The human serotonin transporter gene polymorphism-basic research and clinical implications

Journal of Neural Transmission

Volumn 104, Issue 10, 1997, Pages 1005-1014

  Heils, A ^a   Mossner R ^a   Lesch, K P ^a  

^a UNIVERSITY OF WÜRZBURG   (Germany)

Author keywords

Allelic association; Gene polymorphism; Genetics; Serotonin transporter

Indexed keywords

CYCLIC AMP; PROTEIN KINASE C; SEROTONIN; SEROTONIN TRANSPORTER;

COGNITION; CONFERENCE PAPER; DNA POLYMORPHISM; EMOTION; GENE EXPRESSION; GENE INDUCTION; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; MENTAL DISEASE; MESENCEPHALON; MOLECULAR CLONING; MOOD; PATHOGENESIS; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RAPHE NUCLEUS; SCREENING; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION; TANDEM REPEAT;

B-LYMPHOCYTES; CARRIER PROTEINS; GENE EXPRESSION REGULATION; HERPESVIRUS 4, HUMAN; HUMANS; LUCIFERASES; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; POLYMORPHISM, GENETIC; SEROTONIN; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; TRANSCRIPTION, GENETIC; TRANSFECTION;

EID: 0031435392     PISSN: 03009564     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01273314     Document Type: Conference Paper

References (15)

1. Barker EL, Blakely RD (1995) Norepinephrine and serotonin transporters: molecular targets of antidepressant drugs. In: Bloom FE, Kupfer DJ (eds) Psychopharmcology: the fourth generation of progress. Raven Press, New York, pp 321-333
2. Blakely RD, Berson HE, Fremeau RT, Caron MC, Peek MM, Prince HK, Bradley CC (1991) Cloning and expression of a functional serotonin transporter rat brain. Nature 354: 66-70
3. Blakely R, De Felice LJ, Hartzell HC (1994) Molecular physiology of norepinephrine and serotonin transporters. J Exp Biol 196: 263-281
4. Di Bella D, Catalano M, Balling U, Smeraldi E, Lesch KP (1995) Systematic screening for mutations in the coding region of the 5-HTT gene using PCR and DGGE. Psychiatr Genet 5: S100
5. Ellis PM, Salmond C (1994) Imipramine binding in depression: a meta analysis. Biol Psychiatry 36: 292-299
6. Faraj BA, Olkowski ZL, Jackson RT (1994) Expression of a high-affinity serotonin transporter in human lymphocytes. Int J Immunopharmacol 16: 561-567
7. Heils A, Teufel A, Petri S, Seemann M, Bengel D, Balling U, Riederer P, Lesch KP (1995) Functional promoter and polyadenylation site mapping of the human serotonin (5-HT) transporter gene. J Neural Transm 102: 247-254
8. Heils A, Teufel A, Petri S, Stöber G, Riederer P, Bengel D, Lesch KP (1996) Allelic variation of human serotonin transporter gene expression. J Neurochem 66: 2621-2624
9. Hoffman BJ, Mezey E, Brownstein M (1991) Cloning of a serotonin transporter affested by antidepressants. Science 254: 579-580
10. Jayanthi LD, Ramamoorthy S, Mahesh VB, Leibach FH, Ganapathy V (1994) Calmodulin-dependent regulation of the catalytic function of the human serotonin transporter in placental choriocarcinoma cells. J Biol Chem 269: 14424-14429
11. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, Riederer P (1994) Organization of the human serotonin transporter gene. J Neural Transm 95: 157-164
12. Lesch KP, Franzek E, Gross J, Wolozin BL, Riederer P, Murphy DL (1995) Primary structure of the serotonin transporter in unipolar depression and bipolar disorder. Biol Psychiatry 37: 215-223
13. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, Benjamin J, Müller CR, Hamer DH, Murphy DL (1996) Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 274: 1527
14. Ramamoorthy S, Cool DR, Mahesh VB, Leibach FH, Melikian HE, Blakely RD, Ganapathy V (1993) Regulation of the human serotonin transporter. J Biol Chem 268: 21626-21631
15. Ramamoorthy S, Ramamoorthy JD, Prasad PD, Bhat GK, Mahesh VB, Leibach FH, Ganapathy V (1995) Regulation of the human serotonin transporter by Interleukin -1 beta. Biochem Biophys Res Commun 216: 560-567