Prenatal administration of para-chlorophenylalanine results in suppression of serotonergic system and disturbance of swimming movements in newborn rats

Neuroscience Research

Volumn 31, Issue 2, 1998, Pages 155-169

  Nakajima, Katsumi ^a   Matsuyama, Kiyoji ^a   Mori, Shigemi ^a  

^a NATIONAL INSTITUTE FOR PHYSIOLOGICAL SCIENCES   (Japan)

Author keywords

Interlimb coordination; Para chlorophenylalanine (PCPA); Postnatal development; Rat; Serotonergic system; Swimming movements

Indexed keywords

FENCLONINE; SEROTONIN;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; FORELIMB; HINDLIMB; LOCOMOTION; NERVOUS SYSTEM DEVELOPMENT; NEWBORN; NONHUMAN; POSTNATAL DEVELOPMENT; PREGNANCY; PRENATAL DEVELOPMENT; PRIORITY JOURNAL; RAT; SEROTONINERGIC SYSTEM; SWIMMING;

EID: 0031828270     PISSN: 01680102     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-0102(98)00034-0     Document Type: Article

References (50)

1. Altman J., Sudarshan K. Postnatal development of locomotion in the laboratory rat. Anim. Behav. 23:1975;896-920.
2. Bekoff A., Trainer W. The development of interlimb co-ordination during swimming in postnatal rats. J. Exp. Biol. 83:1979;1-11.
3. Bolles R.C., Woods P.J. The ontogeny of behaviour in the albino rat. Anim. Behav. 12:1964;427-441.
4. Bowker R.M., Steinbusch H.W.M., Coulter J.D. Serotonergic and peptidergic projections to the spinal cord demonstrated by a combined retrograde HRP histochemical and immunocytochemical staining method. Brain Res. 211:1981;412-417.
5. Bowker R.M., Westlund K.N., Sullivan M.C., Wilber J.F., Coulter J.D. Descending serotonergic, peptidergic and cholinergic pathways from the raphe nuclei: a multiple transmitter complex. Brain Res. 288:1983;33-48.
6. Bregman B.S. Development of serotonin immunoreactivity in the rat spinal cord and its plasticity after neonatal spinal cord lesions. Dev. Brain Res. 34:1987;245-263.
7. Cazalets J.R., Menard I., Crémieux J., Clarac F. Variability as a characteristic of immature motor systems: an electromyographic study of swimming in the newborn rat. Behav. Brain Res. 40:1990;215-225.
8. Cazalets J.R., Sqalli-Houssaini Y., Clarac F. Activation of the central pattern generators for locomotion by serotonin and excitatory amino acids in neonatal rat. J. Phyiol. 455:1992;187-204.
9. Deguchi T., Sinha A.K., Barchas J.D. Biosynthesis of serotonin in raphe nuclei of rat brain: effect of p-chlorophenylalanine. J. Neurochem. 20:1973;1329-1336.
10. Drew T., Dubuc R., Rossignol S. Discharge patterns of reticulospinal and other reticular neurons in chronic, unrestrained cats walking on a treadmill. J. Neurophysiol. 55:1986;375-401.
11. Fentress, J.C. 1978. Mus musicus: the developmental orchestration of selected movement patterns in mice, In: G.M. Burghardt, M. Bekoff (Eds.), The Development of Behavior: Comparative and Evolutionary Aspects. Garland STPM Press, New York, pp. 321-342.
12. Gao B.-X., Ziskind-Conhaim L. Development of chemosensitivity in serotonin-deficient spinal cords of rat embryos. Dev. Biol. 158:1993;79-89.
13. Grillner S. Neurobiological bases of rhythmic motor acts in vertebrates. Science. 228:1985;143-149.
14. Jacobs B.L., Fornal C.A. 5-HT and motor control: a hypothesis. Trends Neurosci. 16:1993;346-352.
15. Jacobs B.L., Trimbach C., Eubanks E.E., Trulson M. Hippocampal mediation of raphe lesion- and PCPA-induced hyperactivity in the rat. Brain Res. 94:1975;253-261.
16. Koe B.K., Weissman A. p-Chlorophenylalanine: a specific depletor of brain serotonin. J. Pharmacol. Exp. Ther. 154:1966;499-516.
17. Kojima M., Sano Y. The organization of serotonin fibers in the anterior column of the mammalian spinal cord. Anat. Embryol. 167:1983;1-11.
18. Kudo N., Yamada T. N-methyl-D,L-aspartate-induced locomotor activity in a spinal cord-hindlimb muscles preparation of the newborn rat studied in vitro. Neurosci. Lett. 75:1987;43-48.
19. Lauder J.M., Bloom F.E. Ontogeny of monoamine neurons in the locus coeruleus, raphe nuclei and substantia nigra of the rat. I. Cell differentiation. J. Comp. Neurol. 155:1974;469-482.
20. Lauder J.M., Krebs H. Effects of p-chlorophenylalanine on time of neuronal origin during embryogenesis in the rat. Brain Res. 107:1976;638-644.
21. Lauder J.M., Krebs H. Serotonin as a differentiation signal in early neurogenesis. Dev. Neurosci. 1:1978;15-30.
22. Lauder J.M., Wallace J.A., Krebs H., Petrusz P., McCarthy K. In vivo and in vitro development of serotonergic neurons. Brain Res. Bull. 9:1982;605-625.
23. Lidov H.G.W., Molliver M.E. Immunohistochemical study of the development of serotonergic neurons in the rat CNS. Brain Res. Bull. 9:1982;559-604.
24. Menard, I., Crémieux, J., Cazalets, J.-R., Clarac, F. 1990. Postural tonus and development of motor activity in the rat: comparison between swimming and walking. In: T. Brandt, W. Paulus, W. Bles, M. Dieterich, S. Krafczyk, A. Straube (Eds.), Disorders of Posture and Gait. Georg Thieme, Stuttgart, pp. 132-135.
