor agonist 8-OH-DPAT in spontaneously breathing anesthetized rats. J. Physiol. Pharmacol. 59 (2008) 17-25
198. van Dyck C.H., Malison R.T., Staley J.K., Jacobsen L.K., Seibyl J.P., Laruelle M., Baldwin R.M., Innis R.B., and Gelernter J. Central serotonin transporter availability measured with [123I]beta-CIT SPECT in relation to serotonin transporter genotype. Am. J. Psychiatry 161 (2004) 525-531
199. Vennemann M.M., Bajanowski T., Brinkmann B., Jorch G., Sauerland C., and Mitchell E.A. Sleep environment risk factors for sudden infant death syndrome: the German sudden infant death syndrome study. Pediatrics 123 (2009) 1162-1170
200. Vennemann M.M., Findeisen M., Butterfass-Bahloul T., Jorch G., Brinkmann B., Kopcke W., Bajanowski T., and Mitchell E.A. Modifiable risk factors for SIDS in Germany: results of GeSID. Acta Paediatr. 94 (2005) 655-660
201. Voss M.D., De Castro D., Lipski J., Pilowsky P.M., and Jiang C. Serotonin immunoreactive boutons form close appositions with respiratory neurons of the dorsal respiratory group in the cat. J. Comp. Neurol. 295 (1990) 208-218
202. Wang W., Tiwari J.K., Bradley S.R., Zaykin R.V., and Richerson G.B. Acidosis-stimulated neurons of the medullary raphe are serotonergic. J. Neurophysiol. 85 (2001) 2224-2235
203. Weese-Mayer D.E., Berry-Kravis E.M., Maher B.S., Silvestri J.M., Curran M.E., and Marazita M.L. Sudden infant death syndrome: association with a promoter polymorphism of the serotonin transporter gene. Am. J. Med. Genet. 117A (2003) 268-274
204. Weese-Mayer D.E., Zhou L., Berry-Kravis E.M., Maher B.S., Silvestri J.M., and Marazita M.L. Association of the serotonin transporter gene with sudden infant death syndrome: a haplotype analysis. Am. J. Med. Genet. 122A (2003) 238-245
205. Werner M., Hatt H., and Gottmann K. Synapse formation and morphological differentiation of neuron types in embryonic rat dentate gyrus explants in vitro. Brain Res. Dev. 105 (1998) 9-23
206. Weston M.C., Stornetta R.L., and Guyenet P.G. Glutamatergic neuronal projections from the marginal layer of the rostral ventral medulla to the respiratory centers in rats. J. Comp. Neurol. 473 (2004) 73-85
207. Willinger M., James L.S., and Catz C. Defining the sudden infant death syndrome (SIDS): deliberations of an expert panel convened by the National Institute of Child Health and Human Development. Pediatr. Pathol. 11 (1991) 677-684
208. Winter J.S., Hughes I.A., Reyes F.I., and Faiman C. Pituitary-gonadal relations in infancy: 2. Patterns of serum gonadal steroid concentrations in man from birth to two years of age. J. Clin. Endocrinol. Metab. 42 (1976) 679-686
209. Wisborg K., Kesmodel U., Henriksen T.B., Olsen S.F., and Secher N.J. A prospective study of smoking during pregnancy and SIDS. Arch. Dis. Child. 83 (2000) 203-206
210. Wong-Riley M.T., and Liu Q. Neurochemical development of brain stem nuclei involved in the control of respiration. Respir. Physiol. Neurobiol. 149 (2005) 83-98
211. Xu Z., Seidler F.J., Ali S.F., Slikker Jr. W., and Slotkin T.A. Fetal and adolescent nicotine administration: effects on CNS serotonergic systems. Brain Res. 914 (2001) 166-178
212. Zec N., Filiano J.J., and Kinney H.C. Anatomic relationships of the human arcuate nucleus of the medulla: a DiI-labeling study [published erratum appears in J. Neuropathol. Exp. Neurol. 1997 Sep;56(9):1070]. J. Neuropathol. Exp. Neurol. 56 (1997) 509-522
213. Zec N., and Kinney H.C. Anatomic relationships of the human nucleus paragigantocellularis lateralis: a DiI labeling study. Auton. Neurosci. 89 (2001) 110-124
214. Zec N., and Kinney H.C. Anatomic relationships of the human nucleus of the solitary tract in the medulla oblongata: a DiI labeling study. Auton. Neurosci. 105 (2003) 131-144
215. Zhan W.Z., Ellenberger H.H., and Feldman J.L. Monoaminergic and GABAergic terminations in phrenic nucleus of rat identified by immunohistochemical labeling. Neuroscience 31 (1989) 105-113
216. Zhou F.C., Sari Y., Li T.K., Goodlett C., and Azmitia E.C. Deviations in brain early serotonergic development as a result of fetal alcohol exposure. Neurotox. Res. 4 (2002) 337-342
217. Zhou X.S., Rowley J.A., Demirovic F., Diamond M.P., and Badr M.S. Effect of testosterone on the apneic threshold in women during NREM sleep. J. Appl. Physiol. 94 (2003) 101-107