Effect of testosterone on the apneic threshold in women during NREM sleep

Journal of Applied Physiology

Volumn 94, Issue 1, 2003, Pages 101-107

  Zhou, X S ^a   Rowley, J A ^a,b   Demirovic, F ^a   Diamond, M P ^a   Badr, M S ^a  

^a WAYNE STATE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HUTZEL HOSPITAL   (United States)

Author keywords

Control of breathing; Gender; Hypocapnia

Indexed keywords

TESTOSTERONE;

ADULT; APNEA; ARTICLE; ARTIFICIAL VENTILATION; BREATHING; BREATHING RATE; CLINICAL ARTICLE; END TIDAL CARBON DIOXIDE TENSION; FEMALE; GENDER; HUMAN; HYPOCAPNIA; LUNG MINUTE VOLUME; NONREM SLEEP; NORMAL HUMAN; PRIORITY JOURNAL; SEX DIFFERENCE; TIDAL VOLUME;

EID: 0037214058     PISSN: 87507587     EISSN: None     Source Type: Journal    
DOI: 10.1152/japplphysiol.00264.2002     Document Type: Article

References (34)

1. Arnold AP, Nottebohm F, and Pfaff DW. Hormone concentrating cells in vocal control and other areas of the brain of the zebra finch (Poephila guttata). J Comp Neurol 165: 487-511, 1976.
2. Badr MS. Pathophysiology of upper airway obstruction during sleep. Clin Chest Med 19: 21-32, 1998.
3. Badr MS and Kawak A. Post-hyperventilation hypopnea in humans during NREM sleep. Respir Physiol 103: 137-145, 1996.
4. Badr MS, Kawak A, Skatrud JB, Morrell MJ, Zahn BR, and Babcock MA. Effect of induced hypocapnic hypopnea on upper airway patency in humans during NREM sleep. Respir Physiol 110: 33-45, 1997.
5. Badr MS, Toiber F, Skatrud JB, and Dempsey J. Pharyngeal narrowing/occlusion during central sleep apnea. J Appl Physiol 78: 1806-1815, 1995.
6. Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Rein J, Vela-Bueno A, and Kales A. Prevalence of sleep-disordered breathing in women: effects of gender. Am J Respir Crit Care Med 163: 608-613, 2001.
7. Cistulli PA, Grunstein RR, and Sullivan CE. Effect of testosterone administration on upper airway collapsibility during sleep. Am J Respir Crit Care Med 149: 530-532, 1994.
8. 2 and in arterial pH. In: Handbook of Physiology. The Respiratory System. Control of Breathing. Bethesda, MD: Am. Physiol. Soc., 1986, sect. 3, vol. II, pt. 2, chapt. 15, p. 475-528.
9. Dexter DD and Dovre EJ. Obstructive sleep apnea due to endogenous testosterone production in a woman. Mayo Clin Proc 73:246-248, 1998.
10. Diamond MP, Grainger D, Diamond MC, Sherwin RS, and Defronzo RA. Effects of methyltestosterone on insulin secretion and sensitivity in women. J Clin Endocrinol Metab 83: 4420-4425, 1998.
11. Fogel RB, Malhotra A, Pillar G, Pittman SD, Dunaif A, and White DP. Increased prevalence of obstructive sleep apnea syndrome in obese women with polycystic ovary syndrome. J Clin Endocrinol Metab 86: 1175-1180, 2001.
12. Fontvieille AM, Rising R, Spraul M, Larson DE, and Ravussin E. Relationship between sleep stages and metabolic rate in humans. Am J Physiol Endocrinol Metab 267: E732-E737, 1994.
13. Harman E, Wynne JW, Block AJ, and Malloy-Fisher L. Sleep-disordered breathing and oxygen desaturation in obese patients. Chest 79: 256-260, 1981.
14. Hudgel DW, Chapman KR, Faulks C, and Hendricks C. Changes in inspiratory muscle electrical activity and upper airway resistance during periodic breathing induced by hypoxia during sleep. Am Rev Respir Dis 135: 899-906, 1987.