25. Miller F.P., Cox R.H.J.R., Snodgrass W.R., Maickel R.P. Comparative effects of p-chlorophenylalanine, p-chloroamphetamine and p-chloro-N-methylamphetamine on rat brain norepinephrine, serotonin and 5-hydroxyindole-3-acetic acid. Biochem. Pharmacol. 19:1970;435-442.
26. Mori S. Integration of posture and locomotion in acute decerebrate cats and in awake, freely moving cats. Prog. Neurobiol. 28:1987;161-195.
27. Mori S. Contribution of postural muscle tone to full expression of posture and locomotor movements: multi-faceted analyses of its setting brainstem-spinal cord mechanisms in the cat. Jpn. J. Physiol. 39:1989;785-809.
28. Mori, S., Ohta, Y. 1986. Interaction of posture and locomotion and initiation of locomotion in decerebrate cats and freely moving, intact cats. In: S. Grillner, P.S.G. Stein, D.G. Stuart, H. Forssberg, R.M. Herman (Eds.), Neurobiology of Vertebrate Locomotion. Macmillan, London, pp. 55-71.
29. Myoga H., Nonaka S., Matsuyama K., Mori S. Postnatal development of locomotor movements in normal and para-chlorophenylalanine-treated newborn rats. Neurosci. Res. 21:1995;211-221.
30. Nakajima, K., Myoga, H., Matsuyama, K., Mori, S. 1995a. Contribution of serotonergic system to postnatal development of locomotor movements in newborn rats, Fourth IBRO World Congress of Neuroscience [Abstr. 348].
31. Nakajima K., Myoga H., Matsuyama K., Mori S. Postnatal development of swimming movements in relation to maturation of serotoninergic innervation in newborn rats. Jpn. J. Physiol. 45(Suppl. 1):1995;S179.
32. Nakajima K., Miyashita E., Matsuyama K., Mori S. Postnatal development of locomotor capability in relation to maturation of serotoninergic innervation in newborn rats. Jpn. J. Physiol. 45(Suppl. 2):1995;S63.
33. Nakajima K., Matsuyama K., Mori S. Contribution of serotonergic system to the postnatal development of fore- and hindlimb extensor motoneurons in newborn rats. Jpn. J. Physiol. 46:1996;S140.
34. Nakajima K., Matsuyama K., Mori S. Prenatal suppression of serotonergic system results in movement disorders and hypoplasia of extensor motoneurons in newborn rats. Soc. Neurosci. Abstr. 2:1996;1228.
35. Oades R., Isaacson R.L. p-Chlorophenylalanine-produced effects on behavior in intact and brain-damaged rats. Behav. Biol. 20:1977;500-506.
36. Okado N., Cheng L., Tanatsugu Y., Hamada S., Hamaguchi K. Synaptic loss following removal of serotoninergic fibers in newly hatched and adult chikens. J. Neurobiol. 24:1993;687-1993.
37. Olson L., Seiger R. Early prenatal ontogeny of central monoamine neurons in the rat: fluorescence histochemical observations. Z. Anat. Entwickl.-Gesch. 137:1972;301-316.
38. Orlovsky, G.N., Shik, M.L. 1976. Control of locomotion: a neurophysiological analysis of the cat locomotor system. In: R. Porter (Ed.), International Review of Physiology, vol. 2. University of Park Press, Baltimore, pp. 282-317.
39. Salas M. Effects of early malnutrition on the development of swimming ability in the rat. Physiol. Behav. 8:1972;119-122.
40. Schapiro S., Salas M., Vukovic K. Hormonal effects on ontogeny of swimming ability in the rat: assessment of central nervous system development. Science. 168:1970;147-151.
41. Sqalli-Houssaini Y., Cazalets J.R., Clarac F. Oscillatory properties of the cenral pattern generator for locomotion in neonatal rats. J. Neurophysiol. 70:1993;803-813.
42. Steinbusch H.W.M. Distribution of serotonin-immunoreactivity in the central nervous system of the rat-cell bodies and terminals. Neuroscience. 6:1981;557-618.
43. Tagliamonte A., Tagliamonte P., Gessa G.L., Brodie B.B. Compulsive sexual activity induced by p-chlorophenylalanine in normal and pinealectomized male rats. Science. 166:1969;1433-1435.
44. Takeuchi Y., Kimura H., Sano Y. Immunohistochemical demonstration of the distribution of serotonin neurons in the brainstem of the rat and cat. Cell Tissue Res. 224:1982;247-267.
45. Tamásy V., Korányi L., Phelps C.P. The role of dopaminergic and serotonergic mechanisms in the development of swimming ability of young rats. Dev. Neurosci. 4:1981;389-400.
46. Tanaka H., Mori S., Kimura H. Developmental changes in the serotoninergic innervation of hindlimb extensor motoneurons in neonatal rats. Dev. Brain Res. 65:1992;1-12.
47. Tilney F. Behavior in its relation to the development of the brain. II. Correlation between the development of the brain and behavior in the albino rat from embryonic states to maturity. Bull. Neurol. Inst. NY. 3:1933;252-358.
48. Veasey S.C., Fornal C.A., Metzler C.W., Jacobs B.L. Response of serotonergic caudal raphe neurons in relation to specific motor activities in freely moving cats. J. Neurosci. 15:1995;5346-5359.
49. Wallace J.A., Lauder J.M. Development of the serotonergic system in the rat embryo: an immunocytochemical study. Brain Res. Bull. 10:1983;459-479.
50. Westerga J., Gramsbergen A. The development of locomotion in the rat. Dev. Brain Res. 57:1990;163-174.