Serotonin transporter gene variation in sudden infant death syndrome

Acta Paediatrica, International Journal of Paediatrics

Volumn 97, Issue 7, 2008, Pages 861-865

  Opdal, Siri Hauge ^a,b   Vege, Åshild ^a   Rognum, Torleiv Ole ^a  

^a UNIVERSITY OF OSLO   (Norway)

^b OSLO UNIVERSITY HOSPITAL   (Norway)

Author keywords

Serotonergic network; Serotonin transporter; SLCA4; Sudden infant death syndrome

Indexed keywords

SEROTONIN TRANSPORTER;

ARTICLE; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GEL ELECTROPHORESIS; GENE FREQUENCY; GENETIC ANALYSIS; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HUMAN; INFANT; MAJOR CLINICAL STUDY; MALE; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; RISK FACTOR; SUDDEN INFANT DEATH SYNDROME; VARIABLE NUMBER OF TANDEM REPEAT;

FEMALE; GENE FREQUENCY; GENOTYPE; HUMANS; INFANT; INTRONS; MALE; MINISATELLITE REPEATS; POLYMORPHISM, GENETIC; PROMOTER REGIONS (GENETICS); PRONE POSITION; SEROTONIN PLASMA MEMBRANE TRANSPORT PROTEINS; SLEEP; SUDDEN INFANT DEATH;

EID: 44849088391     PISSN: 08035253     EISSN: 16512227     Source Type: Journal    
DOI: 10.1111/j.1651-2227.2008.00813.x     Document Type: Article

References (30)

