Effects of sex, age, and aggressive traits in man on brain serotonin 5-HT1A receptor binding potential measured by PET using [C-11]WAY-100635

Brain Research

Volumn 954, Issue 2, 2002, Pages 173-182

  Parsey, Ramin V ^a   Oquendo, Maria A ^a   Simpson, Norman R ^a,b   Ogden, R Todd ^a   Van Heertum, Ronald ^a   Arango, Victoria ^a   Mann, J John ^a  

^a Columbia Univ Coll of Phys and Surgs ^*  (United States)

^b NEW YORK STATE PSYCHIATRIC INSTITUTE   (United States)

Author keywords

Cerebellum; Kinetic modeling; Positron emission tomography; Simplified reference tissue

Indexed keywords

N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; SEROTONIN 1A ANTAGONIST; SEROTONIN 1A RECEPTOR;

ADULT; AGE; AGGRESSIVENESS; AMYGDALOID NUCLEUS; ANALYSIS OF VARIANCE; ARTICLE; BINDING AFFINITY; BRAIN SIZE; CADAVER; CINGULATE GYRUS; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE SEVERITY; DORSAL RAPHE NUCLEUS; DRUG RECEPTOR BINDING; FEMALE; HIPPOCAMPUS; HUMAN; HUMAN EXPERIMENT; MALE; NORMAL HUMAN; POSITRON EMISSION TOMOGRAPHY; PREFRONTAL CORTEX; PRIORITY JOURNAL; SEX DIFFERENCE;

ADULT; AGGRESSION; AGING; AMYGDALA; BRAIN; CARBON RADIOISOTOPES; CEREBELLUM; FEMALE; GYRUS CINGULI; HIPPOCAMPUS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MALE; MIDDLE AGED; PIPERAZINES; PREFRONTAL CORTEX; PYRIDINES; RAPHE NUCLEI; RECEPTORS, SEROTONIN; REFERENCE VALUES; SEROTONIN ANTAGONISTS; SEX CHARACTERISTICS; TOMOGRAPHY, EMISSION-COMPUTED;

EID: 0037044881     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-8993(02)03243-2     Document Type: Article

References (50)