15. Johnson MW, Anch AM, and Remmers JE. Induction of the obstructive sleep apnea syndrome in a woman by exogenous androgen administration. Am Rev Respir Dis 129: 1023-1025, 1984.
16. 3H-dihydrotestosterone. J Comp Neurol 199: 221-231, 1981.
17. Leevers AM, Simon PM, Xi L, and Dempsey JA. Apnoea following normocapnic mechanical ventilation in awake mammals: a demonstration of control system inertia. J Physiol 472: 749-768, 1993.
18. Matsumoto AM, Sandblom R, Schoene R, Lee K, Giblin E, Pierson D, and Bremner W. Testosterone replacement in hypogonadal men: effects of obstructive sleep apnea, respiratory drives, and sleep. Clin Endocrinol (Oxf) 22: 713-721, 1985.
19. Morgan BJ, Dempsey JA, Pegelow DF, Jacques A, Finn L, Palta M, Skatrud JB, and Young TB. Blood pressure perturbations caused by subclinical sleep-disordered breathing. Sleep 21:737-746, 1998.
20. Nakayama H, Smith CA, Rodman JR, Skatrud JB, and Dempsey JA. Effect of ventilatory drive on carbon dioxide sensitivity below eupnea during sleep. Am J Respir Crit Care Med 165: 1251-1260, 2002.
21. Onal E, Burrows DL, Hart RH, and Lopata M. Induction of periodic breathing during sleep causes upper airway obstruction in humans. JAppl Physiol 61: 1438-1443, 1986.
22. Rechtschaffen A and Kales AA. A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects. Washington, DC: National Institutes of Health, 1968.
23. Rowley JA, Zhou ZS, Vergine I, Shkoukani BS, and Badr MS. The influence of gender on upper airway mechanics: upper airway resistance and Pcrit. J Appl Physiol 91: 2248-2254, 2001.
24. Sandblom RE, Matsumoto AM, Schoene RB, Lee KA, Giblin EC, Bremner WJ, and Pierson DJ. Obstructive sleep apnea syndrome induced by testosterone administration. N Engl J Med 308: 508-510, 1983.
25. Sheridan PJ and Weaker FJ. Androgen receptor systems in the brain stem of the primate. Brain Res 235: 225-232, 1982.
26. Stumpf WE and Sar M. Steroid hormone target cells in the extrahypothalamic brain stem and cervical spinal cord: neuroendocrine significance. J Steroid Biochem 11: 801-807, 1979.
27. Tatsumi K, Hannhart B, Pickett CK, Weil JV, and Moore LG. Effects of testosterone on hypoxic ventilatory and carotid body neural responsiveness. Am J Respir Crit Care Med 149: 1248-1253, 1994.
28. Vgontzas AN, Legro RS, Bixler EO, Grayev A, Kales A, and Chrousos GP. Polycystic ovary syndrome is associated with obstructive sleep apnea and daytime sleepiness: role of insulin resistance. J Clin Endocrinol Metab 86: 517-520, 2001.
29. Warner G, Skatrud JB, and Dempsey JA. Effect of hypoxia-induced periodic breathing on upper airway obstruction during sleep. J Appl Physiol 62: 2201-2211, 1987.
30. White DP, Douglas NJ, Pickett CK, Weil JV, and Zwillich CW. Sexual influence on the control of breathing. J Appl Physiol 54:874-879, 1983.
31. White DP, Scheider BK, Santen RJ, McDermott M, Pickett CK, Zwillich CW, and Weil JV. Influence of testosterone on ventilation and chemosensitivity in male subjects. J Appl Physiol 59: 1452-1457, 1985.
32. 2 in patients with congestive heart failure. Am J Respir Crit Care Med 165: 1245-1250, 2002.
33. Young T, Palta M, Dempsey J, Skatrud J, Weber S, and Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med 328: 1230-1235, 1993.
34. Zhou XS, Shahabuddin S, Zahn BK, Babcock MA, and Badr MS. Effect of gender on the development of hypocapnic apnea/hypopnea during NREM sleep. J Appl Physiol 89: 192-199, 2000.