Endogenous activation of serotonin-2A receptors is required for respiratory rhythm generation in Vitro

Journal of Neuroscience

Volumn 22, Issue 24, 2002, Pages 11055-11064

  Peña, Fernando ^a   Ramirez, Jan Marino ^a  

^a UNIVERSITY OF CHICAGO   (United States)

Author keywords

5 HT2A receptor; Endogenous serotonin; Pacemaker; Pre B tzinger complex; Respiratory rhythm; Sodium currents

Indexed keywords

1,2,3,5 TETRAHYDRO 5 METHYL 1 (3 PYRIDYLCARBAMOYL)PYRROLO[2,3 F]INDOLE; 4 (3 PHOSPHONOPROPYL) 2 PIPERAZINECARBOXYLIC ACID; 4 IODO 2,5 DIMETHOXYAMPHETAMINE; 6 CYANO 7 NITRO 2,3 QUINOXALINEDIONE; ALAPROCLATE; BICUCULLINE; KETANSERIN TARTRATE; PHORBOL 13 ACETATE 12 MYRISTATE; PIPERIDINE; SEROTONIN 2A ANTAGONIST; SEROTONIN 2A RECEPTOR; SEROTONIN UPTAKE INHIBITOR; SODIUM ION; SPIPERONE; STRYCHNINE;

ANIMAL TISSUE; ARTICLE; BREATHING PATTERN; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVATION; FEMALE; MALE; NERVE CELL NETWORK; NONHUMAN; PACEMAKER; PRIORITY JOURNAL; RECEPTOR BLOCKING; SEROTONINERGIC SYSTEM; SODIUM CURRENT;

EID: 0037114964     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.22-24-11055.2002     Document Type: Article

References (59)