1. Abi-Dargham A., Laruelle M., Seibyl J., Rattner Z., Baldwin R.M., Zoghbi S.S., Zea-Ponce Y., Bremner J.D., Hyde T.M., Charney D.S., Hoffer P.B., Innis R.B. SPECT measurement of benzodiazepine receptors in human brain with [123I]iomazenil: kinetic and equilibrium paradigms. J. Nucl. Med. 35:1994;228-238.
2. Abi-Dargham A., Martinez D., Mawlawi O., Simpson N., Hwang D.R., Slifstein M., Anjilvel S., Pidcock J., Guo N.N., Lombardo I., Mann J.J., Van Heertum R., Foged C., Halldin C., Laruelle M. Measurement of striatal and extrastriatal dopamine D1 receptor binding potential with [11C]NNC 112 in humans: validation and reproducibility. J. Cereb. Blood Flow Metab. 20:2000;225-243.
3. Abi-Dargham A., Simpson N., Kegeles L., Parsey R., Hwang D.R., Anjilvel S., Zea-Ponce Y., Lombardo I., Van Heertum R., Mann J.J., Foged C., Halldin C., Laruelle M. PET studies of binding competition between endogenous dopamine and the D1 radiotracer [11C]NNC 756. Synapse. 32:1999;93-109.
4. Arango V., Underwood M.D., Gubbi A.V., Mann J.J. Localized alterations in pre- and postsynaptic serotonin binding sites in the ventrolateral prefrontal cortex of suicide victims. Brain Res. 688:1995;121-133.
5. Biegon A., Fischette C.T., Rainbow T.C., McEwen B.S. Serotonin receptor modulation by estrogen in discrete brain nuclei. Neuroendocrinology. 35:1982;287-291.
6. Biegon A., McEwen B.S. Modulation by estradiol of serotonin receptors in brain. J. Neurosci. 2:1982;199-205.
7. Blier P., Pineyro G., el Mansari M., Bergeron R., de Montigny C. Role of somatodendritic 5-HT autoreceptors in modulating 5-HT neurotransmission. Ann. N. Y. Acad. Sci. 861:1998;204-216.
8. Brown G.L., Goodwin F.K., Ballenger J.C., Goyer P.F., Major L.F. Aggression in human correlates with cerebrospinal fluid amine metabolites. Psychiatry Res. 1:1979;131-139.
9. Cheetham S.C., Crompton M.R., Katona C.L., Horton R.W. Brain 5-HT1 binding sites in depressed suicides. Psychopharmacology (Berl.). 102:1990;544-548.
10. Cidis Meltzer C., Drevets W.C., Price J.C., Mathis C.A., Lopresti B., Greer P.J., Villemagne V.L., Holt D., Mason N.S., Houck P.R., Reynolds III C.F., DeKosky S.T. Gender-specific aging effects on the serotonin 1A receptor. Brain Res. 895:2001;9-17.
11. Cleare A.J., Bond A.J. The effect of tryptophan depletion and enhancement on subjective and behavioural aggression in normal male subjects. Psychopharmacology (Berl.). 118:1995;72-81.
12. Cleare A.J., Bond A.J. Experimental evidence that the aggressive effect of tryptophan depletion is mediated via the 5-HT1A receptor. Psychopharmacology (Berl.). 147:2000;439-441.
13. Cleare A.J., Bond A.J. Ipsapirone challenge in aggressive men shows an inverse correlation between 5-HT1A receptor function and aggression. Psychopharmacology (Berl.). 148:2000;344-349.
14. Coccaro E.F., Gabriel S., Siever L.J. Buspirone challenge: preliminary evidence for a role for central 5-HT1a receptor function in impulsive aggressive behavior in humans. Psychopharmacol. Bull. 26:1990;393-405.
15. Curzon G. 5-Hydroxytryptamine and corticosterone in an animal model of depression. Prog. Neuropsychopharmacol. Biol. Psychiatry. 13:1989;305-310.
16. Duman R.S., Heninger G.R., Nestler E.J. A molecular and cellular theory of depression [see comments]. Arch. Gen. Psychiatry. 54:1997;597-606.
17. Duvernoy H. The Human Brain. Surface, Three-dimensional Sectional Anatomy and Mri. 1991;Springer-Verlag, Vienna, New York.
18. Ebenezer I.S., Tite R. Sex difference in the feeding responses of non-deprived rats to the 5-HT1A agonists 8-OH-DPAT and gepirone. Methods Find. Exp. Clin. Pharmacol. 16:1994;91-96.
19. Fischette C.T., Biegon A., McEwen B.S. Sex differences in serotonin 1 receptor binding in rat brain. Science. 222:1983;333-335.
20. Flugge G., Pfender D., Rudolph S., Jarry H., Fuchs E. 5HT1A-receptor binding in the brain of cyclic and ovariectomized female rats. J. Neuroendocrinol. 11:1999;243-249.
21. Forster E.A., Cliffe I.A., Bill D.J., Dover G.M., Jones D., Reilly Y., Fletcher A. A pharmacological profile of the selective silent 5-HT1A receptor antagonist, WAY-100635. Eur. J. Pharmacol. 281:1995;81-88.
22. Gelfin Y., Lerer B., Lesch K.P., Gorfine M., Allolio B. Complex effects of age and gender on hypothermic, adrenocorticotrophic hormone and cortisol responses to ipsapirone challenge in normal subjects. Psychopharmacology (Berl.). 120:1995;356-364.
23. Gozlan H., Thibault S., Laporte A.M., Lima L., Hamon M. The selective 5-HT1A antagonist radioligand [3H]WAY 100635 labels both G-protein-coupled and free 5-HT1A receptors in rat brain membranes. Eur. J. Pharmacol. 288:1995;173-186.
24. Gunn R.N., Sargent P.A., Bench C.J., Rabiner E.A., Osman S., Pike V.W., Hume S.P., Grasby P.M., Lammertsma A.A. Tracer kinetic modeling of the 5-HT1A receptor ligand [carbonyl-11C]WAY-100635 for PET. Neuroimage. 8:1998;426-440.
25. Haleem D.J., Kennett G.A., Curzon G. Hippocampal 5-hydroxytryptamine synthesis is greater in female rats than in males and more decreased by the 5-HT1A agonist 8-OH-DPAT. J. Neural Transm. Gen. Sect. 79:1990;93-101.
