Relationship between drug dissolution and leaching of plasticizer for pellets coated with an aqueous Eudragit® S100:L100 dispersion

International Journal of Pharmaceutics

Volumn 323, Issue 1-2, 2006, Pages 11-17

  Bando, Hiroto ^a   McGinity, James W ^a  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

Author keywords

Aqueous film coating; Eudragit L100; Eudragit S100; Theophylline; Triethyl citrate

Indexed keywords

CITRIC ACID TRIETHYL ESTER; EUDRAGIT; PLASTICIZER; POLYMER; THEOPHYLLINE;

ARTICLE; DISSOLUTION; DRUG COATING; DRUG SOLUBILITY; DRUG STORAGE; FILM COATING; HUMIDITY; LEACHING; PELLET EXTRUSION; PH; PRIORITY JOURNAL; SCANNING ELECTRON MICROSCOPY; STEADY STATE; STORAGE TEMPERATURE; TIMED DRUG RELEASE;

CITRATES; DELAYED-ACTION PREPARATIONS; DRUG DELIVERY SYSTEMS; DRUG STABILITY; DRUG STORAGE; HUMIDITY; HYDROGEN-ION CONCENTRATION; MICROSCOPY, ELECTRON, SCANNING; POLYMETHACRYLIC ACIDS; TABLETS, ENTERIC-COATED; THEOPHYLLINE;

EID: 33748714320     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.05.043     Document Type: Article

References (15)

1. ® RS30D film-coated sustained-release theophylline pellets. Eur. J. Pharm. Biopharm. 42 (1996) 29-35
2. Bando H., and McGinity J.W. Physicochemical properties of enteric films prepared from aqueous dispersions and organic solutions. Int. J. Pharm. 313 (2006) 43-48
3. Bodmeier R., and Paeratakul O. Leaching of water-soluble plasticizers from polymeric films prepared from aqueous colloidal polymer dispersion. Drug Dev. Ind. Pharm. 18 (1992) 1865-1882
4. Bodmeier R., and Paeratakul O. Mechanical properties of dry and wet cellulosic and acrylic films prepared from aqueous colloidal polymer dispersions use in the coating of solid dosage forms. Pharm. Res. 11 (1994) 882-888
5. Bodmeier R., and Paeratakul O. The effect of curing on drug release and morphological properties of ethylcellulose pseudolatex-coated beads. Drug Dev. Ind. Pharm. 20 (1994) 1517-1533
6. Frohoff-Hülsmann M.A., Scmitz A., and Lippold B.C. Aqueous ethyl cellulose dispersions containing plasticizers of different water solubility and hydroxypropyl methylcellulose as coating material for diffusion pellets. I. Drug release rates from coated pellets. Int. J. Pharm. 177 (1999) 69-82
7. Harris M.R., and Ghebre-Sellassie I. Water based coating process for sustained release. Pharm. Technol. 10 (1986) 102-107
8. ® S 100 combinations. J. Control Release 58 (1999) 215-222
9. Lecomte F., Siepmann J., Walther M., MacRae R.J., and Bodmeier R. Polymer blends used for the aqueous coating of solid dosage form: importance of the type of plasticizer. J. Control Release 99 (2004) 1-13
10. Lehmann K.O.R. Chemistry and application properties of polymethacrylate coating system. In: McGinity J.W. (Ed). Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms (1997), Dekker, New York 101-176
11. McGinity J.W. Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms. second ed. (1997), Marcel Dekker, New York
12. Nagakami H., Keshikawa T., Matsumura M., and Tsukamoto H. Application of aqueous suspensions and latex dispersions of water-insoluble polymers for tablet and granule coatings. Chem. Pharm. Bull. 39 (1991) 1837-1842
13. Obara S., and MacGinity J.W. Properties of free films prepared from aqueous polymers by a spraying technique. Pharm. Res. 11 (1994) 1562-1567
14. Ocarter T.U., and Singla K. The effects of plasticizers on the release of metoprolol tartrate from granules coated with a polymethacrylate film. Drug Dev. Ind. Pharm. 26 (2000) 323-329
15. Saettone M.F., Perini G., Rijli P., Rodriguez L., and Cini M. Effect of different polymer-plasticizer combinations on 'in vitro' release of theophylline from coated pellets. Int. J. Pharm. 126 (1995) 83-88