1. Al-Zubaidy ZA, Erickson RL, Greer JJ (1996) Serotonergic and noradrenergic effects on respiratory neural discharge in the medullary slice preparation of neonatal rats. Pfügers Arch 431:942-949.
2. Araneda R, Andrade R (1991) 5-Hydroxytryptamine-2 and 5-hydroxytryptamine-1A receptors mediate opposing responses on membrane excitability in rat association cortex. Neuroscience 40:399-412.
3. Arita H, Ochiishi M (1991) Opposing effects of 5-hydroxytryptamine on two types of medullary inspiratory neurons with distinct firing patterns. J Neurophysiol 66:285-292.
4. + current in mouse neocortical slices. J Neurophysiol 80:1547-1551.
5. Bandla HP, Simakajornboon N, Graff GR, Gozal D (1999) Protein kinase C modulates ventilatory patterning in the developing rat. Am J Respir Crit Care Med 159:968-973.
6. Barnes NM, Sharp T (1999) A review of central 5-HT receptors and their function. Neuropharmacology 38:1083-1152.
7. 2 receptor subtypes: A family re-united? Trends Pharmacol Sci 16:105-110.
8. Bianchi AL, Denavit-Saubie M, Champagnat J (1995) Central control of breathing in mammals: Neuronal circuitry, membrane properties, and neurotransmitters. Physiol Rev 75:1-45.
9. 2 receptor activation potentiates N-methyl-D-aspartate receptor-mediated ion currents by a protein kinase C-dependent mechanism. J Neurosci Res 45:153-160.
10. Bobker DH, Williams JT (1990) Ion conductances affected by 5-HT receptor subtypes in mammalian neurons. Trends Neurosci 13:169-173.
11. Bohmer G, Dinse HR, Fallert M, Sommer TJ (1979) Microelectrophoretic application of antagonists of putative neurotransmitters onto various types of bulbar respiratory neurons. Arch Ital Biol 117:13-22.
12. Bou-Flores C, Lajard AM, Monteau R, De Maeyer E, Seif I, Lanoir J, Hilaire G (2000) Abnormal phrenic motoneuron activity and morphology in neonatal monoamine oxidase A-deficient transgenic mice: Possible role of a serotonin excess. J Neurosci 20:4646-4656.
13. Butera Jr RJ, Rinzel J, Smith JC (1999) Models of respiratory rhythm generation in the pre-Bötzinger complex. I. Bursting pacemaker neurons. J Neurophysiol 82:382-397.
14. Carr DB, Cooper DC, Ulrich SL, Spruston N, Surmeier DJ (2002) Serotonin receptor activation inhibits sodium current and dendritic excitability in prefrontal cortex via a protein kinase C-dependent mechanism. J Neurosci 22:6846-6855.
15. Cayetanot F, Gros F, Larincol N (2002) Postnatal changes in the respiratory response of the conscious rat to serotonin-2A/2C receptor activation are reflected in the developmental pattern of fos expression in the brainstem. Brain Res 942:51-57.
16. Champagnat J, Richter DW (1993) Second messenger-induced modulation of the excitability of respiratory neurones. NeuroReport 4:861-863.
17. Champagnat J, Denavit-Saubie M, Henry JL, Leviel V (1979) Catecholaminergic depressant effects on bulbar respiratory mechanisms. Brain Res 160:57-68.
18. Del Negro CA, Morgado-Valle C, Feldman JL (2002) Respiratory rhythm: An emergent network property? Neuron 34:821-830.
19. Di Pasquale E, Monteau R, Hilaire G (1994) Endogenous serotonin modulates the fetal respiratory rhythm: An in vitro study in the rat. Brain Res Dev Brain Res 80:222-232.
20. 2A receptor by site-directed mutagenesis: Revelation of inverse agonist activity of antagonists. Ann NY Acad Sci 861:136-139.
21. Elsen FP, Ramirez JM (1998) Calcium currents of rhythmic neurons recorded in the isolated respiratory network of neonatal mice. J Neurosci 15:10652-10662.
22. + currents increases the excitability of rat neocortical pyramidal neurones. J Physiol (Lond) 528:291-304.
23. Gray PA, Janczewski WA, Mellen N, McCrimmon DR, Feldman JL (2001) Normal breathing requires pre-B6tzinger complex neurokinin-1 receptor-expressing neurons. Nat Neurosci 4:927-930.
24. Haji A, Pierrefiche O, Lalley PM, Richter DW (1996) Protein kinase C pathways modulate respiratory pattern generation in the cat. J Physiol (Lond) 494:297-306.
25. Haji A, Takeda R, Okazaki M (2000) Neuropharmacology of control of respiratory rhythm and pattern in mature mammals. Pharmacol Ther 86:277-304.
26. Hwang LL, Dun NJ (1999) 5-HT modulates multiple conductances in immature rat rostral ventrolateral medulla neurones in vitro. J Physiol (Lond) 517:217-228.
27. 2 receptor subtypes. Eur J Pharmacol 414:23-30.
28. Koshiya N, Smith JC (2000) Subthreshold voltage-activated persistent sodium conductance (g(NαP)) in inspiratory neurons of pre-Bötzinger complex. FASEB J 14:A642.
29. Lalley PM, Bischoff AM, Richter DW (1994) 5-HT-1A receptormediated modulation of medullary expiratory neurones in the cat. J Physiol (Lond) 476:117-130.
30. 2 receptor-controlled modulation of medullary respiratory neurones in the cat. J Physiol (Lond) 487:653-661.
