Phrenic nerve activity is enhanced by 5-HT1A receptor agonist 8-OH-DPAT in spontaneously breathing anesthetized rats

Journal of Physiology and Pharmacology

Volumn 59, Issue 1, 2008, Pages 17-25

  Valic, M ^a   Pecotic, R ^a   Dogas, Zoran ^a  

^a UNIVERSITY OF SPLIT   (Croatia)

Author keywords

Phrenic nerve recordings; Rats; Respiration; Serotonin

Indexed keywords

2 DIPROPYLAMINO 8 HYDROXYTETRALIN; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE; URETHAN;

ANESTHESIA; ANIMAL EXPERIMENT; ARTICLE; BREATHING PATTERN; BREATHING RATE; CONTROLLED STUDY; DOSE RESPONSE; DRUG DOSE INCREASE; MALE; MOTOR ACTIVITY; NERVE CONDUCTION; NERVE STIMULATION; NONHUMAN; PHRENIC NERVE; RAT; RESPIRATORY FUNCTION;

8-HYDROXY-2-(DI-N-PROPYLAMINO)TETRALIN; ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; INJECTIONS, INTRAVENOUS; MALE; PHRENIC NERVE; PIPERAZINES; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, SEROTONIN, 5-HT1A; RESPIRATION; SEROTONIN AGONISTS;

EID: 42049110550     PISSN: 08675910     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Sahibzada N, Ferreira M, Wasserman AM, Taveira-DaSilva AM, Gillis RA. Reversal of morphine-induced apnea in the anesthetized rat by drugs that activate 5-hydroxytryptamine(1A) receptors. J Pharmacol Exp Ther 2000; 292: 704-713.
2. Teng YD, Bingaman M, Taveira-DaSilva AM, Pace PP, Gillis RA, Wrathall JR. Serotonin 1A receptor agonists reverse respiratory abnormalities in spinal cord-injured rats. J Neurosci 2003; 23: 4182-4189.
3. Lalley PM, Bischoff AM, Richter DW. Serotonin 1A-receptor activation suppresses respiratory apneusis in the cat. Neurosci Lett 1994; 172 :59-62.
4. Pierrefiche O, Schwarzacher SW, Bischoff AM, Richter DW. Blockade of synaptic inhibition within the pre-Botzinger complex in the cat suppresses respiratory rhythm generation in vivo. J Physiol 1998; 509 (Pt 1): 245-254.
5. Lalley PM, Bischoff AM, Richter DW. 5-HT-1A receptor-mediated modulation of medullary expiratory neurones in the cat. J Physiol 1994; 476: 117-130.
6. Lalley PM. Serotoninergic and non-serotoninergic responses of phrenic motoneurones to raphe stimulation in the cat. J Physiol 1986; 380: 373-385.
7. Holtman JR, Jr., Dick TE, Berger AJ. Serotonin-mediated excitation of recurrent laryngeal and phrenic motoneurons evoked by stimulation of the raphe obscurus. Brain Res 1987; 417: 12-20.
8. Wilken B, Lalley P, Bischoff AM, et al. Treatment of apneustic respiratory disturbance with a serotonin-receptor agonist. J Pediatr 1997; 130: 89-94.
9. Millhorn DE, Eldridge FL, Waldrop TG, Klingler LE. Centrally and peripherally administered 5-HTP have opposite effects on respiration. Brain Res 1983; 264: 349-354.
10. Smith JC, Morrison DE, Ellenberger HH, Otto MR, Feldman JL. Brainstem projections to the major respiratory neuron populations in the medulla of the cat. The J Comp Neurol 1989; 281: 69-96.
11. Dobbins EG, Feldman JL. Brainstem network controlling descending drive to phrenic motoneurons in rat. The J Comp Neurol 1994; 347: 64-86.
12. Cao Y, Matsuyama K, Fujito Y, Aoki M. Involvement of medullary GABAergic and serotonergic raphe neurons in respiratory control: electrophysiological and immunohistochemical studies in rats. Neurosci Res 2006; 56: 322-331.
13. Connelly CA, Ellenberger HH, Feldman JL. Are there serotonergic projections from raphe and retrotrapezoid nuclei to the ventral respiratory group in the rat? Neurosci Lett 1989; 105: 34-40.
14. Holtman JR, Jr., Marion LJ, Speck DF. Origin of serotonin-containing projections to the ventral respiratory group in the rat. Neuroscience 1990; 37: 541-552.
15. Gaytan SP, Pasaro R. Connections of the rostral ventral respiratory neuronal cell group: an anterograde and retrograde tracing study in the rat. Brain Res Bull 1998; 47: 625-642.
16. Maggi CA, Meli A. Suitability of urethane anesthesia for physiopharmacological investigations. Part 3: Other systems and conclusions. Experientia 1986; 42:531-537.
17. Sapru HN, Krieger AJ. Cardiovascular and respiratory effects of some anesthetics in the decerebrate rat. Eur J Pharm 1979; 53:151-158.
18. Richmonds CR, Hudgel DW. Hypoglossal and phrenic motoneuron responses to serotonergic active agents in rats. Respir Physiol 1996; 106: 153-160.