1. Kinney HC, Filiano JJ, White WF. Medullary serotonergic network deficiency in the sudden infant death syndrome: review of a 15-year study of a single dataset. J Neuropathol Exp Neurol 2001 60 : 228 47.
2. Paterson DS, Trachtenberg FL, Thompson EG, Belliveau RA, Beggs AH, Darnall R, et al. Multiple serotonergic brainstem abnormalities in sudden infant death syndrome. JAMA 2006 296 : 2124 32.
3. Rognum TO, Saugstad OD, Oyasaeter S, Olaisen B. Elevated levels of hypoxanthine in vitreous humor indicate prolonged cerebral hypoxia in victims of sudden infant death syndrome. Pediatrics 1988 82 : 615 8.
4. Opdal SH, Rognum TO, Vege A, Saugstad OD. Hypoxanthine levels in vitreous humor: a study of influencing factors in sudden infant death syndrome. Pediatr Res 1998 44 : 192 6.
5. Poets CF, Meny RG, Chobanian MR, Bonofiglo RE. Gasping and other cardiorespiratory patterns during sudden infant deaths. Pediatr Res 1999 45 : 350 4.
6. Pena F, Ramirez JM. Endogenous activation of serotonin-2A receptors is required for respiratory rhythm generation in vitro. J Neurosci 2002 22 : 11055 64.
7. Lesch KP, Balling U, Gross J, Strauss K, Wolozin BL, Murphy DL, et al. Organization of the human serotonin transporter gene. J Neural Transm Gen Sect 1994 95 : 157 62.
8. Heils A, Teufel A, Petri S, Stober G, Riederer P, Bengel D, et al. Allelic variation of human serotonin transporter gene expression. J Neurochem 1996 66 : 2621 4.
9. Battersby S, Ogilvie AD, Blackwood DH, Shen S, Muqit MM, Muir WJ, et al. Presence of multiple functional polyadenylation signals and a single nucleotide polymorphism in the 3′ untranslated region of the human serotonin transporter gene. J Neurochem 1999 72 : 1384 8.
10. Heinz A, Jones DW, Mazzanti C, Goldman D, Ragan P, Hommer D, et al. A relationship between serotonin transporter genotype and in vivo protein expression and alcohol neurotoxicity. Biol Psychiatry 2000 47 : 643 9.
11. Lesch KP, Bengel D, Heils A, Sabol SZ, Greenberg BD, Petri S, et al. Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science 1996 274 : 1527 31.
12. Fiskerstrand CE, Lovejoy EA, Quinn JP. An intronic polymorphic domain often associated with susceptibility to affective disorders has allele dependent differential enhancer activity in embryonic stem cells. FEBS Lett 1999 458 : 171 4.
13. Narita N, Narita M, Takashima S, Nakayama M, Nagai T, Okado N. Serotonin transporter gene variation is a risk factor for sudden infant death syndrome in the Japanese population. Pediatrics 2001 107 : 690 2.
14. Weese-Mayer DE, Berry-Kravis EM, Maher BS, Silvestri JM, Curran ME, Marazita ML. Sudden infant death syndrome: association with a promoter polymorphism of the serotonin transporter gene. Am J Med Genet 2003 117A : 268 74.
15. Weese-Mayer DE, Zhou L, Berry-Kravis EM, Maher BS, Silvestri JM, Marazita ML. Association of the serotonin transporter gene with sudden infant death syndrome: a haplotype analysis. Am J Med Genet 2003 122A : 238 45.
16. Maher BS, Marazita ML, Rand C, Zhou L, Berry-Kravis EM, Weese-Mayer DE. 3′ UTR polymorphism of the serotonin transporter gene and sudden infant death syndrome: haplotype analysis. Am J Med Genet A 2006 140 : 1453 7.
17. Gregersen M, Rajs J, Laursen H, Baandrup U, Frederiksen P, Gidlund E, et al. Pathologic criteria for the Nordic Study of SIDS. In : Rognum TO, editor. Sudden infant death syndrome, new trends in the nineties. Oslo, Norway : Scandinavian University Press, 1995 : 50 58.
18. Arnestad M, Crotti L, Rognum TO, Insolia R, Pedrazzini M, Ferrandi C, et al. Prevalence of long-QT syndrome gene variants in sudden infant death syndrome. Circulation 2007 115 : 361 7.
19. Boles RG, Buck EA, Blitzer MG, Platt MS, Cowan TM, Martin SK, et al. Retrospective biochemical screening of fatty acid oxidation disorders in postmortem livers of 418 cases of sudden death in the first year of life. J Pediatr 1998 132 : 924 33.
20. Stephens M, Smith NJ, Donnelly P. A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 2001 68 : 978 89.
21. Gelernter J, Cubells JF, Kidd JR, Pakstis AJ, Kidd KK. Population studies of polymorphisms of the serotonin transporter protein gene. Am J Med Genet 1999 88 : 61 6.
22. Adell A, Celada P, Abellan MT, Artigas F. Origin and functional role of the extracellular serotonin in the midbrain raphe nuclei. Brain Res Brain Res Rev 2002 39 : 154 80.
23. Portas CM, Bjorvatn B, Fagerland S, Gronli J, Mundal V, Sorensen E, et al. On-line detection of extracellular levels of serotonin in dorsal raphe nucleus and frontal cortex over the sleep/wake cycle in the freely moving rat. Neuroscience 1998 83 : 807 14.
24. Kinney HC. Abnormalities of the brainstem serotonergic system in the sudden infant death syndrome: a review. Pediatr Dev Pathol 2005 8 : 507 24.
25. Richerson GB. Serotonergic neurons as carbon dioxide sensors that maintain pH homeostasis. Nat Rev Neurosci 2004 5 : 449 61.
26. Obonai T, Takashima S, Becker LE, Asanuma M, Mizuta R, Horie H, et al. Relationship of substance P and gliosis in medulla oblongata in neonatal sudden infant death syndrome. Pediatr Neurol 1996 15 : 189 92.
27. Opdal SH, Rognum TO. The sudden infant death syndrome gene: does it exist? Pediatrics 2004 114 : e506 12.
28. Lim JE, Papp A, Pinsonneault J, Sadee W, Saffen D. Allelic expression of serotonin transporter (SERT) mRNA in human pons: lack of correlation with the polymorphism SERTLPR. Mol Psychiatry 2006 11 : 649 62.
29. Wendland JR, Martin BJ, Kruse MR, Lesch KP, Murphy DL. Simultaneous genotyping of four functional loci of human SLC6A4, with a reappraisal of 5-HTTLPR and rs25531. Mol Psychiatry 2006 11 : 224 6.
30. Martin J, Cleak J, Willis-Owen SA, Flint J, Shifman S. Mapping regulatory variants for the serotonin transporter gene based on allelic expression imbalance. Mol Psychiatry 2007 12 : 421 2.