31. Lalley PM, Benacka R, Bischoff AM, Richter DW (1997) Nucleus raphe obscurus evokes 5-HT-1A receptor-mediated modulation of respiratory neurons. Brain Res 747:156-159.
32. 2 receptors. Neurosci Lett 270:56-58.
33. Lieske SP, Thoby-Brisson M, Telgkamp P, Ramirez JM (2000) Reconfiguration of the neural network controlling multiple breathing patterns: Eupnea, sighs and gasps. Nat Neurosci 3:600-607.
34. Lindsay AD, Feldman JL (1993) Modulation of respiratory activity of neonatal rat phrenic motoneurones by serotonin. J Physiol (Lond) 461:213-233.
35. 2A receptors on interneurons in rat piriform cortex. J Pharmacol Exp Ther 278:1373-1382.
36. Martin GR, Humphrey PP (1994) Receptors for 5-hydroxytryptamine: Current perspectives on classification and nomenclature. Neuropharmacology 33:261-273.
37. McCrimmon DR, Ramirez JM, Alford S, Zuperku EJ (2000) Unraveling the mechanism for respiratory rhythm generation. BioEssays 22:6-9.
38. McCrimmon DR, Monnier A, Ptak K, Zummo G, Zhang Z, Alheid GF (2001) Respiratory rhythm generation: Pre-B6tzinger neuron discharge patterns and persistent sodium current. Adv Exp Med Biol 499:147-152.
39. Morin D, Hennequin S, Monteau R, Hilarie G (1990) Serotonergic influences on central respiratory activity: An in vitro study in the newborn rat. Brain Res 535:281-287.
40. Morin D, Monteau R, Hilaire G (1991) 5-Hydroxytryptamine modulates central respiratory activity in the newborn rat: An in vitro study. Eur J Pharmacol 192:89-95.
41. Neher E (1992) Correction for liquid junction potentials in patch clamp experiments. Methods Enzymol 207:123-131.
42. Nusbaum MP, Beenhakker MP (2002) A small-systems approach to motor pattern generation. Nature 417:343-350.
43. Onimaru H, Shamoto A, Homma I (1998) Modulation of respiratory rhythm by 5-HT in the brainstem-spinal cord preparation from newborn rat. Pflügers Arch 435:485-494.
44. Ramirez JM, Quellmalz UJ, Richter DW (1996) Postnatal changes in the mammalian respiratory network as revealed by the transverse brainstem slice of mice. J Physiol (Lond) 491:799-812.
45. Rauser L, Savage JE, Meltzer HY, Roth BL (2001) Inverse agonist actions of typical and atypical antipsychotic drugs at the human 5-hydroxytryptamine(2C) receptor. J Pharmacol Exp Ther 299:83-89.
46. Rekling JC, Feldman JL (1998) Pre-Bötzinger complex and pacemaker neurons: Hypothesized site and kernel for respiratory rhythm generation. Annu Rev Physiol 60:385-405.
47. Richerson GB, Wang W, Tiwari J, Bradley SR (2001) Chemosensitivity of serotonergic neurons in the rostral ventral medulla. Respir Physiol 129:175-189.
48. Richter DW, Lalley PM, Pierrefiche O, Haji A, Bischoff AM, Wilken B, Hanefeld F (1997) Intracellular signal pathways controlling respiratory neurons. Respir Physiol 110:113-123.
49. Rose D, Khater-Boidin J, Toussaint P, Duron B (1995) Central effects of 5-HT on respiratory and hypoglossal activities in the adult cat. Respir Physiol 101:59-69.
50. Schreibmayer W (1999) Isoform diversity and modulation of sodium channels by protein kinases. Cell Physiol Biochem 9:187-200.
51. Sitges M, Pena F, Chiu LM, Guarneros A (1998) Study on the possible involvement of protein kinases in the modulation of brain presynaptic sodium channels: Comparison with calcium channels. Neurochem Int 32:177-190.
52. Smith JC, Ellenberger HH, Ballanyi K, Richter DW, Feldman JL (1991) Pre-Bötzinger complex: A brainstem region that may generate respiratory rhythm in mammals. Science 254:726-729.
53. Smith JC, Butera RJ, Koshiya N, Del Negro C, Wilson CG, Johnson SM (2000) Respiratory rhythm generation in neonatal and adult mammals: The hybrid pacemaker-network model. Respir Physiol 122:131-147.
54. Telgkamp P, Ramirez JM (1999) Differential responses of respiratory nuclei to anoxia in rhythmic brain stem slices of mice. J Neurophysiol 82:2163-2170.
55. Telgkamp P, Cao YQ, Basbaum AI, Ramirez JM (2002) Long-term deprivation of substance P in PPT-A mutant mice alters the anoxic response of the isolated respiratory network. J Neurophysiol 88:206-213.
56. Thoby-Brisson M, Ramirez JM (2001) Identification of two types of inspiratory pacemaker neurons in the isolated respiratory neural network of mice. J Neurophysiol 86:104-112.
57. Thoby-Brisson M, Telgkamp P, Ramirez JM (2000) The role of the hyperpolarization-activated current in modulating rhythmic activity in the isolated respiratory network of mice. J Neurosci 20:2994-3005.
58. Walaas SI, Greengard P (1991) Protein phosphorylation and neuronal function. Pharmacol Rev 43:299-349.
59. Wang HY, Friedman E (1990) Central 5-hydroxytryptamine receptorlinked protein kinase C translocation: A functional postsynaptic signal transduction system. Mol Pharmacol 37:75-79.