5-HT4(a) receptors avert opioid-induced breathing depression without loss of analgesia

Science

Volumn 301, Issue 5630, 2003, Pages 226-229

  Manzke, Till ^a   Guenther, Ulf ^a   Ponimaskin, Evgeni G ^a   Haller, Miriam ^a   Dutschmann, Mathias ^a   Schwarzacher, Stephan ^b   Richter, Diethelm W ^a  

^a UNIVERSITY OF GÖTTINGEN   (Germany)

^b Department of Anatomy ^*  (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN; NEUROLOGY; RESPIRATORY SYSTEM; SIGNALING;

NEURONS;

ANESTHESIOLOGY;

2,3 DIHYDRO 3 ISOPROPYL 2 OXO 1 BENZIMIDAZOLECARBOXYLIC ACID 3ALPHA TROPANYLAMIDE; FENTANYL; SEROTONIN 4 AGONIST; SEROTONIN 4A RECEPTOR; SEROTONIN RECEPTOR; UNCLASSIFIED DRUG; (ENDO N 8 METHYL 8 AZABICYCLO (3.2.1)OCT 3 YL) 2,3 DIHYDRO 3 ISOPROPYL 2 OXO 1H BENZIMIDAZOL 1 CARBOXAMIDE; (ENDO-N-8-METHYL-8-AZABICYCLO-(3.2.1)OCT-3-YL)-2,3-DIHYDRO-3-ISOPROPYL-2-OXO-1H-BENZIMIDAZOL-1-CARBOXAMIDE; BENZIMIDAZOLE DERIVATIVE; CYCLIC AMP; FUSED HETEROCYCLIC RINGS; MESSENGER RNA; MU OPIATE RECEPTOR; NALOXONE; NARCOTIC ANALGESIC AGENT; NEUROKININ 1 RECEPTOR; SEROTONIN 4 RECEPTOR; SEROTONIN AGONIST;

ANESTHETIC; RESPIRATION;

ANALGESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREATHING DISORDER; BREATHING PATTERN; CELL ACTIVATION; CONTROLLED STUDY; DRUG EFFECT; NERVE CELL; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; ANIMAL; BRAIN STEM; BREATHING; CYTOLOGY; GENETICS; IN VITRO STUDY; INTERNEURON; MEDULLA OBLONGATA; METABOLISM; PAIN ASSESSMENT; PATCH CLAMP; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPINAL CORD; SPRAGUE DAWLEY RAT;

ANIMALIA;

ANALGESICS, OPIOID; ANIMALS; BENZIMIDAZOLES; BICYCLO COMPOUNDS, HETEROCYCLIC; BRAIN STEM; CYCLIC AMP; FENTANYL; INTERNEURONS; MEDULLA OBLONGATA; NALOXONE; NEURONS; PAIN MEASUREMENT; PATCH-CLAMP TECHNIQUES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, NEUROKININ-1; RECEPTORS, OPIOID, MU; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT4; RESPIRATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SEROTONIN AGONISTS; SIGNAL TRANSDUCTION; SPINAL CORD;

EID: 0037477467     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1084674     Document Type: Article

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