26. Haleem D.J., Kennett G.A., Whitton P.S., Curzon G. 8-OH-DPAT increases corticosterone but not other 5-HT1A receptor-dependent responses more in females. Eur. J. Pharmacol. 164:1989;435-443.
27. Hwang D.R., Simpson N., Montoya J., Mann J.J., Laruelle M. An improved one-pot procedure for the preparation of [11C-carbonyl]WAY 100635. Nucl. Med. Biol. 26:1999;815-819.
28. Joppa M.A., Rowe R.K., Meisel R.L. Effects of serotonin 1A or 1B receptor agonists on social aggression in male and female Syrian hamsters. Pharmacol. Biochem. Behav. 58:1997;349-353.
29. Kates W.R., Abrams M.T., Kaufmann W.E., Breiter S.N., Reiss A.L. Reliability and validity of MRI measurement of the amygdala and hippocampus in children with fragile X syndrome. Psychiat. Res. Neuroimag. 75:1997;31-48.
30. Killiany R.J., Moss M.B., Nicholson T., Jolez F., Sandor T. An interactive procedure for extracting features of the brain from magnetic resonance images: the lobes. Human Brain Mapping. 5:1997;355-363.
31. Lammertsma A.A., Hume S.P. Simplified reference tissue model for PET receptor studies. Neuroimage. 4:1996;153-158.
32. Laruelle M., van Dyck C., Abi-Dargham A., Zea-Ponce Y., Zoghbi S.S., Charney D.S., Baldwin R.M., Hoffer P.B., Kung H.F., Innis R.B. Compartmental modeling of iodine-123-iodobenzofuran binding to dopamine D2 receptors in healthy subjects. J. Nucl. Med. 35:1994;743-754.
33. Li Q., Wichems C., Heils A., Lesch K.P., Murphy D.L. Reduction in the density and expression, but not G-protein coupling, of serotonin receptors (5-HT1A) in 5-HT transporter knock-out mice: gender and brain region differences. J. Neurosci. 20:2000;7888-7895.
34. Lowther S., De Paermentier F., Cheetham S.C., Crompton M.R., Katona C.L., Horton R.W. 5-HT1A receptor binding sites in post-mortem brain samples from depressed suicides and controls. J. Affect. Disord. 42:1997;199-207.
35. K. Mardia, J. Kent, J.M. Bibby, Multivariate Analysis, Academic Press, London, 1997.
36. Mendelson S.D., McEwen B.S. Autoradiographic analyses of the effects of restraint-induced stress on 5-HT1A, 5-HT1C and 5-HT2 receptors in the dorsal hippocampus of male and female rats. Neuroendocrinology. 54:1991;454-461.
37. Mintun M.A., Raichle M.E., Kilbourn M.R., Wooten G.F., Welch M.J. A quantitative model for the in vivo assessment of drug binding sites with positron emission tomography. Ann. Neurol. 15:1984;217-227.
38. Newman M.E., Li Q., Gelfin Y., Van de Kar L.D., Lerer B. Low doses of ipsapirone increase growth hormone but not oxytocin secretion in normal male and female subjects. Psychopharmacology (Berl.). 145:1999;99-104.
39. Ollinger J.M. Model-based scatter correction for fully 3D PET. Phys. Med. Biol. 41:1996;153-176.
40. Oquendo M.A., Ellis S.P., Greenwald S., Malone K.M., Weissman M.M., Mann J.J. Ethnic and sex differences in suicide rates relative to major depression in the United States. Am. J. Psychiatry. 158:2001;1652-1658.
41. Palego L., Marazziti D., Rossi A., Giannaccini G., Naccarato A.G., Lucacchini A., Cassano G.B. Apparent absence of aging and gender effects on serotonin 1A receptors in human neocortex and hippocampus. Brain Res. 758:1997;26-32.
42. Parsey R.V., Slifstein M., Hwang D.R., Abi-Dargham A., Simpson N., Mawlawi O., Guo N.N., Van Heertum R., Mann J.J., Laruelle M. Validation and reproducibility of measurement of 5-HT1A receptor parameters with [carbonyl-11C]WAY-100635 in humans: comparison of arterial and reference tissue input functions. J. Cereb. Blood Flow Metab. 20:2000;1111-1133.
43. Rabiner E.A., Messa C., Sargent P.A., Husted-Kjaer K., Montgomery A., Lawrence A.D., Bench C.J., Gunn R.N. P., Cowen, P.M. Grasby, A database of [(11)C]WAY-100635 binding to 5-HT(1A) receptors in normal male volunteers: normative data and relationship to methodological,demographic, physiological, and behavioral variables. Neuroimage. 15:2002;620-632.
44. Spitzer R., Williams J., Gibbon M., First M. The structured clinical interview for DSM-III-R: 1. History, rationale and description. Arch. Gen. Psychiatry. 49:1992;624-629.
45. Steinbusch H.W.M. Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminal. Neuroscience. 6:1981;557-618.
46. Talairach J., Tournoux P. Co-Planar Stereotactic Atlas of the Human Brain. Three-dimensional Proportional System: An Approach of Cerebral Imaging. 1988;Theime, New York.
47. Tauscher J., Verhoeff N.P., Christensen B.K., Hussey D., Meyer J.H., Kecojevic A., Javanmard M., Kasper S., Kapur S. Serotonin 5-HT1A receptor binding potential declines with age as measured by [11C]WAY-100635 and PET. Neuropsychopharmacology. 24:2001;522-530.
48. Uphouse L., Salamanca S., Caldarola-Pastuszka M. Gender and estrous cycle differences in the response to the 5-HT1A agonist 8-OH-DPAT. Pharmacol. Biochem. Behav. 40:1991;901-906.
49. Woods R.P., Cherry S.R., Mazziotta J.C. Rapid automated algorithm for aligning and reslicing PET images. J. Comput. Assist. Tomagr. 16:1992;620-633.
50. Wright D.E., Seroogy K.B., Lundgren K.H., Davis B.M., Jennes L. Comparative localization of serotonin, (1A), (1C) and (2) receptor subtype mRNAs in rat brain. J. Comp. Neurol. 351:1995;357-373.